Skip to main content
SpringerLink
Log in

Pathogenität und Virulenz

  • Chapter
  • First Online:
Medizinische Mikrobiologie und Infektiologie

  • 2995 Accesses

Zusammenfassung

Bakterien können für den Menschen krankmachende (pathogene Bakterien, Infektionserreger) oder schützende Eigenschaften (apathogene und fakultativ pathogene Bakterien der Mikrobiota) haben. Der klinische Verlauf einer bakteriellen Infektionskrankheit wird von den Pathogenitätsfaktoren des Erregers und dem Infektionsabwehrpotenzial des Wirtes entscheidend beeinflusst. In diesem Kapitel werden die evolutionären und pathogenetischen Aspekte bakterieller Erreger im Kontext der Wirtsabwehrmechanismen dargestellt. Die diskutierten Konzepte und mechanistischen Prinzipien der Erregerpathogenität sollen dazu beitragen, die infektionsmedizinischen Strategien in der Diagnostik, Therapie und Prävention von Infektionskrankheiten besser zu verstehen bzw. dem neuesten Wissensstand anzupassen.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 64.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Weiterführende Literatur

  • Ahmed N, Dobrindt U, Hacker J, Hasnain SE (2008) Genomic fluidity ande pathogenic bacteria: applications in diagnostics, epidemiology and intervention. Nat Rev Microbiol 6:387–394

    Article  CAS  Google Scholar 

  • Aktories K (2011) Bacterial protein toxins that modify host regulatory GTPases. Nat Rev Microbiol 9:487–498

    Article  CAS  Google Scholar 

  • Albert-Weissenberger C, Cazalet C, Buchrieser C (2007) Legionella pneumophila – a human pathogen that co-evolved with fresh water protozoa. Cell Mol Life Sci 64:432–448

    Article  CAS  Google Scholar 

  • Bhakdi S, Tranum-Jensen J (1991) Alphatoxin of Staphylococcus aureus. Microbiol Rev 55:733–751

    Article  CAS  Google Scholar 

  • Buffie CG, Pamer EG (2013) Microbiota-mediated colonization resistance against intestinal pathogens. Nat Rev Immunol 13:790–800

    Article  CAS  Google Scholar 

  • Eisenreich W, Rudel T, Heesemann J, Goebel W (2017) To eat and to be eaten: mutual metabolic adaptations of immune cells and intracellular bacterial pathogens upon infection. Front Cell Infect Microbiol 7:316

    Article  Google Scholar 

  • Eisenreich W, Rudel T, Heesemann J, Goebel W (2019) How viral and intracellular bacterial pathogens reprogram the metabolism of host cells to allow their intracellular replication. Front Cell Infect Microbiol 9:42

    Article  CAS  Google Scholar 

  • Falkow S (2004) Molecular Koch’s postulates applied to bacterial pathgenicity – a personal recollection 15 years later. Nat Rev Microbiol 2:67–72

    Article  CAS  Google Scholar 

  • Healy AR, Herzon SB (2017) Molecular basis of gut microbiome-associated colorectal cancer: a synthetic perspective. J Am Chem Soc 139:14817–14824

    Article  CAS  Google Scholar 

  • Heesemann J, Sing A, Trülzsch K (2006) Yersinia’s stratagem: targeting innate and adaptive immune defense. Curr Opin Microbiol 9:55–61

    Article  CAS  Google Scholar 

  • Kawai T, Akira S (2011) Toll-like receptors and their crosstalk with other innate receptors in infection and immunity. Immunity 34:637–650

    Article  CAS  Google Scholar 

  • Kibe S, Adams K, Barlow G (2011) Diagnostic and prognostic biomarkers of sepsis in critical care. J Antimicrobiol Chemother 66(Suppl 2):ii33–ii40

    Google Scholar 

  • Koh E-I, Henderson JP (2015) Microbial copper-binding siderophores at the host-pathogen interface. J Biol Chem 290:18967–18974

    Article  CAS  Google Scholar 

  • Koh E-I, Robinson AE, Bandara N, Rogers BE, Henderson JP (2017) Copper import in Escherichia coli by the yersiniabactin metallophore system. Nat Chem Biol 13:1016–1023

    Article  CAS  Google Scholar 

  • Korea C-G, Ghigo J-M, Beloin C (2011) The sweet connection: solving the riddle of multiple sugar-binding fimbrial adhesins in Escherichia coli. Bioessays 33:300–311

    Article  CAS  Google Scholar 

  • Lamkanfi M, Dixit VM (2010) Manipulation of host cell death pathways during microbial infections. Cell Host Microbe 8:44–54

    Article  CAS  Google Scholar 

  • Martin P, Tronnet S, Garcie C, Oswald E (2017) Interplay between siderophores and colibactin genotoxin in Escherichia coli. IUBMB 69:435–441

    Article  CAS  Google Scholar 

  • Medini D, Serruto D, Parkhill J, Relman DA, Donati C, Moxon R, Falkow S, Rappuoli R (2008) Microbiology in the post-genomic era. Nat Rev Microbiol 6:419–430

    Article  CAS  Google Scholar 

  • Montoy M, Gouanux E (2003) β-Barrel membrane protein folding and structure viewed through the lens of α-hemolysin. Biochim Biophys Acta 1609:19–27

    Article  Google Scholar 

  • Nathan C (2006) Neutrophils and immunity: challenges and opportunities. Nat Rev Immunol 6:173–182

    Article  CAS  Google Scholar 

  • Rathinam VAK, Zhao Y, Shao F (2019) Innate immunity to intracellular LPS. Nat Immunol 20:527–533

    Article  CAS  Google Scholar 

  • Reinhart K, Hartog CS (2010) Biomarkers as a guide for antimicrobial therapy. Int J Antimicrob Agents 36S:S17–S21

    Article  Google Scholar 

  • Shanahan F, Quigley EMM (2014) Manipulation of the microbiota for treatment of IBS and IBS – challenges and controversies. Gastroenterology 146:1554–1563

    Article  Google Scholar 

  • Shi J, Gao W, Shao F (2017) Pyroptosis: gasdermin-mediated programmed necrotic cell death, Trends in Biochem. Sciences 42:245–254

    CAS  Google Scholar 

  • Stecher B, Maier L, Hardt WD (2013) ‚Blooming‘ in the gut: how dysbiosis might contribute to pathogen evolution. Nat Rev Microbiol 11:277–284

    Article  CAS  Google Scholar 

  • Xue M et al (2019) Structure elucidation of colibactin and its DNA cross-links. Science 365:eaax2685

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Max von Pettenkofer-Institut, Ludwig-Maximilians-Universität München, München, Deutschland

    Jürgen Heesemann

Authors
  1. Jürgen Heesemann
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Jürgen Heesemann .

Editor information

Editors and Affiliations

  1. Med Mikrobiologie und Krankenhaushygiene, Max von Pettenkofer Institute, München, Bayern, Germany

    Sebastian Suerbaum

  2. Universitätsklinikum Hamburg-Eppendorf, Sektion Tropenmedizin und Infektiologie Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

    Gerd-Dieter Burchard

  3. Abt. Immunologie, Max Planck Institute for Infection Biolology, Berlin, Berlin, Germany

    Stefan H. E. Kaufmann

  4. Institut für Virologie, Medizinische Hochschule Hannover (MHH), Hannover, Germany

    Thomas F. Schulz

Rights and permissions

Reprints and permissions

Copyright information

© 2020 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Heesemann, J. (2020). Pathogenität und Virulenz. In: Suerbaum, S., Burchard, GD., Kaufmann, S.H.E., Schulz, T.F. (eds) Medizinische Mikrobiologie und Infektiologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-61385-6_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-61385-6_3

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-61384-9

  • Online ISBN: 978-3-662-61385-6

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation