Abstract
Solar keratosis. This term is more specific because “actinic” means that the keratosis is produced by rays of any kind, unlike “solar” that indicates specifically rays of the sun. In several countries, it is also known as senile keratosis, senile hyperkeratosis, keratoma senile and keratosis senilis.
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Abbreviations
- 5-FU:
-
5-fluorouracil
- AK:
-
Actinic keratoses
- ALA:
-
5-aminolevulinic acid
- CIN or SIN:
-
Squamous intraepithelial neoplasia
- CO2:
-
Carbon dioxide
- CPG:
-
Computer pattern generator
- DFS:
-
Diclofenac sodium
- HD-OCT:
-
High-definition optical coherence tomography
- IMG:
-
Ingenol mebutate gel
- IMIQ:
-
Imiquimod
- KIN:
-
Keratinocytic intraepithelial neoplasia
- LED:
-
Light-emitting diodes
- MAL:
-
Methyl ester 5-aminolevulinic acid
- PDT:
-
Photodynamic therapy
- PpIX:
-
Photosensitiser protoporphyrin IX
- RTCs:
-
Randomised controlled trials
- SCC:
-
Squamous-cell carcinoma
- UVR:
-
Ultraviolet radiation
- SORT:
-
Strength of recommendation taxonomy
- SPF:
-
Sun protection factor
References
Ackerman AB. Respect at last for solar keratosis. Dermatopathol. 1997;3:101–3.
Alsner S, González S, Ulrich M. Actinic keratosis. In: González S, editor. Reflectance confocal microscopy in dermatology: fundamentals and clinical applications. Madrid: Aula Médica Ed; 2012. p. 69–71.
Askew DA, Mickan SM, Soyer P, Wilkinson D. Effectiveness of 5-fluorouracil treatment for actinic keratosis – a systematic review of randomized controlled trials. Int J Dermatol. 2009;48:453–63.
Camacho FM. Remodelamiento cutáneo: perspectiva histórica. Piel. 2005a;20:504–17.
Camacho FM. Medium-depth and deep chemical peels. J Cosmet Dermatol. 2005b;4:117–28.
Carlson S, Bordeaux J. Treatment of actinic keratoses. In: Maibach HI, Gorouhi F, editors. Evidence based dermatology. 2nd ed. Shelton: People’s Medical Publishing House; 2011.
Dirschka T, Bierhoff E, Pflugfelder A, Garbe C. Topical 3.0 % diclofenac in 2.5 % hyaluronic acid gel induces regression of cancerous transformation in actinic keratoses. J Eur Acad Dermatol Venereol. 2010;24:258–63.
Gupta AK, Paquet M. Ingenol mebutate: a promising treatment for actinic keratoses and nonmelanoma skin cancers. J Cutan Med Surg. 2013;17:173–9.
Hanke CW, Moy RI, Roenigk RK, Roenigk Jr HH, et al. Current status of surgery in dermatology. J Am Acad Dermatol. 2013;69:972–1001.
Hirokawa D, Lee JB. Dermatoscopy: an overview of subsurface morphology. Clin Dermatol. 2011;29:557–65.
Krawtchenko N, Roewert-Huber J, Ulrich M, Mann I, Sterry W, Stockfleth E. A randomised study of topical 5% imiquimod vs. topical 5-fluorouracil vs. cryosurgery in immunocompetent patients with actinic keratoses: a comparison of clinical and histological outcomes including 1-year follow-up. Br J Dermatol. 2007;157 Suppl 2:34–40.
Lebwohl M, Swanson N, Anderson LL, Melgaard A, Xu Z, Berman B. Ingenol mebutate gel for actinic keratosis. N Engl J Med. 2012;366(11):1010–9.
Lecha CM. Photoprotection and sunscreen. Monogr Dermatol. 2014;27(Supl.1):104–10.
Martin G, Swanson N. Clinical findings using ingenol mebutate gel to treat actinic keratoses. J Am Acad Dermatol. 2013;68(Supp l):S39–48.
Schmitt AR, Bordeaux JS. Solar keratoses: photodynamic therapy, cryotherapy, 5-fluorouracil, imiquimod, diclofenac, or what? Facts and controversies. Clin Dermatol. 2013;31:712–7.
Stockfleth E, Christophers E, Benninghoff B, Sterry W. Low incidence of new actinic keratoses after topical 5 % imiquimod cream treatment: a long-term follow-up study. Arch Dermatol. 2004;140:1542.
Stockfleth E, Kerl H, Zwingers T, Willers C. Low-dose 5-fluorouracil in combination with salicylic acid as a new lesion-directed option to treat topically actinic keratoses: histological and clinical study results. Br J Dermatol. 2011;65:1101–8.
Stockfleth E, Zwingers T, Willers C. Recurrence rates and patient assessed outcomes of 0.5% 5-fluorouracil in combination with salicylic acid treating actinic keratoses. Eur J Dermatol. 2012;22:370–4.
Swanson N, Abramovits W, Berman B, Kulp J, Rigel DS, Levy S. Imiquimod 2.5 % and 3.75 % for the treatment of actinic keratoses: results of two placebo-controlled studies of daily application to the face and balding scalp for two 2-weeks cycles. J Am Acad Dermatol. 2010;62:582–90.
Szeimies RM, Bichel J, Ortonne JP, Stockfleth E, Lee J, Meng TC. A phase II dose-ranging study of topical resiquimod to treat actinic keratosis. Br J Dermatol. 2008;159:205–10.
Weiss ET, Brauer JA, Anolik R, Reddy KK, et al. 1927-nm fractional resurfacing of facial actinic keratoses: a promising new therapeutic option. J Am Acad Dermatol. 2013;68:98–102.
Werner RN, Sammain A, Erdmann R, Hartmann V, Stockfleth E, Nast A. The natural history of actinic keratosis: a systematic review. Br J Dermatol. 2013;169:502–18.
Werner RN, Stockfleth E, Connolly SM, Correia O, et al. International League of Dermatological Societies (ILDS) Evidence-based (S3) Guidelines for the reatment of Actinic Keratosis (ICD L57.0:D04). In cooperation with the European Dermatology Forum (EDF), 2015 (in press)
Zalaudek I, Giacomel J, Schmid K, Bondino S, et al. Dermatoscopy of facial actinic keratoses, intraepidermal carcinoma, and invasive squamous cell carcinoma: a progression model. J Am Acad Dermatol. 2012;66:589–97.
Further Reading
Ballester-Sanchez R, Botella-Estrada R. Etiologic and epidemiologic factor of actinic keratoses. Monogr Dermatol. 2013;26 Suppl 1:11–3.
Berman B, Cohen DE, Amini S. What is the role of field-directed therapy in the treatment of actinic keratosis? Part 1: overview and investigational topical agents. Cutis. 2012;89:241–50.
Callen JP, Bickers DR, Moy RL. Actinic keratoses. J Am Acad Dermatol. 1997;36:650–3.
Camacho FM. Actinic keratosis. Introduction. Concept and classification. Monogr Dermatol. 2014;27 Suppl 1:3–5.
Camacho FM, García-Hernández MJ. Modelado cutáneo (resurfacing). Concepto y fundamentos. In: Cisneros JL, Camacho FM, Trelles MA, editors. Láser en Dermatología y Dermocosmética. 2nd ed. Madrid: Grupo Aula Médica, S.L., Ed; 2008. p. 353–65.
Cassarino DS, Barr RJ. SIN, not KIN. J Cutan Pathol. 2009;36:280.
de Berker D, McGregor JM, Hughes BR. British Association of Dermatologists Therapy Guidelines and Audit Subcommittee Guidelines for the management of actinic keratoses. Br J Dermatol. 2007;156:222–30.
Ebell MH, Siwek J, Weiss BD, et al. Strength of recommendation taxonomy (SORT). Am Fam Physician. 2004;69:548–56.
España A. Actinic keratosis and field cancerization. Monogr Dermatol. 2013;26 Suppl 1:6–10.
Falagas ME, Angelousi AG, Peppas G. Imiquimod for the treatment of actinic keratosis: a meta-analysis of randomized controlled trials. J Am Acad Dermatol. 2006;55:537–8.
Fitzpatrick TB. The skin cancer cascade: from ozone depletion to melanoma. J Dermatol. 1996;28:816–20.
Garza Rodríguez V, Malvehy J. New diagnostic methods of the actinic keratoses. Monogr Dermatol. 2013;26 Suppl 1:40–50.
Gilaberte Y, Pérez Lorenz JB, Juarranz A. Photodynamic therapy in the diagnosis and treatment of actinic keratoses. Monogr Dermatol. 2013;26 Suppl 1:51–8.
Gras J. Ingenol mebutate: a new option for actinic keratosis treatment. Drugs Today (Barc). 2013;49:15–22.
Hadley G, Derry S, Moore RA. Imiquimod for actinic keratosis: systematic review and meta-analysis. J Invest Dermatol. 2006;126:1251–5.
Hepplewhite A. Management of patients with actinic keratoses. Br J Nurs. 2012;21(Suppl):S27–30.
Jansen R, Wang SQ, Burnett M, Osterwalder U, Lim HW. Photoprotection. Part I. Photoprotection by naturally occurring, physical, and systemic agents. J Am Acad Dermatol. 2013;69:853–64.
Jansen R, Wang SQ, Burnett M, Osterwalder U, Lim HW. Photoprotection. Part II. Sunscreen: development, efficacy, and controversial. J Am Acad Dermatol. 2013;69:867–80.
Jorizzo J, Dinehart S, Matheson R, Moore JK, et al. Vehicle-controlled, double-blind, randomized study of imiquimod 5% cream applied 3 days per week in one or two courses of treatment for actinic keratoses on the head. J Am Acad Dermatol. 2007;57:265–8.
Maier T, Braun-Falco M, Laubender RP, Ruzicka T, Berking C. Actinic keratosis in the en-face and slice imaging mode of high-definition optical coherence tomography and comparison with histology. Br J Dermatol. 2013;168:120–8.
Melkonian S, Argos M, Pierce BL, Chen Y, Islam T, Ahmed A, et al. A prospective study of the synergistic effects of arsenic exposure and smoking, sun exposure, fertilizer use, and pesticide use on risk of premalignant skin lesions in Bangladeshi men. Am J Epidemiol. 2011;173:183–91.
Ondo AL, Padilla S, Miedler JD, Cockerell CJ, et al. Treatment-refractory actinic keratoses successfully treated using simultaneous combination topical 5-fluorouracil cream and imiquimod cream: a case-control study. Dermatol Surg. 2012;38:1469–76.
Poziomcyk CS, Dornelles MA, Köche B, Dornelles SI. Pain evaluation in the cryosurgery of actinic keratoses. An Bras Dermatol. 2011;86:645–50.
Rios Martín JJ. Histopathology of actinic keratoses. Histopathological forms. Monogr Dermatol. 2013;26 Suppl 1:26–30.
Rosen RH, Gupta AK, Tyring SK. Dual mechanism of action of ingenol mebutate gel for topical treatment of actinic keratoses: rapid lesion necrosis followed by lesion-specific immune response. J Am Acad Dermatol. 2012;66:486–93.
Sander CA, Pfeiffer C, Kligman AM, Plewig G. Chemotherapy for disseminated actinic keratoses with 5-fluorouracil and isotretinoin. J Am Acad Dermatol. 1997;36:236–8.
Slaughter DP, Southwick HW, Smejkal W. Field cancerization on oral stratified squamous epithelium. Cancer (Phila). 1953;6:963–8.
Xu D, Yuan R, Gu H, et al. The effect of ultraviolet radiation on the transforming growth factor beta 1/Smads pathway and p53 in actinic keratosis and normal skin. Arch Dermatol Res. 2013;305:777–86.
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Camacho-Martinez, F.M. (2015). Actinic Keratosis. In: Katsambas, A.D., Lotti, T.M., Dessinioti, C., D’Erme, A.M. (eds) European Handbook of Dermatological Treatments. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45139-7_2
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