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Esophageal Preservation in Barrett’s Esophagus with High-Grade Dysplasia and Mucosal Adenocarcinoma

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Innovation in Esophageal Surgery

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Abstract

A surgeon may witness a radical shift in therapies a few times during a career. For example, the introduction and refinement of laparoscopic and thoracoscopic techniques have brought about a revolution in the management of a multitude of abdominal and thoracic disease processes over the past generation. Another more recent, yet equally significant, paradigm shift has been the popularization of endoscopic therapies for early esophageal neoplasia.

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References

  1. Spechler SJ, Sharma P, Souza RF et al (2011) American Gastroenterological Association medical position statement on the management of Barrett’s esophagus. Gastroenterology 140:1084–1091

    Article  PubMed  Google Scholar 

  2. Williams VA, Watson TJ, Herbella FA et al (2007) Esophagectomy for high grade dysplasia is safe, curative and results in good alimentary outcome. J Gastrointest Surg 11:1589–1597

    Article  PubMed  Google Scholar 

  3. Schnell TG, Sontag SJ, Chejfec G et al (2001) Long-term nonsurgical management of Barrett’s esophagus with high-grade dysplasia. Gastroenterology 120:1607–1619

    Article  PubMed  CAS  Google Scholar 

  4. Barr H (2003) Ablative mucosectomy is the procedure of choice to prevent Barrett’s cancer. Gut 52(1):14–15

    Article  PubMed  CAS  Google Scholar 

  5. Bailey SH, Bull DA, Harpole DH et al (2003) Outcomes after esophagectomy: a ten-year prospective cohort. Ann Thorac Surg 75:217–222

    Article  PubMed  Google Scholar 

  6. Connors RC, Reuben BC, Neumayer LA, Bull DA (2007) Comparing outcomes after transthoracic and transhiatal esophagectomy: a 5-year prospective cohort of 17,395 patients. J Am Coll Surg 205:735–740

    Article  PubMed  Google Scholar 

  7. Portale G, Hagen JA, Peters JH et al (2006) Modern 5-year survival of resectable esophageal adenocarcinoma: single institution experience with 263 patients. J Am Coll Surg 202:588–596

    Article  PubMed  Google Scholar 

  8. Orringer MB, Marshall B, Chang AC et al (2007) Two thousand transhiatal esophagectomies: changing trends, lessons learned. Ann Surg 246:363–374

    Article  PubMed  Google Scholar 

  9. Swanson SJ, Batirel HF, Bueno R et al (2001) Transthoracic esophagectomy with radical mediastinal and abdominal lymph node dissection and cervical esophagogastrostomy for esophageal carcinoma. Ann Thorac Surg 72:1918–1925

    Article  PubMed  CAS  Google Scholar 

  10. Hulscher JB, Tijssen JG, Obertop H, van Lanschot JJ (2001) Transthoracic versus transhiatal resection for carcinoma of the esophagus: a meta-analysis. Ann Thorac Surg 72:306–313

    Article  PubMed  CAS  Google Scholar 

  11. Fernando HC, Luketich JD, Buenaventura PO et al (2002) Outcomes of minimally invasive esophagectomy (MIE) for high-grade dysplasia of the esophagus. Eur J Cardiothorac Surg 22:1–6

    Article  PubMed  CAS  Google Scholar 

  12. Peyre CG, DeMeester SR, Rizzetto C et al (2007) Vagal-sparing esophagectomy: the ideal operation for intramucosal adenocarcinoma and Barrett’s with high-grade dysplasia. Ann Surg 246:665–671

    Article  PubMed  Google Scholar 

  13. Inoue H, Endo M, Takeshita K et al (1992) A new simplified technique of endoscopic esophageal mucosal resection using a cap-fitted panendoscope. Surg Endosc 6:264–265

    Article  PubMed  CAS  Google Scholar 

  14. Rice TW, Zuccaro G Jr, Adelstein DJ et al (1998) Esophageal carcinoma: depth of tumor invasion is predictive of regional nodal status. Ann Thorac Surg 65:787–792

    Article  PubMed  CAS  Google Scholar 

  15. Buskens CJ, Westerterp M, Lagarde SM et al (2004) Prediction of appropriateness of local endoscopic treatment for high-grade dysplasia and early adenocarcinomas by EUS and histopathologic features. Gastrointest Endosc 60:703–707

    Article  PubMed  Google Scholar 

  16. Liu L, Hofstetter WL, Rashid A et al (2005) Significance of the depth of tumor invasion and lymph node metastasis in superficially invasive (T1) esophageal adenocarcinoma. Am J Surg Pathol 29:1079–1085

    PubMed  Google Scholar 

  17. Altorki NK, Lee PC, Liss Y et al (2008) Multifocal neoplasia and nodal metastases in T1 esophageal carcinoma: implications for endoscopic treatment. Ann Surg 247:434–439

    Article  PubMed  Google Scholar 

  18. Sepesi B, Watson TJ, Zhou D et al (2010) Are endoscopic therapies appropriate for superficial submucosal esophageal adenocarcinoma? An analysis of esophagectomy specimens. J Am Coll Surg 210:418–427

    Article  PubMed  Google Scholar 

  19. Leers JM, DeMeester SR, Oezcelik A et al (2011) The prevalence of lymph node metastases in patients with T1 esophageal adenocarcinoma: a retrospective review of esophagectomy specimens. Ann Surg 253:271–278

    Article  PubMed  Google Scholar 

  20. May A, Gossner L, Behrens A et al (2003) A prospective randomized trial of two different endoscopic resection techniques in 100 consecutive resections in patients with early cancer of the esophagus. Gastrointest Endosc 58:167–175

    Article  PubMed  Google Scholar 

  21. Ell C, May A, Pech O et al (2007) Curative endoscopic resection of early esophageal adenocarcinomas (Barrett’s cancer). Gastrointest Endosc 65:3–10

    Article  PubMed  Google Scholar 

  22. Pech O, Behrens A, May A et al (2008) Long-term results and risk factor analysis for recurrence after curative endoscopic therapy in 349 patients with high-grade intraepithelial neoplasia and mucosal adenocarcinoma in Barrett’s oesophagus. Gut 57:1200–1206

    Article  PubMed  CAS  Google Scholar 

  23. Shaheen NJ, Sharma P, Overholt BF et al (2009) Radiofrequency ablation in Barrett’s esophagus with dysplasia. N Eng J Med 360:2277–2288

    Article  CAS  Google Scholar 

  24. Greenwald BD, Dumot JA, Horwhat JD, Lightdale CJ, Abrams JA (2010) Safety, tolerability, and efficacy of endoscopic low-pressure liquid nitrogen spray cryotherapy in the esophagus. Dis Esophagus 23:13–19

    Article  PubMed  Google Scholar 

  25. van Vilsteren FGI, Pouw RE, Seewald S et al (2011) Stepwise radical endoscopic resection versus radiofrequency ablation for Barrett’s oesophagus with high-grade dysplasia or early cancer: a multicentre randomised trial. Gut 60(6):765–773

    Article  PubMed  Google Scholar 

  26. Prasad GA, Wu TT, Wigle DA et al (2009) Endoscopic and surgical treatment of mucosal (T1a) esophageal adenocarcinoma in Barrett’s esophagus. Gastroenterology 137:816–823

    Article  Google Scholar 

  27. Zehetner J, DeMeester SR, Hagen JA et al (2011) Endoscopic resection and ablation versus esophagectomy for high-grade dysplasia and intramucosal adenocarcinoma. J Thorac Cardiovasc Surg 141:39–47

    Article  PubMed  Google Scholar 

  28. Pech O, Bollschweiler E, Manner H et al (2011) Comparison between endoscopic and surgical resection of mucosal adenocarcinoma in Barrett’s esophagus at two high-volume centers. Ann Surg 254:67–72

    Article  PubMed  Google Scholar 

  29. Galey KM, Wilshire CL, Watson TJ et al (2011) Endoscopic management of early esophageal neoplasia: an emerging standard. J Gastrointest Surg 15:1299–1302

    Article  Google Scholar 

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Authors and Affiliations

  1. Division of Thoracic and Foregut Surgery, Department of Surgery, University of Rochester School of Medicine and Dentistry, 601 Elmwood Avenue, Box Surgery, Rochester, NY, 14642, USA

    Thomas J. Watson & Jeffrey H. Peters

Authors
  1. Thomas J. Watson
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  2. Jeffrey H. Peters
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Corresponding author

Correspondence to Thomas J. Watson .

Editor information

Editors and Affiliations

  1. , Department ofSurgery, IRCCS Policlinico San Donato, San Donato Milanese (Mi), Italy

    Luigi Bonavina

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© 2012 Springer-Verlag Italia

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Watson, T.J., Peters, J.H. (2012). Esophageal Preservation in Barrett’s Esophagus with High-Grade Dysplasia and Mucosal Adenocarcinoma. In: Bonavina, L. (eds) Innovation in Esophageal Surgery. Springer, Milano. https://doi.org/10.1007/978-88-470-2469-4_6

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  • DOI: https://doi.org/10.1007/978-88-470-2469-4_6

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  • Publisher Name: Springer, Milano

  • Print ISBN: 978-88-470-2468-7

  • Online ISBN: 978-88-470-2469-4

  • eBook Packages: MedicineMedicine (R0)

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