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Can monocyte to HDL cholesterol ratio and monocyte to lymphocyte ratio be markers for inflammation and oxidative stress in patients with vitiligo? A preliminary study

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A Letter to the Editor to this article was published on 09 February 2021

Abstract

Both systemic inflammation and oxidative stress play crucial roles in the pathogenesis of vitiligo. In recent studies, monocyte to high-density lipoprotein cholesterol ratio (MHR), monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), mean platelet volume (MPV) and plateletcrit (PCT) have been shown to reflect inflammation and oxidative stress in chronic inflammatory and autoimmune diseases. In this study, we aimed to investigate the hematological and inflammatory parameters in patients with vitiligo and to evaluate their possible relationship with disease severity. The parameters including MHR, MLR, NLR, PLR, MPV, and PCT were retrospectively investigated in patients with vitiligo and healthy controls. Disease severity was evaluated using the vitiligo extent tensity index (VETI) score. A total of 180 patients with vitiligo, and age–gender-matched 180 healthy controls were enrolled in the study. MHR, MLR, PLR, PCT values were found to be significantly higher in patients with vitiligo (p < 0.05). MPV and NLR values showed no statistically significant difference between the two groups. A positive correlation was also detected between MHR and MLR values, disease duration, and VETI score (p < 0.05). We suggest that MHR and MLR can be used as markers of inflammation and oxidative stress in patients with vitiligo. Both markers may also reflect disease severity.

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Authors and Affiliations

  1. Department of Dermatology, Konya Numune Hospital, Konya, Turkey

    Abdullah Demirbaş

  2. Department of Dermatology, Kırşehir Ahi Evran University, Kırşehir, Turkey

    Ömer Faruk Elmas

  3. Department of Dermatology, Health Science University, Kayseri City Hospital, Kayseri, Turkey

    Mustafa Atasoy

  4. Department of Dermatology, Mersin University, Mersin, Turkey

    Ümit Türsen

  5. Department of Dermatology, Guglielmo Marconi University, Rome, Italy

    Torello Lotti

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  1. Abdullah Demirbaş
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  4. Ümit Türsen
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Correspondence to Abdullah Demirbaş.

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All the procedures followed the Helsinki declaration and the study was approved by the KTO Karatay University Institutional Review Board (Decision date and number: 2020/006).

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Demirbaş, A., Elmas, Ö.F., Atasoy, M. et al. Can monocyte to HDL cholesterol ratio and monocyte to lymphocyte ratio be markers for inflammation and oxidative stress in patients with vitiligo? A preliminary study. Arch Dermatol Res 313, 491–498 (2021). https://doi.org/10.1007/s00403-020-02129-3

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