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Extrakorporale Therapien bei Patienten mit Lebererkrankungen auf der Intensivstation

Extracorporeal therapy of patients with liver disease in the intensive care unit

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Zusammenfassung

Akutes und akut-auf-chronisches Leberversagen geht häufig mit der Beeinträchtigung anderer Organsysteme einher. Dies hat eine erhöhte Morbidität und Mortalität zur Folge. Extrakorporale Therapien sind in diesen Patientenpopulationen häufig erforderlich. Die bei diesen Patienten angewandten extrakorporalen Therapien sind einerseits konventionelle Nierenersatzverfahren und andererseits Leberunterstützungsverfahren. Letztere werden in artifizielle und bioartifizielle Leberunterstützungsverfahren unterteilt. Dieses Manuskript beinhaltet eine Übersicht hinsichtlich der derzeitigen Praxis für extrakorporale Therapien bei kritisch kranken Patienten mit Lebererkrankungen.

Abstract

Acute and acute-on-chronic liver failure are often associated with development of organ failure. Its occurrence is associated with high morbidity and mortality. Extracorporeal replacement therapies are frequently necessary in these patient populations. Replacement therapies can be divided into renal replacement therapies and liver support therapies. These therapies consist of artificial liver support systems (i.e., MARS® system, Prometheus®), which are able to remove water-soluble and albumin-bound toxins, and of bioartifical liver support systems. This manuscript provides a review of current practice in the extracorporeal support of patients with liver diseases in the intensive care unit.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. T. Horvatits, A. Drolz·und K. Rutter geben an, dass kein Interessenkonflikt besteht. V. Fuhrmann erhielt Forschungsunterstützung von Baxter/Gambro und war für Baxter/Gambro als Referent tätig. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland

    V. Fuhrmann, T. Horvatits, A. Drolz & K. Rutter

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  1. V. Fuhrmann
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  2. T. Horvatits
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  3. A. Drolz
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  4. K. Rutter
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Correspondence to V. Fuhrmann.

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Fuhrmann, V., Horvatits, T., Drolz, A. et al. Extrakorporale Therapien bei Patienten mit Lebererkrankungen auf der Intensivstation. Med Klin Intensivmed Notfmed 109, 246–251 (2014). https://doi.org/10.1007/s00063-013-0321-4

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  • DOI: https://doi.org/10.1007/s00063-013-0321-4

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