Skip to main content
Log in

Modification of the skin feeding site by tick saliva mediates virus transmission

  • Research Articles
  • Published:
Experientia Aims and scope Submit manuscript

Abstract

A tick vector of Thogoto (THO) virus was shown to secrete a factor in saliva which potentiates the transmission of THO virus to uninfected ticks feeding on an apparently non-viraemic host. The effect of the saliva activated transmission (SAT) factor on the virus occurred at the site of inoculation in the skin and was apparent even when the virus was introduced 3 days after the SAT factor. The results suggest that tick saliva can play an important role in disease transmission by virtue of host modification at the site of feeding.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Karabatsos, N., in: International Catalogue of Arboviruses Including Certain Other Viruses of Vertebrates. American Society of Tropical Medicine and Hygiene, 1985.

  2. World Health Organization, Arthropod-borne and rodent-borne viral diseases. WHO Technical Report, No. 719, 1985.

  3. Haig, D. A., Woodall, J. P., and Danskin, D., J. gen. Microbiol38 (1965) 389.

    Article  CAS  PubMed  Google Scholar 

  4. Davies, F. G., Soi, R. K., and Wariru, B. N., Vet. Rec.115 (1984) 654.

    Article  CAS  PubMed  Google Scholar 

  5. Moore, D. L., Causey, O. R., Carey, D. E., Reddy, S., Cooke, A. R., Akinkugbe, F. M., David-West, T. S., and Kemp, G. E., Ann. trop. Med. Parasit.69 (1975) 49.

    Article  CAS  PubMed  Google Scholar 

  6. Staunton, D., Nuttall, P. A., and Bishop, D. H. L., J. gen. Virol.70 (1989) 2811.

    Article  CAS  PubMed  Google Scholar 

  7. Jones, L. D., Davies, C. R., Steele, G. M., and Nuttall, P. A., Med. Vet. Ent.3 (1989) 195.

    Article  CAS  Google Scholar 

  8. Jones, L. D., Davies, C. R., Steele, G. M., and Nuttall, P. A., Science237 (1987) 775.

    Article  CAS  PubMed  Google Scholar 

  9. Jones, L. D., Hodgson, E., and Nuttall, P. A., J. gen. Virol.70 (1989) 1895.

    Article  PubMed  Google Scholar 

  10. Albanese, M., Bruno-Smiraglia, C., Di Cuonzo, G., Lavignino, A., and Srihongse, S., Acta virol.16 (1972) 267.

    CAS  PubMed  Google Scholar 

  11. Davies, C. R., Jones, L. D., and Nuttall, P. A., Am. J. trop. Med. Hyg.35 (1986) 1256.

    Article  CAS  PubMed  Google Scholar 

  12. Jones, L. D., Davies, C. R., Steele, G. M., and Nuttall, P. A., Anim. Tech.39 (1988) 99.

    Google Scholar 

  13. Kaufman, W. R., and Wong, D. L. P., Eur. J. Pharmac.87 (1983) 43.

    Article  CAS  Google Scholar 

  14. Jones, L. D., and Nuttall, P. A., Trans. Roy. Soc. Trop. Med. Hyg.83 (1989) 712.

    Article  CAS  PubMed  Google Scholar 

  15. Wikel, W. K., in: Current Topics in Vector Research, p. 249. Ed. K. F. Harris. Praeger Publishers, New York 1983.

    Google Scholar 

  16. Neitz, A. W. H., and Vermeulen, N. M. J., Onderstepoort J. vet. Res.54 (1987) 443.

    CAS  PubMed  Google Scholar 

  17. Titus, R. G., and Ribeiro, J. M. C., Science239 (1988) 1306.

    Article  CAS  PubMed  Google Scholar 

  18. Ribeiro, J. M. C., Vachereau, A., Modi, G. B., and Tesh, R. B., Science243 (1989) 212.

    Article  CAS  PubMed  Google Scholar 

  19. Jones, L. D., Hodgson, E., and Nattall, P. A., Arch. Virol., Suppl. 1 (1990) 227.

    Google Scholar 

  20. Streilein, J. W., J. Invest. Dermatol.85 (1985) 10s.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Jones, L.D., Kaufman, W.R. & Nuttall, P.A. Modification of the skin feeding site by tick saliva mediates virus transmission. Experientia 48, 779–782 (1992). https://doi.org/10.1007/BF02124302

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02124302

Key words

Navigation