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Komplementärer Einsatz von Antioxidanzien und Mikronährstoffen in der Onkologie

Update 2013

Complementary use of antioxidants and micronutrients in oncology

Update 2013

  • Leitthema
  • Published:
Der Onkologe Aims and scope

Zusammenfassung

Hintergrund

Je nach Tumorentität und Geschlecht supplementieren bis zu 90% der onkologischen Patienten ihre Therapie mit antioxidativen und immunstabilisierenden Mikronährstoffen, häufig ohne das Wissen des behandelnden Arztes.

Methoden

Anhand der publizierten wissenschaftlichen Daten und anderweitigen verfügbaren Informationen, z. B. Homepages, ESPEN-Guidelines, wurden Alternativen zur Schulmedizin beurteilt.

Ergebnisse

Obwohl berechtigte Bedenken von onkologischer Seite bestehen, dass Nahrungsergänzungsmittel die Effektivität der Chemo- oder Strahlentherapie beeinträchtigen könnten, geben aktuelle Studien zunehmend Hinweise darauf, dass die medikationsorientierte Supplementierung von Antioxidanzien und anderen Mikronährstoffen wie Selen, L-Carnitin und Vitamin D das Ansprechen auf die antineoplastischen Verfahren (CT, RT) durch eine bessere Compliance, eine verringerte Rate an Nebenwirkungen und somit auch an Therapieabbrüchen steigern, sondern auch die Lebensqualität und die Prognose der onkologischen Patienten verbessern kann.

Schlussfolgerung

Onkologisch tätige Ärzte sollten über die Bedeutung von Selen und anderen Mikronährstoffen sowie potenziellen Interaktionen mit der Krebstherapie informiert sein.

Abstract

Context

Many patients being treated for cancer use micronutrient supplements with the intention to complement the cancer treatment or help them cope with the therapy and disease-associated side-effects. Up to 90 % of cancer patients supplement with antioxidants without the knowledge of the treating physician.

Methods

Alternatives to textbook medicine were assessed from published scientific data and otherwise available information, e.g. homepages, ESPEN-Guidelines.

Results

There are many concerns that antioxidants might decrease the effectiveness of chemotherapy but increasing evidence suggests a benefit when antioxidants and other micronutrients, such as selenium, L-carnitine and vitamin D are added to conventional cytotoxic therapies.

Conclusion

However, it is imperative that physicians explore the use of antioxidant and other micronutrient supplements with cancer patients and educate them about potentially negative and also potentially beneficial effects.

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Authors and Affiliations

  1. Akademie für Mikronährstoffmedizin, Zweigertstraße 55, 45130, Essen, Deutschland

    U. Gröber, P. Holzhauer & K. Kisters

  2. Klinik für Strahlentherapie, Klinikum Lippe GmbH, Lemgo, Deutschland

    R. Mücke

  3. Klinik für Strahlentherapie und Radio-Onkologie, Ruhr Universität Bochum, Bochum, Deutschland

    R. Mücke & I.A. Adamietz

  4. Innere Medizin II - Onkologie und Komplementärmedizin, Klinik Bad Trissl, Oberaudorf, Deutschland

    P. Holzhauer

  5. Medizinische Klinik I, St. Anna Hospital, Herne, Deutschland

    K. Kisters

  6. Klinik für Hals-, Nasen- und Ohrenheilkunde, Südharz-Krankenhaus Nordhausen gGmbH, Nordhausen, Deutschland

    J. Büntzel

  7. Klinik für Strahlentherapie und Radioonkologie, Franziskus Hospital Bielefeld gGmbH, Bielefeld, Deutschland

    O. Micke

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  1. U. Gröber
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  2. R. Mücke
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Correspondence to U. Gröber.

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Gröber, U., Mücke, R., Adamietz, I. et al. Komplementärer Einsatz von Antioxidanzien und Mikronährstoffen in der Onkologie. Onkologe 19, 136–143 (2013). https://doi.org/10.1007/s00761-012-2385-9

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