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Clinical Application of Platelet-Rich Fibrin in Plastic and Reconstructive Surgery: A Systematic Review

  • Systemic Review
  • Non-Surgical Aesthetic
  • Published:
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Abstract

Background

Platelet-rich fibrin (PRF) has been applied in the clinical field for more than a decade, but largely in oral surgery and implant dentistry. Its utilization in plastic and reconstructive surgery is limited and lacking a comprehensive review. Hence, this article focuses on the various clinical applications of PRF pertaining to the plastic and reconstructive field through a systematic review.

Methods

In this review, articles describing the clinical application of PRF in plastic and reconstructive surgery were screened using predetermined inclusion and exclusion criteria. The articles were summarized and divided into groups based on the utilization of PRF. The effects and complications of PRF were analyzed and concluded.

Results

Among the 634 articles searched, 7 articles describing 151 cases are eligible. PRF was applied on 116 (76.8%) wounds to facilitate tissue healing, and the complete wound closure rate was 91.4% (106/116). Otherwise, PRF was applied in 10 (6.6%) cases of zygomaticomaxillary fracture to reconstruct orbital floor defects and in 25 (16.6%) cases of facial autologous fat grafts to increase the fat retention rate successfully. There is no report of PRF-related complications.

Conclusions

PRF could facilitate wound healing, including the healing of soft tissues and bony tissues, and facilitate fat survival rate. Further studies are needed to test the mechanism of PRF and expand its scope of application in plastic and reconstructive surgery.

Level of Evidence III

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Acknowledgements

This study was supported by the Beijing Natural Science Foundation Project (7162165), and the Research Innovation Program for Graduates of Chinese Academy of Medical Sciences and Peking Union Medical College (2017-1002-2-08). Otherwise, all the authors declare that they have no financial or personal interference with other people or organizations that could inappropriately influence their work.

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Authors and Affiliations

  1. The 16th Department, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS, PUMC), 33 Badachu Road, Shijingshan District, Beijing, 100144, China

    Panxi Yu, Zhen Zhai, Xiaolei Jin, Xiaonan Yang & Zuoliang Qi

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  1. Panxi Yu
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  2. Zhen Zhai
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  3. Xiaolei Jin
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Correspondence to Xiaonan Yang or Zuoliang Qi.

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Yu, P., Zhai, Z., Jin, X. et al. Clinical Application of Platelet-Rich Fibrin in Plastic and Reconstructive Surgery: A Systematic Review. Aesth Plast Surg 42, 511–519 (2018). https://doi.org/10.1007/s00266-018-1087-0

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  • DOI: https://doi.org/10.1007/s00266-018-1087-0

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