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Low paravertebral muscle mass in patients with bone metastases from lung cancer is associated with poor prognosis

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Abstract

Purpose

Low skeletal muscle mass has been associated with poor prognosis in patients with advanced lung cancer. However, little is known about the relationship between skeletal muscle mass and overall survival in patients with bone metastases from lung cancer. The objective of the present study was to evaluate the prognostic value of low trunk muscle mass in predicting overall survival in these patients.

Methods

The data from 198 patients who were diagnosed with bone metastases from lung cancer from April 2009 to May 2017 were retrospectively reviewed. The areas of the psoas and paravertebral muscles were measured at the level of the third lumbar vertebra on computed tomography scans taken at the time nearest to the diagnosis of bone metastasis. Muscle area was evaluated for male and female cohorts separately using different cutoff points. Cox proportional hazards analysis was performed to evaluate the factors independently associated with overall survival.

Results

The overall survival of patients in the lowest quartile for psoas muscle area or paravertebral muscle area was significantly shorter than that of patients above the 25th percentile for muscle area (p < 0.001). Multivariate analyses showed that paravertebral muscle mass (hazard ratio, 1.73; 95% confidence interval, 1.17–2.56; p = 0.006), epidermal growth factor receptor-targeted therapy, and performance status were independent prognostic factors.

Conclusions

Low paravertebral muscle mass was associated with shorter survival, independently of known prognostic factors.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, Yodogawa Christian Hospital, 1-7-50 Kunijima Higasiyodogawa-ku, Osaka, Osaka, 533-0024, Japan

    Sho Dohzono, Ryuichi Sasaoka & Kiyohito Takamatsu

  2. Department of Orthopaedic Surgery, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi, Abeno-ku, Osaka, Osaka, 545-8585, Japan

    Masatoshi Hoshino & Hiroaki Nakamura

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  1. Sho Dohzono
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  2. Ryuichi Sasaoka
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  3. Kiyohito Takamatsu
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  4. Masatoshi Hoshino
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  5. Hiroaki Nakamura
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Correspondence to Sho Dohzono.

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Dohzono, S., Sasaoka, R., Takamatsu, K. et al. Low paravertebral muscle mass in patients with bone metastases from lung cancer is associated with poor prognosis. Support Care Cancer 28, 389–394 (2020). https://doi.org/10.1007/s00520-019-04843-9

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  • DOI: https://doi.org/10.1007/s00520-019-04843-9

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