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DASH diet and change in serum uric acid over time

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Abstract

The Dietary Approaches to Stop Hypertension (DASH) diet lowers serum uric acid (SUA) levels compared to the typical American (control) diet. However, the time required for the DASH diet to take effect is unknown. We analyzed data from a parallel arm, randomized-controlled trial in pre-hypertensive or hypertensive adults (N = 103), comparing the effects of DASH or a control diet on SUA measured at 30, 60, and 90 days. Effects were examined overall and within stratified subgroups based on baseline SUA status (SUA ≥6 mg/dL vs <6 mg/dL). The mean age of participants was 51.5 ± 9.7 years, 55% were women, 75% were black, 42% were obese, and 34% had hypertension. Twenty-four of the 103 (23%) participants had a baseline SUA ≥6 mg/dL. Overall, compared to the control, DASH lowered SUA by 0.5 mg/dL at 30 and 90 days. Among participants with baseline SUA ≥6 mg/dL, DASH lowered SUA by 0.8 and 1.0 mg/dL at 30 and 90 days, respectively. These findings demonstrate that the DASH diet reduces SUA within 30 days, with a sustained effect at 90 days, which is informative for healthcare providers counseling patients on time course expectations for uric acid reduction in response to dietary modification.

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Abbreviations

SUA:

Serum uric acid

DASH:

Dietary Approaches to Stop Hypertension

CI:

Confidence interval

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Acknowledgements

Supported by cooperative agreements and grants from the National Heart, Lung, and Blood Institute (U01-HL57173, to Brigham and Women’s Hospital; U01-HL57114, to Duke University; U01-HL57190, to Pennington Biomedical Research Institute; U01-HL57139 and K08 HL03857-01, to Johns Hopkins University; and U01-HL57156, to Kaiser Permanente Center for Health Research) and by the General Clinical Research Center Program of the National Center for Research Resources (M01-RR02635, to Brigham and Women’s Hospital, and M01-RR00722, to Johns Hopkins University). NIAMS R01-AR065944, to Massachusetts General Hospital.

OT is supported by the NIH Medical Scientist Training Program Grant 5T32GM007309. SPJ is supported by a NIH/NIDDK T32DK007732-20 Renal Disease Epidemiology Training Grant.

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Authors and Affiliations

  1. Johns Hopkins University School of Medicine, Baltimore, USA

    Olive Tang, Edgar R. Miller III, Allan C. Gelber, Lawrence J. Appel & Stephen P. Juraschek

  2. Johns Hopkins Medical Institutions, 2024 East Monument Street, Suite 1-500, Baltimore, MD, 21205, USA

    Olive Tang, Edgar R. Miller III, Allan C. Gelber, Lawrence J. Appel & Stephen P. Juraschek

  3. The Johns Hopkins Bloomberg School of Public Health, and The Welch Center for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA

    Edgar R. Miller III, Allan C. Gelber, Lawrence J. Appel & Stephen P. Juraschek

  4. Harvard Medical School and Massachusetts General Hospital, Boston, MA, USA

    Hyon K. Choi

Authors
  1. Olive Tang
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  2. Edgar R. Miller III
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  3. Allan C. Gelber
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  4. Hyon K. Choi
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  5. Lawrence J. Appel
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  6. Stephen P. Juraschek
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Correspondence to Stephen P. Juraschek.

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Additional information

This trial is registered at clinicaltrials.gov, number: NCT00000608

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Tang, O., Miller, E.R., Gelber, A.C. et al. DASH diet and change in serum uric acid over time. Clin Rheumatol 36, 1413–1417 (2017). https://doi.org/10.1007/s10067-017-3613-x

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  • DOI: https://doi.org/10.1007/s10067-017-3613-x

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