Skip to main content

A Comparative Evaluation of Clinical Rating Scales and Quantitative Measurements in Assessment pre and post Striatal Implantation of Human Foetal Mesencephalon in Parkinson’s Disease

  • Conference paper
Advances in Stereotactic and Functional Neurosurgery 9

Part of the book series: Acta Neurochirurgica Supplementum ((STEREOTACTIC,volume 52))

Summary

Six patients with advanced Parkinson’s Disease were evaluated before and after implantation of human fetal ventral mesencephalic tissue to the head of the right caudate nucleus. The results of clinical assessment indicate that attempts to characterise patient fluctuations requires a combination of clinical rating scales and timing of specific limb tasks.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Bjorklund A, Stenevi U (1979) Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res 177: 555–560

    Article  PubMed  CAS  Google Scholar 

  2. Brundin P, Strecker RE, Widner H et al (1988) Human fetal dopamine neurons grafted in a rat model of Parkinson’s disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release Exp Brain Res 70: 192–208

    PubMed  CAS  Google Scholar 

  3. Canter GJ, De la Torre R, Mier M (1961) A method for evaluating disability in patients with Parkinson’s Disease. J Nerv Ment Dis 122: 143–147

    Google Scholar 

  4. Freed CR, Breeze RE, Rosenberg NL et al (1990) Transplantation of human fetal dopamine cells for Parkinson’s disease: Results at one year. Arch Neurol 47: 505–512

    Article  PubMed  CAS  Google Scholar 

  5. Hitchcock ER, Kenny BG, Clough CG, Hughes RC, Henderson BTH, Detta A (1990) Stereotactic implantation of Foetal Mesesencephalon (STIM): The UK experience. In: Dunnett SB, Richards SJ (eds) Neural transplantation: from molecular basis to clinical applications. Prog Brain Res 82:723–728 Elsevier, Amsterdam, New York, Oxford

    Google Scholar 

  6. Lindvall O, Rehncrona S, Brundin P et al (1989) Human fetal dopamine neurons grafted into the Striatum in two patients with severe Parkinson’s disease: a detailed account of methodology and a 6-month follow-up. Arch Neurol 46:615–631

    Article  PubMed  CAS  Google Scholar 

  7. Nutt JG (1987) On-ofT Phenomenon: Relation to Levodopa Pharmacokinetics and Pharmacodynamics. Ann Neurol 22: 535–540

    Article  PubMed  CAS  Google Scholar 

  8. Perlow MJ, Freed WJ, Hoffer BJ et al (1979) Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 204: 643–647

    Article  PubMed  CAS  Google Scholar 

  9. Sladek JR Jr, Redmond DE Jr, Collier TJet al (1987) Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. Prog Brain Res 71:309–323

    Article  PubMed  Google Scholar 

  10. Webster DD (1968) Critical analysis of the disability in Parkinson’s disease. Mod Treat 5: 257–282

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer-Verlag/Wien

About this paper

Cite this paper

Henderson, B.T.H., Kenny, B.G., Hitchcock, E.R., Hughes, R.C., Clough, C.G. (1991). A Comparative Evaluation of Clinical Rating Scales and Quantitative Measurements in Assessment pre and post Striatal Implantation of Human Foetal Mesencephalon in Parkinson’s Disease. In: Hitchcock, E.R., Broggi, G., Burzaco, J., Martin-Rodriguez, J., Meyerson, B.A., Tóth, S. (eds) Advances in Stereotactic and Functional Neurosurgery 9. Acta Neurochirurgica Supplementum, vol 52. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9160-6_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-7091-9160-6_14

  • Publisher Name: Springer, Vienna

  • Print ISBN: 978-3-7091-9162-0

  • Online ISBN: 978-3-7091-9160-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics