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Meta-Analysis of Randomized Controlled Trials of Granulocyte Colony-Stimulating Factor Prophylaxis in Adult Cancer Patients Receiving Chemotherapy

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Hematopoietic Growth Factors in Oncology

Part of the book series: Cancer Treatment and Research ((CTAR,volume 157))

Abstract

Granulocyte colony-stimulating factor (G-CSF) reduces the severity and duration of neutropenia associated with cancer chemotherapy [1–5]. In the pivotal phase III trial in patients with small cell lung cancer, patients were randomized to either G-CSF or placebo following combination chemotherapy in a double-blind fashion [3]. A significant difference in the cumulative risk of febrile neutropenia (FN) between the control (77%) and the G-CSF (40%) groups was observed despite the allowed use of secondary G-CSF prophylaxis after an initial occurrence of FN in the control group (P < 0.001). Several additional clinical trials of prophylactic G-CSF in patients with various malignancies receiving different treatment regimens have been reported [6–11].

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  1. Duke University School of Medicine, Durham, NC, 27705, USA

    Nicole M. Kuderer

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Correspondence to Nicole M. Kuderer .

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  1. Department of Medicine, Duke University and the Duke Comprehensi, Durham, 27705, North Carolina, USA

    Gary H. Lyman

  2. Health Sciences Center, Department of Medicine, University of Washington, Seattle, 98195, Washington, USA

    David C. Dale

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Kuderer, N.M. (2010). Meta-Analysis of Randomized Controlled Trials of Granulocyte Colony-Stimulating Factor Prophylaxis in Adult Cancer Patients Receiving Chemotherapy. In: Lyman, G., Dale, D. (eds) Hematopoietic Growth Factors in Oncology. Cancer Treatment and Research, vol 157. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-7073-2_8

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