Zusammenfassung
Primäre dementielle Syndrome können auf der Basis eines ischämischen Insults (vaskuläre Demenz) oder durch neurodegenerative Veränderungen (Demenz vom Alzheimer Typ) entstehen. In jedem Fall wird eine Beteiligung exzitatorischer Aminosäuren (wichtigster Vertreter ist die Aminosäure Glutamat) an der Pathogenese diskutiert.
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Literatur
Armstrong DM, Ikonomovic MD, Sheffield R, Wenthold RJ (1994) AMPA-selective glutamate receptor subtype immunoreactivity in the entorhinal cortex of non-demented elderly and patients with Alzheimer’s disease. Brain Res 639: 207–216
Backhauss C, Karkoutly C, Welsch M, Krieglstein J (1992) A mouse model of focal cerebral ischemia for screening neuroprotective drug effects. Pharmacol Toxicol Method 27: 27–32
Barnes CA, Danysz W, Parsons CG (1996) Effects of the uncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist memantine (1-amino-3, 5-dimethyl-adamantane) on hippocampal long-term potentiation (LTP), short-term exploratory modulation (STEM) and spatial memory in awake, freely moving rats. Eur J Neurosci (in press)
Bresink I, Danysz W, Parsons CG, Mutschier E (1995) Different binding affinities of NMDA receptor channel blockers in various brain regions-indication of NMDA receptor heterogeneity. Neuropharmacology 34: 533–540
Chen, HSV, Pellegrini JW, Aggarwal SK, Lei SZ, Warach S, Jensen FE, Lipton SA (1992) Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine-therapeutic advantage against NMDA-receptor-mediated neurotoxicity. J Neurosci 12: 4427–4436
Danysz W, Misztal M, Filipkowski RK, Kacmarek L, Skangiel-Kramska J (1994) Learning impairment induced by chronic infusion of quinolinic acid — protection by memantine. Soc Neurosci Abstr 20: 1722
Ditzler K (1991) Efficacy and tolerability of memantine in patients with dementia syndrome. Arzeimittelforschung/Drug Res 8: 773–780
Erdö SJ, Schäfer M (1991) Memantine is highly potent in protecting cortical cultures against excitotoxic cell death evoked by glutamate and N-methyl-D-aspartate. Eur J Pharmacol 198: 215–217
Frankiewicz T, Potier B, Bashir ZI, Collingridge GL, Parsons CG (1996) Comparison of the effects of memantine and MK-801 on NMDA-induced current responses in cultured neurones and on synaptic transmission and LTP in area CAI of the rat hippocampus in vitro. Br J Pharmacol 117: 689–697
Görtelmeyer R, Erbler H (1992) Memantine in the treatment of mild to moderate dementia syndrome — a double-blind placebo-controlled study. Arzneimittelforschung/Drug Res 42: 904–913
Görtelmeyer R, Pantev M, Parsons CG, Quack G (1993) The treatment of dementia syndrome with Akatinol Memantine, a modulator of the glutamatergic system. In: von Wild K (Hrsg) Spektrum der Neurohabilitation. Zuckschwerdt, München
Greenamyre JT, Penney JB, D’Amato CH, Young Ab (1987) Dementia of the Alzheimer’s type: changes in hippocampal [3H]-glutamate binding. J Neurochem 48: 543–551
Greenamyre JT, Maragos EF, Albin RL, Penney JB, Young AB (1988) Glutamate transmission and toxicity in Alzheimer’s disease. Prog Neuropsychopharmacol Biol Psychiatry 12: 421–430
Keilhoff G, Wolf G (1992) Memantine prevents quinolinic acid-induced hippocampal damage. Eur J Pharmacol 219: 451–454
Kornhuber J, Bormann J, Hubers M, Rusche K, Riederer P (1991) Effects of the 1-amino-adamantanes at the MK-801-binding site of the NMDA-receptor-gated ion channel-a human postmortem brain study. Eur J Pharmacol 206: 297–300
Kornhuber J, Weiler M, Schoppenmeyer K, Riederer P (1994) Amantadine and mementine are NMDA receptor antagonists. J Neural Transm 43 [Suppl]: 91–104
Osborne NN, Quack G (1992) Memantine stimulates inositol phosphates production in neurones and nullifies N-methyl-D-aspartate-induced destruction of retinal neurones. Neurochem Int 21: 329–336
Pantev M, Ritter R, Görtelmeyer R (1993) Clinical and behavioral evaluation in long-term care patients with mild to moderate dementia under memantine treatment. Gerontol Psychiat 6: 103–117
Parsons CG, Gruner R, Rozental J, Millar J, Lodge D (1993) Patch clamp studies on the kinetics and selectivity of N-methyl-D-aspartate receptor antagonism by memantine (l-amino-3,5-dimethyladamantane). Neuropharmacology 32: 1337–1350
Parsons CG, Krishtal OA, Misgeld U (1994) Comparative studies on NMDA receptor antagonism by amantadine (1-aminoadamantane) and memantine (l-amino-3,5-di-metyhladamantane). Soc Neurosci Abstr 20: 1144
Parsons CG, Pachenko VA, Pinchenko VO, Tsyndrenko AY, Krishtal OA (1996) Comparative patch clamp studies with freshly dissociated rat hippicampal and striatal neurones on the NMDA receptor antagonistic effects of amantadine and memantine. Eur J Neurosci 8: 446–454
Porter RHP, Greenamyre JT (1955) Regional variations in the pharmacology of NMDA receptor channel blockers: implications for therapeutic potential. J Neurochem 64: 614–623
Prado de Carvalho L, Bochet P, Rossier J (1993) NMDA receptors expressed in oocytes: effects of ligands related to HIV infection. Soc Neurosci Abstr 19: 1781
Seif el Nasr M, Peruche B, Rossberg C, Krieglstein J (1990) Neuroprotective effect of memantine demonstrated in vivo und in vitro. Eur J Pharmacol 1985: 19–24
Wenk GL, Danysz W, Mobley SL (1994) Investigations of neurotoxicity and neuroprotection within the nucleus basalis of the rat. Brain Res 655: 7–11
Wenk GL, Danysz W, Mobley SL (1995) MK-801, memantine and amantadine show potent neuroprotective activity against NMDA toxicity in the nucleus basalis — a dose response study. Eur J Pharmacol 293: 267–270
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Quack, G., Parsons, C.G., Danysz, W. (1996). Therapeutische Implikationen der Beteiligung exzitatorischer Aminosäuren an der Pathogenese dementieller Erkrankungen. In: Möller, HJ., Müller-Spahn, F., Kurtz, G. (eds) Aktuelle Perspektiven der Biologischen Psychiatrie. Springer, Vienna. https://doi.org/10.1007/978-3-7091-6889-9_19
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DOI: https://doi.org/10.1007/978-3-7091-6889-9_19
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