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Soluble CSF interleukin 2 receptor as indicator of neurosarcoidosis

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Abstract

Neurosarcoidosis (NS) represents an important differential diagnosis of multiple sclerosis (MS). However, thus far no reliable laboratory marker of neurosarcoidosis exists. The objective of this study was to evaluate whether cerebrospinal fluid (CSF) levels of soluble interleukin 2 receptor (sIL2-R) distinguish NS and other inflammatory disorders of the central nervous system. For this purpose, 139 paired CSF and serum samples from 11 patients with NS, 21 with MS, 10 with CNS vasculitis, 22 with bacterial meningitis, 17 with viral meningitis/encephalitis, seven with neurotuberculosis, and 18 healthy donors were assessed for sIL2-R using an enzyme-linked immunosorbent assay. We found that sIL2-R CSF levels above 150 pg/ml identified untreated NS patients with an overall accuracy of 93% against a group of non-infectious CNS-diseases. Furthermore, an increase in sIL2-R in the CSF was associated with and preceded the outbreak of new neurological symptoms. In conclusion, these findings suggest that sIL2-R measurement in the CSF may be a valuable tool in the diagnosis and follow-up of patients with suspected and proven neurosarcoidosis.

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Acknowledgments

We thank Hendrik Lindeman for excellent technical assistance.

Conflict of interest statement

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Neurology, Holy Ghost Hospital, Graseggerstr. 105, 50737, Cologne, Germany

    Hela-Felicitas Petereit

  2. Department of Neurology, University of Cologne, Cologne, Germany

    Dirk Reske

  3. Department of Neurology, University of Ulm, Ulm, Germany

    Hayrettin Tumani

  4. Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany

    Sven Jarius

  5. Central Institute of Mental Health, Mannheim, Germany

    F. Markus Leweke

  6. Department of Neurology, St. Josef-Hospital, Ruhr-Universität Bochum, Bochum, Germany

    Dirk Woitalla

  7. Department of Neurology, Klinikum Großhadern, University of Munich, Munich, Germany

    Hans-Walter Pfister

  8. Department of Internal Medicine 1, University of Cologne, Cologne, Germany

    Andrea Rubbert

Authors
  1. Hela-Felicitas Petereit
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  2. Dirk Reske
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  3. Hayrettin Tumani
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  4. Sven Jarius
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  5. F. Markus Leweke
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  6. Dirk Woitalla
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  7. Hans-Walter Pfister
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  8. Andrea Rubbert
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Correspondence to Hela-Felicitas Petereit.

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Petereit, HF., Reske, D., Tumani, H. et al. Soluble CSF interleukin 2 receptor as indicator of neurosarcoidosis. J Neurol 257, 1855–1863 (2010). https://doi.org/10.1007/s00415-010-5623-3

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  • DOI: https://doi.org/10.1007/s00415-010-5623-3

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