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Das trockene Auge

Aktuelle Konzepte zu Klassifizierung, Diagnostik und Pathogenese

Dysfunctional tear syndrome

Current concepts on classification, diagnostics, and pathogenesis

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Zusammenfassung

Die Pathogenese des trockenen Auges ist multifaktoriell und komplex. Neue Forschungsergebnisse zeigen, dass sich ein Entzündungsprozess der Augenoberfläche als „gemeinsame Endstrecke“ aller chronischen Formen des trockenen Auges herauskristallisiert. Daneben sind lokale Hormonimbalanzen, vor allem ein Androgenmangel, entscheidend für dessen Entstehung. Aktuelle Konzepte zur Pathogenese des trockenen Auges und die diagnostischen Basis- und Zusatzverfahren werden erläutert. Die In-vivo-Konfokalmikroskopie erlaubt erstmals die Quantifizierung von Entzündungszellen der Augenoberfläche zur Indikationsstellung und Verlaufskontrolle antientzündlicher Therapieoptionen des trockenen Auges.

Abstract

The etiology of dysfunctional tear syndrome (“dry eye”) is multifactorial and complex. Recent evidence suggests an important role of androgens in regulating tear film secretion onto the ocular surface. In addition, inflammatory processes of the ocular surface seem to be the common final pathway of all chronic forms of dry eye. Novel concepts of pathogenesis and state-of-the-art diagnostic tools are discussed. In vivo confocal microscopy allows quantification of ocular surface inflammatory cells. This is of increasing importance for evaluation of anti-inflammatory treatments in dry eye patients.

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Authors and Affiliations

  1. Augenklinik mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen

    C. Jacobi, T. Dietrich, C. Cursiefen & F. E. Kruse

  2. Augenklinik mit Poliklinik, Friedrich-Alexander-Universität Erlangen-Nürnberg, Schwabachanlage 6, 91054 , Erlangen

    C. Jacobi

Authors
  1. C. Jacobi
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  2. T. Dietrich
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  3. C. Cursiefen
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  4. F. E. Kruse
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Corresponding author

Correspondence to C. Jacobi.

Additional information

Unterstützung: Sicca-Forschungsförderung des Ressorts Trockenes Auge des BVA (DOG 2005); Interdisziplinäres Zentrum für Klinische Forschung (IZKF) Erlangen (A9).

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Jacobi, C., Dietrich, T., Cursiefen, C. et al. Das trockene Auge. Ophthalmologe 103, 9–17 (2006). https://doi.org/10.1007/s00347-005-1299-y

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  • DOI: https://doi.org/10.1007/s00347-005-1299-y

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