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Peribulbar block in patients scheduled for eye procedures and treated with clopidogrel

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Abstract

Our hypothesis was that the continuation of clopidogrel does not increase the risk of eye hemorrhage, compared to patients not treated with clopidogrel, when a peribulbar anesthesia is required. Our prospective case-control study enrolled two groups of 1,000 patients scheduled for intraocular eye surgery requiring a peribulbar block. Patients treated with clopidogrel were included in group A (1,000 patients). Patients who had never been treated with clopidogrel constituted the control group (group B, 1,000 patients). Hemorrhages were graded as follows: 1 = spot ecchymosis of eyelid and or subconjunctival hemorrhage; 2 = eyelid ecchymosis involving half the lid surface area; 3 = eyelid ecchymosis all around the eye, no increase in intraocular pressure; 4 = retrobulbar hemorrhage with increased intraocular pressure. Grade 1 hemorrhages were observed in 30 patients (3.0 %) in group A and in 20 patients (2.0 %) in group B. No grade 2, 3, or 4 hemorrhage was encountered. There was no significant difference in the grading of hemorrhage between the groups (p = 0.017). Clopidogrel was not associated with a significant increase in potentially sight-threatening local anesthetic complications.

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Conflict of interest

None of the authors has conflict of interest with the submission.

Informed consent

Approval of our hospital ethics committee was obtained for the prospective case-control study.

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Authors and Affiliations

  1. Département d’Anesthésie Réanimation, Rouen University Hospital, Centre Hospitalier Universitaire de Rouen, 1 rue de Germont, 76031, Rouen cedex, France

    Emile Calenda, Laure Lamothe & Annie Cardon

  2. Department of Ophthalmology, Rouen University Hospital, Centre Hospitalier Universitaire de Rouen, 1 rue de Germont, 76031, Rouen cedex, France

    Olivier Genevois & Marc Muraine

Authors
  1. Emile Calenda
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  2. Laure Lamothe
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  3. Olivier Genevois
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  4. Annie Cardon
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  5. Marc Muraine
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Corresponding author

Correspondence to Emile Calenda.

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Calenda, E., Lamothe, L., Genevois, O. et al. Peribulbar block in patients scheduled for eye procedures and treated with clopidogrel. J Anesth 26, 779–782 (2012). https://doi.org/10.1007/s00540-012-1406-6

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  • DOI: https://doi.org/10.1007/s00540-012-1406-6

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