Skip to main content
SpringerLink
Log in

Therapy of Cutaneous Manifestations

  • Chapter
Aspects of Lyme Borreliosis

Abstract

Cutaneous manifestations of Lyme borreliosis have been treated with antibiotics since the late 1940s. Therapy has first been carried out with penicillin and to a lesser extent with tetracycline, erythromycin, and Chloramphenicol (See Chap. 1). The initial impression gained from these studies had been that the aforementioned antibiotics are quite effective in ridding patients of their manifestations (Weber 1973). Recent developments have made it necessary to look at the treatment of the cutaneous manifestations from a new standpoint.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ackermann R, Boisten HP, Kabatzki J, Runne U, Krüger K, Hermann WP (1984) Serumantikörper gegen Ixodes-ricinus-Spirochäte bei Acrodermatitis chronica atrophicans (Herxheimer). Dtseh Med Wochenschr 109:6–10

    Article  CAS  Google Scholar 

  • Asbrink E (1990) Late dermatological manifestations in Lyme borreliosis. In: Einhäupl KM, Felgenhauer K, Herzer P, Stirenstedt G (eds) Lyme borreliosis. Edit Roche, Basel/Grenzach- Wyhlenpp 109–118

    Google Scholar 

  • Asbrink E, Hovmark A (1985) Successful cultivation of spirochetes from skin lesions of patients with erythema chronicum migrans Afzelius and acrodermatitis chronica atrophicans. Acta Pathol Microbiol Immunol Scand (B) 93:161–163

    CAS  Google Scholar 

  • Asbrink E, Hovmark A (1987) Cutaneous manifestations in Ixodes-borne Borrelia spirochetosis. Int J Dermatol 26:215–223

    Article  PubMed  CAS  Google Scholar 

  • Asbrink E, Hovmark A, Hederstedt B (1985) Serologic studies of erythema chronicum migrans Afzelius and acrodermatitis chronica atrophicans with indirect immunofluorescence and enzyme-linked immunosorbent assays. Acta Derm Venereol (Stockh) 65:509–514

    CAS  Google Scholar 

  • Asbrink E, Olsson I, Hovmark A (1986) Erythema chronicum migrans Afzelius in Sweden. A study on 231 patients. Zentralbl Bakt Mikrobiol Hyg (A) 263:229–236

    CAS  Google Scholar 

  • Berger BW (1984) Treating erythema chronicum migrans of Lyme disease. J Am Acad Dermatol 15:459–463

    Article  Google Scholar 

  • Berger BW (1988) Treatment of erythema chronicum migrans of Lyme disease. Ann NY Acad Sci 539:346–351

    Article  PubMed  CAS  Google Scholar 

  • Betz E (1972) Nachuntersuchungen über den Behandlungserfolg an den Akrodermatitis chronica atrophicans (Herxheimer) Erkrankten der Universitäts-Hautklinik Köln auf Grund von klinischen und histologischen Befunden. Dissertation, Köln, Germany

    Google Scholar 

  • Dattwyler RJ, Volkman DL, Luft BJ, Halperin JJ, Thomas J, Golightly MG (1988) Seronegative Lyme disease: dissociation of the specific T-and B-lymphocyte response to Borrelia burgdorferi. N Engl J Med 319:1441–1446

    Article  PubMed  CAS  Google Scholar 

  • Dattwyler RJ, Volkman DJ, Conaty SM, Platkin SP, Luft BJ (1990) Amoxicillin and probenecide versus doxycycline for treatment of erythema migrans borreliosis. Lancet 11:1404–1406

    Article  Google Scholar 

  • Götz H (1952) Die Acrodermatitis chronica atrophicans Herxheimer als neue Indikation für die Behandlung mit Chloromycetin. Hautarzt 3:310–312

    PubMed  Google Scholar 

  • Götz H, Ludwig E (1951) Die Behandlung der Akrodermatitis chronica atrophicans Herxheimermit Penicillin. Hautarzt 2:6–14

    Google Scholar 

  • Hassler D, Zöller L, Haude M, Hufnagel HD, Heinrich F, Sonntag HG (1990) Cefotaxime versus penicillin in the late stage of Lyme disease — prospective, randomized therapeutic study. Infection 18:16–20

    Article  PubMed  CAS  Google Scholar 

  • Herzer P (1989) Lyme-Borreliose. Steinkopf, Darmstadt

    Google Scholar 

  • Hollström E (1951) Successful treatment of erythema migrans Afzelius. Acta Derm Venereol (Stockh) 31:235–243

    Google Scholar 

  • Hollström E (1958) Penicillin treatment of erythema chronicum migrans Afzelius. Acta Derm Venereol (Stockh) 38:285–289

    Google Scholar 

  • Hopf HC (1966) Acrodermatitis chronica atrophicans (Herxheimer) und Nervensystem. Springer, Berlin Heidelberg New York (Monographien aus dem Gesamtgebiete der Neurology und Psychiatry, vol 114)

    Google Scholar 

  • Hovmark A, Asbrink E, Olsson I (1986) The spirochetal etiology of lymphadenosis benigna cutissolitaria. Acta Derm Venereol (Stockh) 66:479–484

    CAS  Google Scholar 

  • Hovmark A, Olsson I, Asbrink E, Olsson E, Halkier-Sörensen L, Hansen K (1990) A comparative study of the efficacy of roxithromycin and Phenoxymethylpenicillin in the treatment of erythema migrans (abstract). IVth international conference of Lyme borreliosis, Stockholm

    Google Scholar 

  • Johnson RC, Kodner C, Rüssel M (1987) In vitro and in vivo susceptibility of the Lyme disease spirochete, Borrelia burgdorferi, to four antimicrobial agents. Antimicrob Agents Chemother 31:164–167

    PubMed  CAS  Google Scholar 

  • Kaiser M (1972) Neurologische Komplikationen bei Akrodermatitis chronica atrophicans (Herxheimer) und ihre Beeinflussung durch die Penicillintherapie. Dissertation, Göttingen

    Google Scholar 

  • Kristoferitsch W (1989) Neuropathien bei Lyme-Borreliosis. Springer, Wien New York, pp 114–115

    Book  Google Scholar 

  • Krüger H, Reuss K, Pulz M, Rohrbach E, Pflughaupt KW, Martin R, Mertens HG (1989) Meningoradiculitis and encephalomyelitis due to Borrelia burgdorferi — a follow-up study of 72 patients over 27 years. J Neurol 236:322–328

    Article  PubMed  Google Scholar 

  • Kuiper H, de Jongh B, Ramselaar T, Spanjaard L (1990) Evidence of asymptomatic nervous system involvement in localized erythema migrans. IVth internal conference of Lyme Borreliosis, Stockholm, abstract W/Th-P-48

    Google Scholar 

  • Langer K, Diem E (1988) Acrodermatitis chronica atrophicans und sklerodermiforme Hautveränderungen bei Borre/Za-Infektion. Hautarzt 39:647–651

    PubMed  CAS  Google Scholar 

  • Ludwig E (1955) Erfolgreiche Aureomycin- und Terramycinbehandlung als Beitrag zur Klärung der Wirkungsweise von Penicillin bei der Akrodermatitis chronica atrophicans Herxheimer. Dermatol Wochensehr 131:169–178

    Google Scholar 

  • Morel P, Modai J, Dournon E (1990) Treatment of erythema chronicum migrans (ECM) and prevention of stage 2 Lyme disease (Ld) with oral amoxicillin: a one-year follow-up (abstract). IVth international conference on Lyme Borreliosis, Stockholm

    Google Scholar 

  • Neubert U (1987) Erythema migrans in der Gravidität. Hautarzt 38:182–183

    Google Scholar 

  • Neumann R, Aberer E, Stanek G (1986) Treatment and course of erythema chronicum migrans. Zentralbl Bakteriol Hyg (A) 263:372–376

    Google Scholar 

  • Pfister HW, Wilske B, Preac-Mursic V, Einhäupl KM (1989) Clinical and serological follow up of patients with Bannwarth’s syndrome: comparison of patients with and without penicillin treatment. Zentralbl Bakteriol (Suppl) 18:276–279

    Google Scholar 

  • Pirilä V (1951) The penicillin treatment of acrodermatitis atrophicans chronica. Acta Derm Venereol (Stockh) 31:576–591

    Google Scholar 

  • Preac-Mursic V, Wilske B, Herzer P, Schierz G, Bauer M (1985) Acrodermatitis chronicaatrophicans — eine Borreliose. Hautarzt 36:691–693

    PubMed  CAS  Google Scholar 

  • Preac-Mursic V, Wilske B, Schierz G, Holmburger M, Süss E (1987) In vitro and in vivo susceptibility of Borrelia burgdorferi. Eur J Clin Microbiol 6:424–426

    Article  Google Scholar 

  • Preac-Mursic V, Weber K, Pfister HW, Wilske B, Gross B, Baumann A, Prokop J (1989) Survival of Borrelia burgdorferi in antibiotically treated patients with Lyme borreliosis. Infection 17:355–359

    Article  PubMed  CAS  Google Scholar 

  • Steere AC (1989) Lyme disease. N Engl J Med 321:586–596

    Article  PubMed  CAS  Google Scholar 

  • Steere AC, Malawista SE, Newman J, Spieler PN, Bartenhagen HN (1980) Antibiotic therapy in Lyme disease. Ann Intern Med 93:1–8

    PubMed  CAS  Google Scholar 

  • Steere AC, Hutchinson GJ, Rahn DW, Sigal LH, Craft JE, DeSanna ET, Malawista SE (1983) Treatment of the early manifestations of Lyme disease. Ann Intern Med 99:22–26

    PubMed  CAS  Google Scholar 

  • Strle F, Ruzic E, Cimperman J (in press) Erythema migrans: comparison of treatment with azithromycin, doxycycline and pheoxymethylpenicillin. J Antimicrob Chemother

    Google Scholar 

  • Thyresson N (1949) The penicillin treatment of acrodermatitis chronica atrophicans (Herxheimer). Acta Derm Venereol (Stockh) 29:572–621

    CAS  Google Scholar 

  • Weber K (1973) Erkrankungen nach Zeckenbiß und ihre Behandlung. Ther Ggw 112:1402–1409

    PubMed  CAS  Google Scholar 

  • Weber K (1974) Erythema-chronicum-migrans-Meningitis - eine bakterielle Infektionskrankheit? Munch Med Wochenschr 116:1993–1998 Weber K (1984) Jarisch-Herxheimer-Reaktion bei Erythema-migrans-Krankheit. Hautarzt 35: 588–590

    Google Scholar 

  • Weber K (1989) Clinical differences between European and North-American Lyme borreliosis — a review. Zentralbl Bakteriol (Suppl) 18:146–155

    Google Scholar 

  • Weber K, Neubert U (1986) Clincal features of early erythema migrans disease and related disorders. Zentralbl Bakteriol Hyg (A) 263:209–228

    CAS  Google Scholar 

  • Weber K, Thurmayr R (1989) Oral penicillin versus minocycline for the treatment of early Lyme borreliosis. Zentralbl Bakteriol (Suppl) 18:263–268

    Google Scholar 

  • Weber K, Schierz G, Wilske B, Preac-Mursic V (1984) Zur Klinik und Ätiologie der Acrodermatitis chronica atrophicans. Hautarzt 35:571–577

    PubMed  CAS  Google Scholar 

  • Weber K, Neubert U, Thurmayr R (1986) Antibiotic therapy in early erythema migrans disease and related disorders. Zentralbl Bakteriol Hyg (A) 263:377–388

    Google Scholar 

  • Weber K, Preac-Mursic V, Neubert U, Thurmayr R, Herzer P, Wilske B, Schierz G, Marget W (1988a) Antibiotic therapy of early European Lyme borreliosis and acrodermatitis chronica atrophicans. Ann NY Acad Sci 539:324–345

    Article  PubMed  CAS  Google Scholar 

  • Weber K, Bratzke HJ, Neubert U, Wilske B, Duray PH (1988b)Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy. Pediatr Infect Dis 7:286- 289

    Article  CAS  Google Scholar 

  • Weber K, Preac-Mursic V, Wilske B, Thurmayr R, Neubert U, Scherwitz C (1990) A randomized trial of ceftriaxone versus oral penicillin for the treatment of early European Lyme borreliosis. Infection 18:91–96

    Article  PubMed  CAS  Google Scholar 

  • Zöller L, Haude M, Hassler D, Burkard S, Sonntag HG (1989) Spontaneous and post-treatment antibody kinetics in late Lyme borreliosis. Serodiagnosis Immunther Infect Dis 3:345–353

    Article  Google Scholar 

Download references

Authors
  1. K. Weber
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Rosenstr.6, 8000, München 2, Germany

    Klaus Weber (Dermatologist in Private Practice) (Dermatologist in Private Practice)

  2. Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Department of Health and Human Services, Public Health Service,National Institutes of Health, National Institute of Allergy and Infectious Diseases, 59840, Hamilton, MT, USA

    Willy Burgdorfer Ph.D.,M.D.(h.c.)

Rights and permissions

Reprints and permissions

Copyright information

© 1993 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Weber, K. (1993). Therapy of Cutaneous Manifestations. In: Weber, K., Burgdorfer, W., Schierz, G. (eds) Aspects of Lyme Borreliosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77614-4_23

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-77614-4_23

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77616-8

  • Online ISBN: 978-3-642-77614-4

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation