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The role of physical rehabilitation in stem cell transplantation patients

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Abstract

The purpose of this paper is to review the evidence for the role of physical rehabilitation in stem cell transplantation patients. We will also review the literature and discuss professional experiences on how rehabilitation can play a role in stem cell transplant care and survivorship. Hematopoietic stem cell transplantation (HCT) is a procedure that has evolved substantially over the years to help treat multiple conditions, particularly hematologic malignancies. HCT can be very stressful on the body and can leave patients weakened and sometimes quite debilitated. Supportive care measures have advanced to improve the quality of life and overall survival of HCT survivors. One key component of improved supportive care is gaining increased attention, and that is physical medicine and rehabilitation. Its role in HCT survivorship care is expanding, and new insight and research within the discipline have focused on fatigue, inflammation, exercise, and the development of structured rehabilitation programs to improve the musculoskeletal sequelae of transplantation. This literature review has demonstrated the utility of physical rehabilitation in HCT, its impact on cancer-related fatigue, and to outline the current state of the literature on these topics. The paper delves into a background of HCT. Cancer-related fatigue in HCT is then discussed and summarized, and the role that exercise plays in modifying such fatigue is outlined. We then outline the models and the impact that physical rehabilitation may play in HCT recipients.

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Acknowledgments

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The authors report no conflicts of interest.

Disclosures

The topic of this paper was presented as a review session at the 2012 American Academy of Physical Medical & Rehabilitation Annual Assembly.

This manuscript is supported in part by two grants:

1. MD Anderson NIH Institutional Support grant: CA 016672

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Authors and Affiliations

  1. Blood and Marrow Transplantation, Mount Sinai Hospital, 1 Gustave Levy Place, MB 1410, New York City, NY, 10029, USA

    Amir Steinberg

  2. Cancer Survivorship and Rehabilitation, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, 8700 Beverly Blvd, Los Angeles, CA, 90048, USA

    Arash Asher & Charlotte Bailey

  3. Palliative Care & Rehabilitation Medicine, University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Blvd, Unit 1414, Houston, TX, 77030, USA

    Jack B. Fu

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  1. Amir Steinberg
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Steinberg, A., Asher, A., Bailey, C. et al. The role of physical rehabilitation in stem cell transplantation patients. Support Care Cancer 23, 2447–2460 (2015). https://doi.org/10.1007/s00520-015-2744-3

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