Skip to main content
SpringerLink
Log in

Oxidative Stresses and Ageing

  • Chapter
  • First Online:
Aging Research in Yeast

Part of the book series: Subcellular Biochemistry ((SCBI,volume 57))

Abstract

Oxidative damage to cellular constituents has frequently been associated with aging in a wide range of organisms. The power of yeast genetics and biochemistry has provided the opportunity to analyse in some detail how reactive oxygen and nitrogen species arise in cells, how cells respond to the damage that these reactive species cause, and to begin to dissect how these species may be involved in the ageing process. This chapter reviews the major sources of reactive oxygen species that occur in yeast cells, the damage they cause and how cells sense and respond to this damage.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.00
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Aeschbach R, Amado R, Neukom H (1976) Formation of dityrosine cross-links in proteins by oxidation of tyrosine residues. Biochim Biophys Acta 439:292–301

    PubMed  CAS  Google Scholar 

  • Aguilaniu H, Gustafsson L, Rigoulet M, Nystrom T (2003) Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science 299:1751–1753

    PubMed  CAS  Google Scholar 

  • Alic N, Felder T, Temple MD, Gloeckner C, Higgins VJ, Briza P, Dawes IW (2004) Genome-wide transcriptional responses to a lipid hydroperoxide: adaptation occurs without induction of oxidant defenses. Free Radic Biol Med 37:23–35

    PubMed  CAS  Google Scholar 

  • Alic N, Higgins VJ, Dawes IW (2001) Identification of a Saccharomyces cerevisiae gene that is required for G1 arrest in response to the lipid oxidation product linoleic acid hydroperoxide. Mol Biol Cell 12:1801–1810

    PubMed  CAS  Google Scholar 

  • Ames BN, Gold LS (1991) Endogenous mutagens and the causes of aging and cancer. Mutat Res 250:3–16

    PubMed  CAS  Google Scholar 

  • Asad LM, Asad NR, Silva AB, Felzenszwalb I, Leitao AC (1997) Hydrogen peroxide induces protection against N-methyl-N’-nitro-N-nitrosoguanidine (MNNG) effects in Escherichia coli. Mutat Res 383:137–142

    PubMed  CAS  Google Scholar 

  • Ashrafi K, Sinclair D, Gordon JI, Guarente L (1999) Passage through stationary phase advances replicative aging in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 96:9100–9105

    PubMed  CAS  Google Scholar 

  • Avery AM, Avery SV (2001) Saccharomyces cerevisiae expresses three phospholipid hydroperoxide glutathione peroxidases. J Biol Chem 276:33730–33735

    PubMed  CAS  Google Scholar 

  • Ayer A, Tan SX, Grant CM, Meyer AJ, Dawes IW, Perrone GG (2010) The critical role of glutathione in maintenance of the mitochondrial genome. Free Radic Biol Med 49:1956–1968

    PubMed  CAS  Google Scholar 

  • Azevedo D, Tacnet F, Delaunay A, Rodrigues-Pousada C, Toledano MB (2003) Two redox centers within Yap1 for H2O2 and thiol-reactive chemicals signaling. Free Radic Biol Med 35:889–900

    PubMed  CAS  Google Scholar 

  • Babior BM (1984) The respiratory burst of phagocytes. J Clin Invest 73:599–601

    PubMed  CAS  Google Scholar 

  • Bandara PD, Flattery-O’Brien JA, Grant CM, Dawes IW (1998) Involvement of the Saccharomyces cerevisiae UTH1 gene in the oxidative-stress response. Curr Genet 34:259–268

    PubMed  CAS  Google Scholar 

  • Barker MG, Brimage LJ, Smart KA (1999) Effect of Cu,Zn superoxide dismutase disruption mutation on replicative senescence in Saccharomyces cerevisiae. FEMS Microbiol Lett 177:199–204

    PubMed  CAS  Google Scholar 

  • Barros MH, Bandy B, Tahara EB, Kowaltowski AJ (2004) Higher respiratory activity decreases mitochondrial reactive oxygen release and increases life span in Saccharomyces cerevisiae. J Biol Chem 279:49883–49888

    PubMed  CAS  Google Scholar 

  • Beck T, Hall MN (1999) The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors. Nature 402:689–692

    PubMed  CAS  Google Scholar 

  • Beckhouse AG, Grant CM, Rogers PJ, Dawes IW, Higgins VJ (2008) The adaptive response of anaerobically grown Saccharomyces cerevisiae to hydrogen peroxide is mediated by the Yap1 and Skn7 transcription factors. FEMS Yeast Res 8:1214–1222

    PubMed  CAS  Google Scholar 

  • Beckman JS, Chen J, Ischiropoulos H, Crow JP (1994) Oxidative chemistry of peroxynitrite. Meth Enzymol 233:229–240

    PubMed  CAS  Google Scholar 

  • Benov L, Sztejnberg L, Fridovich I (1998) Critical evaluation of the use of hydroethidine as a measure of superoxide anion radical. Free Rad Biol Med 25:826–831

    PubMed  CAS  Google Scholar 

  • Bergamini E, Cavallini G, Donati A, Gori Z (2007) The role of autophagy in aging: its essential part in the anti-aging mechanism of caloric restriction. Ann NY Acad Sci 1114:69–78

    PubMed  CAS  Google Scholar 

  • Berger KH, Yaffe MP (1998) Prohibitin family members interact genetically with mitochondrial inheritance components in Saccharomyces cerevisiae. Mol Cell Biol 18:4043–4052

    PubMed  CAS  Google Scholar 

  • Bissinger PH, Wieser R, Hamilton B, Ruis H (1989) Control of Saccharomyces cerevisiae catalse T gene (CTT1) expression by nutrient supply via the RAS-cyclic AMP pathway. Mol Cell Biol 9:1309–1315

    PubMed  CAS  Google Scholar 

  • Biswas S, Chida AS, Rahman I (2006) Redox modifications of protein-thiols: emerging roles in cell signaling. Biochem Pharmacol 71:551–564

    PubMed  CAS  Google Scholar 

  • Biteau B, Labarre J, Toledano MB (2003) ATP-dependent reduction of cysteine-sulphinic acid by S. cerevisiae sulphiredoxin. Nature 425:980–984

    PubMed  CAS  Google Scholar 

  • Boisnard S, Lagniel G, Garmendia-Torres C, Molin M, Boy-Marcotte E, Jacquet M, Toledano MB, Labarre J, Chedin S (2009) H2O2 activates the nuclear localization of Msn2 and Maf1 through thioredoxins in Saccharomyces cerevisiae. Eukaryot Cell 8:1429–1438

    PubMed  CAS  Google Scholar 

  • Bossie MA, Martin CE (1989) Nutritional regulation of yeast delta9-fatty acid desaturase activity. J Bacteriol 171:6409–6413

    PubMed  CAS  Google Scholar 

  • Boveris A (1984) Determination of the production of superoxide radicals and hydrogen peroxide in mitochondria. Meth Enzymol 105:429–435

    PubMed  CAS  Google Scholar 

  • Boveris A, Cadenas E (1982) Production of superoxide radicals and hydrogen peroxide in mitochondria. In: Oberley LW (ed) Superoxide dismutases, vol 2. CRC Press, Boca Raton, FL, pp 15–30

    Google Scholar 

  • Branco MR, Marinho HS, Cyrne L, Antunes F (2004) Decrease of H2O2 plasma membrane permeability during adaptation to H2O2 in Saccharomyces cerevisiae. J Biol Chem 279:6501–6506

    PubMed  CAS  Google Scholar 

  • Brennan RJ, Swoboda BE, Schiestl RH (1994) Oxidative mutagens induce intrachromosomal recombination in yeast. Mutat Res 308:159–167

    PubMed  CAS  Google Scholar 

  • Briggs NC, Levine RS, Brann EA (2002) Allergies and risk of non-Hodgkin’s lymphoma by subtype. Cancer Epidemiol Biomarkers Prev 11:401–407

    PubMed  Google Scholar 

  • Buchczyk DP, Briviba K, Hartl FU, Sies H (2000) Responses to peroxynitrite in yeast: glyceraldehyde-3-phosphate dehydrogenase (GAPDH) as a sensitive intracellular target for nitration and enhancement of chaperone expression and ubiquitination. Biol Chem 381:121–126

    PubMed  CAS  Google Scholar 

  • Burhans WC, Heintz NH (2009) The cell cycle is a redox cycle: linking phase-specific targets to cell fate. Free Radic Biol Med 47:1282–1293

    PubMed  CAS  Google Scholar 

  • Camougrand N, Grelaud-Coq A, Marza E, Priault M, Bessoule JJ, Manon S (2003) The product of the UTH1 gene, required for Bax-induced cell death in yeast, is involved in the response to rapamycin. Mol Microbiol 47:495–506

    PubMed  CAS  Google Scholar 

  • Camougrand N, Kissova I, Velours G, Manon S (2004) Uth1p: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death. FEMS Yeast Res 5:133–140

    PubMed  CAS  Google Scholar 

  • Campisi J, d’Adda di Fagagna F (2007) Cellular senescence: when bad things happen to good cells. Nat Rev Mol Cell Biol 8:729–740

    PubMed  CAS  Google Scholar 

  • Carmel-Harel O, Stearman R, Gasch AP, Botstein D, Brown PO, Storz G (2001) Role of thioredoxin reductase in the Yap1p-dependent response to oxidative stress in Saccharomyces cerevisiae. Mol Microbiol 39:595–605

    PubMed  CAS  Google Scholar 

  • Carri MT, Galiazzo F, Ciriolo MR, Rotilio G (1991) Evidence for co-regulation of Cu,Zn superoxide dismutase and metallothionein gene expression in yeast through transcriptional control by copper via the ACE 1 factor. FEBS Lett 278:263–266

    PubMed  CAS  Google Scholar 

  • Causton HC, Ren B, Koh SS, Harbison CT, Kanin E, Jennings EG, Lee TI, True HL, Lander ES, Young RA (2001) Remodeling of yeast genome expression in response to environmental changes. Mol Biol Cell 12:323–337

    PubMed  CAS  Google Scholar 

  • Cha M-K, Choi Y-S, Hong S-K, Kim W-C, No KT, Kim I-H (2003) Nuclear thiol peroxidase as a functional alkyl-hydroperoxide reductase necessary for stationary phase growth of Saccharomyces cerevisiae. J Biol Chem 278:24636–24643

    PubMed  CAS  Google Scholar 

  • Charizanis C, Juhnke H, Krems B, Entian KD (1999) The mitochondrial cytochrome c peroxidase Ccp1 of Saccharomyces cerevisiae is involved in conveying an oxidative stress signal to the transcription factor Pos9 (Skn7). Mol Gen Genet 262:437–447

    PubMed  CAS  Google Scholar 

  • Chiu J, Tactacan CM, Tan S-X, Lin RCY, Wouters MA, Dawes IW (2011) Cell cycle sensing of oxidative stress in Saccharomyces cerevisiae by oxidation of a specific cysteine residue in the transcription factor Swi6p. J Biol Chem 286:5204–5214

    PubMed  CAS  Google Scholar 

  • Chrestensen CA, Eckman CB, Stake DW, Mieyal JJ (1995) Cloning. expression and characterization of the human thioltransferase (glutaredoxin) in E. coli. FEBS Lett 374:25–28

    PubMed  CAS  Google Scholar 

  • Christman MF, Morgan RW, Jacobson FS, Ames BN (1985) Positive control of a regulon for defenses against oxidative stress and some heat-shock proteins in Salmonella typhimurium. Cell 41:753–762

    PubMed  CAS  Google Scholar 

  • Cipak A, Hasslacher M, Tehlivets O, Collinson EJ, Zivkovic M, Matijevic T, Wonisch W, Waeg G, Dawes IW, Zarkovic N, Kohlwein SD (2006) Saccharomyces cerevisiae strain expressing a plant fatty acid desaturase produces polyunsaturated fatty acids and is susceptible to oxidative stress induced by lipid peroxidation. Free Radic Biol Med 40:897–906

    PubMed  CAS  Google Scholar 

  • Coleman ST, Epping EA, Steggerda SM, Moye-Rowley WS (1999) Yap1p activates gene transcription in an oxidant-specific fashion. Mol Cell Biol 19:8302–8313

    PubMed  CAS  Google Scholar 

  • Collinson EJ, Wheeler GL, Garrido EO, Avery AM, Avery SV, Grant CM (2002) The yeast glutaredoxins are active as as glutathione peroxidases. J Biol Chem 277:16712–16717

    PubMed  CAS  Google Scholar 

  • Collinson LP, Dawes IW (1992) Inducibility of the response of yeast cells to peroxide stress. J Gen Microbiol 138:329–335

    PubMed  CAS  Google Scholar 

  • Costa V, Moradas-Ferreira P (2001) Oxidative stress and signal transduction in Saccharomyces cerevisiae: insights into ageing, apoptosis and diseases. Mol Aspects Med 22:217–246

    PubMed  CAS  Google Scholar 

  • Costa VM, Amorim MA, Quintanilha A, Moradas-Ferreira P (2002) Hydrogen peroxide-induced carbonylation of key metabolic enzymes in Saccharomyces cerevisiae: the involvement of the oxidative stress response regulators Yap1 and Skn7. Free Radic Biol Med 33:1507–1515

    PubMed  CAS  Google Scholar 

  • Cuervo AM (2004) Autophagy: in sickness and in health. Trends Cell Biol 14:70–77

    PubMed  Google Scholar 

  • Dai DF, Santana LF, Vermulst M, Tomazela DM, Emond MJ, MacCoss MJ, Gollahon K, Martin GM, Loeb LA, Ladiges WC, Rabinovitch PS (2009) Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging. Circulation 119:2789–2797

    PubMed  CAS  Google Scholar 

  • Davidson JF, Whyte B, Bissinger PH, Schiestl RH (1996) Oxidative stress is involved in heat-induced cell death in Saccharomyces cerevisiae. Proc Natl Acad Sci USA 93:5116–5121

    PubMed  CAS  Google Scholar 

  • Davies JM, Lowry CV, Davies KJ (1995) Transient adaptation to oxidative stress in yeast. Arch Biochem Biophys 317:1–6

    PubMed  CAS  Google Scholar 

  • Dawes IW (2004) Stress responses. In: Dickinson JR, Schweizer M (eds) The metabolism and molecular physiology of Saccharomyces cerevisiae. CRC Press LLC, Boca Raton, FL, pp 376–438

    Google Scholar 

  • Delaunay A, Isnard AD, Toledano MB (2000) H2O2 sensing through oxidation of the Yap1 transcription factor. EMBO J 19:5157–5166

    PubMed  CAS  Google Scholar 

  • Delaunay A, Pflieger D, Barrault MB, Vinh J, Toledano MB (2002) A thiol peroxidase is an H2O2 receptor and redox-transducer in gene activation. Cell 111:471–481

    PubMed  CAS  Google Scholar 

  • Di Mascio P (2007) How to measure ROS and RNS in Biology, 2011, from http://www.healthcare.uiowa.edu/research/sfrbm/Papers/Sunrise%20Papers/2007/DiMascioP.pdf

  • Drakulic T, Temple MD, Guido R, Jarolim S, Breitenbach M, Attfield PV, Dawes IW (2005) Involvement of oxidative stress response genes in redox homeostasis, the level of reactive oxygen species, and ageing in Saccharomyces cerevisiae. FEMS Yeast Res 5:1215–1228

    PubMed  CAS  Google Scholar 

  • Droge W (2004) Autophagy and aging – importance of amino acid levels. Mech Ageing Dev 125:161–168

    PubMed  CAS  Google Scholar 

  • Dukan S, Touati D (1996) Hypochlorous acid stress in Escherichia coli: resistance, DNA damage, and comparison with hydrogen peroxide stress. J Bacteriol 178:6145–6150

    PubMed  CAS  Google Scholar 

  • Durchschlag E, Reiter W, Ammerer G, Schuller C (2004) Nuclear localization destabilizes the stress-regulated transcription factor Msn2. J Biol Chem 279:55425–55432

    PubMed  CAS  Google Scholar 

  • Egilmez NK, Chen JB, Jazwinski SM (1990) Preparation and partial characterization of old yeast cells. J Gerontol 45:B9–B17

    PubMed  CAS  Google Scholar 

  • Erjavec N, Cvijovic M, Klipp E, Nystrom T (2008) Selective benefits of damage partitioning in unicellular systems and its effects on aging. Proc Natl Acad Sci USA 105:18764–18769

    PubMed  CAS  Google Scholar 

  • Erjavec N, Larsson L, Grantham J, Nystrom T (2007) Accelerated aging and failure to segregate damaged proteins in Sir2 mutants can be suppressed by overproducing the protein aggregation-remodeling factor Hsp104p. Genes Dev 21:2410–2421

    PubMed  CAS  Google Scholar 

  • Erjavec N, Nystrom T (2007) Sir2p-dependent protein segregation gives rise to a superior reactive oxygen species management in the progeny of Saccharomyces cerevisiae. Proc Natl Acad Sci USA 104:10877–10881

    PubMed  CAS  Google Scholar 

  • Ermini M (1976) Ageing changes in mammalian skeletal muscle: biochemical studies. Gerontology 22:301–316

    PubMed  CAS  Google Scholar 

  • Esterbauer H, Schaur RJ, Zollner H (1991) Chemistry and biochemistry of 4-hydroxynonenal, malonaldehyde and related aldehydes. Free Radic Biol Med 11:81–128

    PubMed  CAS  Google Scholar 

  • Evans MV, Turton HE, Grant CM, Dawes IW (1998) Toxicity of linoleic acid hydroperoxide to Saccharomyces cerevisiae: involvement of a respiration-related process for maximal sensitivity and adaptive response. J Bacteriol 180:483–490

    PubMed  CAS  Google Scholar 

  • Fabrizio P, Battistella L, Vardavas R, Gattazzo C, Liou LL, Diaspro A, Dossen JW, Gralla EB, Longo VD (2004) Superoxide is a mediator of an altruistic aging program in Saccharomyces cerevisiae. J Cell Biol 166:1055–1067

    PubMed  CAS  Google Scholar 

  • Fabrizio P, Hoon S, Shamalnasab M, Galbani A, Wei M, Giaever G, Nislow C, Longo VD (2010) Genome-wide screen in Saccharomyces cerevisiae identifies vacuolar protein sorting, autophagy, biosynthetic, and tRNA methylation genes involved in life span regulation. PLoS Genet 6:e1001024

    PubMed  Google Scholar 

  • Fabrizio P, Liou LL, Moy VN, Diaspro A, Valentine JS, Gralla EB, Longo VD (2003) SOD2 functions downstream of Sch9 to extend longevity in yeast. Genetics 163:35–46

    PubMed  CAS  Google Scholar 

  • Fabrizio P, Pozza F, Pletcher SD, Gendron CM, Longo VD (2001) Regulation of longevity and stress resistance by Sch9 in yeast. Science 292:288–290

    PubMed  CAS  Google Scholar 

  • Fernandes AP, Holmgren A (2004) Glutaredoxins: glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system. Antioxid Redox Signal 6:63–74

    PubMed  CAS  Google Scholar 

  • Fernandes PN, Mannarino SC, Silva CG, Pereira MD, Panek AD, Eleutherio EC (2007) Oxidative stress response in eukaryotes: effect of glutathione, superoxide dismutase and catalase on adaptation to peroxide and menadione stresses in Saccharomyces cerevisiae. Redox Rep 12:236–244

    PubMed  CAS  Google Scholar 

  • Filomeni G, Rotilio G, Ciriolo MR (2002) Cell signalling and the glutathione redox system. Biochem Pharmacol 64:1057–1064

    PubMed  CAS  Google Scholar 

  • Flattery-O’Brien J, Collinson LP, Dawes IW (1993) Saccharomyces cerevisiae has an inducible response to menadione which differs from that to hydrogen peroxide. J Gen Microbiol 139:501–507

    PubMed  Google Scholar 

  • Flattery-O’Brien JA, Dawes IW (1998) Hydrogen peroxide causes RAD9-dependent cell cycle arrest in G2 in Saccharomyces cerevisiae whereas menadione causes G1 arrest independent of RAD9 function. J Biol Chem 273:8564–8571

    PubMed  Google Scholar 

  • Flattery-O’Brien JA, Grant CM, Dawes IW (1997) Stationary-phase regulation of the Saccharomyces cerevisiae SOD2 gene is dependent on additive effects of HAP2/3/4/5- and STRE-binding elements. Mol Microbiol 23:303–312

    PubMed  Google Scholar 

  • Floyd RA (1991) Oxidative damage to behavior during aging. Science 254:1597

    PubMed  CAS  Google Scholar 

  • Fong CS, Temple MD, Alic N, Chiu J, Durchdewald M, Thorpe GW, Higgins VJ, Dawes IW (2008) Oxidant-induced cell-cycle delay in Saccharomyces cerevisiae: the involvement of the SWI6 transcription factor. FEMS Yeast Res 8:386–399

    PubMed  CAS  Google Scholar 

  • Fu S, Gebicki S, Jessup W, Gebicki JM, Dean RT (1995) Biological fate of amino acid, peptide and protein hydroperoxides. Biochem J 311(Pt 3):821–827

    PubMed  CAS  Google Scholar 

  • Gan ZR (1991) Yeast thioredoxin genes. J Biol Chem 266:1692–1696

    PubMed  CAS  Google Scholar 

  • Garrido EO, Grant CM (2003) Role of thioredoxins in the response of Saccharomyces cerevisiae to oxidative stress induced by hydroperoxides. Mol Microbiol 43:993–1003

    Google Scholar 

  • Gasch AP, Spellman PT, Kao CM, Carmel-Harel O, Eisen MB, Storz G, Botstein D, Brown PO (2000) Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell 11:4241–4257

    PubMed  CAS  Google Scholar 

  • Gebicki S, Gill KH, Dean RT, Gebicki JM (2002) Action of peroxidases on protein hydroperoxides. Redox Rep 7:235–242

    PubMed  CAS  Google Scholar 

  • Godon C, Lagniel G, Lee J, Buhler JM, Kieffer S, Perrot M, Boucherie H, Toledano MB, Labarre J (1998) The H2O2 stimulon in Saccharomyces cerevisiae. J Biol Chem 273:22480–22489

    PubMed  CAS  Google Scholar 

  • Goehring AS, Rivers D, Sprague GFJ (2003) Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p. Eukaryot Cell 2:930–936

    PubMed  CAS  Google Scholar 

  • Gorner W, Durchschlag E, Martinez-Pastor MT, Estruch F, Ammerer G, Hamilton B, Ruis H, Schuller C (1998) Nuclear localization of the C2H2 zinc finger protein Msn2p is regulated by stress and protein kinase A activity. Genes Dev 12:586–597

    PubMed  CAS  Google Scholar 

  • Gourlay CW, Ayscough KR (2005) Identification of an upstream regulatory pathway controlling actin-mediated apoptosis in yeast. J Cell Sci 118:2119–2132

    PubMed  CAS  Google Scholar 

  • Gourlay CW, Ayscough KR (2006) Actin-induced hyperactivation of the Ras signaling pathway leads to apoptosis in Saccharomyces cerevisiae. Mol Cell Biol 26:6487–6501

    PubMed  CAS  Google Scholar 

  • Gourlay CW, Carpp LN, Timpson P, Winder SJ, Ayscough KR (2004) A role for the actin cytoskeleton in cell death and aging in yeast. J Cell Biol 164:803–809

    PubMed  CAS  Google Scholar 

  • Gralla EB, Kosman DJ (1992) Molecular genetics of superoxide dismutases. Adv Genet 30:251–319

    PubMed  CAS  Google Scholar 

  • Gralla EB, Thiele DJ, Silar P, Valentine JS (1991) ACE1, a copper-dependent transcription factor, activates expression of the yeast copper, zinc superoxide dismutase gene. Proc Natl Acad Sci USA 88:8558–8562

    PubMed  CAS  Google Scholar 

  • Grant CM, Collinson LP, Roe JH, Dawes IW (1996) Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulation. Mol Microbiol 21:171–179

    PubMed  CAS  Google Scholar 

  • Grant CM, Perrone G, Dawes IW (1998) Glutathione and catalase provide overlapping defenses for protection against hydrogen peroxide in the yeast Saccharomyces cerevisiae. Biochem Biophys Res Commun 253:893–898

    PubMed  CAS  Google Scholar 

  • Grant CM, Quinn KA, Dawes IW (1999) Differential protein S-thiolation of glyceraldehyde-3-phosphate dehydrogenase isozymes influences sensitivity to oxidative stress. Mol Cell Biol 19:2650–2656

    PubMed  CAS  Google Scholar 

  • Greetham D, Grant CM (2009) Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo. Mol Cell Biol 29:3229–3240

    PubMed  CAS  Google Scholar 

  • Gruning NM, Lehrach H, Ralser M (2010) Regulatory crosstalk of the metabolic network. Trends Biochem Sci 35:220–227

    PubMed  Google Scholar 

  • Guarente L (2001) SIR2 and aging – the exception that proves the rule. Trends Genet 17:391–392

    PubMed  CAS  Google Scholar 

  • Gunstone FD (1996) Fatty acids and lipid chemistry. Blackie Academic and Professional, London

    Google Scholar 

  • Halliwell B (1995) The biological significance of oxygen-derived species. In: Valentine JS, Foote CS, Greenberg A, Liebman JF (eds) Active oxygen in biochemistry. Blackie Academic and Professional, London, pp 313–335

    Google Scholar 

  • Harman D (1956) Aging: a theory based on free radical and radiation chemistry. J Gerontol 11:298–300

    PubMed  CAS  Google Scholar 

  • Harris N, Costa V, MacLean M, Mollapour M, Moradas-Ferreira P, Piper PW (2003) Mnsod overexpression extends the yeast chronological (G(0)) life span but acts independently of Sir2p histone deacetylase to shorten the replicative life span of dividing cells. Free Radic Biol Med 34:1599–1606

    PubMed  CAS  Google Scholar 

  • He XJ, Fassler JS (2005) Identification of novel Yap1p and Skn7p binding sites involved in the oxidative stress response of Saccharomyces cerevisiae. Mol Microbiol 58:1454–1467

    PubMed  CAS  Google Scholar 

  • He XJ, Mulford KE, Fassler JS (2009) Oxidative stress function of the Saccharomyces cerevisiae Skn7 receiver domain. Eukaryot Cell 8:768–778

    PubMed  CAS  Google Scholar 

  • Heeren G, Jarolim S, Laun P, Rinnerthaler M, Stolze K, Perrone GG, Kohlwein SD, Nohl H, Dawes IW, Breitenbach M (2004) The role of respiration, reactive oxygen species and oxidative stress in mother cell-specific ageing of yeast strains defective in the RAS signalling pathway. FEMS Yeast Res 5:157–167

    PubMed  CAS  Google Scholar 

  • Heeren G, Rinnerthaler M, Laun P, von Seyerl P, Kossler S, Klinger H, Hager M, Bogengruber E, Jarolim S, Simon-Nobbe B, Schuller C, Carmona-Gutierrez D, Breitenbach-Koller L, Muck C, Jansen-Durr P, Criollo A, Kroemer G, Madeo F, Breitenbach M (2009) The mitochondrial ribosomal protein of the large subunit, Afo1p, determines cellular longevity through mitochondrial back-signaling via TOR1. Aging (Albany NY) 1:622–636

    CAS  Google Scholar 

  • Helfand SL, Rogina B (2003) Genetics of aging in the fruit fly, Drosophila melanogaster. Annu Rev Genet 37:329–348

    PubMed  CAS  Google Scholar 

  • Herker E, Jungwirth H, Lehmann KA, Maldener C, Frohlich KU, Wissing S, Buttner S, Fehr M, Sigrist S, Madeo F (2004) Chronological aging leads to apoptosis in yeast. J Cell Biol 164:501–507

    PubMed  CAS  Google Scholar 

  • Holmgren A (2000) Antioxidant function of thioredoxin and glutaredoxin systems. Antioxid Redox Signal 2:811–820

    PubMed  CAS  Google Scholar 

  • Holmgren A, Aslunf F (1995) Glutaredoxins. Meth Enzymol 252:283–292

    PubMed  CAS  Google Scholar 

  • Houthoofd K, Vanfleteren JR (2007) Public and private mechanisms of life extension in Caenorhabditis elegans. Mol Genet Genomics 277:601–617

    PubMed  CAS  Google Scholar 

  • Huh WK, Lee BH, Kim ST, Kim YR, Rhie GE, Back YW, Hwang CS, Lee JS, Kang SO (1998) D-erythroascorbic acid is an important antioxidant molecule in Saccharomyces cerevisiae. Mol Microbiol 30:895–903

    PubMed  CAS  Google Scholar 

  • Inoue Y, Matsuda T, Sugiyama K-I, Izawa S, Kimura A (1999) Genetic analysis of glutathione peroxidase in oxidative stress response in Saccharomyces cerevisiae. J Biol Chem 274:27002–27009

    PubMed  CAS  Google Scholar 

  • Izawa S, Inoue Y, Kimura A (1996) Importance of catalse in the adaptive response to hydrogen peroxide: analysis of acatalasaemic Saccharomyces cerevisiae. Biochem J 320:61–67

    PubMed  CAS  Google Scholar 

  • Izawa S, Maeda K, Sugiyama K, Mano J, Inoue Y, Kimura A (1999) Thioredoxin deficiency causes the constitutive activation of Yap1, an AP-1-like transcription factor in Saccharomyces cerevisiae. J Biol Chem 274:28459–28465

    PubMed  CAS  Google Scholar 

  • Jamieson DJ (1992) Saccharomyces cerevisiae has distinct adaptive responses to both hydrogen peroxide and menadione. J Bacteriol 174:6678–6681

    PubMed  CAS  Google Scholar 

  • Jarolim S, Millen J, Heeren G, Laun P, Goldfarb DS, Breitenbach M (2004) A novel assay for replicative lifespan in Saccharomyces cerevisiae. FEMS Yeast Res 5:169–177

    PubMed  CAS  Google Scholar 

  • Jiang H, English AM (2006) Phenotypic analysis of the ccp1delta and ccp1delta-ccp1W191F mutant strains of Saccharomyces cerevisiae indicates that cytochrome c peroxidase functions in oxidative-stress signalling. J Inorg Biochem 100:1996–2008

    PubMed  CAS  Google Scholar 

  • Joenje H, Lafleur MVM, Retel J (1991) Biological consequences of oxidative DNA damage. CRC press, Boca Raton, FL

    Google Scholar 

  • Kaeberlein M, Burtner CR, Kennedy BK (2007) Recent developments in yeast aging. PLoS Genet 3:e84

    PubMed  Google Scholar 

  • Kaeberlein M, Kirkland KT, Fields S, Kennedy BK (2005a) Genes determining yeast replicative life span in a long-lived genetic background. Mech Ageing Dev 126:491–504

    PubMed  CAS  Google Scholar 

  • Kaeberlein M, Powers RW 3rd, Steffen KK, Westman EA, Hu D, Dang N, Kerr EO, Kirkland KT, Fields S, Kennedy BK (2005b) Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310:1193–1196

    PubMed  CAS  Google Scholar 

  • Kalmar B, Greensmith L (2009) Induction of heat shock proteins for protection against oxidative stress. Adv Drug Deliv Rev 61:310–318

    PubMed  CAS  Google Scholar 

  • Kelley R, Ideker T (2009) Genome-wide fitness and expression profiling implicate Mga2 in adaptation to hydrogen peroxide. PLoS Genet 5:e1000488

    PubMed  Google Scholar 

  • Kennedy BK, Austriaco NR Jr, Zhang J, Guarente L (1995) Mutation in the silencing gene SIR4 can delay aging in S. cerevisiae. Cell 80:485–496

    PubMed  CAS  Google Scholar 

  • Kharade SV, Mittal N, Das SP, Sinha P, Roy N (2005) Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence. FEBS Lett 579:6809–6813

    PubMed  CAS  Google Scholar 

  • Kim DK, Cho ES, Lee BR, Um HD (2001) NF-kappa B mediates the adaptation of human U937 cells to hydrogen peroxide. Free Radic Biol Med 30:563–571

    PubMed  CAS  Google Scholar 

  • Kim IS, Moon HY, Yun HS, Jin I (2006) Heat shock causes oxidative stress and induces a variety of cell rescue proteins in Saccharomyces cerevisiae KNU5377. J Microbiol 44:492–501

    PubMed  CAS  Google Scholar 

  • Kissova I, Deffieu M, Manon S, Camougrand N (2004) Uth1p is involved in the autophagic degradation of mitochondria. J Biol Chem 279:39068–39074

    PubMed  CAS  Google Scholar 

  • Klinger H, Rinnerthaler M, Lam YT, Laun P, Heeren G, Klocker A, Simon-Nobbe B, Dickinson JR, Dawes IW, Breitenbach M (2010) Quantitation of (a)symmetric inheritance of functional and of oxidatively damaged mitochondrial aconitase in the cell division of old yeast mother cells. Exp Gerontol 45:533–542

    PubMed  CAS  Google Scholar 

  • Klionsky DJ (2005) The molecular machinery of autophagy: unanswered questions. J Cell Sci 118:7–18

    PubMed  CAS  Google Scholar 

  • Klionsky DJ, Emr SD (2000) Autophagy as a regulated pathway of cellular degradation. Science 290:1717–1721

    PubMed  CAS  Google Scholar 

  • Kops GJ, Dansen TB, Polderman PE, Saarloos I, Wirtz KW, Coffer PJ, Huang TT, Bos JL, Medema RH, Burgering BM (2002) Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature 419:316–321

    PubMed  CAS  Google Scholar 

  • Kuge S, Arita M, Murayama A, Maeta K, Izawa S, Inoue Y, Nomoto A (2001) Regulation of the yeast Yap1p nuclear export signal is mediated by redox signal-induced reversible disulfide bond formation. Mol Cell Biol 21:6139–6150

    PubMed  CAS  Google Scholar 

  • Kuge S, Jones N (1994) YAP1 dependent activation of TRX2 is essential for the response of Saccharomyces cerevisiae to oxidative stress by hydroperoxides. EMBO J 13:655–664

    PubMed  CAS  Google Scholar 

  • Kuge S, Jones N, Nomoto A (1997) Regulation of yAP-1 nuclear localization in response to oxidative stress. EMBO J 16:1710–1720

    PubMed  CAS  Google Scholar 

  • Kuge S, Toda T, Iizuka N, Nomoto A (1998) Crm1 (XpoI) dependent nuclear export of the budding yeast transcription factor yAP-1 is sensitive to oxidative stress. Genes Cells 3:521–532

    PubMed  CAS  Google Scholar 

  • Lam YT, Aung-Htut MT, Lim YL, Yang H, Dawes IW (2011) Changes in reactive oxygen species begin early during replicative aging of Saccharomyces cerevisiae cells. Free Rad Biol Med 50: 963–970

    Google Scholar 

  • Lam YT, Stocker R, Dawes IW (2010) The lipophilic antioxidants alpha-tocopherol and coenzyme Q10 reduce the replicative lifespasn of Saccharomyces cerevisiae. Free Rad Biol Med 49:237–244

    PubMed  CAS  Google Scholar 

  • Laun P, Pichova A, Madeo F, Fuchs J, Ellinger A, Kohlwein S, Dawes I, Frohlich KU, Breitenbach M (2001) Aged mother cells of Saccharomyces cerevisiae show markers of oxidative stress and apoptosis. Mol Microbiol 39:1166–1173

    PubMed  CAS  Google Scholar 

  • Laun P, Ramachandran L, Jarolim S, Herker E, Liang P, Wang J, Weinberger M, Burhans DT, Suter B, Madeo F, Burhans WC, Breitenbach M (2005) A comparison of the aging and apoptotic transcriptome of Saccharomyces cerevisiae. FEMS Yeast Res 5:1261–1272

    PubMed  CAS  Google Scholar 

  • Laun P, Rinnerthaler M, Bogengruber E, Heeren G, Breitenbach M (2006) Yeast as a model for chronological and reproductive aging – a comparison. Exp Gerontol 41:1208–1212

    PubMed  CAS  Google Scholar 

  • Le Moan N, Clement G, Le Maout S, Tacnet F, Toledano MB (2006) The Saccharomyces cerevisiae proteome of oxidised protein thiols. Contrasted functions for the thioredoxin and glutathione pathways. J Biol Chem 281:10420–10430

    PubMed  CAS  Google Scholar 

  • Lee J, Dawes IW, Roe JH (1995) Adaptive response of Schizosaccharomyces pombe to hydrogen peroxide and menadione. Microbiology 141(Pt 12):3127–3132

    PubMed  CAS  Google Scholar 

  • Lee J, Godon C, Lagniel G, Spector D, Garin J, Labarre J, Toledano MB (1999) Yap1 and Skn7 control two specialized oxidative stress response regulons in yeast. J Biol Chem 274:16040–16046

    PubMed  CAS  Google Scholar 

  • Lee J, Romeo A, Kosman DJ (1996) Transcriptional remodeling and G1 arrest in dioxygen stress in Saccharomyces cerevisiae. J Biol Chem 271:24885–24893

    PubMed  CAS  Google Scholar 

  • Lee J-C, Straffon MJ, Jang T-Y, Higgins VJ, Grant CM, Dawes IW (2001) The essential and ancillary role of glutathione analysed using a grande gsh1 disruptant strain. FEMS Yeast Res 1:57–65

    PubMed  CAS  Google Scholar 

  • Lee P, Cho BR, Joo HS, Hahn JS (2008) Yeast Yak1 kinase, a bridge between PKA and stress-responsive transcription factors, Hsf1 and Msn2/Msn4. Mol Microbiol 70:882–895

    PubMed  CAS  Google Scholar 

  • Lehne B, Schlitt T (2009) Protein-protein interaction databases: keeping up with growing interactomes. Hum Genomics 3:291–297

    PubMed  CAS  Google Scholar 

  • Lesur I, Campbell JL (2004) The transcriptome of prematurely aging yeast cells is similar to that of telomerase-deficient cells. Mol Biol Cell 15:1297–1312

    PubMed  CAS  Google Scholar 

  • Levine RL, Stadtman ER (2001) Oxidative modification of proteins during aging. Exp Gerontol 36:1495–1502

    PubMed  CAS  Google Scholar 

  • Lin SS, Manchester JK, Gordon JI (2001) Enhanced gluconeogenesis and increased energy storage as hallmarks of aging in Saccharomyces cerevisiae. J Biol Chem 276:36000–36007

    PubMed  CAS  Google Scholar 

  • Lin YJ, Seroude L, Benzer S (1998) Extended life-span and stress resistance in the Drosophila mutant methuselah. Science 282:943–946

    PubMed  CAS  Google Scholar 

  • Lipinski B (2002) Evidence in support of a concept of reductive stress. Br J Nutr 87:93–94

    PubMed  CAS  Google Scholar 

  • Lipton SA, Bossy-Wetzel E (2002) Dueling activities of AIF in cell death versus survival: DNA binding and redox activity. Cell 111:147–150

    PubMed  CAS  Google Scholar 

  • Liu B, Larsson L, Caballero A, Hao X, Oling D, Grantham J, Nystrom T (2010) The polarisome is required for segregation and retrograde transport of protein aggregates. Cell 140:257–267

    PubMed  CAS  Google Scholar 

  • Liu XD, Elashivili I, Gralla EB, Valentine JS, Lapinskas P, Culotta VC (1992) Yeast lacking superoxide dismutase. Isolation of genetioc suppressors. J Biol Chem 267:18298–18302

    PubMed  CAS  Google Scholar 

  • Ludovico P, Rodrigues F, Almeida A, Silva MT, Barrientos A, Corte-Real M (2002) Cytochrome c release and mitochondria involvement in programmed cell death induced by acetic acid in Saccharomyces cerevisiae. Mol Biol Cell 13:2598–2606

    PubMed  CAS  Google Scholar 

  • Madeo F, Frohlich E, Frohlich KU (1997) A yeast mutant showing diagnostic markers of early and late apoptosis. J Cell Biol 139:729–734

    PubMed  CAS  Google Scholar 

  • Madeo F, Frohlich E, Ligr M, Grey M, Sigrist SJ, Wolf DH, Frohlich KU (1999) Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol 145:757–767

    PubMed  CAS  Google Scholar 

  • Madeo F, Herker E, Maldener C, Wissing S, Lachelt S, Herlan M, Fehr M, Lauber K, Sigrist SJ, Wesselborg S, Frohlich KU (2002) A caspase-related protease regulates apoptosis in yeast. Mol Cell 9:911–917

    PubMed  CAS  Google Scholar 

  • Mannarino SC, Amorim MA, Pereira MD, Moradas-Ferreira P, Panek AD, Costa V, Eleutherio EC (2008) Glutathione is necessary to ensure benefits of calorie restriction during ageing in Saccharomyces cerevisiae. Mech Ageing Dev 129:700–705

    PubMed  CAS  Google Scholar 

  • Mariani D, Mathias CJ, da Silva CG, Herdeiro Rda S, Pereira R, Panek AD, Eleutherio EC, Pereira MD (2008) Involvement of glutathione transferases, Gtt1and Gtt2, with oxidative stress response generated by H2O2 during growth of Saccharomyces cerevisiae. Redox Rep 13:246–254

    PubMed  CAS  Google Scholar 

  • Mascarenhas C, Edwards-Ingram LC, Zeef L, Shenton D, Ashe MP, Grant CM (2008) Gcn4 is required for the response to peroxide stress in the yeast Saccharomyces cerevisiae. Mol Biol Cell 19:2995–3007

    PubMed  CAS  Google Scholar 

  • Masoro EJ (2005) Overview of caloric restriction and ageing. Mech Ageing Dev 126:913–922

    PubMed  CAS  Google Scholar 

  • Masoro EJ (2009) Caloric restriction-induced life extension of rats and mice: a critique of proposed mechanisms. Biochim Biophys Acta 1790:1040–1048

    PubMed  CAS  Google Scholar 

  • Mehta LH, Roth GS (2009) Caloric restriction and longevity: the science and the ascetic experience. Ann NY Acad Sci 1172:28–33

    PubMed  Google Scholar 

  • Mesquita A, Weinberger M, Silva A, Sampaio-Marques B, Almeida B, Leao C, Costa V, Rodrigues F, Burhans WC, Ludovico P (2010) Caloric restriction or catalase inactivation extends yeast chronological lifespan by inducing H2O2 and superoxide dismutase activity. Proc Natl Acad Sci USA 107:15123–15128

    PubMed  CAS  Google Scholar 

  • Miwa S, Riyahi K, Partridge L, Brand MD (2004) Lack of correlation between mitochondrial reactive oxygen species production and life span in Drosophila. Ann NY Acad Sci 1019:388–391

    PubMed  CAS  Google Scholar 

  • Molina-Navarro MM, Castells-Roca L, Belli G, Garcia-Martinez J, Marin-Navarro J, Moreno J, Perez-Ortin JE, Herrero E (2008) Comprehensive transcriptional analysis of the oxidative response in yeast. J Biol Chem 283:17908–17918

    PubMed  CAS  Google Scholar 

  • Mortimer RK, Johnston JR (1959) Life span of individual yeast cells. Nature 183:1751–1752

    PubMed  CAS  Google Scholar 

  • Moye-Rowley WS, Harshman KD, Parker CS (1989) Yeast YAP1 encodes a novel form of the jun family of transcriptional activator proteins. Genes Dev 3:283–292

    PubMed  CAS  Google Scholar 

  • Muller EGD (1991) Thioredoxin deficiency in yeast prolongs Sphase and shortens the G1 interval of the cell cycle. J Biol Chem 266:9194–9202

    PubMed  CAS  Google Scholar 

  • Muller FL, Lustgarten MS, Jang Y, Richardson A, Van Remmen H (2007) Trends in oxidative aging theories. Free Radic Biol Med 43:477–503

    PubMed  CAS  Google Scholar 

  • Nestelbacher R, Laun P, Vondrakova D, Pichova A, Schuller C, Breitenbach M (2000) The influence of oxygen toxicity on yeast mother cell-specific aging. Exp Gerontol 35:63–70

    PubMed  CAS  Google Scholar 

  • Ng CH, Tan SX, Perrone GG, Thorpe GW, Higgins VJ, Dawes IW (2008) Adaptation to hydrogen peroxide in Saccharomyces cerevisiae: the role of NADPH-generating systems and the SKN7 transcription factor. Free Radic Biol Med 44:1131–1145

    PubMed  CAS  Google Scholar 

  • Nohl H, Gille L, Staniek K (2005) Intracellular generation of reactive oxygen species by mitochondria. Biochem Pharmacol 69:719–723

    PubMed  CAS  Google Scholar 

  • Nunes E, Siede W (1996) Hyperthermia and paraquat-induced G1 arrest in the yeast Saccharomyces cerevisiae is independent of the RAD9 gene. Radiat Environ Biophys 35:55–57

    PubMed  CAS  Google Scholar 

  • Nunoshiba T, Hashimoto M, Nishioka H (1991) Cross-adaptive response in Escherichia coli caused by pretreatment with H2O2 against formaldehyde and other aldehyde compounds. Mutat Res 255:265–271

    PubMed  CAS  Google Scholar 

  • Nystrom T (2005) Role of oxidative carbonylation in protein quality control and senescence. EMBO J 24:1311–1317

    PubMed  Google Scholar 

  • Ojeda L, Keller G, Muhlenhoff U, Rutherford JC, Lill R, Winge DR (2006) Role of glutaredoxin-3 and glutaredoxin-4 in the iron regulation of the Aft1 transcriptional activator in Saccharomyces cerevisiae. J Biol Chem 281:17661–17669

    PubMed  CAS  Google Scholar 

  • Okazaki S, Tachibana T, Naganuma A, Mano N, Kuge S (2007) Multistep disulfide bond formation in Yap1 is required for sensing and transduction of H2O2 stress signal. Mol Cell 27:675–688

    PubMed  CAS  Google Scholar 

  • Olsen A, Vantipalli MC, Lithgow GJ (2006) Using Caenorhabditis elegans as a model for aging and age-related diseases. Ann NY Acad Sci 1067:120–128

    PubMed  CAS  Google Scholar 

  • Osborne TB, Mendel LB, Ferry EL (1917) The effect of retardation of growth upon the breeding period and duration of life of rats. Science 45:294–295

    PubMed  CAS  Google Scholar 

  • Pedrajas JR, Kosmidou E, Miranda-Vizuete A, Gustafsson JA, Wright APH, Spyrou G (1999) Identification and functional characterization of a novel mitochondrial thioredoxin system in Saccharomyces cerevisiae. J Biol Chem 274:6366–6373

    PubMed  CAS  Google Scholar 

  • Pedrajas JR, Porras P, Nartinez-Galisteo E, Padilla CA, Miranda-Vizuete A, Barcena JA (2002) Two isoforms of Saccharomyces cerevisie glutaredoxin 2 are expressed in vivo and localize to different subcellular compartments. Biochem J 364:617–623

    PubMed  CAS  Google Scholar 

  • Perrone GG, Grant CM, Dawes IW (2005) Genetic and environmental factors influencing glutathione homeostasis in Saccharomyces cerevisiae. Mol Biol Cell 16:218–230

    PubMed  CAS  Google Scholar 

  • Peskin A, Low FM, Paton LN, Maghzai GJ, Hampton MB, Winterbourn CC (2007) The high reactivity of peroxiredoxin 2 with H(2)O(2) is not reflected in its reaction with other oxidants and thiol reagents. J Biol Chem 282:11885–11892

    PubMed  CAS  Google Scholar 

  • Peskin AV, Cox AG, Nagy P, Morgan PE, Hampton MB, Davies MJ, Winterbourn CC (2010) Removal of amino acid, peptide and protein hydro-peroxides by reaction with peroxiredoxins 2 and 3. Biochem J 432:313–321

    PubMed  CAS  Google Scholar 

  • Piper PW (2006) Long-lived yeast as a model for ageing research. Yeast 23:215–226

    PubMed  CAS  Google Scholar 

  • Piper PW, Harris NL, MacLean M (2006) Preadaptation to efficient respiratory maintenance is essential both for maximal longevity and the retention of replicative potential in chronologically ageing yeast. Mech Ageing Dev 127:733–740

    PubMed  Google Scholar 

  • Powell CD, Quain DE, Smart KA (2000) The impact of media composition and petite mutation on the longevity of a polyploid brewing yeast strain. Lett Appl Microbiol 31:46–51

    PubMed  CAS  Google Scholar 

  • Powers RW 3rd, Kaeberlein M, Caldwell SD, Kennedy BK, Fields S (2006) Extension of chronological life span in yeast by decreased TOR pathway signaling. Genes Dev 20:174–184

    PubMed  CAS  Google Scholar 

  • Pozniakovsky AI, Knorre DA, Markova OV, Hyman AA, Skulachev VP, Severin FF (2005) Role of mitochondria in the pheromone- and amidiarone-induced programmed death of yeast. J Cell Biol 168:257–269

    PubMed  CAS  Google Scholar 

  • Pujol-Carrion N, Belli G, Herrero E, Nogues A, de la Torre-Ruiz MA (2006) Glutaredoxins Grx3 and Grx4 regulate nuclear localisation of Aft1 and the oxidative stress response in Saccharomyces cerevisiae. J Cell Sci 119:4554–4564

    PubMed  CAS  Google Scholar 

  • Ralser M, Wamelink MM, Kowald A, Gerisch B, Heeren G, Struys EA, Klipp E, Jakobs C, Breitenbach M, Lehrach H, Krobitsch S (2007) Dynamic rerouting of the carbohydrate flux is key to counteracting oxidative stress. J Biol 6:10

    PubMed  Google Scholar 

  • Ralser M, Wamelink MM, Latkolik S, Jansen EE, Lehrach H, Jakobs C (2009) Metabolic reconfiguration precedes transcriptional regulation in the antioxidant response. Nature Biotechnol 27:604–605

    CAS  Google Scholar 

  • Reinke LA, Bailey SM, Rau JM, McCay PB (1994) Oxygen radical formation in well-washed rat liver microsomes: spin trapping studies. Free Radic Res 20:51–60

    PubMed  CAS  Google Scholar 

  • Ren B, Robert F, Wyrick JJ, Aparicio O, Jennings EG, Simon I, Zeitlinger J, Schreiber J, Hannett N, Kanin E, Volkert TL, Wilson CJ, Bell SP, Young RA (2000) Genome-wide location and function of DNA binding proteins. Science 290:2306–2309

    PubMed  CAS  Google Scholar 

  • Reverter-Branchat G, Cabiscol E, Tamarit J, Ros J (2004) Oxidative damage to specific proteins in replicative and chronological-aged Saccharomyces cerevisiae: common targets and prevention by calorie restriction. J Biol Chem 279:31983–31989

    PubMed  CAS  Google Scholar 

  • Rodriguez-Manzaneque MT, Tamarit J, Belli G, Ros J, Herrero E (2002) Grx5 is a mitochondrial glutaredoxin required for the activity of iron/sulfur enzymes. Mol Biol Cell 13:1109–1021

    PubMed  CAS  Google Scholar 

  • Rosenfeld E, Beauvoit B (2003) Role of the non-respiratory pathways in the utilization of molecular oxygen by Saccharomyces cerevisiae. Yeast 20:1115–1144

    PubMed  CAS  Google Scholar 

  • Rosenfeld E, Beauvoit B, Rigoulet M, Salmon JM (2002) Non-respiratory oxygen consumption pathways in anaerobically-grown Saccharomyces cerevisiae: evidence and partial characterization. Yeast 19:1299–1321

    PubMed  CAS  Google Scholar 

  • Ruis H, Hamilton B (1992) Regulation of yeast catalase genes. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY

    Google Scholar 

  • Salmon TB, Evert BA, Song B, Doetsch PW (2004) Biological consequences of oxidative stress-induced DNA damage in Saccharomyces cerevisiae. Nucleic Acids Res 32:3712–3723

    PubMed  CAS  Google Scholar 

  • Salwinski L, Miller CS, Smith AJ, Pettit FK, Bowie JU, Eisenberg D (2004) The Database of Interacting Proteins: 2004 update. Nucleic Acids Res 32:D449–D451

    PubMed  CAS  Google Scholar 

  • Scandalios JG (1987) The antioxidant enzyme genes Cat and Sod of maize: regulation, functional significance, and molecular biology. Isozymes Curr Top Biol Med Res 14:19–44

    PubMed  CAS  Google Scholar 

  • Schafer FQ, Buettner GR (2001) Redox environment of the cell as viewed through the redox state of the glutathione disulfide/glutathione couple. Free Radic Biol Med 30:1191–1212

    PubMed  CAS  Google Scholar 

  • Scheckhuber CQ, Erjavec N, Tinazli A, Hamann A, Nystrom T, Osiewacz HD (2007) Reducing mitochondrial fission results in increased life span and fitness of two fungal ageing models. Nat Cell Biol 9:99–105

    PubMed  CAS  Google Scholar 

  • Schriner SE, Linford NJ, Martin GM, Treuting P, Ogburn CE, Emond M, Coskun PE, Ladiges W, Wolf N, Van Remmen H, Wallace DC, Rabinovitch PS (2005) Extension of murine life span by overexpression of catalase targeted to mitochondria. Science 308:1909–1911

    PubMed  CAS  Google Scholar 

  • Schwikowski B, Uetz P, Fields S (2000) A network of protein-protein interactions in yeast. Nat Biotechnol 18:1257–1261

    PubMed  CAS  Google Scholar 

  • Shapira M, Segal E, Botstein D (2004) Disruption of yeast forkhead-associated cell cycle transcription by oxidative stress. Mol Biol Cell 15:5659–5669

    PubMed  CAS  Google Scholar 

  • Shenton D, Smirnova JB, Selley JN, Carroll K, Hubbard SJ, Pavitt GD, Ashe MP, Grant CM (2006) Global translational responses to oxidative stress impact upon multiple levels of protein synthesis. J Biol Chem 281:29011–29021

    PubMed  CAS  Google Scholar 

  • Sidorova JM, Breeden LL (1997) Rad53-dependent phosphorylation of Swi6 and down-regulation of CLN1 and CLN2 transcription occur in response to DNA damage in Saccharomyces cerevisiae. Genes Dev 11:3032–3045

    PubMed  CAS  Google Scholar 

  • Sies H (1993) Strategies of antioxidant defense. Eur J Biochem 215:213–219

    PubMed  CAS  Google Scholar 

  • Sitte N, Merker K, von Zglinicki T, Grune T (2000) Protein oxidation and degradation during proliferative senescence of human MRC-5 fibroblasts. Free Radic Biol Med 28:701–708

    PubMed  CAS  Google Scholar 

  • Smeal T, Claus J, Kennedy B, Cole F, Guarente L (1996) Loss of transcriptional silencing causes sterility in old mother cells of S. cerevisiae. Cell 84:633–642

    PubMed  CAS  Google Scholar 

  • Smith MC, Sumner ER, Avery SV (2007) Glutathione and Gts1p drive beneficial variability in the cadmium resistances of individual yeast cells. Mol Microbiol 66:699–712

    PubMed  CAS  Google Scholar 

  • Spitz DR, Dewey WC, Li GC (1987) Hydrogen peroxide or heat shock induces resistance to hydrogen peroxide in Chinese hamster fibroblasts. J Cell Physiol 131:364–373

    PubMed  CAS  Google Scholar 

  • Stadtman ER (1992) Protein oxidation and aging. Science 257:1220–1224

    PubMed  CAS  Google Scholar 

  • Stephen DW, Rivers SL, Jamieson DJ (1995) The role of the YAP1 and YAP2 genes in the regulation of the adaptive oxidative stress responses of Saccharomyces cerevisiae. Mol Microbiol 16:415–423

    PubMed  CAS  Google Scholar 

  • Stockl P, Zankl C, Hutter E, Unterluggauer H, Laun P, Heeren G, Bogengruber E, Herndler-Brandstetter D, Breitenbach M, Jansen-Durr P (2007) Partial uncoupling of oxidative phosphorylation induces premature senescence in human fibroblasts and yeast mother cells. Free Radic Biol Med 43:947–958

    PubMed  Google Scholar 

  • Sumner ER, Avery AM, Houghton JE, Robins RA, Avery SV (2003) Cell cycle- and age-dependent activation of Sod1p drives the formation of stress resistant cell subpopulations within clonal yeast cultures. Mol Microbiol 50:857–870

    PubMed  CAS  Google Scholar 

  • Sumner ER, Avery SV (2002) Phenotypic heterogeneity: differential stress resistance among individual cells of the yeast Saccharomyces cerevisiae. Microbiology 148:345–351

    PubMed  CAS  Google Scholar 

  • Suzuki K, Ohsumi Y (2007) Molecular machinery of autophagosome formation in yeast, Saccharomyces cerevisiae. FEBS Lett 581:2156–2161

    PubMed  CAS  Google Scholar 

  • Tan SX, Teo M, Lam YT, Dawes IW, Perrone GG (2009) Cu, Zn superoxide dismutase and NADP(H) homeostasis are required for tolerance of endoplasmic reticulum stress in Saccharomyces cerevisiae. Mol Biol Cell 20:1493–1508

    PubMed  CAS  Google Scholar 

  • Teramoto S, Tomita T, Matsui H, Ohga E, Matsuse T, Ouchi Y (1999) Hydrogen peroxide-induced apoptosis and necrosis in human lung fibroblasts: protective roles of glutathione. Jpn J Pharmacol 79:33–40

    PubMed  CAS  Google Scholar 

  • Terman A, Dalen H, Eaton JW, Neuzil J, Brunk UT (2003) Mitochondrial recycling and aging of cardiac myocytes: the role of autophagocytosis. Exp Gerontol 38:863–876

    PubMed  CAS  Google Scholar 

  • Thompson DM, Parker R (2009) The RNase Rny1p cleaves tRNAs and promotes cell death during oxidative stress in Saccharomyces cerevisiae. J Cell Biol 185:43–50

    PubMed  CAS  Google Scholar 

  • Thorpe GW, Fong CS, Alic N, Higgins VJ, Dawes IW (2004) Cells have distinct mechanisms to maintain protection against different reactive oxygen species: oxidative-stress-response genes. Proc Natl Acad Sci USA 101:6564–6569

    PubMed  CAS  Google Scholar 

  • Toledano MB, Delaunay A, Monceau L, Tacnet F (2004) Microbial H2O2 sensors as archetypical redox signaling modules. Trends Biochem Sci 29:351–357

    PubMed  CAS  Google Scholar 

  • Tong AH, Lesage G, Bader GD, Ding H, Xu H, Xin X et al (2004) Global mapping of the yeast genetic interaction network. Science 303:808–813

    PubMed  CAS  Google Scholar 

  • Trotter EW, Grant CM (2002) Thioredoxins are required for protection against a reductive stress in the yeast Saccharomyces cerevisiae. Mol Microbiol 46:869–878

    PubMed  CAS  Google Scholar 

  • Trotter EW, Grant CM (2003) Non-reciprocal regulation of the redox state of the glutaredoxin and thioredoxin systems. EMBO Rep 4:184–188

    PubMed  Google Scholar 

  • Trotter EW, Rand JD, Vickerstaff J, Grant CM (2008) The yeast Tsa1 peroxiredoxin is a ribosome-associated antiioxidant. Biochem J 412:73–80

    PubMed  CAS  Google Scholar 

  • Tu BP, Ho-Schleyer SC, Travers KJ, Weissman JS (2000) Biochemical basis of oxidative protein folding in the endoplasmic reticulum. Science 290:1571–1574

    PubMed  CAS  Google Scholar 

  • Tu BP, Weissman JS (2002) The FAD- and O(2)-dependent reaction cycle of Ero1-mediated oxidative protein folding in the endoplasmic reticulum. Mol Cell 10:983–994

    PubMed  CAS  Google Scholar 

  • Tu BP, Weissman JS (2004) Oxidative protein folding in eukaryotes: mechanisms and consequences. J Cell Biol 164:341–346

    PubMed  CAS  Google Scholar 

  • Tucker CL, Fields S (2004) Quantitative genome-wide analysis of yeast deletion strain sensitivities to oxidative and chemical stress. Comp Funct Genomics 5:216–224

    PubMed  CAS  Google Scholar 

  • Turton HE, Dawes IW, Grant CM (1997) Saccharomyces cerevisiae exhibits a yAP-1-mediated adaptive response to malondialdehyde. J Bacteriol 179:1096–1101

    PubMed  CAS  Google Scholar 

  • Tyedmers J, Madariaga ML, Lindquist S (2008) Prion switching in response to environmental stress. PLoS Biol 6:e294

    PubMed  Google Scholar 

  • Unlu ES, Koc A (2007) Effects of deleting mitochondrial antioxidant genes on life span. Ann NY Acad Sci 1100:505–509

    PubMed  CAS  Google Scholar 

  • Vahsen N, Cande C, Briere JJ, Benit P, Joza N, Larochette N et al (2004) AIF deficiency compromises oxidative phosphorylation. EMBO J 23:4679–4689

    PubMed  CAS  Google Scholar 

  • Vellai T (2009) Autophagy genes and ageing. Cell Death Differ 16:94–102

    PubMed  CAS  Google Scholar 

  • Vellai T, Takacs-Vellai K, Zhang Y, Kovacs AL, Orosz L, Muller F (2003) Genetics: influence of TOR kinase on lifespan in C. elegans. Nature 426:620

    PubMed  CAS  Google Scholar 

  • Wadskog I, Maldener C, Proksch A, Madeo F, Adler L (2004) Yeast lacking the SRO7/SOP1-encoded tumor suppressor homologue show increased susceptibility to apoptosis-like cell death on exposure to NaCl stress. Mol Biol Cell 15:1436–1444

    PubMed  CAS  Google Scholar 

  • Wawryn J, Krzepilko A, Myszka A, Bilinski T (1999) Deficiency in superoxide dismutases shortens life span of yeast cells. Acta Biochim Pol 46:249–253

    PubMed  CAS  Google Scholar 

  • Wheeler GL, Grant CM (2004) Regulation of redox homeostasis in the yeast Saccharomyces cerevisiae. Physiol Plant 120:12–20

    PubMed  CAS  Google Scholar 

  • Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B et al (1999) Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science 285:901–906

    PubMed  CAS  Google Scholar 

  • Wiseman H, Halliwell B (1996) Damage to DNA by reactive oxygen and nitrogen species: role in inflammatory disease and progression to cancer. Biochem J 313:17–29

    PubMed  CAS  Google Scholar 

  • Wissing S, Ludovico P, Herker E, Buttner S, Engelhardt SM, Decker T, Link A, Proksch A, Rodrigues F, Corte-Real M, Frohlich KU, Manns J, Cande C, Sigrist SJ, Kroemer G, Madeo F (2004) An AIF orthologue regulates apoptosis in yeast. J Cell Biol 166:969–974

    PubMed  CAS  Google Scholar 

  • Wong C-M, Siu K-L, Jin D-Y (2004) Peroxoredoxin-null yeast cells are hypersensitive to oxidative stress and are genomically unstable. J Biol Chem 279:23207–23213

    PubMed  CAS  Google Scholar 

  • Wong CM, Zhou Y, Ng RWM, Kung HF, Jin DY (2002) Cooperation of yeast peroxiredoxins Tsa1p and Tsa2p in the cellular defense against oxidative stress. J Biol Chem 277:5385–5394

    PubMed  CAS  Google Scholar 

  • Wonisch W, Kohlwein SD, Schaur J, Tatzber F, Guttenberger H, Zarkovic N, Winkler R, Esterbauer H (1998) Treatment of the budding yeast Saccharomyces cerevisiae with the lipid peroxidation product 4-HNE provokes a temporary cell cycle arrest in G1 phase. Free Radic Biol Med 25:682–687

    PubMed  CAS  Google Scholar 

  • Wood MJ, Storz G, Tjandra N (2004) Structural basis for redox regulation of Yap1 transcription factor localization. Nature 430:917–921

    PubMed  CAS  Google Scholar 

  • Yan C, Lee LH, Davis LI (1998) Crm1p mediates regulated nuclear export of a yeast AP-1-like transcription factor. EMBO J 17:7416–7429

    PubMed  CAS  Google Scholar 

  • Zhu C, Byers KJ, McCord RP, Shi Z, Berger MF, Newburger DE, Saulrieta K, Smith Z, Shah MV, Radhakrishnan M, Philippakis AA, Hu Y, De Masi F, Pacek M, Rolfs A, Murthy T, Labaer J, Bulyk ML (2009) High-resolution DNA-binding specificity analysis of yeast transcription factors. Genome Res 19:556–566

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, 2052, Australia

    May T. Aung-Htut, Anita Ayer & Ian W. Dawes

  2. Division of Genetics, Department of Cell Biology, University of Salzburg, Salzburg, Austria

    Michael Breitenbach

Authors
  1. May T. Aung-Htut
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Anita Ayer
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Michael Breitenbach
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Ian W. Dawes
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Ian W. Dawes .

Editor information

Editors and Affiliations

  1. , Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, 5020, Austria

    Michael Breitenbach

  2. , Tulane Center for Aging and Department o, Tulane University Health Sciences Center, Tulane Avenue SL-12 1430, New Orleans, 70112, Louisiana, USA

    S. Michal Jazwinski

  3. , Department of Cell Biology, University of Salzburg, Hellbrunnerstrasse 34, Salzburg, 5020, Austria

    Peter Laun

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer Science+Business Media B.V.

About this chapter

Cite this chapter

Aung-Htut, M.T., Ayer, A., Breitenbach, M., Dawes, I.W. (2011). Oxidative Stresses and Ageing. In: Breitenbach, M., Jazwinski, S., Laun, P. (eds) Aging Research in Yeast. Subcellular Biochemistry, vol 57. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-2561-4_2

Download citation

Publish with us

Policies and ethics

Search

Navigation