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Ocular morbidities of juvenile idiopathic arthritis-associated uveitis in adulthood: results from a tertiary center study

  • Inflammatory Disorders
  • Published:
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Abstract

Purpose

To describe the clinical and visual outcomes of juvenile idiopathic arthritis (JIA)-associated uveitis in adults and to examine risk factors for ongoing inflammation in adulthood.

Methods

Medical records were reviewed for patients with JIA-associated uveitis who were >16 years old at the final visit (the last visit prior to data collection).

Results

In total, 135 eyes of 77 patients (70 female, 7 male) were included. The mean age of patients at the final visit was 29.72 ± 11.27 years. The number of eyes with visual acuity of ≤20/50 and ≤20/200 at the final visit was 37 (28 %) and 20 (15 %), respectively; at least one ocular complication was present in 72 % of eyes. Band keratopathy was the most frequent complication (42 %), followed by cataract (25 %), posterior synechiae (22 %), maculopathy (22 %), ocular hypertension (13 %), and hypotony (5 %). At the final visit, patients who were >16 years of age at presentation to the Massachusetts Eye Research and Surgery Institution had more ocular complications and a greater degree of vision loss than patients who were ≤16 years of age. Ongoing inflammation at the final visit was noted in 40 patients (52 %). The presence of posterior synechiae, hypotony, cataract at presentation, and a history of cataract surgery prior to presentation were predictive of ongoing inflammation in adulthood in univariate analysis. The presence of hypotony and posterior synechiae at the initial visit were predictive factors in multivariate analysis.

Conclusions

JIA-associated uveitis may be associated with ongoing inflammation, ocular complications, and severe visual impairment in adulthood. The presence of posterior synechiae and hypotony at the initial visit is predictive of ongoing inflammation.

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Authors and Affiliations

  1. Massachusetts Eye Research and Surgery Institution (MERSI), 1440 Main Street, Suite 201, Waltham, MA, 02451, USA

    Merih Oray, Nazanin Ebrahimiadib, Khawla Abu Samra, Stacey Lee & C. Stephen Foster

  2. Ocular Immunology and Uveitis Foundation, Waltham, MA, USA

    Merih Oray, Nazanin Ebrahimiadib, Khawla Abu Samra, Stacey Lee & C. Stephen Foster

  3. Istanbul Faculty of Medicine, Department of Ophthalmology, Istanbul University, Istanbul, Turkey

    Merih Oray

  4. Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania School of Medicine, Philadelphia, PA, USA

    Naira Khachatryan

  5. Harvard Medical School, Boston, MA, USA

    C. Stephen Foster

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  1. Merih Oray
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  2. Naira Khachatryan
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  3. Nazanin Ebrahimiadib
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  4. Khawla Abu Samra
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  5. Stacey Lee
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  6. C. Stephen Foster
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Corresponding author

Correspondence to C. Stephen Foster.

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Funding

No funding was received for this research.

Conflict of interest

C. Stephen Foster has the following financial disclosures: Consultancies with Aldeyra Therapeutics (Lexington, MA), Bausch & Lomb Surgical, Inc. (Rancho Cucamonga, CA), EyeGate Pharma (Waltham, MA), Novartis (Cambridge, MA), pSivida Corp. (Watertown, MA), and Xoma Ltd. (Berkeley, CA). Grants or grants pending with Alcon (Aliso Viejo, CA), Aldeyra Therapeutics (Lexington, MA), Bausch & Lomb (Bridgewater, NJ), Clearside Biomedical (Alpharetta, GA), Dompé pharmaceutical S.p.A. (Milan, Italy), EyeGate Pharma (Waltham, MA), Mallinckrodt pharmaceuticals (Dublin, Ireland), Novartis Pharmaceuticals (Cambridge, MA), pSivida Corp. (Watertown, MA), and Santen Pharmaceutical (Osaka, Japan). Payment for lectures including service on speaking bureaus: Alcon (Aliso Viejo, CA), Allergan (Dublin, Ireland). Stock or stock options: EyeGate Pharma (Waltham, MA)

Merih Oray received a postdoctoral fellowship grant from the Scientific and Technological Research Council of Turkey. The organization had no role in the design or conduct of this research. None of the other authors have any financial disclosures. No further acknowledgements.

Ethical approval

All procedures performed in the present study were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study, formal consent is not required.

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Oray, M., Khachatryan, N., Ebrahimiadib, N. et al. Ocular morbidities of juvenile idiopathic arthritis-associated uveitis in adulthood: results from a tertiary center study. Graefes Arch Clin Exp Ophthalmol 254, 1841–1849 (2016). https://doi.org/10.1007/s00417-016-3340-z

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  • DOI: https://doi.org/10.1007/s00417-016-3340-z

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