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Metabolism of citrulline in man

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Summary

Citrulline is a non protein amino acid involved in three important metabolic pathways, the intrahepatic transformation of ammonia to urea, the de novo synthesis of arginine from glutamine in gut and kidney, the nitric oxide synthesis. The two first pathways use the same enzyme activities but are regulated in different way. This review describe these pathways and their regulation in different tissues. In the light of our knowledge we tried to explain the physiological and pathological (inherited or acquired) variations in man.

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  1. Laboratoire Biochimie Médicale B-URA CNRS 1335, Université René Descartes Hôpital Necker -Enfants Malades, 149, rue de Sèvres, F-75743, Paris Cedex 15, France

    D. Rabier & P. Kamoun

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  1. D. Rabier
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  2. P. Kamoun
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Rabier, D., Kamoun, P. Metabolism of citrulline in man. Amino Acids 9, 299–316 (1995). https://doi.org/10.1007/BF00807268

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