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Intestinal secretion as a cause of hypokalemia and cardiac arrest in a patient with Strongyloidiasis

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Summary

A 32-year-old white American male contracted strongyloidiasis in Nigeria. Prolonged and severe watery diarrhea was complicated by hypokalemia and cardiac arrest. Steady-state perfusion studies with a plasma-like electrolyte solution revealed net secretion of water, sodium, potasssium, and chloride in a segment of jejunum. Mucosal permeability measured by the ration of [14C]urea and tritiated water diffusion was unchanged. Chloride secretion occurred against both an electrical and chemical gradient, which suggests that chloride secretion was active. Intestinal water and electrolyte secretion may be the mechanism of watery diarrhea in patients with strongyloidiasis.

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Authors and Affiliations

  1. the Divison of Gastroenterology and Infectious Diseases, University of Texas Health Science Center at Dallas, Southwestern Medical School, 5323 Harry Hines, 75235, Dallas, Texas

    Mary G. Kane MD, James P. Luby MD &  Guenter J. Krejs MD

Authors
  1. Mary G. Kane MD
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  2. James P. Luby MD
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  3. Guenter J. Krejs MD
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Additional information

This work was supported by USPHS research grant 1R01-AM28390-02 and 5-M01-RR-00633.

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Kane, M.G., Luby, J.P. & Krejs, G.J. Intestinal secretion as a cause of hypokalemia and cardiac arrest in a patient with Strongyloidiasis. Digest Dis Sci 29, 768–772 (1984). https://doi.org/10.1007/BF01312953

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  • DOI: https://doi.org/10.1007/BF01312953

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