Abstract
Purpose
The aim of the present review was to determine effects of strength exercise on secondary lymphedema in breast cancer patients.
Methods
Research was conducted by using the databases PubMed/Medline and Embase. Randomized controlled trials published from January 1966 to May 2015 investigating the effects of resistance exercise on breast cancer patients with or at risk of secondary lymphedema in accordance with the American College of Sports Medicine exercise guidelines for cancer survivors were included in the present study.
Results
Nine original articles with a total of 957 patients met the inclusion criteria. None of the included articles showed adverse effects of a resistance exercise intervention on lymphedema status. In all included studies, resistance exercise intensity was described as moderate to high.
Conclusions
Strength exercise seems not to have negative effects on lymphedema status or might not increase risk of development of lymphedema in breast cancer patients. Further research is needed in order to investigate the effects of resistance exercise for patients suffering from lymphedema.
Similar content being viewed by others
References
Rabe E, Pannier-Fischer F, Bonner (2007) Venenstudie der deutschen Gesellschaft für Phlebologie-Epidemiologische Untersuchung zur Frage der Häufigkeit und Ausprägung von chronischen Venenkrankheiten in der städtischen und ländlichen wohnbevölkerung. Phlebologie 32:1–14
Pannier F, Hoffmann B, Stang JK, Rabe E (2007) Prevalence of Stemmer’s sign in the general population—results from the Bonn Vein Study. Phlebologie 36:287–342
DiSipio T, Rye S, Newman B, Hayes S (2013) Incidence of unilateral arm lymphoedema after breast cancer: a systematic review and meta-analysis. The Lancet oncology 14:500–515
Cormier JN, Askew RL, Mungovan KS, Xing Y, Ross MI, Armer JM (2010) Lymphedema beyond breast cancer: a systematic review and meta-analysis of cancer-related secondary lymphedema. Cancer 116:5138–5149
Oberaigner W, Geiger-Gritsch S (2014) Prediction of cancer incidence in Tyrol/Austria for year of diagnosis 2020. Wien Klin Wochenschr 126:642–649
Ahmed RL, Prizment A, Lazovich D, Schmitz KH, Folsom AR (2008) Lymphedema and quality of life in breast cancer survivors: the Iowa Women’s Health Study. J Clin Oncol Off J Am Soc Clin Oncol 26:5689–5696
Cormier JN, Xing Y, Zaniletti I, Askew RL, Stewart BR, Armer JM (2009) Minimal limb volume change has a significant impact on breast cancer survivors. Lymphology 42:161–175
Lymphedema: what every woman with breast cancer should know: American Cancer Society; [cited 2014 26.08]. Available from: http://www.cancer.org/treatment/treatmentsandsideeffects/physicalsideeffects/lymphedema/whateverywomanwithbreastcancershouldknow/lymphedema-with-breast-cancer-if-at-risk-for-lymphedema.
Schmitz KH (2010) Balancing lymphedema risk: exercise versus deconditioning for breast cancer survivors. Exerc Sport Sci Rev 38:17–24
Shih YC, Xu Y, Cormier JN, et al. (2009) Incidence, treatment costs, and complications of lymphedema after breast cancer among women of working age: a 2-year follow-up study. J Clin Oncol Off J Am Soc Clin Oncol 27:2007–2014
Liebl ME, Preiß S, Pögel S, et al. (2014) Elastic tape as a therapeutic intervention in the maintenance phase of complex decongestive therapy (CDT) in lymphedema. Phys Med Rehab Kuror 24:34–41
Crevenna R, Zielinski C, Keilani MY, et al. (2003) Aerobic endurance training for cancer patients. Wien Med Wochenschr 153:212–216
Hasenoehrl T, Keilani M, Sedghi Komanadj T, et al. (2015) The effects of resistance exercise on physical performance and health-related quality of life in prostate cancer patients: a systematic review. Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer 23:2479–2497
Hayden JA, van Tulder MW, Malmivaara AV, Koes BW (2005) Meta-analysis: exercise therapy for nonspecific low back pain. Ann Intern Med 142:765–775
Kampshoff CS, Buffart LM, Schep G, van Mechelen W, Brug J, Chinapaw MJ (2010) Design of the Resistance and Endurance exercise After ChemoTherapy (REACT) study: a randomized controlled trial to evaluate the effectiveness and cost-effectiveness of exercise interventions after chemotherapy on physical fitness and fatigue. BMC Cancer 10:658
Battaglini CLMR, Phillips BL, Lee JT, Story CE, Nascimento MG, Hackney AC (2014) Twenty-five years of research on the effects of exercise training in breast cancer survivors: a systematic review of the literature. World J Clin Oncol 5:177–190
Strasser BSK, Wiskemann J, Ulrich CM (2013) Impact of resistance training in cancer survivors: a meta-analysis. Med Sci Sports Exerc 45:2080–2090
Kwan ML, Cohn JC, Armer JM, Stewart BR, Cormier JN (2011) Exercise in patients with lymphedema: a systematic review of the contemporary literature. J Cancer Surviv: Res Pract 5:320–336
Paskett ED, Dean JA, Oliveri JM, Harrop JP (2012) Cancer-related lymphedema risk factors, diagnosis, treatment, and impact: a review. J Clin Oncol Off J Am Soc Clin Oncol 30:3726–3733
Stuiver MM, ten Tusscher MR, Agasi-Idenburg CS, Lucas C, Aaronson NK, Bossuyt PM (2015) Conservative interventions for preventing clinically detectable upper-limb lymphoedema in patients who are at risk of developing lymphoedema after breast cancer therapy. Cochrane Database Syst Rev 2:CD009765
Schmitz KH, Courneya KS, Matthews C, Demark-Wahnefried W, Galvao DA, Pinto BM, Irvin ML, Wolin KY, Segal RJ, Lucia A, Schneider CM, von Grueningen VE, Schwartz AL (2010) American College of Sports Medicine roundtable on exercise guidelines for cancer survivors. Med Sci Sports Exerc 42:1409–1426
Ahmed RL, Thomas W, Yee D, Schmitz KH (2006) Randomized controlled trial of weight training and lymphedema in breast cancer survivors. J Clin Oncol 24:2765–2772
Anderson RT, Kimmick GG, McCoy TP, et al. (2012) A randomized trial of exercise on well-being and function following breast cancer surgery: the RESTORE trial. J Cancer Surviv: Res Pract 6:172–181
Cormie P, Pumpa K, Galvao DA, et al. (2013) Is it safe and efficacious for women with lymphedema secondary to breast cancer to lift heavy weights during exercise: a randomized controlled trial. J Cancer Surviv: Res Pract 7:413–424
Cormie P, Galvao DA, Spry N, Newton RU (2013a) Neither heavy nor light load resistance exercise acutely exacerbates lymphedema in breast cancer survivor. Integr Cancer Ther 12:423–432
Courneya KS, Segal RJ, Mackey JR, Gelmon K, Reid RD, Friedenreich CM, et al. (2007) Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. J Clin Oncol Off J Am Soc Clin Oncol 25:4396–4404
Hayes SC, Reul-Hirche H, Turner J (2009) Exercise in secondary lymphedema: safety, potential benefits, and research issues. Med Sci Sports Exerc 41:483–489
Kilbreath SL, Refshauge KM, Beith JM, et al. (2012) Upper limb progressive resistance training and stretching exercises following surgery for early breast cancer: a randomized controlled trial. Breast Cancer Res Treat 133:667–676
Schmitz KH, Ahmed RL, Troxel A, et al. (2009) Weight lifting in women with breast-cancer-related lymphedema. N Engl J Med 361:664–673
Schmitz KH, Ahmed RL, Troxel AB, et al. (2010) Weight lifting for women at risk for breast cancer-related lymphedema: a randomized trial. JAMA: J Am Med Assoc 304:2699–2705
Downs SH, Black N (1998) The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions. J Epidemiol Community Health 52:377–384
Gardner JR, Livingston PM, Fraser SF (2014) Effects of exercise on treatment-related adverse effects for patients with prostate cancer receiving androgen-deprivation therapy: a systematic review. J Clin Oncol 32:335–346. doi:10.1200/JCO.2013.49.5523
Cheville AL, McGarvey CL, Petrek JA, Russo SA, Thiadens SR, Taylor ME (2003) The grading of lymphedema in oncology clinical trials. Semin Radiat Oncol 13:214–225
Youlden DR, Cramb SM, Dunn NAM, Mullen JM, Pyke CM, Baade PD (2012) The descriptive epidemiology of female breast cancer: an international comparison of screening, incidence, survival and mortality. Cancer Epidemiol 36:237–248
Harris SR, Niesen-Vertommen SL (2000) Challenging the myth of exercise-induced lymphedema following breast cancer: a series of case reports. J Surg Oncol 74:95–99
Padberg Jr FT, Johnston MV, Sisto SA (2004) Structured exercise improves calf muscle pump function in chronic venous insufficiency: a randomized trial. J Vasc Surg 39:79–87
Kaulesar Sukul D, den Hoed P, Johannes E, van Dolder R, Benda E (1993) Direct and indirect methods for the quantification of leg volume: comparison between water displacement volumetry, the disk model method and the frustum sign model method, using the correlation coefficient and the limits of agreement. J Biomed Eng 15:477–480
Sander AP, Hajer NM, Hemenway K, Miller AC (2002) Upper-extremity volume measurements in women with lymphedema: a comparison of measurements obtained via water displacement with geometrically determined volume. Phys Ther 82:1201–1212
Taylor R, Jayasinghe UW, Koelmeyer L, Ung O, Boyages J (2006) Reliability and validity of arm volume measurements for assessment of lymphedema. Phys Ther 86:205–214
Phillips SM (2014) A brief review of critical processes in exercise-induced muscular hypertrophy. Sports Med 44(Suppl 1):S71–S77
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
The authors declare that they have no competing interests.
Rights and permissions
About this article
Cite this article
Keilani, M., Hasenoehrl, T., Neubauer, M. et al. Resistance exercise and secondary lymphedema in breast cancer survivors—a systematic review. Support Care Cancer 24, 1907–1916 (2016). https://doi.org/10.1007/s00520-015-3068-z
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00520-015-3068-z