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Blood Antioxidant Status, Dysglycemia and Obstructive Sleep Apnea

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Respiratory Regulation - The Molecular Approach

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 756))

Abstract

Obstructive sleep apnea (OSA) patients present increased cardiovascular morbidity and mortality. Oxidative stress is involved in OSA and cardiovascular pathology. The aim of the study was to assess oxidative stress markers in the blood of OSA males during oral glucose tolerance test (OGTT). The study involved OSA-suspected obese males (BMI ≥ 25 kg/m2) aged 35–64, with no acute or chronic disorders, appointed for polysomnography to diagnose OSA (AHI ≥ 5). The results of OGTT allowed to select prediabetic (Pre) subjects and normal glucose tolerance (N), excluding newly diagnosed diabetes. Blood was collected at 0 min (fasting) and 120 min of the test. Plasma glucose, total antioxidant status (TAS), thiobarbituric acid-reacting substances (TBARS), and activity of superoxide dismutase-1 (SOD) in erythrocytes, were determined at the two time points and the difference (D) between the 120 and 0 min time points was calculated for either oxidative stress variable (D-TAS, D-SOD and D-TBARS). Fasting serum insulin and lipids also were measured fasting. There were four groups of subjects, each consisting of 22 individuals N-OSA-neg(ative), N-OSA-pos(itive), Pre-OSA-neg and Pre-OSA-pos. The N-OSA-pos and Pre-OSA-pos subjects demonstrated decreased SOD-0 compared with OSA-negative groups. In N-OSA-neg and N-OSA-pos groups, the positive differences D-SOD and D-TAS were observed, while Pre-OSA subjects presented negative differences. In conclusion, prediabetic OSA patients may consume blood antioxidant factors to counter the effects of oxidative stress, more than individuals with normal glucose tolerance.

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Author information

Authors and Affiliations

  1. Department of Clinical Biochemistry and Laboratory Medicine, Poznan University of Medical Sciences, Grunwaldzka 6 St, 60-780, Poznan, Poland

    Ewa Wysocka, Sylwia Dziegielewska-Gesiak & Lech Torlinski

  2. Department of Pneumology, Allergology and Respiratory Oncology, Poznan University of Medical Sciences, Szamarzewskiego 84 St, 60-569, Poznan, Poland

    Szczepan Cofta & Tomasz Piorunek

  3. Department of Internal Medicine, Hypertension and Metabolic Disorders, Poznan University of Medical Sciences, Szamarzewskiego 84 St, 60-569, Poznan, Poland

    Wieslaw Bryl

Authors
  1. Ewa Wysocka
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  2. Szczepan Cofta
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  3. Tomasz Piorunek
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  4. Sylwia Dziegielewska-Gesiak
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  5. Wieslaw Bryl
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  6. Lech Torlinski
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Corresponding author

Correspondence to Ewa Wysocka .

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Editors and Affiliations

  1. Medical Research Center, Respiratory Research, Polish Academy of Sciences, Pawinskiego 5, Warsaw, 02-106, Poland

    Mieczyslaw Pokorski

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Conflicts of interest: No conflict of interests were declared by the authors in relation to this work.

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Wysocka, E., Cofta, S., Piorunek, T., Dziegielewska-Gesiak, S., Bryl, W., Torlinski, L. (2013). Blood Antioxidant Status, Dysglycemia and Obstructive Sleep Apnea. In: Pokorski, M. (eds) Respiratory Regulation - The Molecular Approach. Advances in Experimental Medicine and Biology, vol 756. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-4549-0_16

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