Abstract
Despite its infrequent occurrence, the possible development of lymphoma or lymphoid lung disease in patients with Sjögren’s syndrome should always be borne in mind. We describe a case of bronchus-associated lymphoid tissue (BALT) lymphoma in a patient with Sjögren’s syndrome that clearly exemplifies the wide-ranging problems of diagnosing, treating and following such patients. This difficulty is due to the fact that the clinical and radiological findings suggest interstitial lung disease, and histological assays are required for a correct diagnosis. A precise knowledge of the various histological and radiological patterns of lung involvement can aid patient management.
References
Fox RI, Stern M, Michelson P (2000) Update in Sjögren’s syndrome. Curr Opin Rheumatol 12:391–398
Kassan SS, Thomas TL, Moustsoupoulos HM et al (1978) Increased risk of lymphoma in sicca syndrome. Ann Intern Med 89:888–892
Royer B, Cazals-Hatem D, Sibilia J et al (1997) Lymphomas in patients with Sjögren’s syndrome are marginal zone B-cell neoplasms, arise in diverse extranodal and nodal sites, and are not associated with viruses. Blood 90:766–775
Cain HC, Noble PW, Matthay RA (1998) Pulmonary manifestations of Sjögren’s syndrome. Clin Chest Med 19:687–699
Linstow M, Kriegbaum NJ, Backer V, Ulrik C, Oxholm P (1990) A follow-up study of pulmonary function in patients with primary Sjögren’s syndrome. Rheumatol Int 10:47–49
Mialon P, Barthélémy L, Sébert P, Le Hénaff C, Sarni D, Pennec YL et al (1997) A longitudinal study of lung impairment in patients with primary Sjögren’s syndrome. Clin Exp Rheumatol 15:349–354
Davidson BK, Kelly CA, Griffiths ID (2000) Ten year follow up of pulmonary function in patients with primary Sjögren’s syndrome. Ann Rheum Dis 59:709–712
Quismorio FP Jr (1996) Pulmonary involvement in primary Sjögren’s syndrome. Curr Opin Pulm Med 2:424–428
Constantopoulos SH, Tsianos EV, Moutsopoulos HM (1992) Pulmonary and gastrointestinal manifestations of Sjögren’s syndrome. Rheum Dis Clin North Am 18:617–635
Fox RI (2005) Sjögren’s syndrome. Lancet 366:321–331
Bae YA, Soo Lee K, Han J, Ko YH, Kim BT, Jin Chung M, et al. Marginal Zone B-Cell Lymphoma of Bronchus-Associated Lymphoid Tissue (BALT): Imaging Findings in 21 Patients. Chest 2007 [Epub ahead of print].
Ahmed S, Kussick SJ, Siddiqui AK, Bhuiya TA, Khan A, Sarewitz S et al (2004) Bronchial-associated lymphoid tissue lymphoma: a clinical study of a rare disease. Eur J Cancer 40:1320–1326
Kurtin PJ, Myers JL, Adlakha H, Strickler JG, Lohse C, Pankratz VS et al (2001) Pathologic and clinical features of primary pulmonary extranodal marginal zone B-cell lymphoma of MALT type. Am J Surg Pathol 25:997–1008
Ahmed S, Siddiqui AK, Rai KR (2002) Low-grade B-cell bronchial associated lymphoid tissue (BALT) lymphoma. Can Invest 20:1059–1068
Cordier JF, Chailleux E, Lauque D, Reynaud-Gaubert M, Dietemann-Molard A, Dalphin JC et al (1993) Primary pulmonary lymphoma. A clinical study of 70 cases in nonimmunocompromised patients. Chest 103:201–208
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ingegnoli, F., Sciascera, A., Galbiati, V. et al. Bronchus-associated lymphoid tissue lymphoma in a patient with primary Sjögren’s syndrome. Rheumatol Int 29, 207–209 (2008). https://doi.org/10.1007/s00296-008-0645-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-008-0645-1