Zusammenfassung
Lipidmediatoren sind als lokal agierende Lipide nach dem Eindringen eines Krankheitserregers oder nach Gewebsverletzung im Zusammenspiel mit Interleukinen und Chemokinen zunächst für die sinnvollen proinflammatorischen Prozesse wie Calor, Rubor, Dolor, Tumor verantwortlich. Nach erfolgreich abgewehrter Infektion sind es wieder Lipidmediatoren, die mithelfen, die unschädlich gemachten Viren und Bakterien sowie nekrotisches Material aus dem Gewebe zu eliminieren, die Entzündungsreaktion zu stoppen und geschädigtes oder zerstörtes Gewebe zu regenerieren. Mit den Lipidmediatoren hat die Evolution wunderbare molekulare Netzwerke für kontrollierte Immunantworten auf Infektionen und Verletzungen geschaffen, die perfekt koordiniert zu einer Restitutio ad integrum führen und die die Homöostase im Gewebe wiederherstellen. Lange Zeit konzentrierte man sich auf die wissenschaftliche Beobachtung der entzündungsauslösenden Wirkung der Prostaglandine und Leukotriene. In letzter Zeit fokussiert die Forschung jedoch immer mehr auch die antiinflammatorischen und entzündungsauflösenden, schützenden und die Regeneration mediierenden Effekte der Lipidmediatoren, weil diese vor der Pathogenese von chronischen Erkrankungen, wie zum Beispiel Allergien, schützen können.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Literatur
Abbate R, Gori AM, Martini F, Brunelli T, Filippini M, Francalanci I, Paniccia R, Prisco D, Gensini GF, Serneri GGN (1996) N-3 PUFA supplementation, monocyte PCA expression and interleukin-6 production. Prostaglandins Leukot Essent Fat Acids 54:439–444
Abdulnour RE, Dalli J, Colby JK, Krishnamoorthy N, Timmons JY, Tan SH, Colas RA, Petasis NA, Serhan CN, Levy BD (2014) Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. Proc Natl Acad Sci U S A 111:16526–16531
Adamusiak AM, Stasikowska-Kanicka O, Lewandowska-Polak A et al (2012) Expression of arachidonate metabolism enzymes and receptors in nasal polyps of aspirin-hypersensitive asthmatics. Int Arch Allergy Immunol 157(4):354–362
Aggarwal S, Moodley YP, Thompson PJ et al (2010) Prostaglandin E2 and cysteinyl leukotriene concentrations in sputum: association with asthma severity and eosinophilic inflammation. Clin Exp Allergy 40(1):85–93
Aoki H, Hisada T, Ishizuka T, Utsugi M, Kawata T, Shimizu Y, Okajima F, Dobashi K, Mori M (2008) Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthma. Biochem Biophys Res Commun 367:509–515
Ariel A, Serhan CN (2012) New lives given by cell death: macrophage differentiation following their encounter with apoptotic leukocytes during the resolution of inflammation. Front Immunol 3:4
Ariel A, Li PL, Wang W, Tang WX, Fredman G, Hong S, Gotlinger KH, Serhan CN (2005) The docosatriene protectin D1 is produced by TH2 skewing and promotes human T cell apoptosis via lipid raft clustering. J Biol Chem 280:43079–43086
Arita M, Bianchini F, Aliberti J, Sher A, Chiang N, Hong S, Yang R, Petasis NA, Serhan CN (2005) Stereochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1. J Exp Med 201:713–722
Arita M et al (2007) Resolvin E1 selectively interacts with leukotriene B4 receptor BLT1 and ChemR23 to regulate inflammation. J Immunol 178(6):3912–3917
Aso H, Ito S, Mori A, Suganuma N, Morioka M, Takahara N, Kondo M, Hasegawa Y (2013) Differential regulation of airway smooth muscle cell migration by E-prostanoid receptor subtypes. Am J Respir Cell Mol Biol 48:322–329
Austen KF, Maekawa A, Kanaoka Y, Boyce JA (2009) The leukotriene E4 puzzle: finding the missing pieces and revealing the pathobiologic implications. J Allergy Clin Immunol 124:406–414. quiz 415–406
Bandeira-Melo C, Bozza PT, Diaz BL, Cordeiro RS, Jose PJ, Martins MA, Serhan CN (2000a) Cutting edge: lipoxin (LX) A4 and aspirin-triggered 15-epi-LXA4 block allergen-induced eosinophil trafficking. J Immunol 164:2267–2271
Bandeira-Melo C, Serra MF, Diaz BL et al (2000b) Cyclooxygenase-2-derived prostaglandin E2 and lipoxin A4 accelerate resolution of allergic edema in Angiostrongylus costaricensis-infected rats: relationship with concurrent eosinophilia. J Immunol 164:1029–1036
Barnes N, Pavord I, Chuchalin A et al (2012) A randomized, double-blind, placebo-controlled study of the CRTH2 antagonist OC000459 in moderate persistent asthma. Clin Exp Allergy 42(1):38–48
Barnig C, Cernadas M, Dutile S et al (2013) Lipoxin A4 regulates natural killer cell and type 2 innate lymphoid cell activation in asthma. Sci Transl Med 5(174). https://doi.org/10.1126/scitranslmed.3004812
Barrett NA, Maekawa A, Rahman OM, Austen KF, Kanaoka Y (2009) Dectin-2 recognition of house dust mite triggers cysteinyl leukotriene generation by dendritic cells. J Immunol 182:1119–1128
Barrett NA, Rahman OM, Fernandez JM et al (2011) Dectin-2 mediates Th2 immunity through the generation of cysteinyl leukotrienes. J Exp Med 208:593–604
Basil CB, Levy BD (2016) Specialized pro-resolving mediators: endogenous regulators of infection and inflammation. Nat Rev Immunol 16:51
Bazan NG, Calandria JM, Serhan CN (2010) Rescue and repair during photoreceptor cell renewal mediated by docosahexaenoic acid-derived neuroprotectin D1. J Lipid Res 51:2018–2031
Beller TC, Maekawa A, Friend DS, Austen KF, Kanaoka Y (2004) Targeted gene disruption reveals the role of the cysteinyl leukotriene 2 receptor in increased vascular permeability and in bleomycin-induced pulmonary fibrosis in mice. J Biol Chem 279:46129–46134
Bettelli E et al (2006) Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441(7090):235–238
Bhavsar P, Levy B, Hew M, Pfeffer M, Kazani S, Israel E, Chung K (2010) Corticosteroid suppression of lipoxin A4 and leukotriene B4 from alveolar macrophages in severe asthma. Respir Res 11(1):71
Bisgaard H, Stokholm J, Chawes BL et al (2016) Fish oil–derived fatty acids in pregnancy and wheeze and asthma in offspring. N Engl J Med 375:2530–2539
Borgeson E et al (2011) Lipoxin A(4) and benzo-lipoxin A(4) attenuate experimental renal fibrosis. FASEB J 25:2967–2979
Bozyk PD, Moore BB (2011) Prostaglandin E2 and the pathogenesis of pulmonary fibrosis. Am J Respir Cell Mol Biol 45(3):445–452
Buchheit KM et al (2016) Update on the Management of Aspirin-Exacerbated Respiratory Disease. Allergy, Asthma Immunol Res 8(4):298–304
Buczynski MW, Dumlao DS, Dennis EA (2009) Thematic review series: proteomics. An integrated omics analysis of eicosanoid biology. J Lipid Res 50:1015–1038
Calder PC (2006) Polyunsaturated fatty acids and inflammation. Prostaglandins Leukot Essent Fat Acids 75(3):197–202
Calder PC (2010) Omega-3 fatty acids and inflammatory processes. Nutrients 2(3):355–374
Campbell EL, Louis NA, Tomassetti SE, Canny GO, Arita M, Serhan CN, Colgan SP (2007) Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J 21:3162–3170
Capdevila JH et al (1996) The highly stereoselective oxidation of polyunsaturated fatty acids by cytochrome P450BM-3. J Biol Chem 271(37):22663–22671
Castro-Rodriguez JA, Garcia-Marcos L, Sanchez-Solis M, Pérez-Fernández V, Martinez-Torres A, Mallol J (2010) Olive oil during pregnancy is associated with reduced wheezing during the first year of life of the offspring. Pediatr Pulmonol 45:395–402
Cheong HS, Park SM, Kim MO, Park JS, Lee JY, Byun JY, Park BL, Shin HD, Park CS (2011) Genome-wide methylation profile of nasal polyps: relation to aspirin hypersensitivity in asthmatics. Allergy 66:637–644
Chiang N, Bermudez EA, Ridker PM, Hurwitz S, Serhan CN (2004) Aspirin triggers anti-inflammatory 15-epi-lipoxin A4 and inhibits thromboxane in a randomized human trial. Proc Natl Acad Sci U S A 101:15178–15183
Chiang N et al (2006) The lipoxin receptor ALX: potent ligand-specific and stereoselective actions in vivo. Pharmacol Rev 58(3):463–487
Chiang N et al (2012) Infection regulates pro-resolving mediators that lower antibiotic requirements. Nature 484:524–528
Chinen T, Komai K, Muto G, Morita R, Inoue N, Yoshida H et al (2011) Prostaglandin E2 and SOCS1 have a role in intestinal immune tolerance. Nat Commun 2:190
Christie PE, Tagari P, Ford-Hutchinson AW et al (1991) Urinary leukotriene E4 concentrations increase after aspirin challenge in aspirin-sensitive asthmatic subjects. Am Rev Respir Dis 143:1025
Christie PE et al (1992) The effects of lipoxin A4 on airway responses in asthmatic subjects. Am Rev Respir Dis 145:1281
Chung EH et al (2014) Leukotriene B4 receptor 1 is differentially expressed on peripheral T cells of steroid-sensitive and -resistant asthmatics. Ann Allergy Asthma Immunol 112(3):211–216.e1
Cicerale S, Lucas LJ, Keast RS (2012) Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil. Curr Opin Biotechnol 23:129–135
Claar D et al (2015) The role of prostaglandins in allergic lung inflammation and asthma. Expert Rev Respir Med 9(1):55–72
Claria J, Lee MH, Serhan CN (1996) Aspirin-triggered lipoxins (15-epi-LX) are generated by the human lung adenocarcinoma cell line (A549)-neutrophil interactions and are potent inhibitors of cell proliferation. Mol Med 2:583–596
Coleman RA et al (1989) Prostanoid- induced contraction of human bronchial smooth muscle is mediated by TP-receptors. Br J Pharmacol 96:688–692
Cooray SN, Gobbetti T, Montero-Melendez T et al (2013) Ligand-specific conformational change of the G-protein-coupled receptor ALX/FPR2 determines proresolving functional responses. Proc Natl Acad Sci U S A 110(45):18232–18237
Corrigan CJ, Napoli RL, Meng Q et al (2012) Reduced expression of the prostaglandin E2 receptor E-prostanoid 2 on bronchial mucosal leukocytes in patients with aspirin-sensitive asthma. J Allergy Clin Immunol 129(6):1636–1646
D’Auria I et al (2014) Omega-3 fatty acids and asthma in children. Allergy Asthma Proc 35(3):233–240
D’Vaz N et al (2012) Postnatal fish oil supplementation in high-risk infants to prevent allergy: randomized controlled trial. Pediatrics 130(4):674–682
Daham K, Song WL, Lawson JA et al (2011) Effects of celecoxib on major prostaglandins in asthma. Clin Exp Allergy 41(1):36–45
Dalli J, Serhan C (2012) Specific lipid mediator signatures of human phagocytes: microparticles stimulate macrophage efferocytosis and pro-resolving mediators. Blood 120:e60–e72
Dalli J, Zhu M, Vlasenko NA, Deng B, Haeggstrom JZ, Petasis NA, Serhan CN (2013) The novel 13S,14S-epoxy-maresin is converted by human macrophages to maresin 1 (MaR1), inhibits leukotriene A4 hydrolase (LTA4H), and shifts macrophage phenotype. FASEB J 27:2573–2583
Dalli J et al (2015) Elucidation of novel 13-series resolvins that increase with atorvastatin and clear infections. Nat Med 21(9):1071–1075
Demerouti E, Manginas A, Athanassopoulos G, Karatasakis G, Leontiadis E, Pavlides G (2013) Successful epoprostenol withdrawal in pulmonary arterial hypertension. Case report and literature review. Respir Care 58:e1–e35
Dennis EA, Norris PC (2015) Eicosanoid storm in infection and inflammation. Nat Rev Immunol 15(8):511–523
Deutsche Gesellschaft für Fettwissenschaft. http://www.dgfett.de/material/fszus.php. Zugriff: 5.8.17
DGE (Deutsche Gesellschaft für Ernährung), ÖGE (Österreichische Gesellschaft für Ernährung), SGE (Schweizerische Gesellschaft für Ernährungsforschung), SVE (Schweizerische Vereinigung für Ernährung) (Hrsg) (2008) Referenzwerte für die Nährstoffzufuhr. Neuer Umschau Buchverlag, Neustadt a. d. Weinstraße, 3. korr. Nachdruck, S 53
Diamant Z, Hiltermann JT, van Rensen EL, Callenbach PM, Veselic-Charvat M, van der Veen H, Sont JK, Sterk PJ (1997) The effect of inhaled leukotriene D4 and methacholine on sputum cell differentials in asthma. Am J Respir Crit Care Med 155:1247–1253
Doyle WJ, Boehm S, Skoner DP (1990) Physiologic responses to intranasal dose-response challenges with histamine, methacholine, bradykinin, and prostaglandin in adult volunteers with and without nasal allergy. J Allergy Clin Immunol 86(6 Pt 1):924–935
Drazen JM, O’Brien J, Sparrow D et al (1992) Recovery of leukotriene E4 from the urine of patients with airway obstruction. Am Rev Respir Dis 146:104–108
Dunstan JA, Mori TA, Barden A et al (2003) Fish oil supplementation in pregnancy modifies neonatal allergen-specific immune responses and clinical outcomes in infants at high risk of atopy: a randomized, controlled trial. J Allergy Clin Immunol 112:1178–1184
Eke Gungor H et al (2014) Decreased levels of lipoxin A4 and annexin A1 in wheezy infants. Int Arch Allergy Immunol 163(3):193–197
Elias JA et al (1985) Human alveolar macrophage inhibition of lung fibroblast growth. A prostaglandin-dependent process. Am Rev Respir Dis 131:94–99
Erlewyn-Lajeunesse M, Hunt L, Pohunek P et al (2008) Bronchoalveolar lavage MMP-9 and TIMP-1 in preschool wheezers and their relationship to persistent wheeze. Pediatr Res 64:194–199. https://doi.org/10.1203/PDR.0b013e318175dd2d
Ermert L, Ermert M, Goppelt-Struebe M, Walmrath D, Grimminger F, Steudel W, Ghofrani HA, Homberger C, Duncker H, Seeger W (1998) Cyclooxygenase isoenzyme localization and mRNA expression in rat lungs. Am J Respir Cell Mol Biol 18:479–488
FDA. https://www.fda.gov/Food/ResourcesForYou/Consumers/ucm393070.htm
Fitzgerald GA (2004) Coxibs and cardiovascular disease. N Engl J Med 351(17):1709–1711
Flesher RP et al (2014) Resolvin E1 promotes resolution of inflammation in a mouse model of an acute exacerbation of allergic asthma. Clin Sci (Lond) 126(11):805–814
Fogarty A et al (2000) The role of diet in the aetiology of asthma. Clin Exp Allergy 30:615–627
Folco G, Murphy RC (2006) Eicosanoid transcellular biosynthesis: from cell-cell interactions to in vivo tissue responses. Pharmacol Rev 58:375–388
Freire MO et al (2017) Neutrophil resolvin E1 receptor expression and function in type 2 diabetes. J Immunol 198(2):718–728
Fukunaga K, Kohli P, Bonnans C, Fredenburgh LE, Levy BD (2005) Cyclooxygenase 2 plays a pivotal role in the resolution of acute lung injury. J Immunol 174:5033–5039
Garcia-Marcos L, Castro-Rodriguez JA, Weinmayr G, Panagiotakos DB, Priftis KN, Nagel G (2013) Influence of Mediterranean diet on asthma in children: a systematic review and meta-analysis. Pediatr Allergy Immunol 24:330–338
Gauvreau GM, Watson RM, O’Byrne PM (1999) Protective effects of inhaled PGE2 on allergen-induced airway responses and airway inflammation. Am J Respir Crit Care Med 159:31
Gauvreau GM, Parameswaran KN, Watson RM et al (2001) Inhaled leukotriene E(4), but not leukotriene D(4), increased airway inflammatory cells in subjects with atopic asthma. Am J Respir Crit Care Med 164:1495
Gervais FG, Sawyer N, Stocco R et al (2011) Pharmacological characterization of MK-7246, a potent and selective CRTH2 (chemoattractant receptor-homologous) molecule expressed on T-helper type 2 cells antagonist. Mol Pharmacol 79(1):69–76
Godson C, Mitchell S, Harvey K et al (2000) Cutting edge: lipoxins rapidly stimulate nonphlogistic phagocytosis of apoptotic neutrophils by monocyte-derived macrophages. J Immunol 164(4):1663–1667
Goldberg RJ, Katz J (2007) A meta-analysis of the analgesic effects of omega-3 polyunsaturated fatty acid supplementation for inflammatory joint pain. Pain 129:210–223
Goldman DW, Pickett WC, Goetzl EJ (1983) Human neutrophil chemotactic and degranulating activities of leukotriene B5 (LTB5) derived from eicosapentaenoic acid. Biochem Biophys Res Commun 117:282–288
Gonçalves de Matos O et al (2012) Dietary supplementation with omega-3-PUFA-rich fish oil reduces signs of food allergy in ovalbumin-sensitized mice. Clin Dev Immunol 2012:236564
Gunaratne AW, Makrides M, Collins CT (2015) Maternal prenatal and/or postnatal n-3 long chain polyunsaturated fatty acids (LCPUFA) supplementation for preventing allergies in early childhood. Cochrane Database Syst Rev 7:CD010085
Hallstrand TS, Moody MW, Wurfel MM, Schwartz LB, Henderson WR Jr, Aitken ML (2005) Inflammatory basis of exercise-induced bronchoconstriction. Am J Respir Crit Care Med 172:679–686
Hansen S et al (2017) Fish oil supplementation during pregnancy and allergic respiratory disease in the adult offspring. J Allergy Clin Immunol 139(1):104–111
Hartney JM, Coggins KG, Tilley SL et al (2006) Prostaglandin E2 protects lower airways against bronchoconstriction. Am J Phys Lung Cell Mol Phys 290(1):L105–L113
Hata AN, Breyer RM (2004) Pharmacology and signaling of prostaglandin receptors: multiple roles in inflammation and immune modulation. Pharmacol Ther 103(2):147–166
Haworth O, Cernadas M, Yang R, Serhan CN, Levy BD (2008) Resolvin E1 regulates interleukin 23, interferon-gamma and lipoxin A4 to promote the resolution of allergic airway inflammation. Nat Immunol 9:873–879
Henderson WR Jr, Chiang GK, Tien YT, Chi EY (2006) Reversal of allergen-induced airway remodeling by CysLT1 receptor blockade. Am J Respir Crit Care Med 173:718–728
Hill AM, Worthley C, Murphy KJ, Buckley JD, Ferrante A, Howe PR (2007) n-3 Fatty acid supplementation and regular moderate exercise: differential effects of a combined intervention on neutrophil function. Br J Nutr 98:300–309
Holgate ST, Peters-Golden M, Panettieri RA, Henderson WR Jr (2003) Roles of cysteinyl leukotrienes in airway inflammation, smooth muscle function, and remodeling. J Allergy Clin Immunol 111:S18–S34. https://doi.org/10.1067/mai.2003.25
Honda K, Arima M, Cheng G et al (2003) Prostaglandin D2 reinforces Th2 type inflammatory responses of airways to low-dose antigen through bronchial expression of macrophage-derived chemokine. J Exp Med 198(4):533–543
Hsiao HM et al (2013) A novel anti-inflammatory and pro-resolving role for resolvin D1 in acute cigarette smoke-induced lung inflammation. PLoS ONE 8:e58258
Huang SK, Wettlaufer SH, Hogaboam CM et al (2008) Variable prostaglandin E2 resistance in fibroblasts from patients with usual interstitial pneumonia. Am J Respir Crit Care Med 177:66
Huang SK et al (2009) Prostaglandin E(2) induces fibroblast apoptosis by modulating multiple survival pathways. FASEB J 23:4317–4326
Idzko M, Hammad H, van Nimwegen M et al (2007) Inhaled iloprost suppresses the cardinal features of asthma via inhibition of airway dendritic cell function. J Clin Invest 117(2):464–472
Israel E, Cohn J, Dube L, Drazen JM (1996) Effect of treatment with zileuton, a 5-lipoxygenase inhibitor, in patients with asthma. A randomized controlled trial. Zileuton Clinical Trial Group. JAMA 275:931–936
Jeffery PK (2004) Remodeling and inflammation of bronchi in asthma and chronic obstructive pulmonary disease. Proc Am Thorac Soc 1:176–183
Jinnai N, Sakagami T, Sekigawa T et al (2004) Polymorphisms in the prostaglandin E2 receptor subtype 2 gene confer susceptibility to aspirin-intolerant asthma: a candidate gene approach. Hum Mol Genet 13(24):3203–3217
Johnston SL, Freezer NJ, Ritter W et al (1995) Prostaglandin D2-induced bronchoconstriction is mediated only in part by the thromboxane prostanoid receptor. Eur Respir J 8(3):411–415
Jozsef L, Zouki C, Petasis NA, Serhan CN, Filep JG (2002) Lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 inhibit peroxynitrite formation, NF-κB and AP-1 activation, and IL-8 gene expression in human leukocytes. Proc Natl Acad Sci U S A 99:13266–13271
Kang YJ, Mbonye UR, Delong CJ et al (2007) Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation. Prog Lipid Res 46(2):108–125
Kasuga K, Yang R, Porter TF, Agrawal N, Petasis NA, Irimia D, Toner M, Serhan CN (2008) Rapid appearance of resolvin precursors in inflammatory exudates: novel mechanisms in resolution. J Immunol 181:8677–8687
Kay LJ, Yeo WW, Peachell PT (2006) Prostaglandin E2 activates EP2 receptors to inhibit human lung mast cell degranulation. Br J Pharmacol 147:707–713
Keelan JA, Mas E, D’Vaz N et al (2015) Effects of maternal n-3 fatty acid supplementation on placental cytokines, pro-resolving lipid mediators and their precursors. Reproduction 149:171–178
Khalfoun B, Thibault F, Watier H, Bardos P, Lebranchu Y (1997) Docosahexaenoic and eicosapentaenoic acids inhibit in vitro human endothelial cell production of interleukin-6. Adv Exp Med Biol 400:589–597
Kim TH, Kim GD, Jin YH, Park YS, Park CS (2012) Omega-3 fatty acid-derived mediator, Resolvin E1, ameliorates 2,4-dinitrofluorobenzene-induced atopic dermatitis in NC/Nga mice. Int Immunopharmacol 14:384–391
Kolodsick JE et al (2003) Prostaglandin E2 inhibits fibroblast to myofibroblast transition via E prostanoid receptor 2 signaling and cyclic adenosine monophosphate elevation. Am J Respir Cell Mol Biol 29:537–544
Korn JH et al (1983) Fibroblast prostaglandin E2 synthesis. Persistence of an abnormal phenotype after short-term exposure to mononuclear cell products. J Clin Invest 71:1240–1246
Kowalski ML, Pawliczak R, Wozniak J et al (2000) Differential metabolism of arachidonic acid in nasal polyp epithelial cells cultured from aspirin-sensitive and aspirin-tolerant patients. Am J Respir Crit Care Med 161:391
Kremmyda LS et al (2011) Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-chain omega-3 fatty acids: a systematic review. Clin Rev Allergy Immunol 41(1):36–66
Krishnamoorthy S, Recchiuti A, Chiang N, Yacoubian S, Lee CH, Yang R, Petasis NA, Serhan CN (2010) Resolvin D1 binds human phagocytes with evidence for proresolving receptors. Proc Natl Acad Sci U S A 107:1660–1665
Krishnamoorthy N, Burkett PR, Dalli J, Abdulnour RE, Colas R, Ramon S, Phipps RP, Petasis NA, Kuchroo VK, Serhan CN, Levy BD (2015) Cutting edge: maresin-1 engages regulatory T cells to limit type 2 innate lymphoid cell activation and promote resolution of lung inflammation. J Immunol 194(3):863–867
Kull I et al (2006) Fish consumption during the first year of life and development of allergic diseases during childhood. Allergy 61(8):1009–1015
Kunikata T et al (2005) Suppression of allergic inflammation by the prostaglandin E receptor subtype EP3. Nat Immunol 6(5):524–531. Epub 2005 Apr 3
Laidlaw TM, Boyce JA (2012) Cysteinyl leukotriene receptors, old and new; implications for asthma. Clin Exp Allergy 42(9):1313–1320
Lama V, Moore B, Christensen P, Toews G, Peters-Golden M (2002) Prostaglandin E2 synthesis and suppression of fibroblast proliferation by alveolar epithelial cells is cyclooxygenase-2 dependent. Am J Respir Cell Mol Biol 27:752–758
Lammermann T et al (2013) Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo. Nature 498:371–375
Laneuville O et al (1995) Fatty acid substrate specificities of human prostaglandin-endoperoxide H synthase-1 and -2. Formation of 12-hydroxy-(9Z, 13E/Z, 15Z)- octadecatrienoic acids from alpha-linolenic acid. J Biol Chem 270(33):19330–19336
Levy BD (2012) Resolvin D1 and Resolvin E1 promote the resolution af allergic airway inflammation via shared and distinct molecular counter-regulatory pathways. Front Immunol 3:390. https://doi.org/10.3389/fimmu.2012.00390. Published 2012 Dec 28
Levy BD, Clish CB, Schmidt B, Gronert K, Serhan CN (2001) Lipid mediator class switching during acute inflammation: signals in resolution. Nat Immunol 2(7):612–619. https://doi.org/10.1038/89759
Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt BA, Szczeklik W, Drazen JM, Serhan CN (2002) Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med 8:1018–1023
Levy BD, Bonnans C, Silverman ES, Palmer LJ, Marigowda G, Israel E, Blood I (2005) Severe Asthma Research Program NHL. Diminished lipoxin biosynthesis in severe asthma. Am J Respir Crit Care Med 172:824–830
Levy BD, Kohli P, Gotlinger K, Haworth O, Hong S, Kazani S, Israel E, Haley KJ, Serhan CN (2007) Protectin D1 is generated in asthma and dampens airway inflammation and hyperresponsiveness. J Immunol 178:496–502
Lex C, Zacharasiewicz A, Payne DN, Wilson NM, Nicholson AG, Kharitonov SA, Barnes PJ, Bush A (2006) Exhaled breath condensate cysteinyl leukotrienes and airway remodeling in childhood asthma: a pilot study. Respir Res 7:63
Li Y, Cai L, Wang H et al (2011) Pleiotropic regulation of macrophage polarization and tumorigenesis by formyl peptide receptor-2. Oncogene 30(36):3887–3899. https://doi.org/10.1038/onc.2011.112
Liu T, Laidlaw TM, Katz HR, Boyce JA (2013) Prostaglandin E2 deficiency causes a phenotype of aspirin sensitivity that depends on platelets and cysteinyl leukotrienes. Proc Natl Acad Sci U S A 110:16987–16992
Loynes CA, Lee JA et al (2018) PGE2 production at sites of tissue injury promotes an anti-inflammatory neutrophil phenotype and determines the outcome of inflammation resolution in vivo. Sci Adv 4(9):eaar8320
Lukiw WJ et al (2005) A role for docosahexaenoic acid-derived neuroprotectin D1 in neural cell survival and Alzheimer disease. J Clin Invest 115:2774–2783
Luo M, Jones SM, Flamand N et al (2005) Phosphorylation by protein kinase A inhibits nuclear import of 5-lipoxygenase. J Biol Chem 280:40609
Luschnig-Schratl P, Sturm EM, Konya V, Philipose S, Marsche G, Frohlich E (2011) EP4 receptor stimulation down-regulates human eosinophil function. Cell Mol Life Sci 68:3573–3587
Maderna P, Godson C (2009) Lipoxins: resolutionary road. Br J Pharmacol 158:947–959
Magnusson J et al (2015) Fish and polyunsaturated fat intake and development of allergic and nonallergic rhinitis. J Allergy Clin Immunol 136(5):1247–1253
Maher SA, Birrell MA, Belvisi M (2009) Prostaglandn E2 mediates cough via the EP3 receptor. Implications for future disease therapy. Am J Respir Crit Care Med 180:923–992
Marcheselli VL, Hong S, Lukiw WJ, Tian XH, Gronert K et al (2003) Novel docosanoids inhibit brain ischemia-reperfusion-mediated leukocyte infiltration and pro-inflammatory gene expression. J Biol Chem 278:43807–43817
Maric J et al (2018) Prostaglandin E2 suppresses human group 2 innate lymphoid cell function. J Allergy Clin Immunol 141(5):1761–1773.e62017 Dec 5. pii: S0091-6749(17)31877-8. https://doi.org/10.1016/j.jaci.2017.09.050
Martins V et al (2009) ATLa, an aspirin-triggered lipoxin A4 synthetic analog, prevents the inflammatory and fibrotic effects of bleomycin-induced pulmonary fibrosis. J Immunol 182(9):5374–5381
Matute-Bello G, Liles WC, Radella F 2nd, Steinberg KP, Ruzinski JT, Jonas M, Chi EY, Hudson LD, Martin TR (1997) Neutrophil apoptosis in the acute respiratory distress syndrome. Am J Respir Crit Care Med 156:1969–1977
McCoy JM, Wicks JR, Audoly LP (2002) The role of prostaglandin E2 receptors in the pathogenesis of rheumatoid arthritis. J Clin Invest 110:651–658
Medeiros R, Kitazawa M, Passos GF et al (2013) Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice. Am J Pathol 182(5):1780–1789
Medina L, Perez-Ramos J, Ramirez R, Selman M, Pardo A (1994) Leukotriene C4 upregulates collagenase expression and synthesis in human lung fibroblasts. Biochim Biophys Acta 1224:168–174. https://doi.org/10.1016/0167-4889(94)90187-2
Menni C, Zierer J, Pallister T, Jackson MA, Long T, Mohney RP, Steves CJ, Spector TD, Valdes AM (2017) Omega-3 fatty acids correlate with gut microbiome diversity and production of N-carbamylglutamate in middle aged and elderly women. Sci Rep 7(1):11079. https://doi.org/10.1038/s41598-017-10382-2
Miles EA, Thies F, Wallace FA, Powell JR, Hirst TL, Newsholme EA, Calder PC (2001) Influence of age and dietary fish oil on plasma soluble adhesion molecule concentrations. Clin Sci 100:91–100
Miyata J, Fukunaga K, Iwamoto R, Isobe Y, Niimi K, Takamiya R, Takihara T, Tomomatsu K, Suzuki Y, Oguma T, Sayama K, Arai H, Betsuyaku T, Arita M, Asano K (2013) Dysregulated synthesis of protectin D1 in eosinophils from patients with severe asthma. J Allergy Clin Immunol 131:353–360
Montuschi P, Sala A, Dahlén SE, Folco G (2007) Pharmacological modulation of the leukotriene pathway in allergic airway disease. Drug Discov Today 12:404–412. https://doi.org/10.1016/j.drudis.2007.03.004
Morita I, Schindler M, Regier MK, Otto JC, Hori T, DeWitt DL, Smith WL (1995) Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J Biol Chem 270:10902–10908
Morita M et al (2013) The lipid mediator protectin D1 inhibits influenza virus replication and improves severe influenza. Cell 153:112–125
Murakami M, Kudo I (2004) Recent advances in molecular biology and physiology of the prostaglandin E2-biosynthetic pathway. Prog Lipid Res 43:3–35
Murphy G (2017) Riding the metalloproteinase roller coaster. J Biol Chem 292(19):7708–7771
Murray M, Webb MS, O’Callaghan C et al (1992) Respiratory status and allergy after bronchiolitis. Arch Dis Child 67(4):482–487
Naclerio RM, Meier HL, Kagey-Sobotka A et al (1983) Mediator release after nasal airway challenge with allergen. Am Rev Respir Dis 128(4):597–602
Nathan C, Ding A (2010) Nonresolving inflammation. Cell 140:871–882
Navarro-Xavier RA, Newson J, Silveira VL, Farrow SN, Gilroy DW, Byström J (2010) A new strategy for the identification of novel molecules with targeted proresolution of inflammation properties. J Immunol 184:1516–1525
Nemeth K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K et al (2009) Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med 15(1):42–49
Norris PC, Dennis EA (2012) Omega-3 fatty acids cause dramatic changes in TLR4 and purinergic eicosanoid signaling. Proc Natl Acad Sci U S A 109:8517–8522
Norris PC, Gosselin D, Reichart D, Glass CK, Dennis EA (2014) Phospholipase A2 regulates eicosanoid class switching during inflammasome activation. Proc Natl Acad Sci U S A 111(35):12746–12745
Novak TE, Babcock TA, Jho DH, Helton WS, Espat NJ (2003) NF-kappa B inhibition by omega -3 fatty acids modulates LPS-stimulated macrophage TNF-alpha transcription. Am J Phys 284:L84–L89
Okano M, Fujiwara T, Haruna T et al (2009) Prostaglandin E(2) suppresses staphylococcal enterotoxin-induced eosinophilia-associated cellular responses dominantly through an E-prostanoid 2-mediated pathway in nasal polyps. J Allergy Clin Immunol 123(4):868–874.e813
de Oliveira JR et al (2015) AT-RvD1 modulates CCL-2 and CXCL-8 production and NF-κB, STAT-6, SOCS1, and SOCS3 expression on bronchial epithelial cells stimulated with IL-4. Biomed Res Int 2015:178369. https://doi.org/10.1155/2015/178369
Panettieri RA, Tan EM, Ciocca V, Luttmann MA, Leonard TB, Hay DW (1998) Effects of LT D4 on human airway smooth muscle cell proliferation, matrix expression, and contraction In vitro: differential sensitivity to cysteinyl leukotriene receptor antagonists. Am J Respir Cell Mol Biol 19:453–461
Papayianni A, Serhan CN, Brady HR (1996) Lipoxin A4 and B4 inhibit leukotriene-stimulated interactions of human neutrophils and endothelial cells. J Immunol 156:2264–2272
Parameswaran K, Radford K, Fanat A et al (2007) Modulation of human airway smooth muscle migration by lipid mediators and Th-2 cytokines. Am J Respir Cell Mol Biol 37:240–247
Park JY, Pillinger MH, Abramson SB (2006) Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases. Clin Immunol 119(3):229–240
Park CK et al (2011) Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. J Neurosci 31:18433–18438
Parker CW, Huber MG, Godt SM (1995) Suppression of IL-4 production in murine lymphocytes by orally effective prostaglandin E(1) analogs. Am J Ther 2(10):772–776
Paruchuri S, Tashimo H, Feng C, Maekawa A, Xing W, Jiang Y, Kanaoka Y, Conley P, Boyce JA (2009) Leukotriene E4-induced pulmonary inflammation is mediated by the P2Y12 receptor. J Exp Med 206:2543–2555
Pavord ID, Tattersfield AE (1995) Bronchoprotective role for endogenous prostaglandin E2. Lancet 345(8947):436–438
Pavord ID, Wong CS, Williams J, Tattersfield AE (1993) Effect of inhaled prostaglandin E2 on allergen-induced asthma. Am Rev Respir Dis 148(1):87–90
Peachell PT, MacGlashan DW Jr, Lichtenstein LM et al (1988) Regulation of human basophil and lung mast cell function by cyclic adenosine monophosphate. J Immunol 140:571
Pearlman DS, van Adelsberg J, Philip G, Tilles SA, Busse W, Hendeles L, Loeys T, Dass SB, Reiss TF (2006) Onset and duration of protection against exercise-induced bronchoconstriction by a single oral dose of montelukast. Ann Allergy Asthma Immunol 97:98–104
Perez-Novo CA, Watelet JB, Claeys C et al (2005) Prostaglandin, leukotriene, and lipoxin balance in chronic rhinosinusitis with and without nasal polyposis. J Allergy Clin Immunol 115(6):1189–1196
Pierzchalska M, Szabo Z, Sanak M et al (2003) Deficient prostaglandin E2 production by bronchial fibroblasts of asthmatic patients, with special reference to aspirin-induced asthma. J Allergy Clin Immunol 111(5):1041–1048
Planaguma A, Kazani S, Marigowda G, Haworth O, Mariani TJ, Israel E, Bleecker ER, Curran-Everett D, Erzurum SC, Calhoun WJ, Castro M, Chung KF, Gaston B, Jarjour NN, Busse WW, Wenzel SE, Levy BD (2008) Airway lipoxin A4 generation and lipoxin A4 receptor expression are decreased in severe asthma. Am J Respir Crit Care Med 178:574–582
Prage EB et al (2012) Observation of two modes of inhibition of human microsomal prostaglandin E synthase 1 by the cyclopentenone 15-deoxy-Δ(12,14)-prostaglandin J(2). Biochemistry 51(11):2348–2356. https://doi.org/10.1021/bi2019332. Epub 2012 Mar 8
Proud D, Sweet J, Stein P et al (1990) Inflammatory mediator release on conjunctival provocation of allergic subjects with allergen. J Allergy Clin Immunol 85(5):896–905
Qian YM, Jones RL, Chan KM, Stock AI, Ho JK (1994) Potent contractile actions of prostanoid EP3-receptor agonists on human isolated pulmonary artery. Br J Pharmacol 113:369–374
Rainsford KD (2007) Anti-inflammatory drugs in the 21st century. Subcell Biochem 42:3–27
Rajasagi NK, Reddy PB, Suryawanshi A, Mulik S, Gjorstrup P, Rouse BT (2011) Controlling herpes simplex virus-induced ocular inflammatory lesions with the lipid-derived mediator resolvin E1. J Immunol 186(3):1735–1746
Ramon S et al (2014) The specialized proresolving mediator 17-HDHA enhances the antibody-mediated immune response against influenza virus: a new class of adjuvant? J Immunol 193:6031–6040
Regan JW (2003) EP2 and EP4 prostanoid receptor signaling. Life Sci 74(2–3):143–153
Ricciotti E, FitzGerald GA (2011) Prostaglandins and inflammation. Arterioscler Thromb Vasc Biol 31:986–1000
Richard C et al (2016) A dietary supply of docosahexaenoic acid early in life is essential for immune development and the establishment of oral tolerance in female rat offspring. J Nutr 146(11):2398–2406
Roca-Ferrer J, Garcia-Garcia FJ, Pereda J et al (2011) Reduced expression of COXs and production of prostaglandin E(2) in patients with nasal polyps with or without aspirin-intolerant asthma. J Allergy Clin Immunol 128:66
Saba S, Soong G, Greenberg S, Prince A (2002) Bacterial stimulation of epithelial G-CSF and GM-CSF expression promotes PMN survival in CF airways. Am J Respir Cell Mol Biol 27:561–567
Säfholm J et al (2015) Prostaglandin E2 inhibits mast cell-dependent bronchoconstriction in human small airways through the E prostanoid subtype 2 receptor. J Allergy Clin Immunol 136(5):1232–1239
Sampsonas F, Kaparianos A, Lykouras D et al (2007) DNA sequence variations of metalloproteinases: their role in asthma and COPD. Postgrad Med J 83:244–250
Samuelsson B, Dahlen SE, Lindgren JA, Rouzer CA, Serhan CN (1987) Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science 237:1171–1176
Sanak M, Levy BD, Clish CB, Chiang N, Gronert K, Mastalerz L, Serhan CN, Szczeklik A (2000) Aspirin-tolerant asthmatics generate more lipoxins than aspirin-intolerant asthmatics. Eur Respir J 16:44–49
Schmidt EB, Pedersen JO, Varming K, Ernst E, Jersild C, Grunnet N, Dyerberg J (1991) N-3 fatty acids and leukocyte chemotaxis: effects in hyperlipidemia, and dose-response studies in healthy males. Arterioscler Thromb 11:429–435
Schmidt EB, Varming K, Moller JM, Bulow PI, Madsen P, Dyerberg J (1996) No effect of a very low dose of n-3 fatty acids on monocyte function in healthy humans. Scandinavian J Clin Investig 56:87–92
Schmidt LM, Belvisi MG, Bode KA et al (2011) Bronchial epithelial cell-derived prostaglandin E2 dampens the reactivity of dendritic cells. J Immunol 186(4):2095–2105
Schwab JM, Chiang N, Arita M, Serhan CN (2007) Resolvin E1 and protectin D1 activate inflammation-resolution programmes. Nature 447:869–874
Scotton CJ, Chambers RC (2007) Molecular targets in pulmonary fibrosis: the myofibroblast in focus. Chest 132:1311–1321
Seki H, Fukunaga K, Arita M, Arai H, Nakanishi H, Taguchi R, Miyasho T, Takamiya R, Asano K, Ishizaka A, Takeda J, Levy BD (2010) The anti-inflammatory and proresolving mediator resolvin E1 protects mice from bacterial pneumonia and acute lung injury. J Immunol 184:836–843
Serhan CN (1997) Lipoxins and novel aspirin-triggered 15-epi-lipoxins (ATL): a jungle of cell-cell interactions or a therapeutic opportunity? Prostaglandins 53:107–137
Serhan CN (2002) Lipoxins and aspirin-triggered 15-epi-lipoxin biosynthesis: an update and role in anti-inflammation and pro-resolution. Prostaglandins Other Lipid Mediat 68–69:433–455
Serhan CN (2014) Novel Pro-resolving lipid mediators are leads for resolution physiology. Nature 510:92–101
Serhan CN, Chiang N (2013) Resolution phase lipid mediators of inflammation: agonists of resolution. Curr Opin Pharmacol 13:632–640
Serhan CN, Maddox JF, Petasis NA et al (1995) Design of lipoxin A4 stable analogs that block transmigration and adhesion of human neutrophils. Biochemistry 34:14609–14615
Serhan CN et al (2002) Resolvins: a family of bioactive products of omega-3 fatty acid transformation circuits initiated by aspirin treatment that counter proinflammation signals. J Exp Med 196(8):1025–1037
Serhan CN, Hong S, Lu Y (2006) Lipid mediator informatics-lipidomics: novel pathways in mapping resolution. AAPS J 8:E284–E297
Serhan CN et al (2007) Resolution phase of inflammation: novel endogenous anti-inflammatory and proresolving lipid mediators and pathways. Annu Rev Immunol 25:101–113
Serhan CN, Yang R, Martinod K, Kasuga K, Pillai PS et al (2009) Maresins: novel macrophage mediators with potent antiinflammatory and proresolving actions. J Exp Med 206:15–23
Serhan CN et al (2011) Novel pro-resolving aspirin-triggered DHA pathway. Chem Biol 18(8):976–987
Serhan CN, Dalli J, Karamnov S, Choi A, Park CK, Xu ZZ, Ji RR, Zhu M, Petasis NA (2012) Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. FASEB J 26:1755–1765
Sestini P, Armetti L, Gambaro G, Pieroni MG, Refini RM, Sala A, Vaghi A, Folco GC, Bianco S, Robuschi M (1996) Inhaled PGE2 prevents aspirin-induced bronchoconstriction and urinary LTE4 excretion in aspirin-sensitive asthma. Am J Respir Crit Care Med 153(2):572–575
Sherry CL et al (2015) Docosahexaenoic acid supplementation in lactating women increases breast milk and plasma docosahexaenoic acid concentrations and alters infant omega 6:3 fatty acid ratio. Prostaglandins Leukot Essent Fat Acids 95:63–69
Shi H, Yokoyama A, Kohno N et al (1998) Effect of thromboxane A2 inhibitors on allergic pulmonary inflammation in mice. Eur Respir J 11(3):624–629
Shinomiya S et al (2001) Regulation of TNFalpha and interleukin-10 production by prostaglandins I(2) and E(2): studies with prostaglandin receptor-deficient mice and prostaglandin E-receptor subtype-selective synthetic agonists. Biochem Pharmacol 61:1153–1116
Shirey KA et al (2014) Role of the lipoxygenase pathway in RSV-induced alternatively activated macrophages leading to resolution of lung pathology. Mucosal Immunol 7:549–557
Simon LS (1999) Role and regulation of cyclooxygenase-2 during inflammation. Am J Med 106:37S–42S
Simopoulos AP (2002) The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomed Pharmacother 56(8):365–379
Smith AP, Cuthbert MF, Dunlop LS (1975) Effects of inhaled prostaglandins E1, E2, and F2alpha on the airway resistance of healthy and asthmatic man. Clin Sci Mol Med 48(5):421–430
Smith WL, Urade Y, Jakobsson PJ (2011) Enzymes of the cyclooxygenase pathways of prostanoid biosynthesis. Chem Rev 111(10):5821–5865
Sodin-Semrl S, Taddeo B, Tseng D, Varga J, Fiore S (2000) Lipoxin A4 inhibits IL-1ß-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovialfibroblasts and enhances synthesis of tissueinhibitors of metalloproteinases. J Immunol 164:2660–2666
Sousa AR, Parikh A, Scadding G et al (2002) Leukotriene-receptor expression on nasal mucosal inflammatory cells in aspirin-sensitive rhinosinusitis. N Engl J Med 347:1493
Spera PA, Ellison JA, Feuerstein GZ, Barone FC (1998) IL-10 reduces rat brain injury following focal stroke. Neurosci Lett 251:189–192
Sperling RI, Benincaso AI, Knoell CT, Larkin JK, Austen KF, Robinson DR (1993) Dietary ω-3 polyunsaturated fatty acids inhibit phosphoinositide formation and chemotaxis in neutrophils. J Clin Investig 91:651–960
Spite M, Norling LV, Summers L, Yang R, Cooper D, Petasis NA, Flower RJ, Perretti M, Serhan CN (2009) Resolvin D2 is a potent regulator of leukocytes and controls microbial sepsis. Nature 461:1287–1291
Starosta V, Pazdrak K, Boldogh I, Svider T, Kurosky A (2008) Lipoxin A4 counterregulates GM-CSF signaling in eosinophilic granulocytes. J Immunol 181:8688–8699
Straus DS et al (2000) 15-Deoxy-D12,14-prostaglandin J2 inhibits multiple steps in the NF-kB signaling pathway. Proc Natl Acad Sci U S A 97(9):4844–4849
Stumm CL, Wettlaufer SH, Jancar S et al (2011) Airway remodeling in murine asthma correlates with a defect in PGE2 synthesis by lung fibroblasts. Am J Phys Lung Cell Mol Phys 301(5):L636–L644
Sturm EM, Schratl P, Schuligoi R et al (2008) Prostaglandin E2 inhibits eosinophil trafficking through E-prostanoid 2 receptors. J Immunol 181:7273
Tabas I, Glass CK (2013) Anti-inflammatory therapy in chronic disease: challenges and opportunities. Science 339(6116):166–172
Takayama K, García-Cardena G, Sukhova GK, Comander J, Gimbrone MA Jr, Libby P (2002) Prostaglandin E2 suppresses chemokine production in human macrophages through the EP4 receptor. J Biol Chem 277:44147–44154. https://doi.org/10.1074/jbc.M204810200
Takayama K, Sukhova GK, Chin MT, Libby P (2006) A novel prostaglandin E receptor 4-associated protein participates in antiinflammatory signaling. Circ Res 98:499–504
Talbot S et al (2015) Silencing nociceptor neurons reduces allergic airway inflammation. Neuron 87:341–354
Toki S, Goleniewska K, Huckabee MM et al (2013) PGI2 signaling inhibits antigen uptake and increases migration of immature dendritic cells. J Leukoc Biol 94:77–88
Tull SP, Yates CM, Maskrey BH, O’Donnell VB, Madden J, Grimble RF, Calder PC, Nash GB, Rainger GE (2009) Omega-3 fatty acids and inflammation: novel interactions reveal a new step in neutrophil recruitment. PLoS Biol 7(8):e1000177
Uddin M, Levy B (2011) Resolvins: natural agonists for resolution of pulmonary inflammation. Prog Lipid Res 50(1):75–88
Vecchio AJ, Simmons DM, Malkowski MG (2010) Structural basis of fatty acid substrate binding to cyclooxygenase-2. J Biol Chem 285:22152–22163
Vecchio AJ, Orlando BJ, Nandagiri R, Malkowski MG (2012) Investigating substrate promiscuity in cyclooxygenase-2: the role of Arg-120 and residues lining the hydrophobic groove. J Biol Chem 287:24619–24630
Wang X et al (2015) Resolution of inflammation is altered in Alzheimer’s disease. Alzheimers Dement 11(1):40–50.e2
Weiss SJ (1989) Tissue destruction by neutrophils. N Engl J Med 320:365–376
Werz O, Gerstmeier J, Libreros S, De la Rosa X, Werner M, Norris PC, Chiang N, Serhan CN (2018) Human macrophages differentially produce specific resolvin or leukotriene signals that depend on bacterial pathogenicity. Nat Commun 9(1):59. https://doi.org/10.1038/s41467-017-02538-5
White ES et al (2005) Prostaglandin E(2) inhibits fibroblast migration by E-prostanoid 2 receptor-mediated increase in PTEN activity. Am J Respir Cell Mol Biol 32:135–141
Whittle BJ, Moncada S (1983) Pharmacological interactions between prostacyclin and thromboxanes. Br Med Bull 39(3):232–238
Wilborn J et al (1995) Cultured lung fibroblasts isolated from patients with idiopathic pulmonary fibrosis have a diminished capacity to synthesize prostaglandin E2 and to express cyclooxygenase-2. J Clin Invest 95:1861–1868
Woods RK, Thien FC, Abramson MJ (2002) Dietary marine fatty acids (fish oil) for asthma in adults and children. Cochrane Database Syst Rev 3:CD001283
Woodward DF, Jones RL, Narumiya S (2011) International union of basic and clinical pharmacology: LXXXIII: classification of prostanoid receptors, updating 15 years of progress. Pharmacol Rev 63:471–538
Wu SH, Chen XQ, Liu B, Wu HJ, Dong L (2013) Efficacy and safety of 15(R/S)-methyl-lipoxin A4 in topical treatment of infantile eczema. Br J Dermatol 168:172–178
Yang L, Yamagata N, Yadav R et al (2003) Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor. J Clin Invest 111(5):727–735
Yaqoob P, Pala HS, Cortina-Borja M, Newsholme EA, Calder PC (2000) Encapsulated fish oil enriched in α-tocopherol alters plasma phospholipid and mononuclear cell fatty acid compositions but not mononuclear cell functions. J Clin Investig 30:260–274
Yates CM, Calder PC, Ed Rainger G (2014) Pharmacology and therapeutics of omega-3 polyunsaturated fatty acids in chronic inflammatory disease. Pharmacol Ther 141(3):272–228
Yoshimura T, Yoshikawa M, Otori N et al (2008) Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma. Allergol Int 57:429
Zaslona Z et al (2014) Prostaglandin E2 suppresses allergic sensitization and lung inflammation by targeting the E prostanoid 2 receptor on T cells. J Allergy Clin Immunol 133(2):379–387.e1
Zhang MZ et al (1999) Regulation of cyclooxygenase-2 (COX-2) in rat renal cortex by adrenal glucocorticoids and mineralocorticoids. Proc Natl Acad Sci U S A 96(26):15280–15285
Zhang D et al (2014) Glucocorticoids sensitize rat placental inflammatory responses via inhibiting lipoxin A4 biosynthesis. Biol Reprod 90(4):74
Zhang Y, Desai A, Yang SY, Bae KB, Antczak MI, Fink SP et al (2015) Tissue regeneration. Inhibition of the prostaglandin-degrading enzyme 15-pgdh potentiates tissue regeneration. Science 348(6240):aaa2340. https://doi.org/10.1126/science.aaa2340
Zhou W et al (2014) Cyclooxygenase inhibition abrogates aeroallergen-induced immune tolerance by suppressing prostaglandin I2 receptor signaling. J Allergy Clin Immunol 134(3):698–705
Zhu J, Qiu YS, Figueroa DJ, Bandi V, Galczenski H, Hamada K, Guntupalli KK, Evans JF, Jeffery PK (2005) Localization and upregulation of cysteinyl leukotriene-1 receptor in asthmatic bronchial mucosa. Am J Respir Cell Mol Biol 33:531–540
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
Copyright information
© 2020 Springer-Verlag GmbH Deutschland, ein Teil von Springer Nature
About this chapter
Cite this chapter
Stockert, K. (2020). Lipidmediatoren und ihre Rolle bei Entzündungen und Allergien. In: Allergieprävention. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-58140-7_6
Download citation
DOI: https://doi.org/10.1007/978-3-662-58140-7_6
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-58139-1
Online ISBN: 978-3-662-58140-7
eBook Packages: Medicine (German Language)