Abstract
The results of tests of intellectual and psychomotor performance and school performance in a group of school children from a rural impoverished and iodine deficient Andean community whose mothers received injections of iodinated oil prior to the end of the first trimester of pregnancy have been compared with results in children from a neighboring comparable community whose mothers had received no iodinated oil. Subjects between ages 8 and 15 were studied. Statistically significant differences were not observed between the two groups in tests of intellectual function, but children of mothers who had received iodinated oil performed better on tests of psychomotor maturation. The group whose mothers had received oil performed distinctly better when assessed in terms of school drop-out rates, grades achieved, grades repeated, and in overall performance as judged by teacher notes in school records. Performance of both groups on standard tests of intellectual and psychomotor function was lower than standard scores. This may be a result of social and cultural deprivation, the general malnutrition prevailing in the region or other unidentified factors. The improved scoring and school performance exhibited by the children of mothers who received iodinated oil underlines the importance of prophylaxis with iodine in iodine deficient regions as one important contributor to community development.
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Fierro-Benitez R., De Groot L.J., Parades M., Penafiel W. Yodo, bocio y cretinismo endemicos en la region andina del Ecuador. Rev. Ecuat. Med. Cienc. Biol. 5: 15, 1967.
Fierro-Benitez R., Penafiel W., De Groot L.J., Ramirez I. Endemic goiter and endemic cretinism in the Andean region. N. Engl. J. Med. 280: 296, 1969.
Fierro-Benitez R., Stanbury J.B. The effectiveness of iodized oil in goiter prevention in rural Ecuador. Western Hemisphere Nutrition Congress II. AMA, San Juan de Puerto Rico, 1968, p. 58.
Fierro-Benitez R., Ramirez I., Estrella E., Jaramillo C., Diaz C., Urresta J. Iodized oil in the prevention of endemic goiter and associated defects in the Andean region of Ecuador. I. Program design, effects on goiter prevalence, thyroid function and iodine excretion. In: Stanbury, J.B. (Ed.), Endemic goiter. Scientific publication No. 193, PAHO, Washington, D.C., 1969, P. 306.
Kevany J., Fierro-Benitez R., Pretell E., Stanbury J.B. Prophylaxis and treatment of endemic goiter with iodized oil in rural Ecuador and Peru. Am. J. Clin. Nutr. 22: 1597, 1969.
Ramirez I., Fierro-Benitez R., Estrella E., Gomez A., Jaramillo C., Hermida C., Moncayo F. The results of prophylaxis of endemic cretinism with iodized oil in rural Andean Ecuador. In: Stanbury J.B., Kroc R.L.C. (Eds.), Human development and the thyroid gland: relation to endemic cretinism. Plenum Press, New York, 1972, p. 223.
Fierro-Benitez R., Ramirez I., Reinhart J. The role of iodine on intellectual deficiency in areas of chronic iodine deficiency and protein-calorie malnutrition. Xth International Congress of Nutrition, Kyoto, 1975, p. 37.
Fierro-Benitez R., Estrella E., Cruz M., Suarez J. The role of iodine on language development in areas of chronic iodine deficiency and protein-calorie malnutrition. Xth International Congress of Nutrition, Kyoto, p. 187.
Hetzel B.S., Thilly C.H., Fierro-Benitez R., Pretell E.A., Buttfield I.H., Stanbury J.B. Iodized oil in the prevention of endemic goiter and cretinism. In: Stanbury J.B., Hetzel B.S. (Eds.), Endemic goiter and endemic cretinism. John Wiley & Sons, Inc., New York, 1980, p. 513.
Fierro-Benitez R., Ramirez I., Suarez J. Effect of iodine correction early in fetal life on intelligence quotient: a preliminary report. In: Stanbury J.B., Kroc R.L. (Eds.), Human development and the thyroid gland: relation to endemic cretinism. Plenum Press, New York, 1972, p. 239.
Trowbridge F.L. Intellectual assessment in primitive societies, with a preliminary report of a study of the effects of early iodine supplementation on intelligence. In: Stanbury J.B., Kroc R.L. (Eds.), Human development and the thyroid gland: relation to endemic cretinism. Plenum Press, New York, 1972, p. 137.
Fierro-Benitez R., Ramirez I., Suarez J., Jaramillo C., Moncayo F. Effect of the chronic iodine deficiency correction on intelligence. Isr. J. Med. Sci. 8: 17, 1972.
Fierro-Benitez R., Ramirez I., Estrella E., Stanbury J.B. The role of iodine intellectual development in an area of endemic goiter. In: Dunn J.T., Medeiros-Neto G.A. (Eds.), Endemic goiter and cretinism: continuing threats to world health. PAHO Scientific Publication no. 292, Washington, 1974, p. 135.
Profesores y Estudiantes de la Catedra de Endocrinologia, Facultad de Medicina, Universitad Central. Yoduria y prevalencia de bocio en escolares de la provincia. Congress of Endocrinology, Quito, 1978, p. 42.
Fierro-Benitez R., Jativa E., Jijon M., Gomez D., Florez Y., Espinoza N., Lobato P., Sempertegui F., Ramirez I. Prevalencia de bocio en escolares de la parroquia “La Libertad de Quito”. I Anuario de Investigaciones, Facultad de Ciencias Medicas, Instituto de Investigaciones, Quito, 1982, p. 75.
Piaget J., Inhelder B. The psychology of the child. Basic Books Inc., New York, 1969.
Elkind D. Children and adolescents: interpretative essays on Jean Piaget. Oxford University Press, New York, 1970.
Athey I.J., Rubadeau D.O. Educational implications of Piaget’s theory. Blaisdell, Walthan, 1970.
Piaget J. Psicologia de la intelligencia. Psique, Buenos Aires, 1973.
Kagan J. Desarollo psicologico nel nino. In: Faulkner F. (Ed.), Desarollo humano. Salvat, Barcelona, 1969.
Child D. Psicologia para los nocentes. Kapeluez, Buenos Aires, 1975.
Drenth P.J.D. Psychological tests for developing countries: rationale and objectives. Ned. Tijdschr. voor de Psychologie 30, 1975.
Vernon P.E. Intelligence and cultural environment. Methuen, London, 1969.
Querido A., Delange F., Dunn J.T., Fierro-Benitez R., Ibberston H.K., Koutras D.A., Perinetti H. Definitions of endemic goiter and cretinism, classification and cretinism, classification of goiter size and severity of endemias, and survey techniques. In: Dunn J.T, Medeiros-Neto G.A. (Eds.), Endemic goiter and cretinism: continuing threats to world health. PAHO Scientific Publication, no. 292, Washington, D.C., 1974, p. 267.
Terman L.M., Merrill M.A. Stanford-Binet intelligence scale. Houghton Mifflin Co. Boston, 1962.
Navas M. Escala de aptitud intelectual Binet-Terman. Quito, 1971.
Pichot P. Los tests mentales. Paidos, Buenos Aires, 1963.
Navas M. Prueba de aptitud intelectual de Weschler. Quito, 1969.
Goodenough F. Test de inteligencia infantil por medio del dibugo de la figura humana. Paidos, Buenos Aires, 1957.
Goddard S. Test de reintegration motriz. Paidos, Buenos Aires, 1975.
Bender L. Test gestaltico visomotor: usos y aplicaciones clinicas. Paidos, Buenos Aires, 1977.
Raven J.C. Coloured progressive matrices. London, 1962.
Bernstein J. Tests de matrices progresives de Raven. Paidos, Buenos Aires, 1976.
Navas M. La medicion de la aptitud y el aprovechamiento academico: Teoria y aplicacion. Rev. Psic. Gen. Aplic. 6: 26, 1970.
Jolin T., Escobar del Rey F. Evaluation of iodine-creatinine ratios of casual samples as indices of daily iodine output during field studies. J. Clin. Endocrinol. Metab. 25: 540, 1965.
Benotti J., Benotti N. Protein-bound iodine, total iodine, and butanol-extractable iodine by partial automation. Clin. Chem. 9: 408, 1963.
Ramirez I., Fierro-Benitez R., Estrella E., Jaramillo C., Diaz C., Urresta J. Iodized oil in the prevention of endemic goiter and associated defects in the Andean region of Ecuador. II. Effects on neuro-motor development and somatic growth in children before two years. In: Stanbury J.B. (Ed.), Endemic goiter. PAHO Scientific Publication no. 196, Washington, D.C., 1969, p. 341.
Greene L.S. Physical growth and development, neurological maturation and behavioral functioning in two Ecuadorian Andean communities in which goiter is endemic. Am. J. Phys. Anthropol. 38: 119, 1973.
Winick M. Nutrition and mental development. Med. Clin. North Am. 54: 1413, 1970.
Galler J.R., Ramsey F., Solimano G. The influence of early malnutrition on subsequent behavioral development. 1. Degree of impairment in intellectual performance. 2. Classroom behavior. J. Am. Acad. Child Psychiatry 22: 8, 1983.
Bleichrodt N., Garcia I., Rubio C., Morreale de Escobar G., Escobar del Rey F. Developmental disorders associated with severe iodine deficiency. In: Hetzel B.S., Dunn J.T., Stanbury J.B. (eds.), The prevention and control of iodine deficiency disorders. Elsevier, Amsterdam, 1987, p. 65.
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Supported in part by the Public Health Ministry of Ecuador, the Pan American Health Organization, and the U.S. National Institutes of Health.
These studies were reported in the proceedings of a meeting held in Lima, Peru in November, 1983 and published in modified form in PAHO Scientific Publication No. 502, page 182.
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Fierro-Benitez, R., Cazar, R., Stanbury, J.B. et al. Effects on school children of prophylaxis of mothers with iodized oil in an area of iodine deficiency. J Endocrinol Invest 11, 327–335 (1988). https://doi.org/10.1007/BF03349050
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DOI: https://doi.org/10.1007/BF03349050