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Letal verlaufende Capnocytophaga-canimorsus-Sepsis nach Hundebiss

Fatal Sepsis Due to Capnocytophaga Canimorsus After Dog Bite

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Zusammenfassung

Ein 56-jähriger Mann wurde 8 Tage nach einem Hundebiss schwerkrank in eine Klinik eingewiesen. Er zeigte ein septisches Bild. Trotz aller intensivmedizinischen Maßnahmen kam es zum Exitus letalis. In der Blutkultur wurde Capnocytophaga canimorsus nachgewiesen. Diese Bakterien gehören zur normalen oralen Flora von Hunden und Katzen. Bei der Übertragung auf den Menschen durch Beißen, Lecken oder Kratzen kann es zu schweren Infektionen kommen. Oft handelt es sich dabei um Menschen mit besonderen Dispositionsfaktoren (Asplenie, Alkoholismus). Die Letalitätsrate der Capnocytophaga- canimorsus-Sepsis liegt bei 25–30%.

Abstract

A 56-year-old man was bitten by a dog. 8 days later he was admitted to a hospital because of severe deterioration of his clinical situation. He developed the clinical picture of fulminant septsis. In spite of aggressive intensive care therapy the patient died 24 hours later. Capnocytophaga canimorsus was identified from initial blood cultures. This gram-negative rod is part of the normal oral flora of dogs and cats. It can be spread to humans by bites, licking or scratches and causes severe infections, especially in persons with special risk factors (splenectomy, alcoholism). The mortality rate in the published cases is 25–30%.

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Literatur

  1. Alberio L, Lämmle B. Capnocytophaga canimorsus sepsis. New Engl J Med 1998;339:1827.

    Article  CAS  PubMed  Google Scholar 

  2. Band RA, et al. A 52-year-old man with malaise and petechial rash. J Emerg Med 2008 (Epub ahead of print).

  3. Biedermann P, Deligne D. Méningite à Capnocytophaga canimorsus dans un tableau digestif initial trompeur. Ann Biol Clin (Paris) 2004;62:110–14.

    CAS  Google Scholar 

  4. Blanche P, et al. Capnocytophaga canimorsus lymphocytic meningitis in an immunocompetent man who was bitten by a dog. Clin Infect Dis 1994;18:654–55.

    CAS  PubMed  Google Scholar 

  5. Case records of the Massachusetts General Hospital. Case 17 — 1999. New Engl J Med 1999;340:1819–26.

  6. Chambers GW, Westblom TU. Pleural infection caused by Capnocytophaga canimorsus, formerly CDC group DF-2. Clin Infect Dis 1992;15:325–26.

    CAS  PubMed  Google Scholar 

  7. Clarke K, et al. Dog-bite induced Capnocytophaga canimorsus septicaemia. Austr NZ J Med 1992;22:86–7.

    CAS  Google Scholar 

  8. De Boer MGJ, et al. Meningitis caused by Capnocytophaga canimorsus: when to expect the unexpected. Clin Neurol Neurosurg 2007;109:393–8.

    Article  PubMed  Google Scholar 

  9. Deshmukh PM, et al. Capnocytophaga canimorsus sepsis with purpura fulminans and symmetrical grangrene following a dog bite in a shelter employee. Am J Med Sci 2004;327:369–72.

    Article  PubMed  Google Scholar 

  10. Dudley MH, Czarnecki LA, Wells MA. Fatal Capnocytophaga infection associated with splenectomy. J Forensic Sci 2006;51:664–6.

    Article  PubMed  Google Scholar 

  11. Duong M, et al. Vertebral osteomyelitis due to Capnocytophaga species in immunocompetent patients: report of two cases and review. Clin Infect Dis 1996;22:1099–101.

    CAS  PubMed  Google Scholar 

  12. Evans RJ. DF2 septicaemia. J Roy Soc Med 1991;84:749–50.

    CAS  PubMed  Google Scholar 

  13. Finn M, Dale B, Isles C. Beware of the dog! A syndrome resembling thrombotic thrombocytopenic purpura associated with Capnocytophaga canimorsus septicaemia. Nephrol Dial Transplant 1996;11:1839–40.

    CAS  PubMed  Google Scholar 

  14. Frigiola A, et al. Case report. Infective endocarditis due to Capnocytophaga canimorsus. Ital Heart J 2003;4:725–27.

    PubMed  Google Scholar 

  15. Gasch O, et al. Community-acquired Capnocytophaga canimorsus meningitis in adults. Report of one case with a subacute course and deafness, and literature review. Enferm Infecc Microbiol Clin 2009;27:33–6.

    Article  PubMed  Google Scholar 

  16. Gibou D, et al. Méningites à Capnocytophaga canimorsus. Méd malad infect 2008;38:32–3.

    Article  CAS  Google Scholar 

  17. Gouin P, et al. Un choc septique d'étiologie inhabituelle: Capnocytophaga canimorsus. Le chien estil toujours le meilleur ami de l'homme? Ann Fr Anesth Réanim 2004;23:1185–8.

    CAS  PubMed  Google Scholar 

  18. Handrick W, et al. Infektionen durch Bissverletzungen bei Kindern — eine Übersicht. Sozialpädiatrie 1999;21:310–3.

    Google Scholar 

  19. Hantson P, et al. Fatal Capnocytophaga canimorsus septicemia in a previously healthy woman. Ann Emerg Med 1991;20:126–7.

    Article  Google Scholar 

  20. Hayani O, et al. Man's best friend? Infective endocarditis due to Capnocytophaga canimorsus. Can J Cardiol 2009;25:e130–e132.

    PubMed  Google Scholar 

  21. Janda JM, et al. Diagnosing Capnocytophaga canimorsus infections. Emerg Infect Dis 2006;12:340–2.

    PubMed  Google Scholar 

  22. Krol-van Straaten MJ, Landheer JE, de Maat CEM. Beware of the dog: meningitis in a splenectomised woman. Netherl J Med 1990;36:301–3.

    CAS  Google Scholar 

  23. Krol-van Straaten MJ, Landheer JE, de Maat CEM. Capnocytophaga canimorsus (formerly DF-2) infections: review of the literature. Netherl J Med 1990;36:304–9.

    CAS  Google Scholar 

  24. Kullberg B-J, et al. Purpura fulminans and symmetrical peripheral gangrene caused by Capnocytophaga canimorsus (formerly DF-2) septicemia — a complication of dog bite. Medicine 1991;70:287–92.

    Article  CAS  PubMed  Google Scholar 

  25. Le Moal G, et al. Meningitis due to Capnocytophaga canimorsus after receipt of a dog bite: case report and review of the literature. Clin Infect Dis 2003;36:e42–e46.

    Article  PubMed  Google Scholar 

  26. Linton DM, et al. Fatal Capnocytophaga canimorsus (DF-2) septicemia: a case report. South Afr Med J 1994;84:857–60.

    CAS  Google Scholar 

  27. Chiang-Mei Low S, Greenwood JE. Capnocytophaga canimorsus: infection, septicaemia, recovery and reconstruction. J Med Microbiol 2008;57:901–3.

    Article  Google Scholar 

  28. Mardelle V, et al. Choc septique à Capnocytophaga canimorsus. Ann Fr Anesth Réanim 2007;26:617–8.

    CAS  PubMed  Google Scholar 

  29. Meybeck A, et al. Meningitis due to Capnocytophaga canimorsus: contribution of 16S RNA ribosomal sequencing for species identification. Scand Infect Dis 2006;38:375–7.

    Article  CAS  Google Scholar 

  30. Nelson MJ, Westfal RE. Case report: vertebral osteomyelitis/discitis as a complication of Capnocytophaga canimorsus bacteremia. J Emerg Med 2008;35:269–71.

    Article  PubMed  Google Scholar 

  31. Ngaage DL, et al. Do not snog the dog: infective endocarditis due to Capnocytophaga canimorsus. Eur J Cardio-thorac Surg 1999;16:362–3.

    Article  CAS  Google Scholar 

  32. Papadaki TG, et al. Capnocytophaga canimorsus endogenous endophthalmitis in an immunocompetent host. Br J Opthalmol 2008;92:1566–7.

    Article  CAS  Google Scholar 

  33. Pers C, et al. Fatal septicaemia caused by DF-2 in a previously healthy man. Scand J Infect Dis 1986;18:265–7.

    Article  CAS  PubMed  Google Scholar 

  34. Pers C, Gahrn-Hansen B, Frederiksen W. Capnocytophaga canimorsus septicemia in Denmark, 1982–1985: review of 39 cases. Clin Infect Dis 1996;23:71–5.

    CAS  PubMed  Google Scholar 

  35. Rolle U, Bennek J, Handrick W. Bissverletzungen bei Kindern. Eine Übersicht. Sozialpädiatrie 1999;21:387–9.

    Google Scholar 

  36. Rolle U, Handrick W. Haemophilus influenzae cellulitis after bite injuries in children. J Pediatr Surg 2000;35:1408–9.

    CAS  PubMed  Google Scholar 

  37. Rosenman JR, Reynolds JK, Kleiman MB. Capnocytophaga canimorsus meningitis in a newborn: an avoidable infection. Pediatr Infect Dis J 2003;22:204–5.

    PubMed  Google Scholar 

  38. Saab M, et al. Fatal septicaemia in a previously healthy man following a dog bite. Int J Clin Pract 1998;52:205.

    CAS  PubMed  Google Scholar 

  39. Sacks R, Kerr K. A 42-year-old woman with septic shock: an unexpected source. J Emerg Med 2009 (Epub ahead of print).

  40. Sandoe J A. Capnocytophaga canimorsus endocarditis. J Med Microbiol 2004;53:245–8.

    Article  PubMed  Google Scholar 

  41. Sawmiller CJ, et al. Postsplenectomy Capnocytophaga canimorsus sepsis presenting as an acute abdomen. Arch Surg 1998;133:1362–65.

    Article  CAS  PubMed  Google Scholar 

  42. Tierney DM, Strauss LP, Sanchez JL. Capnocytophaga canimorsus mycotic abdominal aortic aneurysm: why the mailman is afraid of dogs. J Clin Microbiol 2006;44:649–51.

    Article  PubMed  Google Scholar 

  43. Valtonen M, et al. Capnocytophaga canimorsus septicemia: fifth report of a cat-associated infection and five other cases. Eur J Clin Microbiol Infect Dis 1995;14:520–3.

    Article  CAS  PubMed  Google Scholar 

  44. Van Dam AP, Jansz A. Capnocytophaga canimorsus infections in the Netherlands: a nationwide survey. Clin Microbiol Infect 2010 (Epub ahead of print).

  45. Vanhonsebrouck AY, et al. Fatal septicemia with Capnocytophaga canimorsus in a compromised host. A case report with review of the literature. Acta Clin Belg 1991;46:364–70.

    CAS  PubMed  Google Scholar 

  46. Wald K, Martinez A, Moll S. Capnocytophaga canimorsus infection with fulminant sepsis in an asplenic patient: diagnosis by review of peripheral blood smear. Am J Hematol 2008;83:879.

    Article  PubMed  Google Scholar 

  47. Warwicker P, et al. Acute renal failure with hypocomplementaemic microangiopathy secondary to presumed capnocytophaga sepsis; response to fresh frozen plasma. Nephrol Dial Transplant 1997;12:2800–1.

    Article  CAS  PubMed  Google Scholar 

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Handrick, W., Schwede, I. & Steffens, U. Letal verlaufende Capnocytophaga-canimorsus-Sepsis nach Hundebiss. Med Klin 105, 739–741 (2010). https://doi.org/10.1007/s00063-010-1126-5

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