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The CDK inhibitors in cancer research and therapy

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Abstract

Chemical compounds that interfere with an enzymatic function of kinases are useful for gaining insight into the complicated biochemical processes in mammalian cells. Cyclin-dependent kinases (CDK) play an essential role in the control of the cell cycle and/or proliferation. These kinases as well as their regulators are frequently deregulated in different human tumors. Aberrations in CDK activity have also been observed in viral infections, Alzheimer’s, Parkinson’s diseases, ischemia and some proliferative disorders. This led to an intensive search for small-molecule CDK inhibitors not only for research purposes, but also for therapeutic applications. Here, we discuss seventeen CDK inhibitors and their use in cancer research or therapy. This review should help researchers to decide which inhibitor is best suited for the specific purpose of their research. For this purpose, the targets, commercial availability and IC50 values are provided for each inhibitor. The review will also provide an overview of the clinical studies performed with some of these inhibitors.

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Authors and Affiliations

  1. Department of Medicine, Institute of Anatomy, University of Fribourg, Rte. Albert- Gockel 1, 1700, Fribourg, Switzerland

    Jonas Cicenas

  2. MAP Kinase Resource, Bern, Switzerland

    Jonas Cicenas

  3. Department of Developmental Biology, Institute of Biochemistry, Vilnius, Lithuania

    Mindaugas Valius

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  1. Jonas Cicenas
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  2. Mindaugas Valius
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Correspondence to Jonas Cicenas.

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Cicenas, J., Valius, M. The CDK inhibitors in cancer research and therapy. J Cancer Res Clin Oncol 137, 1409–1418 (2011). https://doi.org/10.1007/s00432-011-1039-4

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