Skip to main content
  • 1952 Accesses

Zusammenfassung

Auffällig ist das weiter steigende Verordnungsvolumen der neueren Antiepileptika, die inzwischen doppelt so häufig wie traditionelle Antiepileptika (z. B. Valproinsäure, Carbamazepin, Phenytoin) verordnet werden. Die Verordnungen von Valproinsäure sind seit mehreren Jahren konstant, dagegen hat das früher führende Carbamazepin seit 2003 um fast 50% abgenommen. Häufig verordnete Vertreter der neueren Antiepileptika sind das mit Abstand führende Pregabalin, gefolgt von Levetiracetam, Lamotrigin und Gabapentin.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • BackonjaM,BeydounA,EdwardsKR,SchwartzSL,FonsecaV,HesM,etal.fortheGabapentinDiabeticNeuropathyStudyGroup(1998):Gabapentinforthesymptomatictreatmentofpainfulneuropathyinpatientswithdiabetesmellitus.JAMA280:1831–1836

    Google Scholar 

  • Ben-MenachemE,BitonV,JatuzisD,Abou-KhalilB,DotyP,RuddGD(2007):Efficacyandsafetyoforallacosamideasadjunctivetherapyinadultswithpartial-onsetseizures.Epilepsia48:1308–1317

    Article  CAS  PubMed  Google Scholar 

  • BeydounA(1999):Monotherapytrialswithgabapentinforpartialepilepsy.Epilepsia40(Suppl6):S13–S16

    PubMed  Google Scholar 

  • BoyleJ,ErikssonME,GribbleL,GouniR,JohnsenS,CoppiniDV,KerrD(2012):Randomized,placebo-controlledcomparisonofamitriptyline,duloxetine,andpregabalininpatientswithchronicdiabeticperipheralneuropathicpain:impactonpain,polysomnographicsleep,daytimefunctioning,andqualityoflife.DiabetesCare35:2451–2458

    CAS  Google Scholar 

  • BrodieMJ(2004):Pregabalinasadjunctivetherapyforpartialseizures.Epilepsia45Suppl6:19–27

    Article  CAS  PubMed  Google Scholar 

  • BrodieMJ,PeruccaE,RyvlinP,Ben-MenachemE,MeenckeHJ(2007):Comparisonofleveti-racetamandcontrolled-releasecarbamazepineinnewlydiagnosedepilepsy.Neurology68:402–408

    Article  CAS  PubMed  Google Scholar 

  • CarmichaelK,PulmanJ,LakhanSE,ParikhP,MarsonAG(2013):Zonisamideadd-onfordrug-resistantpartialepilepsy.CochraneDatabaseSystRev.2013Dec19;12:CD001416CostaJ,FareleiraF,Ascen^äoR,BorgesM,SampaioC,Vaz-CarneiroA(2011):Clinicalcompara-bilityofthenewantiepilepticdrugsinrefractorypartialepilepsy:asystematicreviewandmeta-analysis.Epilepsia52:1280–1291

    Google Scholar 

  • DeutscheGesellschaftfürNeurologie(2012):LeitlinienfürDiagnostikundTherapieinderNeurologie.ErsterepileptischerAnfallundEpilepsienimErwachsenenalter.Internet:http://www.awmf.org/leitlinien/detail/ll/030-041.html

  • Devinsky O (2011): Sudden, unexpected death in epilepsy. N Engl J Med 365: 1801–1811

    Google Scholar 

  • Dooley M, Plosker GL (2000): Levetiracetam. A review of its adjunctive use in the management of partial onset seizures. Drugs 60: 871–893

    Article  CAS  PubMed  Google Scholar 

  • European Medicines Agency (2004): Europäischer öffentlicher Beurteilungsbericht (EPAR) Lyrica. Scientific discussion. Internet: www.emea.europa.eu/humandocs/PDFs/EPAR/>lyrica/084504en6.pdf

  • French JA, Kanner AM, Bautista J, Abou-Khalil B, Browne T, Harden CL, Theodore WH, Bazil C, Stern J, Schachter SC, Bergen D, Hirtz D, Montouris GD, Nespeca M, Gidal B, Marks WJ Jr, Turk WR, Fischer JH, Bourgeois B, Wilner A, Faught RE Jr, Sachdeo RC, Beydoun A, Glauser TA; American Academy of Neurology Therapeutics and Technology Assessment Subcom- mittee; American Academy of Neurology Quality Standards Subcommittee; American Epilepsy Society Quality Standards Subcommittee; American Epilepsy Society Therapeu- tics and Technology Assessment Subcommittee (2004): Efficacy and tolerability of the new antiepileptic drugs, I: Treatment of new-onset epilepsy: report of the TTA and QSS Sub- committees of the American Academy of Neurology and the American Epilepsy Society. Epilepsia 45: 401–409

    Article  CAS  PubMed  Google Scholar 

  • Gamble CL, Williamson PR, Marson AG (2006): Lamotrigine versus carbamazepine monothera- py for epilepsy. Cochrane Database Syst Rev 25(1):CD001031 Goa KL, Ross SR, Chrisp P (1993): Lamotrigine. A review of its pharmacological properties and clinical efficacy in epilepsy. Drugs 46: 152–176

    Google Scholar 

  • Hitiris N, Brodie MJ (2006): Modern antiepileptic drugs: guidelines and beyond. Curr Opin Neurol 19: 175–180

    PubMed  Google Scholar 

  • Holmes D (2012): NICE epilepsy guidance „may be detrimental to patient care". Lancet 379: 399 Kassenärztliche

    Google Scholar 

  • Bundesvereinigung (2007): Wirkstoff AKTUELL. Pregabalin (Lyrica® Hartkapseln). Internet: www.kbv.de/publikationen/116.html

  • Koch MW, Polman SK (2009): Oxcarbazepine versus carbamazepine monotherapy for partial onset seizures. Cochrane Database Syst Rev. 2009 Oct 7;(4):CD00645–3

    Google Scholar 

  • LaRoche SM, Helmers SL (2004): The new antiepileptic drugs: scientific review. JAMA 291: 605–614

    Article  CAS  PubMed  Google Scholar 

  • Lynch BA, Lambeng N, Nocka K, Kensel-Hammes P, Bajjalieh SM, Matagne A, Fuks B (2004): The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. PNAS 101: 9861–9866

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, Cramp C, Cocker- ell OC, Cooper PN, Doughty J, Eaton B, Gamble C, Goulding PJ, Howell SJL, Hughes A, Jackson M, Jacoby A, Kellett M, Lawson GR, Leach JP, Nicolaides P, Roberts R, Shackley P, Shen J, Smith DS, Smith PEM, Tudor Smith C, Vanoli A, Williamson PR, on behalf of the SANAD Study group (2007a): The SANAD study of effectiveness of carbamazepine, gaba- pentin, lamotrigine, oxcarbazepine, or topiramate for treatment of partial epilepsy: an unblinded randomised controlled trial. Lancet 369: 1000–1015

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Marson AG, Al-Kharusi AM, Alwaidh M, Appleton R, Baker GA, Chadwick DW, Cramp C,

    Google Scholar 

  • Cockerell OC, Cooper PN, Doughty J, Eaton B, Gamble C, Goulding PJ, Howell SJL, Hughes A, Jackson M, Jacoby A, Kellett M, Lawson GR, Leach JP, Nicolaides P, Roberts R, Shackley P, Shen J, Smith DS, Smith PEM, Tudor Smith C, Vanoli A, Williamson PR, on behalf of the SANAD Study group (2007b): The SANAD study of effectiveness of valproate, lamotrigine, or topiramate for generalized and unclassifiable epilepsy: an unblinded randomized controlled trial. Lancet 369: 1016–1026

    Article  PubMed Central  PubMed  Google Scholar 

  • Mbizvo GK, Dixon P, Hutton JL, Marson AG (2012): Levetiracetam add-on for drug-resistant focal epilepsy: an updated Cochrane Review. Cochrane Database Syst Rev. 2012 Sep 12; 9: CD00190–1

    Google Scholar 

  • McCorry D, Chadwick D, Marson A (2004): Current drug treatment of epilepsy in adults. Lancet Neurol 3: 729–735

    Article  CAS  PubMed  Google Scholar 

  • Milburn-McNulty P, Powell G, Sills GJ, Marson AG (2014): Sulthiame monotherapy for epilepsy.

    Google Scholar 

  • Cochrane Database Syst Rev. 2014 Mar 9; 3: CD010062 Moore RA, Straube S, Wiffen PJ, Derry S, McQuay HJ (2009): Pregabalin for acute and chronic pain in adults. Cochrane Database Syst Rev. 2009 Jul 8; (3): CD007076 Morello CM, Leckband SG, Stoner CP, Moorhouse DF, Sahagian GA (1999): Randomized doubleblind study comparing the efficacy of gabapentin with amitriptyline on diabetic peripher- al neuropathy pain. Arch Intern Med 159: 1931–1937

    Google Scholar 

  • Moshe SL, Perucca E, Ryvlin P, Tomson T (2015): Epilepsy: new advances. Lancet 385: 884–898

    Article  PubMed  Google Scholar 

  • National Institute for Health and Clinical Excellence (NICE) (2012): The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care. January 2012, NICE clinical guideline 137. Internet: www.nice.org.uk/page.aspx- ?o=CG020NICEguideline

  • Nunes VD, Sawyer L, Neilson J, Sarri G, Cross JH (2013): Profile of lacosamide and its role in the long-term treatment of epilepsy: a perspective from the updated NICE guideline. Neuropsychiatr Dis Treat 9: 467–476

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  • Perucca E, Yasothan U, Clincke G, Kirkpatrick P (2008): Lacosamide. Nat Rev Drug Discov 7: 973–974

    Article  CAS  PubMed  Google Scholar 

  • Pulman J, Jette N, Dykeman J, Hemming K, Hutton JL, Marson AG (2014): Topiramate add-on for drug-resistant partial epilepsy. Cochrane Database Syst Rev. 2014 Feb 25; 2: CD00141–7

    Google Scholar 

  • Shorvon SD (2009): Drug treatment of epilepsy in the century of the ILAE: the second 50 years, 1959-2009. Epilepsia 50 Suppl 3: 93–130

    Article  PubMed  Google Scholar 

  • Steinhoff BJ (2014): Efficacy of perampanel: a review of pooled data. Epilepsia 55 Suppl 1: 9–12

    Article  CAS  PubMed  Google Scholar 

  • Tomson T, Battino D (2012): Teratogenic effects of antiepileptic drugs. Lancet Neurol 11: 803–813

    Article  CAS  PubMed  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2015 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schwabe, U. (2015). Antiepileptika. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2015. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-47186-9_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-662-47186-9_12

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-662-47185-2

  • Online ISBN: 978-3-662-47186-9

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics