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Pulsatile Therapie mit LH-RH

  • Zweites Hauptthema/Deuxième Thême Principal Evolution des Méthodes Diagnostiques et Thérapeutiques des Troubles de L'ovulation
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Zusammenfassung

Bei der reinen hypothalamischen Amenorrhoe ist die pulsatile Gabe von LH-RH die Methode der Wahl zur Ovulationsinduktion. Wegen der geringeren Komplikationenrate ist der subkutanen Verabreichungsform der Vorzug zu geben. Eine intravenöse pulsatile Gabe von LH-RH sollte denjenigen Frauen vorgehalten werden, die auf eine subkutane Verabreichung nicht oder ungenügend ansprechen. Die pulsatile Verabreichung von LH-RH kann mit Erfolg auch bei hyperprolaktinämischen Patientinnen zur Ovulationsinduktion eingesetzt werden, wenn die Gabe eines Prolaktinhemmers nicht möglich ist [15, 41]. Schließlich ist es möglich, auch bei Frauen mit polyzystischem Ovarsyndrom eine pulsatile Gabe von LH-RH zu wählen, wenn die Risiken einer Ovulations-induktion mit Gonadotropinen nicht in Kauf genommen werden können. Dabei ist allerdings zu berücksichtigen, daß sich die Ovulations- und Erfolgsrate umgekehrt proportional zu den Androgenspiegeln verhält.

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  1. Abteilung für gynäkologische Endokrinologie, Universitätsfrauenklinik, Bern, Schweiz

    M. H. Birkhäuser

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Birkhäuser, M.H. Pulsatile Therapie mit LH-RH. Arch Gynecol Obstet 246 (Suppl 1), S38–S44 (1989). https://doi.org/10.1007/BF00935851

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