Abstract
A 48-year-old woman developed a mobile abdominal mass in the course of treatment for recurrent breast cancer. Imaging studies indicated linitis plastica of the colon. She underwent surgery because of the stenosis of the transverse colon. An examination of the resected specimen revealed a segmental stricture, thickening of the entire wall, and a granular mucosa resembling cobblestones. Microscopic findings of the colon lesion were very similar to those of her primary, invasive lobular carcinoma of the breast. Atypical cells showed immunoreactivity for cytokeratin-7, but not for cytokeratin-20. These findings suggested that the lesion of the colon was a colonic metastasis of breast cancer. Metastatic gastrointestinal diseases originating from breast carcinoma are unusual, and colonic metastases are especially rare. Although colon cancer may occur in patients with a history of breast cancer, metastatic colon cancer should be suspected if linitis plastica is detected.
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References
Fahr JC, Dockerty MB, Judd ES. Scirrhous carcinoma of the colon and rectum. Surg Gynecol Obstet 1960;111:759–766.
Law WL, Chu KW. Scirrhous colonic metastasis from ductal carcinoma of the breast. Dis Colon Rectum 2003;46:1424–1427.
Voravud N, El-Naggar AK, Balch CM, Theriault RL. Metastatic lobular breast carcinoma simulating primary colon cancer. Am J Clin Oncol 1992;15:365–369.
Rabau MY, Alon RJ, Werbin N, Yossipov Y. Colonic metastases from lobular carcinoma of the breast; Report of a case. Dis Colon Rectum 1988;31:401–402.
Fayemi AO, Ali M, Braun EV. Metastatic carcinoma simulating linitis plastica of the colon. Am J Gastroenterol 1979;71:311–314.
Savanis G, Simatos G, Tzaida O, Tsikkinis C, Ammari S, Mylonas A, et al. Gastrointestinal tract metastasis as first presentation of breast cancer. J BUON 2006;11:79–81.
Dhar S, Kulaylat MN, Gordon K, Lall P, Doerr RJ. Solitary papillary breast carcinoma metastasis to the large bowel presenting as primary colon carcinoma: case report and review of the literature. Am Surg 2003;69:799–803.
Signorelli C, Pomponi-Formiconi D, Nelli F, Pollera CF. Single colon metastasis from breast cancer: A clinical case report. Tumori 2005;91:424–427.
Koutsomanis D, Renier JF, Ollivier R, Moran A, el-Haite AA. Colonic metastasis of breast carcinoma. Hepatogastroenterology 2000;47:681–682.
Schwarz RE, Klimstra DS, Turnbull AD. Metastatic breast cancer masquerading as gastrointestinal primary. Am J Gastroenterol 1998;93:111–114.
Ohkawa Y, Misawa K, Taguchi K, Kikuchi K, Takeda K, Sano H. A case of colon metastasis from breast cancer diagnosed by laparoscopic biopsy. J Jpn Surg Assoc 2006;67:2136–2141.
Harris M, Howell A, Chrissohou M, Swindell RIC, Hudson M, Sellwood RA. A comparison of the metastatic pattern of infiltrating lobular carcinoma and infiltrating duct carcinoma of the breast. Br J Cancer 1984;50:23–30.
Borst MJ, Ingold JA. Metastatic patterns of invasive lobular versus invasive ductal carcinoma of the breast. Surgery 1993;114:637–642.
Acs G, Lawton TJ, Rebbeck TR, LiVolsi VA, Zhang PJ. Differential expression of E-cadherin in lobular and ductal neoplasms of the breast and its biologic and diagnostic implications. Am J Clin Pathol 2001;115:85–98.
Graham WP III, Goldman L. Gastro-intestinal metastases from carcinoma of the breast. Ann Surg 1964;159:447–480.
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Okido, M., Seo, M., Hamada, Y. et al. Metastatic breast carcinoma simulating linitis plastica of the colon: Report of a case. Surg Today 41, 542–545 (2011). https://doi.org/10.1007/s00595-009-4305-1
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DOI: https://doi.org/10.1007/s00595-009-4305-1