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Lymphoma-associated hemophagocytic lymphohistiocytosis: experience in adults from a single institution

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Abstract

Lymphoma-associated hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disease. Differences between B cell and T cell lymphoma-associated HLH remain unclear, specifically clinical characteristics and survival. We retrospectively analyzed 30 lymphoma-associated HLH patients from July 2004 to October 2012. Patients were divided into B cell (n = 13) and T cell (n = 17) lymphoma groups. Patients’ age, performance status, presence of Epstein–Barr virus infection, international prognostic index, presence of disseminated intravascular coagulopathy, serum triglyceride, fibrinogen, and lactate dehydrogenase levels were not significantly different between B cell and T cell lymphoma groups. HLH was an indicator for treatment resistance in patients with B cell (p = 0.048), but not T cell (p = 0.217), lymphoma. Patients in the T cell lymphoma group, however, had higher serum ferritin levels than patients in the B cell lymphoma group (11,525.6 versus 3,790.6 ng/mL; p = 0.043). The median survival time for patients in the B cell and T cell lymphoma groups was 330 and 96 days, respectively. Although the difference was not statistically significant (p = 0.273), our results suggested a trend toward a better overall survival time in patients with B cell lymphoma. This survival advantage could be at least partially due to use of rituximab (p = 0.045) for the treatment of patients with B cell lymphoma. Our results also suggested that allogeneic hematopoietic stem cell transplantation could possibly provide survival benefits to T cell lymphoma-associated HLH by graft-versus-lymphoma effect.

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Potential conflicts of interests

The authors declare no conflict of interest.

Statement of informed consent

Informed consent from patients was not required for this study according to the regulation of Taichung Veterans General Hospital institutional review board (CE12253).

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Authors and Affiliations

  1. Division of Hematology/Medical Oncology, Department of Medicine, Taichung Veterans General Hospital, 160, Section 3, Taichung Port Road, Taichung, 407, Taiwan, Republic of China

    Jui-Ting Yu, Youngsen Yang, Wen-Li Hwang & Chieh-Lin Jerry Teng

  2. Division of Intensive Care Unit, Department of Medicine, Taichung Veterans General Hospital, Taichung, 407, Taiwan, Republic of China

    Chen-Yu Wang

  3. Department of Pathology, Taichung Veterans General Hospital, Taichung, 407, Taiwan, Republic of China

    Ren-Ching Wang

  4. Department of Medical Research and Education, Taichung Veterans General Hospital, Taichung, 407, Taiwan, Republic of China

    Kuang-Hsi Chang

  5. Department of Life Science, Tunghai University, Taichung, Taiwan, Republic of China

    Chieh-Lin Jerry Teng

  6. Department of Medicine, Chung Shan Medical University, Taichung, Taiwan, Republic of China

    Chieh-Lin Jerry Teng

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  1. Jui-Ting Yu
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  2. Chen-Yu Wang
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  3. Youngsen Yang
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  4. Ren-Ching Wang
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  5. Kuang-Hsi Chang
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  6. Wen-Li Hwang
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  7. Chieh-Lin Jerry Teng
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Corresponding authors

Correspondence to Wen-Li Hwang or Chieh-Lin Jerry Teng.

Additional information

Jui-Ting Yu and Chen-Yu Wang equally contributed to this study.

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Yu, JT., Wang, CY., Yang, Y. et al. Lymphoma-associated hemophagocytic lymphohistiocytosis: experience in adults from a single institution. Ann Hematol 92, 1529–1536 (2013). https://doi.org/10.1007/s00277-013-1784-3

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  • DOI: https://doi.org/10.1007/s00277-013-1784-3

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