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Regulation der Laktation

Regulation of lactation

  • Leitthema
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Gynäkologische Endokrinologie Aims and scope

Zusammenfassung

Das menschliche Neugeborene ist zum Zeitpunkt der Geburt unreif. Diese Unreife betrifft u. a. die Funktion des Magen-Darm-Traktes sowie das Immunsystem. Während der Laktation erwirbt das Neugeborene nach und nach die zum Zeitpunkt der Geburt fehlenden Kompetenzen. Daher stellt die Laktation einen elementar wichtigen Vorgang für die physiologische Entwicklung des Kindes dar. Die Regulation der Laktation erfolgt in einem komplexen Zusammenspiel zahlreicher hormoneller Faktoren, bei denen insbesondere Prolaktin und Oxytocin eine Schlüsselrolle besitzen. Die Prolaktin- und Oxytocinsekretion der Hypophyse unterliegt ihrerseits komplexen zentralen Regelmechanismen, die z. T. auch durch äußere Einflüsse—z. B. Medikamenteneinwirkung—empfindlich gestört werden können. In diesen Fällen kann es u. a. zu einer Störung der Laktation kommen. Die Kenntnis der physiologischen Zusammenhänge stellt die Grundlage zum Verständnis des Laktationsvorganges dar und erlaubt eine Einordnung der verschiedenen Faktoren, die sich z. T. negativ auf die Laktation auswirken können.

Abstract

At birth the human newborn is immature and has not yet acquired fully competent organ functions. During lactation especially the digestive tract and the immune system gain competence. Lactation is regulated by a complex interaction of numerous hormonal factors. Most important are probably prolactin and oxytocin—two hormones produced and secreted in the pituitary. The production and secretion of these two hormones is again regulated by several factors in the central nervous system and these mechanisms can be disturbed by a variety of exogenous factors such as drugs and any other substances interacting with dopamine metabolism in the brain. It is important to know these physiological interactions to be able to understand the regulation of lactation and to be able to assess which factors could interfere with this process.

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Authors and Affiliations

  1. Universitätsfrauenklinik, Freiburg

    C. Keck & C. Kissel

  2. Universitätsfrauenklinik, Hugstetter Straße 55, 79106 , Freiburg

    C. Keck

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  1. C. Keck
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  2. C. Kissel
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Correspondence to C. Keck.

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Keck, C., Kissel, C. Regulation der Laktation. Gynäkologische Endokrinologie 2, 127–132 (2004). https://doi.org/10.1007/s10304-004-0076-3

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  • DOI: https://doi.org/10.1007/s10304-004-0076-3

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