Summary
Six patients with advanced Parkinson’s Disease were evaluated before and after implantation of human fetal ventral mesencephalic tissue to the head of the right caudate nucleus. The results of clinical assessment indicate that attempts to characterise patient fluctuations requires a combination of clinical rating scales and timing of specific limb tasks.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Similar content being viewed by others
References
Bjorklund A, Stenevi U (1979) Reconstruction of the nigrostriatal dopamine pathway by intracerebral nigral transplants. Brain Res 177: 555–560
Brundin P, Strecker RE, Widner H et al (1988) Human fetal dopamine neurons grafted in a rat model of Parkinson’s disease: immunological aspects, spontaneous and drug-induced behaviour, and dopamine release Exp Brain Res 70: 192–208
Canter GJ, De la Torre R, Mier M (1961) A method for evaluating disability in patients with Parkinson’s Disease. J Nerv Ment Dis 122: 143–147
Freed CR, Breeze RE, Rosenberg NL et al (1990) Transplantation of human fetal dopamine cells for Parkinson’s disease: Results at one year. Arch Neurol 47: 505–512
Hitchcock ER, Kenny BG, Clough CG, Hughes RC, Henderson BTH, Detta A (1990) Stereotactic implantation of Foetal Mesesencephalon (STIM): The UK experience. In: Dunnett SB, Richards SJ (eds) Neural transplantation: from molecular basis to clinical applications. Prog Brain Res 82:723–728 Elsevier, Amsterdam, New York, Oxford
Lindvall O, Rehncrona S, Brundin P et al (1989) Human fetal dopamine neurons grafted into the Striatum in two patients with severe Parkinson’s disease: a detailed account of methodology and a 6-month follow-up. Arch Neurol 46:615–631
Nutt JG (1987) On-ofT Phenomenon: Relation to Levodopa Pharmacokinetics and Pharmacodynamics. Ann Neurol 22: 535–540
Perlow MJ, Freed WJ, Hoffer BJ et al (1979) Brain grafts reduce motor abnormalities produced by destruction of nigrostriatal dopamine system. Science 204: 643–647
Sladek JR Jr, Redmond DE Jr, Collier TJet al (1987) Transplantation of fetal dopamine neurons in primate brain reverses MPTP induced parkinsonism. Prog Brain Res 71:309–323
Webster DD (1968) Critical analysis of the disability in Parkinson’s disease. Mod Treat 5: 257–282
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1991 Springer-Verlag/Wien
About this paper
Cite this paper
Henderson, B.T.H., Kenny, B.G., Hitchcock, E.R., Hughes, R.C., Clough, C.G. (1991). A Comparative Evaluation of Clinical Rating Scales and Quantitative Measurements in Assessment pre and post Striatal Implantation of Human Foetal Mesencephalon in Parkinson’s Disease. In: Hitchcock, E.R., Broggi, G., Burzaco, J., Martin-Rodriguez, J., Meyerson, B.A., Tóth, S. (eds) Advances in Stereotactic and Functional Neurosurgery 9. Acta Neurochirurgica Supplementum, vol 52. Springer, Vienna. https://doi.org/10.1007/978-3-7091-9160-6_14
Download citation
DOI: https://doi.org/10.1007/978-3-7091-9160-6_14
Publisher Name: Springer, Vienna
Print ISBN: 978-3-7091-9162-0
Online ISBN: 978-3-7091-9160-6
eBook Packages: Springer Book Archive