Skip to main content
  • 1937 Accesses

Zusammenfassung

Größte Gruppe der Antidementiva sind die Cholinesterasehemmer gefolgt von Memantin, das aber nur etwa halb so viel verordnet wird. In beiden Gruppen überwiegen inzwischen die Generika. Traditionelle Antidementiva (Piracetam, Ginkgoextrakt, Nicergolin) ohne gesicherten Nutzen haben ihren rückläufigen Trend fortgesetzt.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • AD2000 Collaborative Group (2004): Long-term donepezil treatment in 565 patients with Alzheimer's disease (AD2000): randomised double-blind trial. Lancet 363: 2105–2115

    Google Scholar 

  • Ballard C, Gauthier S, Corbett A, Brayne C, Aarsland D, Jones E (2011): Alzheimer's disease. Lancet 377: 1019–1031

    Article  PubMed  Google Scholar 

  • Bateman R (2015): Alzheimer's disease and other dementias: advances in 2014. Lancet Neurol 14: 4–6

    Article  PubMed  Google Scholar 

  • Bickel H (2001): Demenzen im höheren Lebensalter: Schätzungen des Vorkommens und der Versorgungskosten. Z Gerontol Geriat 34: 108–115

    Article  CAS  Google Scholar 

  • Birks J (2006): Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst Rev. 2006 Jan 25;(1):CD00559–3

    Google Scholar 

  • Birks J, Grimley Evans J (2006): Ginkgo biloba for cognitive impairment and dementia. Cochrane Database Syst Rev. 2007 Apr 18;(2):CD00312–0

    Google Scholar 

  • Birks J, Harvey RJ (2006): Donepezil for dementia due to Alzheimer's disease. Cochrane Database Syst Rev. 2006 Jan 25; (1): CD00119–0

    Google Scholar 

  • Birks JS, Grimley Evans J (2015): Rivastigmine for Alzheimer's disease. Cochrane Database Syst Rev. 2015 Apr 10; 4: CD00119–1

    Google Scholar 

  • Davies P, Maloney AJ (1976): Selective loss of central cholinergic neurons in Alzheimer's disease. Lancet 2: 140–3

    Google Scholar 

  • Deutsche Gesellschaft für Psychiatrie, Psychotherapie und Nervenheilkunde, Deutsche Gesellschaft für Neurologie (2009): S3-Leitlinie Demenzen. Internet: www.dgn.org/images/>stories/dgn/pdf/s3_leitlinie_demenzen.pdf

  • Doody RS, Thomas RG, Farlow M, Iwatsubo T, Vellas B, Joffe S, Kieburtz K, Raman R, Sun X, Aisen PS, Siemers E, Liu-Seifert H, Mohs R; Alzheimer's Disease Cooperative Study Steering Committee; Solanezumab Study Group (2014): Phase 3 trials of solanezumab for mild-to-moderate Alzheimer's disease. N Engl J Med 370: 311–321

    Article  Google Scholar 

  • Flicker L, Grimley Evans G (2001): Piracetam for dementia or cognitive impairment. Cochrane Database Syst Rev. 2001;(2):CD001011

    Google Scholar 

  • Holmes C, Boche D, Wilkinson D, Yadegarfar G, Hopkins V, Bayer A, Jones RW, Bullock R, Love S, Neal JW, Zotova E, Nicoll JA (2008): Long-term effects of Abeta42 immunisation in Alzheimer's disease: follow-up of a randomised, placebo-controlled phase I trial. Lancet 372: 216–223

    Article  CAS  PubMed  Google Scholar 

  • Howard R, McShane R, Lindesay J, Ritchie C, Baldwin A, Barber R, Burns A, Dening T, Findlay D, Holmes C, Hughes A, Jacoby R, Jones R, Jones R, McKeith I, Macharouthu A, O'Brien J, Passmore P, Sheehan B, Juszczak E, Katona C, Hills R, Knapp M, Ballard C, Brown R, Banerjee S, Onions C, Griffin M, Adams J, Gray R, Johnson T, Bentham P, Phillips P (2012): Donepezil and memantine for moderate-to-severe Alzheimer's disease. N Engl J Med 366: 893–903

    Article  CAS  PubMed  Google Scholar 

  • Loy C, Schneider L (2006): Galantamine for Alzheimer's disease and mild cognitive impairment. Cochrane Database Syst Rev. 2006 Jan 25; (1): CD00174–7

    Google Scholar 

  • McShane R, Areosa Sastre A, Minakaran N (2006): Memantine for dementia. Cochrane Database Syst Rev. 2006 Apr 19;(2):CD00315–4

    Google Scholar 

  • Muayqil T, Camicioli R (2012): Systematic review and meta-analysis of combination therapy with cholinesterase inhibitors and memantine in Alzheimer's disease and other demen- tias. Dement Geriatr Cogn Dis Extra 2: 546–572

    Article  PubMed Central  PubMed  Google Scholar 

  • National Institute for Health and Clinical Excellence (2011): NICE technology appraisal guid- ance 217 Donepezil, galantamine, rivastigmine and memantine for the treatment of Alzheimer's disease (review of NICE technology appraisal guidance 111). Internet: www. nice.org.uk/nicemedia/live/13419/53619/53619.pdf

  • Petersen RC, Thomas RG, Grundman M, Bennett D, Doody R, Ferris S, Galasko D, Jin S, Kaye J, Levey A, Pfeiffer E, Sano M, van Dyck CH, Thal LJ; Alzheimer's Disease Cooperative Study Group (2005): Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med 352: 2379–2388

    Article  Google Scholar 

  • Raina P, Santaguida P, Ismaila A, Patterson C, Cowan D, Levine M, Booker L, Oremus M (2008): Effectiveness of cholinesterase inhibitors and memantine for treating dementia: evidence review for a clinical practice guideline. Ann Intern Med 148: 379–397

    Article  PubMed  Google Scholar 

  • Salloway S, Sperling R, Fox NC, Blennow K, Klunk W, Raskind M, Sabbagh M, Honig LS, Por- steinsson AP, Ferris S, Reichert M, Ketter N, Nejadnik B, Guenzler V, Miloslavsky M, Wang D, Lu Y, Lull J, Tudor IC, Liu E, Grundman M, Yuen E, Black R, Brashear HR; Bapineuzumab 301 and 302 Clinical Trial Investigators (2014): Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease. N Engl J Med 370: 322–333

    Google Scholar 

  • Vellas B, Coley N, Ousset PJ, Berrut G, Dartigues JF, Dubois B, Grandjean H, Pasquier F, Piette F, Robert P, Touchon J, Garnier P, Mathiex-Fortunet H, Andrieu S; GuidAge Study Group (2012): Long-term use of standardised Ginkgo biloba extract for the prevention of Alzheimer's disease (GuidAge): a randomised placebo-controlled trial. Lancet Neurol 11: 851–859

    Article  Google Scholar 

  • Winblad B (2005): Piracetam: a review of pharmacological properties and clinical uses. CNS Drug Rev 11:169–182

    Article  CAS  PubMed  Google Scholar 

  • Winblad B, Gauthier S, Scinto L, Feldman H, Wilcock GK, Truyen L, Mayorga AJ, Wang D,

    Google Scholar 

  • Brashear HR, Nye JS; The GAL-INT-11/18 Study Group (2008): Safety and efficacy of galantamine in subjects with mild cognitive impairment. Neurology 70: 2024–2035

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schwabe, U. (2015). Antidementiva. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2015. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47186-9_9

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-47186-9_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47185-2

  • Online ISBN: 978-3-662-47186-9

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics