Skip to main content
SpringerLink
Log in

Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: the impact on renal function

  • Article
  • Published:
European Journal of Clinical Microbiology & Infectious Diseases Aims and scope Submit manuscript

Abstract

Dobrava (DOBV) and Puumala (PUUV) viruses are endemic throughout the Balkans and cause haemorrhagic fever with renal syndrome (HFRS). The aim of this study was to assess the impact of two different hantaviruses on renal function in HFRS patients during the acute stage of illness. We also aimed to assess the DOBV and PUUV distribution between symptomatic HFRS patients and asymptomatic hantavirus antibody-positive subjects. The study included 264 symptomatic HFRS patients and 63 asymptomatic hantavirus antibody-positive healthy subjects. In our study, 131 (49.6%) HFRS patients were regarded as PUUV- and 69 (26.1%) as DOBV-infected patients, while in 64 (24.2%) of HFRS patients that showed all clinical and biochemical signs of HFRS, the causal hantavirus could not be determined with commercially available tests. DOBV-infected patients were associated with more requirements for haemodialysis treatment, lower diuresis and higher serum creatinine and urea values compared to PUUV-infected patients. PUUV was significantly predominant in asymptomatic hantavirus antibody-positive subjects (69.8%) compared to HFRS patients. DOBV was present in 17.5% of asymptomatic subjects and, interestingly, the preferential hantavirus serotype could not be determined in 12.7% of the asymptomatic antibody-positive subjects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Heyman P, Vaheri A; ENIVD Members (2008) Situation of hantavirus infections and haemorrhagic fever with renal syndrome in European countries as of December 2006. Euro Surveill 13(28). Available online at: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=18925

  2. Bi Z, Formenty PB, Roth CE (2008) Hantavirus Infection: a review and global update. J Infect Dev Ctries 2(1):3–23

    Article  PubMed  Google Scholar 

  3. Lednicky JA (2003) Hantaviruses. A short review. Arch Pathol Lab Med 127:30–35

    PubMed  Google Scholar 

  4. Vapalahti O, Mustonen J, Lundkvist A et al (2003) Hantavirus infections in Europe. Lancet Infect Dis 3:653–752

    Article  PubMed  Google Scholar 

  5. Gaon J, Karlovac M, Gresikova M et al (1968) Epidemiological features of hemorrhagic fever. Folia Med Sar 3:23–43

    Google Scholar 

  6. Hukić M, Muzaferović S, Tulumović D et al (2003) Puumala and Dobrava viruses in the northeastern and central regions of Bosnia. Acta Med Croatica 57:373–380

    PubMed  Google Scholar 

  7. Gligic A, Stojanovic R, Obradovic M et al (1992) Hemorrhagic fever with renal syndrome in Yugoslavia: epidemiologic and epizootiologic features of a nationwide outbreak in 1989. Eur J Epidemiol 8:816–825

    Article  CAS  PubMed  Google Scholar 

  8. Markotić A, LeDuc JW, Hlaca D et al (1996) Hantaviruses are likely threat to NATO forces in Bosnia and Herzegovina and Croatia. Nat Med 2:269–270

    Article  PubMed  Google Scholar 

  9. Hukić M, Kurt A, Torstensson S et al (1996) Haemorrhagic fever with renal syndrome in north-east Bosnia. Lancet 347:56–57

    PubMed  Google Scholar 

  10. Lundkvist A, Hukić M, Hörling J et al (1997) Puumala and Dobrava viruses cause hemorrhagic fever with renal syndrome in Bosnia-Herzegovina: evidence of highly cross-neutralizing antibody responses in early patient sera. J Med Virol 53:51–59

    Article  CAS  PubMed  Google Scholar 

  11. Hukić M, Tulumović D, Calkić L (2005) The renal failure and capillary leak during the acute stage of (Dobrava) DOB and PUU (Puumala) infection. Med Arh 59(4):227–230

    PubMed  Google Scholar 

  12. Tulumovic D, Imamovic G, Mesic E et al (2009) Comparison of the effects of Puumala and Dobrava viruses on early and long-term renal outcomes in patients with haemorrhagic fever with renal syndrome. Nephrology 15(3):340–343

    Article  Google Scholar 

  13. Cebalo L, Dusek T, Kuzman I et al (2003) Grading the severity of disease in patients with Puumala or Dobrava virus infections from 1995 to 2000 in Croatia. Acta Med Croatica 57(5):355–359

    PubMed  Google Scholar 

  14. Puljiz I, Kuzman I, Turcinov D et al (2003) Clinical and epidemiologic characteristics of hemorrhagic fever with renal syndrome in patients treated at the Dr. Fran Mihaljević Clinic for Infectious Diseases in Zagreb. Acta Med Croatica 57(5):347–353

    PubMed  Google Scholar 

  15. Pal E, Strle F, Avsic-Zupanc T (2005) Hemorrhagic fever with renal syndrome in the Pomurje region of Slovenia—an 18-year survey. Wien Klin Wochenschr 117(11–12):398–405

    Article  PubMed  Google Scholar 

  16. Medved MM, Markotić A, Cebalo L et al (2002) Haemorrhagic fever with renal syndrome in Croatia. Lancet 360(9330):415–416

    Article  PubMed  Google Scholar 

  17. Markotić A, Nichol ST, Kuzman I et al (2002) Characteristics of Puumala and Dobrava infections in Croatia. J Med Virol 66(4):542–551

    Article  PubMed  Google Scholar 

  18. Kuzman I (2003) Clinical picture of hemorrhagic fever with renal syndrome in Croatia. Acta Med Croatica 57(5):393–397

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Clinical Microbiology, Clinical Center University of Sarajevo, Sarajevo, Bosnia and Herzegovina

    M. Hukić

  2. Department of Physiology, Institute of Physiology and Biochemistry, Medical Faculty, University of Sarajevo, Sarajevo, Bosnia and Herzegovina

    A. Valjevac

  3. Clinic for Nephrology, Urology, Dialysis and Renal Transplantation, University Clinical Centre Tuzla, Tuzla, Bosnia and Herzegovina

    D. Tulumovic

  4. Department of Microbiology, Clinic for Laboratory Diagnosis, University Clinic Centre Tuzla, Tuzla, Bosnia and Herzegovina

    F. Numanovic

  5. Research Laboratory for Vector-Borne Diseases, National Reference Laboratory for Hantavirus Infections, Div. Well-Being/Health/Epi&Biostat, Queen Astrid Military Hospital, Bruynstraat 1, Brussels, 1120, Belgium

    P. Heyman

Authors
  1. M. Hukić
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. A. Valjevac
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Tulumovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. F. Numanovic
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. P. Heyman
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to P. Heyman.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Hukić, M., Valjevac, A., Tulumovic, D. et al. Pathogenicity and virulence of the present hantaviruses in Bosnia and Herzegovina: the impact on renal function. Eur J Clin Microbiol Infect Dis 30, 381–385 (2011). https://doi.org/10.1007/s10096-010-1097-6

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10096-010-1097-6

Keywords

Search

Navigation