Zusammenfassung
Seit 1995 sind die Verordnungen der Antitussiva und der Expektorantien stark zurückgegangen. Hauptgrund des rückläufigen Trends ist die zweifelhafte Wirksamkeit dieser Substanzen. Auch der Ausschluss rezeptfreier Arzneimittel aus der Erstattung hat die Abnahme des Verordnungsvolumens seit 2004 weiter beschleunigt. Im Jahre 2014 ist eine weitere Abnahme der Verordnungen zu verzeichnen.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
AgenceNationaledeSecuriteduMedicamentetdesProduitsdeSante(Afssaps)(2010):Retraitdesspecialitemucolytiqueschezlenourrisson:derniereetapedel'operationderappel.MED10/A17/B09.29.4.2010
American Academy of Pediatrics Committee on Drugs(1997):Useofcodeine-anddex-tromethorphan-containingcoughremediesinchildren.Pediatrics99:918–920
ArzneimittelkommissionderdeutschenÄrzteschaft(2009):Arzneiverordnungen,22.Auflage;
Arzneimittelkommission,Hrsg.Neu-Isenburg:Med.MedienInformationsGmbH,p. 793Bundesgesundheitsamt(1981):Monographieentwürfefüranthroposophischeundphyto-therapeutischeArzneimittel.DtschApothZtg52:2910–2913
CeglaUH(1988):Langzeittherapieüber2JahremitAmbroxol(Mucosolvan)RetardkapselnbeiPatientenmitchronischerBronchitis.ErgebnisseeinerDoppelblindstudiean180Patienten.PraxKlinPneumol42:715–721
Celli BR, Decramer M, Wedzicha JA, Wilson KC, Augusti A, et al. (2015). An official Ameriocan Thoracis Society/>European Respiratory Society statement: reseach questions in COPD. Eur Respir J 45:879–905
Cotgreave IA, Eklund A, Larsson K, Moldeus PW (1987): No penetration of orally administered N-acetylcysteine into bronchoalveolar lavage fluid. Eur J Respir Dis 70: 73–77
Cwientzek U, Ottillinger B, Arenberger P (2011): Acute bronchitis therapy with ivy leaves extracts in a two-arm study. A double-blind, randomised study vs. an other ivy leaves extract. Phytomedicine 18: 1105–1109
Decramer M, Rutten-van Molken M, Dekhuijzen PN, Troosters T, van Herwaarden C, Pellegrino R, van Schayck CP, Oliveri D, Del Donno M, De Backer W, Lankhorst I, Ardia A (2005): Effects of N-acetylcysteine on outcomes in chronic obstructive pulmonary disease (Bronchitis Randomized on NAC Cost-Utility Study, BRONCUS): a randomised placebo-controlled trial. Lancet365: 1552–1560
Dicpinigaitis PV, Morice AH, Birrung SS, McGarvey L, Smith JA, Canning BJ, Page CP (2014): Antitussive drugs - past, present, and future. Pharmacol Rev 66: 468–512
European Medicines Agency (2011): Community herbal monograph on Hedera helix L., folium. Final assessment report on Hedera helix L., folium. Internet: http://www.ema.europa.eu/ema/index.jsp?curl=pages/medicines/herbal/medicines/herbal_med_000115. jsp & mid=WC0b01ac058001fa1d
European Medicines Agency (2012): Opinion of the HMPC on a community herbal monograph on Hedera helix L., folium. Internet: http://www.ema-europa.eu/docs/en_GB/document_ library/Herbal_-_HMPC_opinion_on_Community_herbal_monograph/2012/01/WC500120649.pdf
European Medicines Agency (2015): Ambroxol and bromhexine expectorants: safety information to be updated. Press Release 25. February EMA/130676/2015.
Global Initiative for Chronic Obstructive Lung Disease (GOLD) 2010: Global Strategy for the Diag- nosis, Management and Prevention of COPD. Available from: http://www.goldcopd.org
Grandjean EM, Berthet PH, Ruffmann R, Leuenberger PH (2000): Efficacy of oral long-term N-acetylcysteine in chronic bronchopulmonary disease: a meta-analysis of published double-blind, placebo-controlled clinical trials. Clin Ther 22: 209–221
Guyatt GH, Townsend M, Kazim F, Newhouse MT (1987): A controlled trial of ambroxol in chronic bronchitis. Chest 92: 618–620
Jones AP, Wallis C (2010): Dornase alfa for cystic fibrosis. Cochrane Database Syst Rev 2010 Mar 17; (3): CD001127
Kayser O, Kolodziej H (1997): Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med 63: 508–510
Kurz H (1986): Expektorantien und Antitussiva. Dtsch Apoth Ztg 126: 1024–1029
Lemmer B (2000): Antitussiva und Expektorantien. In: Schwabe U, Paffrath D (Hrsg): Arzneiver- ordnungs-Report 2001, Springer-Verlag, Berlin Heidelberg, S. 234–256
Lemmer B (2012): Antitussiva und Expektorantien. In: Schwabe U, Paffrath D (Hrsg): Arzneiver- ordnungs-Report 2012, Springer-Verlag, Berlin Heidelberg, S. 469-84
Malerba M, Ponticiello A, Radaeli A, Bensi G, Grassi V (2004): Effect of twelve-months therapy with oral ambroxol in preventing exacerbations in patients with COPD. Double-blind, randomised, mulicenter, placebo-controlled study (the AMETHIST Trial). Pulm Pharmacol Therpeut 17: 27–34
Mutschler E, Geisslinger G, Kroemer HK, Menzel S, Ruth P (2013): Arzneimittelwirkungen, 10. Aufl., Wissenschaftliche Verlagsgesellschaft Stuttgart, S. 581–582
Müller S, Jaffan L, Kloiber E, Läer S (2014): Dextrometorphan-Missbrauch bei Jugendlichen: Wie kann sich der Apotheker verhalten? Med Mo Pharm 37: 95–100
Oduwole O, Meremikwu MM, Oyo-Ita A, Udoh E.E. (2014): Honey for acute cough in children. Cochrane Database Syst Rev Dec 13;12:CD 007094.
Olivieri D, Zavattini G, Tomasini G (1987): Ambroxol for the prevention of chronic bronchitis exacerbations: long-term multicenter trial. Respiration 51: Suppl 1, 42–51
Olsson B, Johansson M, Gabrielsson J, Bolme P (1988): Pharmacokinetics and bioavailability of reduced and oxidized N-acetylcysteine. Eur J Clin Pharmacol 34: 77-82 0ymar K, Skjerven HO, Mikalsen IB (2014): Acute bronchiolitis in infants, a review. Scand J Trauma Resusc Emerg Med 22: 2–3
Poole P, Black PN, Cates CJ. (2012): Mucolytic agents for chronic bronchitis or chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 15: 8: CD001287 Schmidt M, Thomsen M, Schmidt U (2012): Suitability of ivy extract for the treatment of paediatric cough. Phytother Res 26: 1942–1947
Sharfstein JM, North M, Serwint JR (2007): Over the counter but no longer under the radar - pediatric cough and cold medications. N Engl J Med 357: 2321–2324
Smith SM, Schroeder K, Fahey T (2008): Over-the-counter medications for acute cough in children and adults in ambulatory settings. Cochrane Database Syst Rev 1:CD0011831 Stauss-Grabo M, Atiye S, Warnke A, Wedemeyer RS, Donath F, Blume HH. (2010): Observational study on the tolerability and safety of film-coated tablets containing ivy extract (Prospan® Cough Tablets) in the treatment of colds accompanied by coughing. Phytomedicine. 15: 433–436
Timmer A, Günther J, Rücker G, Motschall E, Antes G, Kern WV (2013): Pelargonium sidoides extract for acute respiratory tract infections. Cochrane Database Syst Rev. 2013 Oct 22; 1D: CD00632–3
Tse HN, Raiteri L, Wong KY, Yee KS, Wai KY, Loo CK, Houng CM. (2013): High-Dose N-acetyl- cysteine in stable chronic obstructive pulmonary disease: the 1-year, double-blind, rand- omized, placebo-controlled HIACE study. Chest 144: 106–118
Virchow JC, Backer V, de Blay F, Kuna P, Lj0rring C, Prieto JL, Villesen HH (2015): Defining moderate asthma exacerbations in clinical trials based on ATS/ERS joint statement. Resp Med 109: 547–556
Wark P, McDonald VM (2009): Nebulised hypertonic saline for cystic fibrosis. Cochrane Database Syst Rev. 2009 Apr 15; (2): CD00150–6
Zhang L, Mendoza-Sassi RA, Wainwright C, Klassen TP (2013): Nebulised hypertonic saline solution for acute bronchiolitis in infants. Cochrane Database Syst Rev. 2013 Jul 31; 7: CD006458 54–4
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2015 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Lemmer, B. (2015). Antitussiva und Expektorantien. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2015. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47186-9_16
Download citation
DOI: https://doi.org/10.1007/978-3-662-47186-9_16
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-662-47185-2
Online ISBN: 978-3-662-47186-9
eBook Packages: Medicine (German Language)