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New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone Cancer Pain via TRPV1 Activation

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Translational Research in Pain and Itch

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 904))

Abstract

In recent years, our serial investigations focused on the role of cancer cells-derived endogenous formaldehyde in bone cancer pain. We found that cancer cells produced formaldehyde through demethylation process by serine hydroxymethyltransferase (SHMT1 and SHMT2) and lysine-specific histone demethylase 1 (LSD1). When the cancer cells metastasized into bone marrow, the elevated endogenous formaldehyde induced bone cancer pain through activation on the transient receptor potential vanilloid subfamily member 1 (TRPV1) in the peripheral nerve fibers. More interestingly, TRPV1 expressions in the peripheral fibers were upregulated by the local insulin-like growth factor I (IGF-I) produced by the activated osteoblasts. In conclusion, tumor tissue-derived endogenous formaldehyde induced bone cancer pain via TRPV1 activation.

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Acknowledgments

These serial research works were supported by grants from the National Natural Science Foundation of China (NSFC) (81070893, 81171042, 81221002) and supported by the “111 Project” of the Ministry of Education of China (B07001). I would also like to thank Drs. Zhiqian Tong, Yan Li, Jia Liu, Ying Han, Feng-Yu Liu for their contributions to the research and Ph.D. students Shan Shao and Bingxuan Han who helped to prepare the manuscript. A relative review was published in Chinese in Chin J Pain Med 2014; 20(7): 449-453.

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  1. Neuroscience Research Institute, Peking University, Beijing, 100191, People’s Republic of China

    You Wan

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  1. Dep of Anatomy,Histology and Embryology, Inst of Basic Med Sci Neroscien Cntr, Beijing, China

    Chao Ma

  2. Department of Anesthesiology, Peking Union Medical College Hospital, Beijing, China

    Yuguang Huang

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Wan, Y. (2016). New Mechanism of Bone Cancer Pain: Tumor Tissue-Derived Endogenous Formaldehyde Induced Bone Cancer Pain via TRPV1 Activation. In: Ma, C., Huang, Y. (eds) Translational Research in Pain and Itch. Advances in Experimental Medicine and Biology, vol 904. Springer, Dordrecht. https://doi.org/10.1007/978-94-017-7537-3_4

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