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Health-related quality of life and treatment preferences in adolescents with type 1 diabetes. The VIPKIDS study

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Abstract

A multi-centre, observational, cross-sectional study was carried out to determine whether the health-related quality of life (HRQOL) of adolescents with type 1 diabetes is affected by different insulin treatment systems, and which features of HRQOL are impacted by the respective insulin treatment. The study regarded 577 adolescents, aged 10–17 years, with type 1 diabetes treated with continuous subcutaneous insulin infusion (CSII) (n = 306) or multiple daily injections (MDI) (n = 271). The Insulin Delivery System Rating Questionnaire was validated in Italian and was self-completed by the subjects during a routine visit to the centres. Subjects were compared following the domains of the questionnaire. Good HRQOL was seen in subjects treated with either MDI or CSII. Significant differences were not found in the domains for general diabetes, including diabetes worries, social burden and psychological well-being. Multiple quantile regression analysis showed that CSII confers significant advantages in terms of HRQOL with improvements in treatment satisfaction, perceived clinical efficacy and reduction in treatment interference with daily activities. This favourable impact was more evident in subjects reporting lower HRQOL scores, suggesting that CSII may be especially useful for individuals perceiving a poor HRQOL. Analysis of the domains indicated that CSII was associated with a higher HRQOL than MDI. Life-course HRQOL evaluation using a standardised questionnaire can ensure better chronic disease management. This is particularly important when providing individualised care for adolescents, as they become increasingly responsible for managing their diabetes.

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References

  1. Diabetes Control and Complications Trial Research Group (1994) Effect of intensive diabetes treatment on the development and progression of long-term complications in adolescents with insulin-dependent diabetes mellitus. J Pediatr 125:177–188

    Article  Google Scholar 

  2. Kaufman FR, Halvorson M, Miller D, Mackenzie M, Fisher LK, Pitukcheewanont P (1999) Insulin pump therapy in type 1 pediatric patients: now and into the year 2000. Diabetes Metab Res Rev 15:338–352

    Article  CAS  PubMed  Google Scholar 

  3. Pickup J, Keen H (2002) Continuous subcutaneous insulin infusion at 25 years: evidence base for expanding use of insulin pump therapy in type 1 diabetes. Diabetes Care 25:593–598

    Article  PubMed  Google Scholar 

  4. Sulmont V, Lassmann-Vague V, Guerci B et al (2011) Access of children and adolescents with type 1 diabetes to insulin pump therapy has greatly increased in France since 2001. Diabetes Metab 37:59–63

    Article  CAS  PubMed  Google Scholar 

  5. Pinelli L, Rabbone I, Salardi S et al (2008) Insulin pump therapy in children and adolescents with type 1 diabetes: the Italian viewpoint. Acta Biomed 79:57–64

    PubMed  Google Scholar 

  6. Jeitler K, Horvath A, Berghold TW et al (2008) Continuous subcutaneous insulin infusion versus multiple daily insulin injections in patients with diabetes mellitus: systematic review and meta-analysis. Diabetologia 51:941–951

    Article  CAS  PubMed  Google Scholar 

  7. Pickup JC, Sutton AJ (2008) Severe hypoglycaemia and glycaemic control in type 1 diabetes: meta-analysis of multiple daily insulin injections compared with continuous subcutaneous insulin infusion. Diabet Med 25:765–774

    Article  CAS  PubMed  Google Scholar 

  8. Pańkowska E, Błazik M, Dziechciarz P, Szypowska A, Szajewska H (2009) Continuous subcutaneous insulin infusion versus multiple daily injections in children with type 1 diabetes: a systematic review and meta-analysis of randomized control trials. Pediatr Diabetes 10:52–58

    Article  PubMed  Google Scholar 

  9. Valenzuela JM, Patino AM, McCullough J et al (2006) Insulin pump therapy and health-related quality of life in children and adolescents with type 1 diabetes. J Pediatr Psychol 31:650–660

    Google Scholar 

  10. Nuboera R, Bruining GJ (2006) Cost-effectiveness of continuous subcutaneous insulin infusion (CSII) in children: illusion or delusion? Pediatr Diabetes 7(Suppl 4):39–44

    Article  Google Scholar 

  11. Peyrot M, Rubin RR (2005) Validity and reliability of an instrument for assessing health-related quality of life and treatment preferences: the insulin delivery system rating questionnaire. Diabetes Care 28:53–58

    Article  PubMed  Google Scholar 

  12. Koenker R (2005) Quantile regression. Cambridge University Press, New York

    Book  Google Scholar 

  13. Lawshe CH (1975) A quantitative approach to content validity. Pers Psychol 28:563–575

    Article  Google Scholar 

  14. Ghazanfari Z, Niknami S, Ghofranipour F, Hajizadeh E, Montazeri A (2010) Development and psychometric properties of a belief-based physical activity questionnaire for diabetic patients (PAQ-DP). BMC Med Res Methodol 10:104

    Article  PubMed Central  PubMed  Google Scholar 

  15. Misso ML, Egberts KJ, Page M, O’Connor D, Shaw J (2010) Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus. Cochrane Database Syst Rev 20:CD005103

    Google Scholar 

  16. Cummins E, Royle P, Snaith A et al (2010) Clinical effectiveness and cost-effectiveness of continuous subcutaneous insulin infusion for diabetes: systematic review and economic evaluation. Health Technol Assess 14:1–181

    Google Scholar 

  17. Bangstad HJ, Danne T, Deeb L, Jarosz-Chobot P, Urakami T, Hanas R (2009) Insulin treatment in children and adolescents. Pediatr Diabetes 10(Suppl 12):82–99

    Article  PubMed  Google Scholar 

  18. Rubin RR, Peyrot M, STAR 3 Study Group (2012) Health-related quality of life and treatment satisfaction in the sensor-augmented pump therapy for A1C reduction 3 (STAR 3) trial. Diabetes Technol Ther 14(2):143–151

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

The authors thank the patients and their families for their participation and Renee Bowers (42 Rue De Namur, 100, Brussels, Belgium, renee.bowers13@gmail.com) for her assistance in writing the manuscript.

Conflict of interest

Authors have no relevant conflict of interest to disclose.

Author information

Authors and Affiliations

  1. Division of Pediatric Diabetes, Maternal-Infant Department, AOU OO RR Ancona, “G. Salesi” Hospital, Via Corridoni, 11, 60123, Ancona, Italy

    V. Cherubini

  2. Centre of Epidemiology and Biostatistics, Polytechnic University of Marche, Ancona, Italy

    R. Gesuita & F. Carle

  3. Centre of Paediatric Diabetology, San Raffaele Hospital, Milan, Italy

    R. Bonfanti

  4. Centre of Paediatric Diabetology, University Federico II, Naples, Italy

    A. Franzese

  5. Unit of Paediatric Diabetes, Brotzu Hospital, Cagliari, Italy

    A. P. Frongia

  6. Centre of Paediatric Diabetology, Second University of Naples, Naples, Italy

    D. Iafusco

  7. Maternal-Infant Department, AOU OO RR Ancona, Ancona, Italy

    A. Iannilli

  8. Department of Paediatrics, University of Messina, Messina, Italy

    F. Lombardo

  9. Centre of Paediatric Diabetology, University of Verona, Verona, Italy

    A. Sabbion

  10. SCDU Paediatric Diabetes, University of Turin, Turin, Italy

    I. Rabbone

  11. Department of Paediatrics, Insubria University, Varese, Italy

    A. Salvatoni

  12. Centre of Paediatric Diabetology, Sacco Hospital, Milan, Italy

    A. Scaramuzza

  13. Centre of Paediatric Diabetology, Bambino Gesù Hospital, Rome, Italy

    R. Schiaffini

  14. Centre of Paediatric Diabetology, University La Sapienza, Rome, Italy

    N. Sulli

  15. Centre of Paediatric Diabetology, AOU Meyer, Florence, Italy

    S. Toni

  16. Centre of Paediatric Diabetology, University of Chieti, Chieti, Italy

    S. Tumini

  17. Department of Sciences and Biomedical Technologies, University of Milan, Milan, Italy

    A. Mosca

Authors
  1. V. Cherubini
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  2. R. Gesuita
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  3. R. Bonfanti
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  4. A. Franzese
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  5. A. P. Frongia
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  6. D. Iafusco
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  7. A. Iannilli
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  8. F. Lombardo
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  9. I. Rabbone
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  10. A. Sabbion
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  11. A. Salvatoni
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  12. A. Scaramuzza
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  13. R. Schiaffini
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  14. N. Sulli
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  15. S. Toni
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  16. S. Tumini
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  17. A. Mosca
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  18. F. Carle
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Consortia

VIPKIDS Study Group

Corresponding author

Correspondence to V. Cherubini.

Additional information

Communicated by Guido Pozza.

Valentino Cherubini and Rosaria Gesuita contributed equally to this paper.

Appendix

Appendix

VIPKIDS Study Group.

Salzano Giusy (Messina).

Daniele Spiri, Gian Vincenzo Zuccotti (Milano).

Biagioni Martina, Francesca Rosati, Chiara Giorgetti (Ancona).

Pietro Buono (Napoli).

Renata Paleari (Milano).

Chiara Carducci (Roma).

Giulio Frontino, Roselia Battaglino (Milano).

Alessia Di Stefano (Chieti).

Franco Cerutti (Torino).

Claudio Maffeis (Verona).

Monica Guasti, Lorenzo Lenzi (Firenze).

Stefano Chiaravalli (Varese).

Alessia Di Stefano (Chieti).

Angela Zanfardino (Napoli).

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Cherubini, V., Gesuita, R., Bonfanti, R. et al. Health-related quality of life and treatment preferences in adolescents with type 1 diabetes. The VIPKIDS study. Acta Diabetol 51, 43–51 (2014). https://doi.org/10.1007/s00592-013-0466-x

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  • DOI: https://doi.org/10.1007/s00592-013-0466-x

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