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Schmerztherapie mit Nicht-Opioiden

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Kompendium der medikamentösen Schmerztherapie

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Zusammenfassung

In diesem ersten Hauptteil des Buches wird Schmerztherapie mit Nicht-Opioiden abgehandelt. Eingeteilt werden sie in nicht-saure, antipyretische Analgetika, Nicht-Opioidanalgetika ohne antipyretische und antiphlogistische Wirkung, saure antiphlogistisch und antipyretische Analgetika und selektive COX-2-Hemmer. Nach einer ausführlichen Beschreibung der Cyclooxygenase werden für einzelne Substanzen Informationen über Wirkung, Nebenwirkungen, Kombinationsmöglichkeiten, gefährliche Wechselwirkungen, Verwendung in Schwangerschaft und Stillzeit, sowie Notfallmaßnahmen bei Überdosierung angeführt. In den Tabellen finden sich Angaben zu den Wirkungseigenschaften, Dosierungsangaben, Halbwertszeit und ein empfohlenes Dosierungsintervall. Die meisten Vertreter dieser Arzneimittelgruppe werden peroral verabreicht, auf die topische Anwendung und auch auf die intravenöse Möglichkeit der Gabe von Nicht-Opioiden wird hingewiesen.

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Notes

  1. 1.

    A: Mexalen; CH: Panadol, Dafalgan; D: Paracetamol.

  2. 2.

    A, CH, D: Novalgin.

  3. 3.

    A: Coffo-Selt; CH:–; D: Eu-Med.

  4. 4.

    A, CH, D: z. Z. nicht im Handel.

  5. 5.

    A, CH, D: Aspirin.

  6. 6.

    A, CH, D: Voltaren.

  7. 7.

    A, CH: Brufen, D: Aktren.

  8. 8.

    A: Parkemed; CH: Ponstan; D: –.

  9. 9.

    A: Movalis, CH: –; D: Mobec.

  10. 10.

    A, CH, D: Perfalgan.

  11. 11.

    A, CH, D: Zaldiar.

  12. 12.

    A, CH, D: Novalgin.

  13. 13.

    A, CH, D: z. Z. nicht im Handel.

  14. 14.

    A: Cyprostol; CH: Cytotec; D: MisoOne.

  15. 15.

    A, CH: Arthrotec; D: Arthotec.

  16. 16.

    A, CH, D: Aspirin.

  17. 17.

    A: –; CH: Aspegic; D: Aspirin i. v.

  18. 18.

    A, CH, D: Voltaren.

  19. 19.

    A, CH: Indocid; D: Indomet.

  20. 20.

    A, CH: Brufen; D: Ibuprofen.

  21. 21.

    A: Thomaduo; CH, D: –.

  22. 22.

    A, CH: Seractil; D: Deltaran.

  23. 23.

    A, CH, D: Proxen.

  24. 24.

    A: Movalis; CH: –; D: Meloxicam.

  25. 25.

    A, CH: Felden; D: Piroxicam.

  26. 26.

    A, CH: Xefo; D: –.

  27. 27.

    A, D: – CH: Aulin;.

  28. 28.

    A, CH, D: Celebrex.

  29. 29.

    A, D: Dynastat; CH: –.

  30. 30.

    A, CH, D: Arcoxia;.

  31. 31.

    A, D: Dynastat; CH: –.

  32. 32.

    A, CH, D: Arcoxia.

  33. 33.

    A, CH, D: Voltaren.

  34. 34.

    A: –; CH: Dolocyl; D: DOC Ibuprofen Schmerzgel.

  35. 35.

    A:–; CH: Elmetacin; D: Indomet.

  36. 36.

    A: Felden; CH:–; D: Piroxicam.

Weiterführende Literatur

  • Anderson GD, Hauser SD, McGarity KL et al (1996) Selective inhibition of cyclooxygenase (COX)-2 reverses inflammation and expression of COX-2 and interleukin 6 in rat adjuvant arthritis. J Clin Invest 97:2672–2679

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Bakhriansyah M, Souverein PC, de Boer A, Klungel OH (2019) Risk of myocardial infarction associated with non-steroidal anti-inflammatory drugs: impact of additional confounding control for variables collected from self-reported data. J Clin Pharm Ther 44:623–631

    CAS  PubMed  PubMed Central  Google Scholar 

  • Bannwarth B, Netter P, Lapicque F et al (1992) Plasma and cerebrospinal fluid concentrations of paracetamol after a single intravenous dose of propacetamol. Br J Clin Pharmacol 34:79–81

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Brooks PM, Day RO (1991) Nonsteroidal antiinflammatory drugs differences and similarities. N Engl J Med 324:1716–1725

    Article  CAS  PubMed  Google Scholar 

  • Brunton LL (2018) Goodman & Gilman The pharmacological Basics of Therapeutics, 13. Aufl. McGraw-Hill, New York

    Google Scholar 

  • Bürkle H, Gogarten W, Van Aken H (2003) Injizierbare Nicht-Opioid-Analgetika in der Anästhesie (CME 4/03). Anästhesiologie und Intensivmedizin 44:311–322

    Google Scholar 

  • Busti AJ, Hooper JS, Amaya CJ, Kazi S (2005) Effects of perioperative antiiflammatory and immunomodulating therapy on surgical wound healing. Pharmacotherapy 25:1566–1591

    Article  CAS  PubMed  Google Scholar 

  • Chen MR, Dragoo JL (2013) The effect of nonsteroidal anti-inflammatory drugs on tissue healing. Knee Surg Sports Traumatol Arthrosc 21:540–549

    Article  PubMed  Google Scholar 

  • Claridge LC, Eksteen B, Smith A et al (2010) Acute liver failure after administration of paracetamol at the maximum recommended daily dose in adults. BMJ 341:c6764

    Article  PubMed  Google Scholar 

  • Crofford LJ, Wilder RL, Ristimaki AP et al (1994) Cycylooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J Clin Invest 93:1095–1101

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Derry S, Moore RA, Gaskell H et al (2015) Topical NSAIDs for acute musculoskeletal pain in adults. Cochrane Database Syst Rev 6:CD007402

    Google Scholar 

  • Donnerer J (2015) Einfluss von NSAR auf die Nierenfunktion. Schmerz-Nachrichten Nr. 5:10–13

    Google Scholar 

  • Forman JP, Stampfer MJ, Curhan GC (2005) Non-narcotic analgesic dose and risk of incident hypertension in US women. Hypertension 46:500–507

    Article  CAS  PubMed  Google Scholar 

  • Garcia Rodriguez LA, Tacconelli S, Patrignani P (2008) Role of dose potency in the prediction of risk of myocardial infarction associated with nonsteroidal anti-inflammatory drugs in the general population. J Am Coll Cardiol 52:1628–1636

    Article  PubMed  CAS  Google Scholar 

  • Geusens P, Emans PJ, de Jong JJ, van den Bergh J (2013) NSAIDs and fracture healing. Curr Opin Rheumatol 25:524–531

    Article  CAS  PubMed  Google Scholar 

  • Gonzalez-Perez A, Rodriquez LA (2006) Upper gastrointestinal complications among users of paracetamol. Basic Clin Pharmacol Toxicol 98:297–303

    Article  CAS  PubMed  Google Scholar 

  • Grohte DR, Schnecker B, Albano D (2004) Treatment of pain syndromes with venlafaxine. Pharmacotherapy 24:621–629

    Article  Google Scholar 

  • Harris RC (2013) Physiologic and pathophysiologic roles of cyclooxygenase-2 in the kidney. Trans Am Clin Climatol Assoc 124:139–151

    PubMed  PubMed Central  Google Scholar 

  • Henrich WL, Agodoa LE, Barrett B et al (1996) Analgesics and the kidney: summary and recommendations to the Scientific Advisory Board of the National Kidney Foundation from an Ad Hoc Committee of the National Kidney Foundation. Am J Kidney Dis 27:162–165

    Article  CAS  PubMed  Google Scholar 

  • Hinz B, Cheremina O, Brune K (2007) Acetaminophen (paracetamol) is a selective cyclooxygenase-2 inhibitor in man. FASEB J 22:383–390

    Article  PubMed  CAS  Google Scholar 

  • Hippisley-Cox J, Coupland C (2005) Risk of myocardial infarction in patients taking cyclo-oxygenase-2 inhibitors or conventional non-steroidal anti-inflammatory drugs: population based nested case-control analysis. BMJ 330:1366

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hohlfeld T, Zimmermann N, Weber AA et al (2008) Pyrazoline analgesics prevent the antiplatelet effect of aspirin and preserve human platelet thromboxane synthesis. J Thromb Haemost 6:166–173

    Article  CAS  PubMed  Google Scholar 

  • Hudson M, Richard H, Pilote L (2005) Differences in outcomes of patients with congestive heart failure prescribed celecoxib, rofecoxib, or non-steroidal antiinflammatory drugs: population based study. BMJ 330:1370

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hyllested M, Jones S, Pedersen JL, Kehlet H (2002) Comparative effect of paracetamol, NSAIDs or their combination in postoperative pain management: a qualitative review. Br J Anaesth 88:199–214

    Article  CAS  PubMed  Google Scholar 

  • Ibànez L, Viodal X, Ballarin E, Laporte JR (2005) Agranulocytosis associated with dipyrone (metamizol). Eur J Clin Pharmacol 60:821–829

    Article  PubMed  CAS  Google Scholar 

  • Jarde O, Boccard E (1997) Parenteral versus oral route increases paracetamol efficacy. Clin Drug Invest 14:474–481

    Article  Google Scholar 

  • Kötter T, daCosta BR, Fässler M et al (2015) Metamizole-associated adverse events: a systematic review and meta-analysis. PLoS ONE 10:e0122918

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Kurmis AP, Kurmis TP, O’Brien JX, Dalen T (2012) The effect of nonsteroidal anti-inflammatory drug administration on acute phase fracture-healing: a review. J Bone Joint Surg Am 94:815–823

    Article  PubMed  Google Scholar 

  • Lipsky LP, Abramson SB, Crofford L et al (1998) The classification of cyclooxygenase inhibitors. J Rheumatol 25:2298–2303

    CAS  PubMed  Google Scholar 

  • Lipsky PE, Isakson PC (1997) Outcome of specific COX-2 inhibition in rheumatoid arthritis. J Rheumatol suppl 49:9–14

    Google Scholar 

  • Mahe I, Bertrand N, Drouet L et al (2005) Paracetamol: a haemorrhagic risk factor in patients on warfarin. Br J Clin Pharmacol 59:371–374

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Merida Rodrigo L, Faus Felipe V, Poveda Gomez F, Garcia Alegria J (2009) Agranulocytosis from metamizole: a potential for the Brisith population. Rev Clin Esp 209:176–179

    Article  CAS  PubMed  Google Scholar 

  • Miles FK, Kamath R, Dorney SF et al (1999) Accidental paracetamol overdosing and fulminant hepatic failure in children. Med J Aust 171:472–479

    Article  CAS  PubMed  Google Scholar 

  • Munsterhjelm E, Munsterhjelm NM, Niemi TT et al (2005a) Dose-dependent inhibition of platelet function by acetaminophen in healthy volunteers. Anesthesiology 103:712–717

    Article  CAS  PubMed  Google Scholar 

  • Munsterhjelm E, Niemi TT, Ylikorkala O et al (2005b) Characterization of inhibition of platelet function by paracetamol and its interaction with diclofenac in vitro. Acta Anaesthesiol Scand 49:840–846

    Article  CAS  PubMed  Google Scholar 

  • Nderitu P et al (2014) Analgesia dose prescribing and estimated glomerular filtration rate decline: a general practice database linkage cohort study. BMJ Open 19:4

    Google Scholar 

  • Parkhutik V, Lago A, Tembl JI et al (2012) Influence of COX-inhibiting analgesics on the platelet function of patients with subarachnoid haemorrhage. Stroke Cerebrovasc Dis 21:755–759

    Article  Google Scholar 

  • Patrignani P, Panara MR, Greco A et al (1994) Biochemical and pharmacological characterization of the cyclooxygenase activity of human blood prostaglandin endoperoxide synthases. J Pharmacol Exp Ther 271:17051712

    Google Scholar 

  • Peskar BM, Maricic N, Gretzera B, Schuligoi R et al (2001) Role of cyclooxygenase-2 in gastric mucosal defense. Life Sci 69:2993–3003

    Article  CAS  PubMed  Google Scholar 

  • Pickering G, Loriot MA, Libert F et al (2006) Analgesic effect of acetaminophen in humans: first evidence of a central serotonergic mechanism. Clin Pharmacol Ther 79:371–378

    Article  CAS  PubMed  Google Scholar 

  • Piguet V, Desmeules J, Dayer P (1998) Lack of acetaminophen ceiling effect on R-III nociceptive flexion reflex. Eur J Clin Pharmacol 53:321–324

    Article  CAS  PubMed  Google Scholar 

  • Prescott LF (2000) Therapeutic misadventure with paracetamol: fact or fiction? Am J Ther 7:99–114

    Article  CAS  PubMed  Google Scholar 

  • Richardson CE, Emery P (1995) New cyclo-oxygenase and cytokine inhibitors. Bailliere´s Clin Rheumatology 9: 731–758

    Article  CAS  Google Scholar 

  • Romsing J, Moiniche S, Dahl JB (2002) Rectal and parenteral paracetamol, and paracetamol in combination with NSAIDs, for postoperative analgesia. Br J Anaesth 88:215–226

    Article  CAS  PubMed  Google Scholar 

  • Schmidt H, Geisslinger G (2001) Selektive Cyclooxygenase-2-Hemmer. Pharmakologie und Kenntnisstand nach Markteinführung. Der Schmerz 15:207–219

    Article  CAS  PubMed  Google Scholar 

  • Su WH, Cheng MH, Lee WL et al (2010) Nonsteroidal anti-inflammatory drugs for wounds: pain relief or excessive scar formation? Mediators Inflamm 2010:413238

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Vane JR (1971) Inhibition of prostaglandin synthesis as a mechanism of action for aspirin-like drugs. Nat New Biol 231:232–235

    Article  CAS  PubMed  Google Scholar 

  • Van der Woude FJ et al (2007) Analgesics use and ESRD in younger age: a case-control study. BMC Nephrol 5:8–15

    Google Scholar 

  • Waldvogel HH (Hrsg) (2001) Analgetika – Antinozizeptiva – Adjuvanzien, 2. Aufl. Springer, Berlin

    Google Scholar 

  • Warner TW, Mitchell JA (2002) Cyclooxigenase-3 (COX-3): Filling in the gaps toward a COX continuum? PNAS 99:13371–13373

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Weiss W (1997) Therapie und Prophylaxe gastrointestinaler Läsionen unter NSAR-Therapie. Arzt und Praxis 51:120–125

    Google Scholar 

  • Wörz R (2001) Differenzierte medikamentöse Schmerztherapie, 2. Aufl. Urban & Fischer, München

    Google Scholar 

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  1. Medizinische Universität Graz, Graz, Österreich

    Eckhard Beubler

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Beubler, E. (2020). Schmerztherapie mit Nicht-Opioiden. In: Kompendium der medikamentösen Schmerztherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-60346-8_3

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  • DOI: https://doi.org/10.1007/978-3-662-60346-8_3

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