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Nephrolithiasis as a risk factor of chronic kidney disease: a meta-analysis of cohort studies with 4,770,691 participants

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Abstract

The objective of the study was to investigate the association between nephrolithiasis and the risk of chronic kidney disease (CKD). PubMed, Embase and ScienceDirect databases were searched for relevant cohort studies. A meta-analysis was conducted by pooling data from these studies via an inverse variance method. The Q statistic and I 2 were used to measure heterogeneity. Sensitivity analysis was conducted to ascertain whether the results were stable. Nine studies with eight cohorts involving 4,770,691 participants were identified. Compared to individuals without a history of nephrolithiasis, the pooled relative risk was 1.52 [95% confidence interval (CI) 1.24, 1.68; I 2 = 93.7%] for all stages of CKD and 2.16 (95% CI 1.83–2.54; I 2 = 0.00%) for end-stage kidney disease. Publication bias was not detected. Sensitivity analysis indicated that the results were stable. Nephrolithiasis may increase the risk of CKD, regardless of the patient population (region), and may be an important risk factor for end-stage kidney disease.

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Authors and Affiliations

  1. Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan University, 169 Donghu Road, 430071, Wuhan, People’s Republic of China

    Meng Zhe & Zheng Hang

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  1. Meng Zhe
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  2. Zheng Hang
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Correspondence to Zheng Hang.

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This article does not contain any studies with human participants performed by any of the authors.

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Zhe, M., Hang, Z. Nephrolithiasis as a risk factor of chronic kidney disease: a meta-analysis of cohort studies with 4,770,691 participants. Urolithiasis 45, 441–448 (2017). https://doi.org/10.1007/s00240-016-0938-x

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  • DOI: https://doi.org/10.1007/s00240-016-0938-x

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