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Medical complications of intravenous drug use

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References

  1. Cherubin CE. The medical sequelae of narcotic addiction. Ann Intern Med. 1967;67:23–33.

    PubMed  CAS  Google Scholar 

  2. White AG. Medical disorders in drug addicts. JAMA. 1973;223:1469–71.

    Article  PubMed  CAS  Google Scholar 

  3. Kerr P. Concerns about AIDS and crime spurring push to expand drug treatment programs. New York Times. Sept 7, 1988.

  4. Des Jarlais DC, Friedman SR. HIV infection among persons who inject illicit drugs: problems and prospects. J AIDS. 1988;1:267–73.

    Google Scholar 

  5. Hahn RA, Onorato IM, Jones S, Dougherty J. Prevalence of HIV infection among intravenous drug users in the United States. JAMA. 1989;261:2677–84.

    Article  PubMed  CAS  Google Scholar 

  6. Curtis JL, Crummey FC, Baker SN, Foster RE, Khanyile CS, Wilkins R. HIV screening and counseling for intravenous drug abuse patients. JAMA. 1989;261:258–62.

    Article  PubMed  CAS  Google Scholar 

  7. Brickner PW, Torres RA, Barnes M, et al. Recommendations for control and prevention of human immunodeficiency virus (HIV) infection in intravenous drug users. Ann Intern Med. 1989;110:833–7.

    PubMed  CAS  Google Scholar 

  8. Levine DP, Crane LR, Zervos MJ. Bacteremia in narcotic addicts at the Detroit Medical Center. II. Infectious endocarditis: a prospective comparative study. Rev Infect Dis. 1986;8:374–96.

    PubMed  CAS  Google Scholar 

  9. Louria DB, Hensle T, Rose J. The major medical complications of heroin addiction. Ann Intern Med. 1967;67:1–22.

    PubMed  CAS  Google Scholar 

  10. Levine LH, Hirsch CS, White LW. Quinine cardiotoxicity: a mechanism for sudden death in narcotic addicts. J Forensic Sci. 1973;18:167–72.

    PubMed  CAS  Google Scholar 

  11. Pastan RS, Silverman SL, Goldenberg DL. A musculoskeletal syndrome in intravenous heroin users—association with brown heroin. Ann Intern Med. 1977;87:22–9.

    PubMed  CAS  Google Scholar 

  12. Von Glahn WC, Hall JW. The reaction produced in the pulmonary arteries by emboli of cotton fibers. Am J Pathol. 1949;25:573–9.

    Google Scholar 

  13. Lindell TD, Porter JM, Langston C. Intra-arterial injections of oral medications—a complication of drug addiction. N Engl J Med. 1972;287:1132–3.

    Article  PubMed  CAS  Google Scholar 

  14. Wright CB, Lamoy RE, Hobson RW. Hemodynamic effects of intra-arterial injection of drugs of abuse. Surgery. 1976;79:425–31.

    PubMed  CAS  Google Scholar 

  15. Yeager RA, Hobson RW, Padberg FT, Lynch TG, Chakravarty M. Vascular complications related to drug abuse. J Trauma. 1987;27:305–8.

    PubMed  CAS  Google Scholar 

  16. Cregler LL, Mark H. Medical complications of cocaine abuse. N Engl J Med. 1986;315:1495–500.

    Article  PubMed  CAS  Google Scholar 

  17. Isner JM, Estes NAM, Thompson PD, et al. Acute cardiac events temporally related to cocaine abuse. N Engl J Med. 1986;315:1438–43.

    Article  PubMed  CAS  Google Scholar 

  18. Galdun JP, Paris PM, Weiss LD, Heller MB. Central embolization of needle fragments: a complication of intravenous drug abuse. Am J Emerg Med. 1987;5:379–82.

    Article  PubMed  CAS  Google Scholar 

  19. Angelos MG, Sheets CA, Zych PR. Needle emboli to lung following intravenous drug abuse. J Emerg Med. 1986;4:391–6.

    Article  PubMed  CAS  Google Scholar 

  20. Douglass RE, Levison MA. Pneumothorax in drug abusers: an urban epidemic? Am Surg. 1986;52:377–80.

    PubMed  CAS  Google Scholar 

  21. Lewis JW, Groux N, Elliott JP, Jara FM, Obeid FN, Magilligan DJ. Complications of attempted central venous injections performed by drug abusers. Chest. 1980;78:613–7.

    PubMed  Google Scholar 

  22. Geelhoed GW. The addict’s angioaccess. Complications of exotic vascular injection sites. N Y State J Med. 1984;84:585–6.

    PubMed  CAS  Google Scholar 

  23. Pace BW, Doscher W, Margolis IB. The femoral triangle: a potential death trap for the drug abuser. N Y State J Med. 1974;84:596–8.

    Google Scholar 

  24. Garriott JC, Sturner WQ. Morphine concentrations and survival periods in acute heroin fatalities. N Engl J Med. 1973;289:1276–8.

    Article  PubMed  CAS  Google Scholar 

  25. Paranthaman SK, Khan F. Acute cardiomyopathy with recurrent pulmonary edema and hypotension following heroin overdose. Chest. 1976;69:117–9.

    PubMed  CAS  Google Scholar 

  26. Labi M. Paroxysmal atrial fibrillation in heroin intoxication. Ann Intern Med. 1969;71:951–9.

    PubMed  CAS  Google Scholar 

  27. Lipski J, Stimmel B, Donoso E. The effect of heroin and multiple drug abuse on the electrocardiogram. Am Heart J. 1974;86:663–8.

    Article  Google Scholar 

  28. Huber DH. Heroin deaths—mystery or overdose? JAMA. 1974;229:689–90.

    Article  PubMed  CAS  Google Scholar 

  29. Kaufman RE, Levy SB. Overdose treatment: addict folklore and medical reality. JAMA. 1974;227:411–3.

    Article  PubMed  CAS  Google Scholar 

  30. Layon J, Idris A, Warzynski M, et al. Altered T-lymphocyte subsets in hospitalized intravenous drug abusers. Arch Intern Med. 1984;144:1376–80.

    Article  PubMed  CAS  Google Scholar 

  31. Hewlett D, Maayan S, Miller SN, et al. Reversal of T cell helper/suppressor ratios in intravenous drug abusers with nonopportunistic infections. J Infect Dis. 1985;151:748–9.

    PubMed  Google Scholar 

  32. Husby G, Pierce PE, Williams RC. Smooth muscle antibody in heroin addicts. Ann Intern Med. 1975;83:801–5.

    PubMed  CAS  Google Scholar 

  33. McDonough RJ, Madden JJ, Flaek A, et al. Alteration of T and null lymphocyte frequencies in the peripheral blood of human opiate addicts: in vivo evidence for opiate receptor sites on T lymphocytes. J Immunol. 1980;125:2539–43.

    PubMed  CAS  Google Scholar 

  34. Brown SM, Stimmel B, Taub RN, Kochwa S, Rosenfield RE. Immunologic dysfunction in heroin addicts. Arch Intern Med. 1974;134:1001–6.

    Article  PubMed  CAS  Google Scholar 

  35. Savona S, Nardi MA, Lennette ET, Karpatkin S. Thrombocytopenic purpura in narcotics addicts. Ann Intern Med. 1985;102:737–41.

    PubMed  CAS  Google Scholar 

  36. Ryan DH. heroin and thrombocytopenia. Ann Intern Med. 1979;90:852–3.

    PubMed  CAS  Google Scholar 

  37. Geller SA, Stimmel B. Diagnostic confusion from lymphatic lesions in heroin addicts. Ann Intern Med. 1973;78:703–5.

    PubMed  CAS  Google Scholar 

  38. Des Jarlais DC, Friedman SR, Stoneburner RL. HIV infection and intravenous drug use: critical issues in transmission dynamics, infection outcomes, and prevention. Rev Infect Dis. 1988;10:151–8.

    PubMed  Google Scholar 

  39. Tuazon CV, Hill R, Sheayren JN. Microbiologic study of street heroin and injection paraphernalia. J Infect Dis. 1974;129:327–9.

    PubMed  CAS  Google Scholar 

  40. Tuazon CU, Elin RJ. Endotoxin content of street heroin. Arch Intern Med. 1981;141:1385–6.

    Article  PubMed  CAS  Google Scholar 

  41. Spiro TE, Jaffe R, Holland PV, et al. A study of street heroin lots for the presence of the hepatitis B surface antigen. Drug Alcohol Dep. 1978;3:393–7.

    Article  CAS  Google Scholar 

  42. Orangio GR, Della Latta P, Marino C, et al. Infections in parenteral drug abusers, further immunologic studies. Am J Surg. 1983;146:738–41.

    Article  PubMed  CAS  Google Scholar 

  43. Orangio GR, Pitlick SD, Della Latta P, et al. Soft tissue infections in parenteral drug abusers. Ann Surg. 1984;199:97–100.

    Article  PubMed  CAS  Google Scholar 

  44. Saravolatz LD, Markowitz N, Arking LM, Pohlod D, Fisher E. Methicillin-resistantStaphylococcus aureus: epidemiologic observations during a community-acquired outbreak. Ann Intern Med. 1982;96:11–6.

    PubMed  CAS  Google Scholar 

  45. Marantz PR, Linzer M, Feiner CJ, Feinstein SA, Kozin AM, Friedland GH. Inability to predict diagnosis in febrile intravenous drug abusers. Ann Intern Med. 1987;106:823–8.

    PubMed  CAS  Google Scholar 

  46. Crane LR, Levine DP, Zervos MJ, Cummings G. Bacteremia in narcotic addicts at the Detroit Medical Center. I. Microbiology, epidemiology, risk factors, and empiric therapy. Rev Infect Dis. 1986;8:364–73.

    PubMed  CAS  Google Scholar 

  47. Borow KM, Alpert JS, Pennington J. Transient Pseudomonas bacteremia in a heroin addict—resemblance to right-sided endocarditis. JAMA. 1978;240:560–1.

    Article  PubMed  CAS  Google Scholar 

  48. Dunne JH, Johnson WC. Necrotizing skin lesions in heroin addicts. Arch Dermatol. 1975;105:544–7.

    Article  Google Scholar 

  49. Webb D, Thadepolli. Skin and soft tissue polymicrobial infections from intravenous abuse of drugs. West J Med. 1979;130:200–4.

    PubMed  CAS  Google Scholar 

  50. Cherubin CE. Clinical severity of tetanus in narcotic addicts in New York City. Arch Intern Med. 1968;121:156–8.

    Article  PubMed  CAS  Google Scholar 

  51. Macdonald KL, Rutherford GW, Friedman SM, et al. Botulism and botulism-like illness in chronic drug abusers. Ann Intern Med. 1985;102:616–8.

    PubMed  CAS  Google Scholar 

  52. Jacobson JM, Hirschman SZ. Necrotizing fasciitis complicating intravenous drug abuse. Arch Intern Med. 1982;142:634–5.

    Article  PubMed  CAS  Google Scholar 

  53. Firooznia H, Golimbu C, Rafii M, Lichtman EA. Radiology of musculoskeletal complications of drug addiction. Sem Roentgen. 1983;18:198–206.

    Article  CAS  Google Scholar 

  54. Roca RP, Yoshikawa TT. Primary skeletal infections in heroin users: a clinical characterization, diagnosis and therapy. Clin Orthop. 1979;144:238–48.

    PubMed  Google Scholar 

  55. Chandrasekar PH, Narula AP. Bone and joint infections in intravenous drug abusers. Rev Infect Dis. 1986;8:904–11.

    PubMed  CAS  Google Scholar 

  56. Firooznia H, Seligel G, Abrams RM, Valensi V, Shamoun J. Disseminated extrapulmonary tuberculosis in association with heroin addiction. Radiology. 1973;109:291–6.

    PubMed  CAS  Google Scholar 

  57. Jaffe RB. Cardiac and vascular involvement in drug abuse. Sem Roentgen. 1983;8:207–12.

    Article  Google Scholar 

  58. Nallathambi MN, Ivatury RR, Lankin DH, Wapnir IL, Stahl WM. Pyogenic splenic abscess in intravenous drug addiction. Am Surg. 1987;53:342–6.

    PubMed  CAS  Google Scholar 

  59. Fry DE, Richardson JD, Flint LM. Occult splenic abscess: an unrecognized complication of heroin abuse. Surgey. 1978;84:650–4.

    CAS  Google Scholar 

  60. Dupont B, Drouhet E. Cutaneous, ocular, and osteoarticular candidiasis in heroin addicts: new clinical and therapeutic aspects in 38 patients. J Infect Dis. 1985;152:577–91.

    PubMed  CAS  Google Scholar 

  61. Collignon PJ, Sorrell TC. Disseminated candidiasis: evidence of a distinctive syndrome in heroin abusers. B Med J. 1983;287:861–2.

    CAS  Google Scholar 

  62. Collignon PJ, Sorrell T. Candidiasis in heroin addicts. J Infect Dis. 1987;155:595.

    PubMed  CAS  Google Scholar 

  63. Podzamczer D, Gudiol F. Systemic candidiasis in heroin addicts. J Infect Dis. 1986;153:1182–3.

    PubMed  CAS  Google Scholar 

  64. Durack DT, Beeson PB. Experimental bacterial endocarditis: I. Colonization of a sterile vegetation. Br J Exp Pathol. 1972;53:44–9.

    PubMed  CAS  Google Scholar 

  65. Martin RP, Meltzer RS, Chia BL, Stinson EB, Rakowski H, Popp RL. Clinical utility of two-dimensional echocardiography in infective endocarditis. Am J Cardiol. 1980;46:379–85.

    Article  PubMed  CAS  Google Scholar 

  66. Davis RS, Strom JA, Frishman W, et al. The demonstration of vegetations by echocardiography in the evaluation of patients with infective endocarditis. Am J Cardiol. 1979;43:738–44.

    Article  Google Scholar 

  67. Dubois RW, Ginzton LE. Role of echocardiography in suspected infective endocarditis in intravenous drug abusers. Am J Cardiol. 1986;58:649–50.

    Article  PubMed  CAS  Google Scholar 

  68. Come PC, Isaacs RE, Riley MF. Diagnostic accuracy of M-mode echocardiography in active infective endocarditis and prognostic implications of ultrasound-detectable vegetations. Am Heart J. 1982;103:839–47.

    Article  PubMed  CAS  Google Scholar 

  69. Chambers HF, Morris L, Tauber MG. Cocaine use and the risk for endocarditis in intravenous drug abusers. Ann Intern Med. 1987;106:833–6.

    PubMed  CAS  Google Scholar 

  70. Scheld WM, Zak O, Vosbeck K, Sande MA. Bacterial adhesion in the pathogenesis of infective endocarditis. Effect of subinhibitory antibiotic concentrations on streptococcal adhesion in vitro and the development of endocarditis in rabbits. J Clin Invest. 1981;68:1381–4.

    PubMed  CAS  Google Scholar 

  71. Ramirez-Ronda CH. Adherence of glucan-positive and glucannegative streptococcal strains to normal and damaged heart valves. J Clin Invest. 1978;62:805–14.

    Article  PubMed  CAS  Google Scholar 

  72. Neu HC, Srinivasan S. Infective endocarditis increases among narcotic addicts. J Card Med. 1981;675–87.

  73. Bayer AS, Blomquist IK, Bello E, Chiu CY, Ward JI, Ginzton LE. Tricuspid valve endocarditis due toStaphylococcus aureus: correlation of two-dimensional echocardiography with clinical outcome. Chest. 1988;2:247–53.

    Google Scholar 

  74. Reiner NE, Gopalakrishna KV, Lerner PI. Enterococcal endocarditis in heroin addicts. JAMA. 1976;235:1861–3.

    Article  PubMed  CAS  Google Scholar 

  75. Barg NL, Kish MA, Kauffman CA, Supena RB. Group A streptococcal bacteremia in intravenous drug abusers. Am J Med. 1985;78:569–74.

    Article  PubMed  CAS  Google Scholar 

  76. Gerac JE, Wilson WR. Symposium in infective endocarditis. III. Endocarditis due to gram-negative bacteria: report to 56 cases. Mayo Clin Proc. 1982;57:145–8.

    Google Scholar 

  77. Wong D, Chandraratna PAN, Wishnow RM, Dusitnanond V, Nimalasuriya A. Clinical implications of large vegetations in infectious endocarditis. Arch Intern Med. 1983;143:1874–7.

    Article  PubMed  CAS  Google Scholar 

  78. Saravolatz LD, Burch KH, Quinn EL, Cox F, Madhavan T, Fisher E. Polymicrobial infective endocarditis: an increasing clinical entity. Am Heart J. 1978;95:163–8.

    Article  PubMed  CAS  Google Scholar 

  79. Korzeniowski O., Sande MA, and the National Collaborative Endocarditis Study Group. Combination antimicrobial therapy forStaphylococcus aureus endocarditis in patients addicted to parenteral drugs and in nonaddicts: a prospective study. Ann Intern Med. 1982;97:496–503.

    PubMed  CAS  Google Scholar 

  80. Chambers HF, Miller RT, Newman MD. Right-sidedStaphylococcus aureus endocarditis in intravenous drug abusers: two week combination therapy. Ann Intern Med. 1988;109:619–24.

    PubMed  CAS  Google Scholar 

  81. Denbile M. Surgery for addiction related tricuspid valve endocarditis: caveat emptor. Am J Med. 1987;82:811–3.

    Article  Google Scholar 

  82. Denubile MJ. Surgery in active endocarditis. Ann Intern Med. 1982;96:650–9.

    Google Scholar 

  83. Frand UI, Shim CS, Williams MH. Heroin-induced pulmonary edema. Sequential studies of pulmonary function. Ann Intern Med. 1972;77:29–35.

    PubMed  CAS  Google Scholar 

  84. Saba GP, James AE, Johnson BA, et al. Pulmonary complications of narcotic abuse. AJR. 1974;122:733–9.

    Google Scholar 

  85. Stern WZ, Subbarao K. Pulmonary complications of drug addiction. Semin Roentgenol. 1983;18:183–97.

    Article  PubMed  CAS  Google Scholar 

  86. Louria DB. Lung disease in heroin addicts. JAMA. 1982;248:2536.

    Google Scholar 

  87. Helpern M. Fatalities from narcotic addiction in New York City. Incidence, circumstances, and pathologic findings. Hum Pathol. 1972;3:13–21.

    PubMed  CAS  Google Scholar 

  88. Katz S, Aberman A, Frand UI, et al. Heroin pulmonary edema. Evidence for increased pulmonary capillary permeadility. Am Rev Respir Dis. 1972;106:472–4.

    PubMed  CAS  Google Scholar 

  89. Felman AH. Neurogenic pulmonary edema. AJR. 1971;112:393–6.

    CAS  Google Scholar 

  90. Phillips JF, Neiman HL, Reeder MM. Noncardiac causes of pulmonary edema. JAMA. 1975;234:531–2.

    Article  PubMed  CAS  Google Scholar 

  91. Warnock ML, Ghahremani GG, Rattenborg C, Ginsberg M, Valanyuela J. Pulmonary complications of heroin intoxication: aspiration pneumonia and diffuse bronchiectasis. JAMA. 1972;219:1051–3.

    Article  PubMed  CAS  Google Scholar 

  92. Anderson K. Bronchospasm and intravenous street heroin. Lancet. 1986;1:1208.

    Article  PubMed  CAS  Google Scholar 

  93. Jaffe RB, Koschmann EB. Septic pulmonary emboli. Radiology. 1970;96:527–32.

    PubMed  CAS  Google Scholar 

  94. Danner PK, McFarland DR, Felson B. Massive pulmonary gangrene. AJR. 1968;103:548–54.

    CAS  Google Scholar 

  95. Lamb D, Roberts G. Starch and talc emboli in drug addicts’ lungs. J Clin Pathol. 1972;25:876–81.

    PubMed  CAS  Google Scholar 

  96. Pare PJA, Fraser RG, Hogg JC, Howlett SG, Murphy JB. Pulmonary “mainline” granulomatosis: talcosis of intravenous methadone abuse. Medicine. 1979;58:229–39.

    PubMed  CAS  Google Scholar 

  97. Robertson CH, Reynolds RC, Wilson JE. Pulmonary hypertension and foreign body granulomas in intravenous drug abusers. Documentation by cardiac catheterization and lung biopsy. Am J Med. 1976;61:657–64.

    Article  PubMed  Google Scholar 

  98. Farber HW, Fairman RP, Glauser FL. Talc granulomatosis: laboratory findings similar to sarcoidosis. Am Rev Respir Dis. 1982;125:259–61.

    Google Scholar 

  99. Overland ES, Nolan AJ, Hopewell PC. Alteration of pulmonary function in intravenous drug abusers. Prevalence, severity, and characterization of gas exchange abnormalities. Am J Med. 1980;68:231–7.

    Article  PubMed  CAS  Google Scholar 

  100. Camargo G, Cold C. Pulmonary function studies in ex-heroin users. Chest. 1975;67:331–4.

    PubMed  CAS  Google Scholar 

  101. Soin JS, Wagner HN, Thomashow D, Brown TC. Increased sensitivity of regional measurements in early detection of narcotic lung disease. Chest. 1975;325–30.

  102. Goldstein DS, Karpel JP, Appel D, Williams MH. Bullous pulmonary damage in users of intravenous drugs. Chest. 1986;89:266–9.

    PubMed  CAS  Google Scholar 

  103. Sieniewicz DJ, Nidecker AC. Conglomerate pulmonary disease: a form of talcosis in intravenous methadone abusers. AJR. 1980;135:697–702.

    PubMed  CAS  Google Scholar 

  104. Richter RW, Challenor YB, Pearson J, Kagen LJ, Hamilton LL, Ramsey WH. Acute myoglobinuria associated with heroin addiction. JAMA. 1971;216:1172–6.

    Article  PubMed  CAS  Google Scholar 

  105. Schreiber SN, Liebowitz MR, Bernstein LH, et al. Limb compression and renal impairment (crush syndrome) complicating narcotic overdose. N Engl J Med. 1971;284:368–9.

    Article  PubMed  CAS  Google Scholar 

  106. Tu WH, Shearn MA, Lee JC. Acute diffuse glomerulonephritis in acute staphylococcal endocarditis. Ann Intern Med. 1969;71:335–41.

    PubMed  CAS  Google Scholar 

  107. Melchior J, Mebust WK, Valk WL. Ureteral colic from a fungus ball: unusual presentations of systemic aspergillosis. J Urol. 1972;108:698–9.

    PubMed  CAS  Google Scholar 

  108. Levy M, Kleinknecht C. Membranous glomerulonephritis and hepatitis B virus infection. Nephron. 1980;26:259–65.

    PubMed  CAS  Google Scholar 

  109. Kohler PF, Cronin RE, Hammond WS, Olin D, Carr RI. Chronic membranous glomerulonephritis caused by hepatitis B antigen-antibody immune complexes. Ann Intern Med. 1974;81:448–51.

    PubMed  CAS  Google Scholar 

  110. Eknoyan G, Gyorkey F, Dischoso C, et al. Renal involvement in drug abuse. Arch Intern Med. 1973;132:801–6.

    Article  PubMed  CAS  Google Scholar 

  111. Citron BP, Halpern M, McCarron M, et al. Necrotizing angiitis associated with drug abuse. N Engl J Med. 1970;283:1003–11.

    Article  PubMed  CAS  Google Scholar 

  112. Salomon MI, Pui Poon T, Goldblatt M, et al. Renal lesions in heroin addicts—a study based on kidney biopsies. Nephron. 1972;9:356–63.

    PubMed  CAS  Google Scholar 

  113. Cunningham EE, Brentjens JR, Zielezny MA, Andres GA, Venuto RC. Heroin nephropathy: a clinicopathologic and epidemiologic study. Am J Med. 1980;68:47–53.

    Article  PubMed  CAS  Google Scholar 

  114. Treser G, Cherubin C, Lonergan ET, et al. Renal lesions in narcotic addicts. Am J Med. 1974;57:687–94.

    Article  PubMed  CAS  Google Scholar 

  115. Rao TKS, Nicastri AD, Friedman EA. Natural history of heroinassociated nephropathy. N Engl J Med. 1974;290:19–23.

    Article  PubMed  CAS  Google Scholar 

  116. McGinn JT, McGinn TG, Hoffman RS. Nephrotic syndrome in heroin and cocaine addicts. Clin Res. 1970;18:699.

    Google Scholar 

  117. Kilcoyne MM, Daly JJ, Gocke DJ, et al. Nephrotic syndrome in heroin addicts. Lancet. 1972;1:17–20.

    Article  PubMed  CAS  Google Scholar 

  118. Friedman EA, Rao TKS. Why does uremia in heroin abusers occur predominantly among blacks? JAMA. 1983;250:2965–6.

    Article  PubMed  CAS  Google Scholar 

  119. Marchand G, Cantin M, Cote M. Evidence for the nephrotoxicity of morphine sulfate in rats. Can J Physiol Pharmacol. 1969;47:649–55.

    PubMed  CAS  Google Scholar 

  120. Cunningham EE, Zielezny MA, Venuto RC. Heroin-associated nephropathy: a nationwide problem. JAMA. 1983;250:2935–6.

    Article  PubMed  CAS  Google Scholar 

  121. Ross G, Weinstein S, Dutton S, Whittier FC. Renal transplantation in the end stage renal disease of drug abuse. J Urol. 1983;129:14–5.

    PubMed  Google Scholar 

  122. Neugarten J, Gallo GR, Buxbaum J, Katz LA, Rubenstein J, Baldwin DS. Amyloidosis in subcutaneous heroin abusers (“skin poppers’ amyloidosis”) Am J Med. 1986;81:635–40.

    Article  PubMed  CAS  Google Scholar 

  123. Menchel S, Cohen D, Gross E, Frangione B, Gallo G. AA proteinrelated renal amyloidosis in drug addicts. Am J Pathol. 1983;112:195–9.

    PubMed  CAS  Google Scholar 

  124. Meador KH, Sharon Z, Lewis EJ. Renal amyloidosis and subcutaneous drug abuse. Ann Intern Med. 1979;91:565–7.

    PubMed  CAS  Google Scholar 

  125. Jacob H, Charytan C, Rascoff JH, Golden R, Janis R. Amyloidosis secondary to drug abuse and chronic skin suppuration. Arch Intern Med. 1978;138:1150–1.

    Article  PubMed  CAS  Google Scholar 

  126. Ferraro EM, Alfelor FR, Lee M, Poon TT. Hepatic amyloidosis in an IV drug abuser detected by bone scintigraphy. Clin Nuc Med. 1987;12:274–6.

    Article  CAS  Google Scholar 

  127. Derosena R, Koss MN, Pirani CL. Demonstration of amyloid fibrils in urinary sediment. N Engl J Med. 1975;293:1131–3.

    Article  PubMed  CAS  Google Scholar 

  128. Dikman SH, Kahn T, Gribetz D, Churg J. Resolution of renal amyloidosis. Am J Med. 1977;63:430–3.

    Article  PubMed  CAS  Google Scholar 

  129. Francis DP, Hadler SC, Prendergast TJ, et al. Occurrence of hepatitis A, B, and non-A/non-B in the United States—CDC Sentinel County Hepatitis Study 1. Am J Med. 1984;76:69–74.

    Article  PubMed  CAS  Google Scholar 

  130. Kreek MJ, Dodes L, Kanes S, Knobler J, Martin R. Long-term methadone maintenance therapy: effects on liver function. Ann Intern Med. 1972;77:598–602.

    PubMed  CAS  Google Scholar 

  131. Novick DM, Gelb AM, Stenger RJ, et al. Hepatitis B serologic studies in narcotic users with chronic liver disease. Am J Gastroenterol. 1981;75:111–5.

    PubMed  CAS  Google Scholar 

  132. Center for Disease Control. Hepatitis B—New Bern, North Carolina. MMWR. 1979;28:373–4.

    Google Scholar 

  133. Min K, Gyorkey F, Cain GD. Talc granulomata in liver disease in narcotic addicts. Arch Pathol. 1974;98:331–5.

    PubMed  CAS  Google Scholar 

  134. Cherubin CE, Rosenthal WS, Stenger RE, et al. Chronic liver disease in asymptomatic narcotic addicts. Ann Intern Med. 1972;76:391–5.

    PubMed  CAS  Google Scholar 

  135. Kunches LM, Craven DE, Werner BG. Seroprevalence of hepatitis B virus and delta agent in parenteral drug abusers—immunogenicity of hepatitis B vaccine. Am J Med. 1986;81:591–5.

    Article  PubMed  CAS  Google Scholar 

  136. Seeff LB. Hepatitis in the drug abuser. Med Clin North Am. 1975;59:843–8.

    PubMed  CAS  Google Scholar 

  137. Mosley JW, Redeker AG, Feinstone SM, Purcell RH, Multiple hepatitis viruses in multiple attacks of acute viral hepatitis. N Engl J Med. 1977;296:75–80.

    Article  PubMed  CAS  Google Scholar 

  138. Lettau LA, McCarthy JG, Smith MH, et al. Outbreak of severe hepatitis due to delta and hepatitis B viruses in parenteral drug abusers and their contacts. N Engl J Med. 1987;317:1256–61.

    Article  PubMed  CAS  Google Scholar 

  139. Shattock AG, Irwin FM, Morgan BM, et al. Increased severity and morbidity of acute hepatitis in drug abusers with simultaneously acquired hepatitis B and hepatitis D virus infections. Br Med J. 1985;290:1377–80.

    Article  CAS  Google Scholar 

  140. Hansson BG, Moestrup T, Widell A, Nordenfelt E. Infection with delta agent in Sweden: introduction of a new hepatitis agent. J Infect Dis. 1982;146:472–8.

    PubMed  CAS  Google Scholar 

  141. Nishioka NS, Dienstag JL. Delta hepatitis—a new scourge? N Engl J Med. 1985;312:1515–6.

    Article  PubMed  CAS  Google Scholar 

  142. De Cock KM, Govindarajan S, Chin KP, Redeker AG. Delta hepatitis in the Los Angeles area: a report of 126 cases. Ann Intern Med. 1986;105:108–14.

    PubMed  Google Scholar 

  143. Govindarajan S, Valinluck B, Peters RL. Relapse of acute B viral hepatitis: the role of delta agent. Gut. 1986;27:19–22.

    PubMed  CAS  Google Scholar 

  144. Shih JWK, Esteban JI, Alter HJ. Non-A, non-B hepatitis: advances and unfulfilled expectations of the first decade. Progr Liver Dis. 1986;8:433–52.

    PubMed  CAS  Google Scholar 

  145. Hoofnagle KH, Gerety RJ, Tabor E, Feinstone SH, Barker LF, Purcell RH. Transmission of non-A, non-B hepatitis. Ann Intern Med. 1977;87:14–20.

    PubMed  CAS  Google Scholar 

  146. Hollinger FB, Khan NC, Oefinger PE, et al. Posttransfusion hepatitis type A. JAMA. 1983;250:2313–7.

    Article  PubMed  CAS  Google Scholar 

  147. Moestrup T, Hansson BG, Widell A, Nordenfelt E, Hagerstrand I. Long term follow up of chronic hepatitis B virus infection in intravenous drug abusers and homosexual men. Br Med J. 1986;292:854–7.

    CAS  Google Scholar 

  148. Kanel GC, Govindarajan S, Peters RL. Chronic delta infection and liver biopsy changes in chronic active hepatitis B. Ann Intern Med. 1984;101:51–4.

    PubMed  CAS  Google Scholar 

  149. Richter RW, Pearson J, Bruun B, Challenor YB, Brust JCM, Baden MM. Neurological complications of addiction to heroin. Bull NY Acad Med. 1973;49:3–21.

    CAS  Google Scholar 

  150. Rubin AM. Neurologic complications of intravenous drug abuse. Hosp Pract. 1987;(15 April)279–88.

  151. Mittelman RE, Wetli CV. Death caused by recreational cocaine use—an update. JAMA. 1984;252:1889–93.

    Article  Google Scholar 

  152. Smith WR, Wilson AF. Guillain-Barré syndrome in heroin addiction. JAMA. 1975;231:1367–8.

    Article  PubMed  CAS  Google Scholar 

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Received from the Division of General Internal Medicine, Brown University, Rhode Island Hospital, 593 Eddy Street, Providence, Rhode Island 02903.

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Stein, M.D. Medical complications of intravenous drug use. J Gen Intern Med 5, 249–257 (1990). https://doi.org/10.1007/BF02600544

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