Skip to main content
SpringerLink
Log in

Neues zu Tumoren der Speicheldrüsen

WHO-Klassifikation 2017

Updates on tumours of the salivary glands

2017 WHO classification

  • Schwerpunkt: Kopf-Hals-Tumoren
  • Published:
Der Pathologe Aims and scope Submit manuscript

Zusammenfassung

In der neuen WHO-Klassifikation 2017 für Tumoren der Kopf-Hals-Region gelingt erstmals eine Verminderung der hohen Zahl der Karzinomentitäten der Speicheldrüsen. Die einzig neue Karzinomentität ist das sekretorische Karzinom. Die Zahl der reaktiven bzw. benignen Entitäten steigt leicht durch die Einbeziehung schon etablierter, bisher nicht in der Klassifikation erfasster Entitäten. Daneben gibt es konzeptionelle Änderungen und vereinzelt reine Änderungen der Terminologie. Die Bedeutung von molekularpathologischen Befunden steigt insbesondere für maligne Tumoren, bleibt bislang aber weitgehend auf diagnostische Aspekte beschränkt.

Abstract

In the new 2017 WHO classification, a reduction of the high number of entities of salivary carcinomas was implemented. There is only one new carcinoma entity: secretory carcinoma. There is a slight increase of reactive and benign entities by the inclusion of rare and well-established, but so far not included, lesions. Furthermore, there are some conceptual changes and pure changes in terminology. The impact of molecular findings is increasing and is so far restricted to diagnostic aspects.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5

Literatur

  1. Agaimy A, Ihrler S, Markl B et al (2013) Lipomatous salivary gland tumors: a series of 31 cases spanning their morphologic spectrum with emphasis on sialolipoma and oncocytic lipoadenoma. Am J Surg Pathol 37:128–137

    Article  PubMed  Google Scholar 

  2. Antonescu CR, Katabi N, Zhang L et al (2011) EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer 50:559–570

    Article  CAS  PubMed  Google Scholar 

  3. Barnes L, Eveson J, Reichart P et al (Hrsg) (2005) Word Health Organization classification of tumours: pathology and genetics of head and neck tumours. IARC Press, Lyon

    Google Scholar 

  4. Chenevert J, Duvvuri U, Chiosea S et al (2012) DOG1: a novel marker of salivary acinar and intercalated duct differentiation. Mod Pathol 25:919–929

    Article  CAS  PubMed  Google Scholar 

  5. Di Palma S (2013) Carcinoma ex pleomorphic adenoma, with particular emphasis on early lesions. Head Neck Pathol 7(Suppl 1):S68–S76

    Article  PubMed  Google Scholar 

  6. Di Palma S, Simpson RH, Marchio C et al (2012) Salivary duct carcinomas can be classified into luminal androgen receptor-positive, HER2 and basal-like phenotypes. Histopathology 61:629–643

    Article  PubMed  Google Scholar 

  7. El-Naggar A, Chan J, Grandis J et al (Hrsg) (2017) World Health Organization classification of head and neck tumours. IARC Press, Lyon

    Google Scholar 

  8. Fehr A, Loning T, Stenman G (2011) Mammary analogue secretory carcinoma of the salivary glands with ETV6-NTRK3 gene fusion. Am J Surg Pathol 35:1600–1602

    Article  PubMed  Google Scholar 

  9. Flucke U, Palmedo G, Blankenhorn N et al (2011) EWSR1 gene rearrangement occurs in a subset of cutaneous myoepithelial tumors: a study of 18 cases. Mod Pathol 24:1444–1450

    Article  CAS  PubMed  Google Scholar 

  10. Ihrler S, Guntinas-Lichius O, Agaimy A et al (2017) Histological, immunohistological and molecular characteristics of intraductal precursor of carcinoma ex pleomorphic adenoma support a multistep carcinogenic process. Virchows Arch 470:601–609

    Article  CAS  PubMed  Google Scholar 

  11. Ihrler S, Schwarz S, Zengel P et al (2009) Pleomorphic adenoma: pitfalls and clinicopathological forms of progression. Pathologe 30:446–456

    Article  CAS  PubMed  Google Scholar 

  12. Ihrler S, Weiler C, Eckert F et al (2014) Cutaneous adnexal and salivary gland tumours. Similarities and differences. Pathologe 35:476–486

    Article  CAS  PubMed  Google Scholar 

  13. Keller G, Steinmann D, Quaas A et al (2017) New concepts of personalized therapy in salivary gland carcinomas. Oral Oncol 68:103–113

    Article  CAS  PubMed  Google Scholar 

  14. Petersson F (2013) Sclerosing polycystic adenosis of salivary glands: a review with some emphasis on intraductal epithelial proliferations. Head Neck Pathol 7(Suppl 1):S97–S106

    Article  PubMed  Google Scholar 

  15. Seethala RR, Thompson LD, Gnepp DR et al (2012) Lymphadenoma of the salivary gland: clinicopathological and immunohistochemical analysis of 33 tumors. Mod Pathol 25:26–35

    Article  PubMed  Google Scholar 

  16. Shah AA, Legallo RD, Van Zante A et al (2013) EWSR1 genetic rearrangements in salivary gland tumors: a specific and very common feature of hyalinizing clear cell carcinoma. Am J Surg Pathol 37:571–578

    Article  PubMed  Google Scholar 

  17. Simpson RH (2013) Salivary duct carcinoma: new developments-morphological variants including pure in situ high grade lesions; proposed molecular classification. Head Neck Pathol 7(Suppl 1):S48–S58

    Article  PubMed  Google Scholar 

  18. Simpson RH, Desai S, Di Palma S (2008) Salivary duct carcinoma in situ of the parotid gland. Histopathology 53:416–425

    Article  CAS  PubMed  Google Scholar 

  19. Skalova A, Sima R, Kaspirkova-Nemcova J et al (2011) Cribriform adenocarcinoma of minor salivary gland origin principally affecting the tongue: characterization of new entity. Am J Surg Pathol 35:1168–1176

    Article  PubMed  Google Scholar 

  20. Skalova A, Vanecek T, Sima R et al (2010) Mammary analogue secretory carcinoma of salivary glands, containing the ETV6-NTRK3 fusion gene: a hitherto undescribed salivary gland tumor entity. Am J Surg Pathol 34:599–608

    PubMed  Google Scholar 

  21. Skalova A, Weinreb I, Hyrcza M et al (2015) Clear cell myoepithelial carcinoma of salivary glands showing EWSR1 rearrangement: molecular analysis of 94 salivary gland carcinomas with prominent clear cell component. Am J Surg Pathol 39:338–348

    Article  PubMed  Google Scholar 

  22. Stenman G (2013) Fusion oncogenes in salivary gland tumors: molecular and clinical consequences. Head Neck Pathol 7(Suppl 1):S12–S19

    Article  PubMed  Google Scholar 

  23. Weiler C, Agaimy A, Zengel P et al (2012) Nonsebaceous lymphadenoma of salivary glands: proposed development from intraparotid lymph nodes and risk of misdiagnosis. Virchows Arch 460:467–472

    Article  PubMed  Google Scholar 

  24. Weiler C, Zengel P, Van Der Wal JE et al (2011) Carcinoma ex pleomorphic adenoma with special reference to the prognostic significance of histological progression: a clinicopathological investigation of 41 cases. Histopathology 59:741–750

    Article  PubMed  Google Scholar 

  25. Weinreb I (2013) Hyalinizing clear cell carcinoma of salivary gland: a review and update. Head Neck Pathol 7(Suppl 1):S20–S29

    Article  PubMed  Google Scholar 

  26. Weinreb I, Piscuoglio S, Martelotto LG et al (2014) Hotspot activating PRKD1 somatic mutations in polymorphous low-grade adenocarcinomas of the salivary glands. Nat Genet 46:1166–1169

    Article  CAS  PubMed  Google Scholar 

  27. Williams L, Thompson LD, Seethala RR et al (2015) Salivary duct carcinoma: the predominance of apocrine morphology, prevalence of histologic variants, and androgen receptor expression. Am J Surg Pathol 39:705–713

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Labor für Dermatohistologie und Oralpathologie, Bayerstr. 69, 80335, München, Deutschland

    S. Ihrler & C. Haas

  2. Pathologisches Institut, Ludwig-Maximilians-Universität, München, Deutschland

    S. Ihrler

  3. Klinik für Hals‑, Nasen- und Ohrenheilkunde, Universitätsklinikum Jena, Jena, Deutschland

    O. Guntinas-Lichius

  4. Institut für Pathologie, Technische Universität München, München, Deutschland

    M. Mollenhauer

Authors
  1. S. Ihrler
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. O. Guntinas-Lichius
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. C. Haas
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Mollenhauer
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. Ihrler.

Ethics declarations

Interessenkonflikt

S. Ihrler, O. Guntinas-Lichius, C. Haas und M. Mollenhauer geben an, dass kein Interessenkonflikt besteht.

Dieser Beitrag beinhaltet keine von den Autoren durchgeführten Studien an Menschen oder Tieren.

Additional information

Schwerpunktherausgeber

A. Hartmann, Erlangen

A. Agaimy, Erlangen

In Auszügen vorgetragen beim 492. Tutorial „Speicheldrüsentumoren“ der deutschen Abteilung der Internationalen Akademie für Pathologie in Bonn am 14.10.2017

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Ihrler, S., Guntinas-Lichius, O., Haas, C. et al. Neues zu Tumoren der Speicheldrüsen. Pathologe 39, 11–17 (2018). https://doi.org/10.1007/s00292-017-0407-5

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00292-017-0407-5

Schlüsselwörter

Keywords

Search

Navigation