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Surgical and financial impact of delayed cholecystectomy in mild and moderate acute cholecystitis

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Summary

Background

Emergency cholecystectomy (EC) for acute cholecystitis (AC) has developed an increasing interest in recent years but is still not widely employed in the UK. This study aims to address the impact of delayed cholecystectomy (DC) for mild and moderate AC, with a special focus on the financial aspect, which has not been discussed much in the literature.

Methods

In this prospective cohort study, we included two groups of patients in whom cholecystectomy was performed for mild or moderate cholecystitis between March and September 2018. The first group included all patients who underwent EC while the second included patients who underwent elective cholecystectomy following a previous admission with AC. Operative complications, length of stay (LOS), number of investigations, and the financial difference between both groups were compared.

Results

There were 45 patients in each group. In the DC group, 7 patients (15%) had their laparoscopic cholecystectomies converted to open, and 5 (11%) developed postoperative complications (one postoperative bleeding requiring emergency laparotomy, one biliary leakage treated with biliary stenting, and three postoperative infected collections). While awaiting DC, 19 patients (42%) were readmitted with gallstone complications. The total LOS for hospital readmissions was 98 days vs. 5 days in the EC group. The estimated cost of the repeated admissions and reinvestigations in the DC group was £ 71,456. There was one postoperative complication in the EC group.

Conclusion

Delayed cholecystectomy for mild and moderate cholecystitis was associated with more operative complications and extra financial costs compared to emergency cholecystectomy.

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References

  1. Beckingham I, Macutkiewicz C, Toogood G, Maynard N. Pathway for the management of acute gallstone diseases. Assoc. Up. Gastrointest Surg. 2014;:1–12. https://doi.org/10.1007/s10353-021-00701-3.

  2. National Institute for Health and Care Excellence. Gallstone Disease. NICE Guidelines CG188. 2014. https://www.nice.org.uk/guidance/cg188. Accessed 27 Dec 2020.

  3. Suter M, Meyer A. A 10-year experience with the use of laparoscopic cholecystectomy for acute cholecystitis: is it safe? Surg Endosc. 2001;15:1187–92.

    Article  CAS  Google Scholar 

  4. Hunter JG. Acute cholecystitis revisited: get it while it’s hot. Ann Surg. 1998;227:468–9.

    Article  CAS  Google Scholar 

  5. Cox MR, Wilson TG, Luck AJ, Jeans PL, Padbury RT, Toouli J. Laparoscopic cholecystectomy for acute inflammation of the gallbladder. Ann Surg. 1993;218:630–4.

    Article  CAS  Google Scholar 

  6. Miller RE, Kimmelstiel FM. Laparoscopic cholecystectomy for acute cholecystitis. Surg Endosc. 1993;7:296–9.

    Article  CAS  Google Scholar 

  7. Song G‑M, Bian W, Zeng X‑T, Zhou J‑G, Luo Y‑Q, Tian X. Laparoscopic cholecystectomy for acute cholecystitis: early or delayed?: Evidence from a systematic review of discordant meta-analyses. Medicine. 2016;95:e3835.

    Article  CAS  Google Scholar 

  8. Mayumi T, Takada T, Kawarada Y, Nimura Y, Yoshida M, Sekimoto M, et al. Results of the Tokyo consensus meeting Tokyo guidelines. J Hepatobiliary Pancreat Surg. 2007;14:114–21.

    Article  Google Scholar 

  9. Yamashita Y, Takada T, Strasberg SM, Pitt HA, Gouma DJ, Garden OJ et al. TG13 surgical management of acute cholecystitis. J Hepatobiliary Pancreat Sci. 2013;20:89–96.

    Article  Google Scholar 

  10. Okamoto K, Suzuki K, Takada T, Strasberg SM, Asbun HJ, Endo I et al. Tokyo Guidelines 2018: flowchart for the management of acute cholecystitis. J Hepatobiliary Pancreat Sci. 2018;25:55–72.

    Article  Google Scholar 

  11. Boshnaq MH, Merali N, El Abbassy IH, Eldesouky SA, Rabie MA. Financial burden secondary to delay in cholecystectomy following mild biliary pancreatitis. J Investig Surg. 2017;30:170–6.

    Article  Google Scholar 

  12. Lau H, Lo CY, Patil NG, Yuen WK. Early versus delayed-interval laparoscopic cholecystectomy for acute cholecystitis: a metaanalysis. Surg Endosc. 2006;20:82–7.

    Article  CAS  Google Scholar 

  13. Shikata S, Noguchi Y, Fukui T. Early versus delayed cholecystectomy for acute cholecystitis: a meta-analysis of randomized controlled trials. Surg Today. 2005;35:553–60.

    Article  Google Scholar 

  14. Siddiqui T, MacDonald A, Chong PS, Jenkins JT. Early versus delayed laparoscopic cholecystectomy for acute cholecystitis: a meta-analysis of randomized clinical trials. Am J Surg. 2008;195:40–7.

    Article  Google Scholar 

  15. Amin A, Haider MI, Aamir IS, Khan MS, Khalid Choudry U, Amir M, et al. Preoperative and operative risk factors for conversion of laparoscopic cholecystectomy to open cholecystectomy in Pakistan. Cureus. 2019;11:e5446.

    PubMed  PubMed Central  Google Scholar 

  16. Sanjay P, Mittapalli D, Marioud A, White RD, Ram R, Alijani A. Clinical outcomes of a percutaneous cholecystostomy for acute cholecystitis: a multicentre analysis. HPB. 2013;15:511–6.

    Article  Google Scholar 

  17. Senapati PSP, Bhattarcharya D, Harinath G, Ammori BJ. A survey of the timing and approach to the surgical management of cholelithiasis in patients with acute biliary pancreatitis and acute cholecystitis in the UK. Ann R Coll Surg Engl. 2003;85:306–12.

    Article  CAS  Google Scholar 

  18. Cao AM, Eslick GD, Cox MR. Early cholecystectomy is superior to delayed cholecystectomy for acute cholecystitis: a meta-analysis. J Gastrointest Surg. 2015;19:848–57.

    Article  Google Scholar 

  19. Gurusamy K, Samraj K, Gluud C, Wilson E, Davidson BR. Meta-analysis of randomized controlled trials on the safety and effectiveness of early versus delayed laparoscopic cholecystectomy for acute cholecystitis. Br J Surg. 2010;97:141–50.

    Article  CAS  Google Scholar 

  20. Kerwat D, Zargaran A, Bharamgoudar R, Arif N, Bello G, Sharma B, et al. Early laparoscopic cholecystectomy is more cost-effective than delayed laparoscopic cholecystectomy in the treatment of acute cholecystitis. Clinicoecon Outcomes Res. 2018;10:119–25.

    Article  Google Scholar 

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Correspondence to Mohamed Rabie MD MRCS.

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Conflict of interest

M. Rabie, M. Boshnaq, S. Eldesouky, and I. Elabbassy declare that they have no competing interests.

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Institutional approval was granted through registration as a clinical audit.

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The data that support the findings of this study are available from the corresponding author (MR) upon reasonable request.

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Rabie, M., Boshnaq, M., Eldesouky, S. et al. Surgical and financial impact of delayed cholecystectomy in mild and moderate acute cholecystitis. Eur Surg 54, 39–43 (2022). https://doi.org/10.1007/s10353-021-00701-3

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