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Rektumadenome und Rektumkarzinom : Morphologie, Staging mit Endosonografie

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Proktologische Diagnostik

Zusammenfassung

Die Prävalenz kolorektaler Adenome steigt mit zunehmendem Alter. Man geht davon aus, dass in der westlichen Welt ab einem Alter von 50–60 Jahren bei etwa 30 % der Bevölkerung ein kolorektales Adenom vorhanden ist. Adenome sind Neoplasien, da es in etwa 5 % der Fälle über die Adenom- Dysplasie-Karzinom-Sequenz zu einer malignen Entartung kommt. Anders betrachtet ist davon auszugehen, dass etwa 60 % aller sporadischen kolorektalen Karzinome über die Adenom-Dysplasie-Karzinom- Sequenz entstehen. Die erste Mutation auf dem Weg zum kolorektalen Karzinom ist der APC-Gen-Verlust. Weitere Mutationen, wie die von TP53 und KRAS folgen. Darüber hinaus entwickelt sich meist eine chromosomale Instabilität.

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Authors and Affiliations

  1. Klinik für Gastroenterologie und interventionelle Endoskopie, Krankenhaus Barmherzige Brüder Regensburg, Prüfeninger Straße 86, 93049, Regensburg

    PD Dr. med. O. Pech

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  1. PD Dr. med. O. Pech
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Editors and Affiliations

  1. Abteilung für Proktologie, Krankenhaus Barmherzige Brüder, Regensburg, Germany

    Oliver Schwandner

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Pech, O. (2016). Rektumadenome und Rektumkarzinom : Morphologie, Staging mit Endosonografie. In: Schwandner, O. (eds) Proktologische Diagnostik. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47262-0_14

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  • DOI: https://doi.org/10.1007/978-3-662-47262-0_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47261-3

  • Online ISBN: 978-3-662-47262-0

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