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Kutane Arzneireaktionen

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Histopathologie der Haut

Part of the book series: Springer Reference Medizin ((SRM))

Zusammenfassung

Eine Arzneireaktion (AR) ist eine unerwünschte und schädliche Wirkung eines in vorgeschriebener Dosis verabreichten Medikaments (WHO-Definition). Die Reaktion kann dabei an die spezifischen Eigenschaften des Medikamentes (Toxizität) oder des Patienten (genetische Prädisposition) gebunden sein. Diese Reaktionen sind absehbar und nicht-immunologisch bedingt. Nicht absehbare, immunologische AR sind Ausdruck verschiedener Arten von Hypersensibilitätsreaktion (Typen I-IV). Typische Vertreter von medikamentösen Hypersensibilitätsreaktionen vom Soforttyp sind die Urtikaria oder das Angioödem, während z. B. die fixe Arzneireaktion oder die toxische epidermele Nekrolyse Vertreter von Spättyp-Allergien sind. Manchmal spielen auch virale Infekte eine Triggerrolle. Der genaue pathogenetische Mechanismus ist bei vielen AR jedoch nicht bekannt.

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Authors and Affiliations

  1. Universitätsklinik für Dermatologie und Venerologie, Gloriastr. 31, 8091, Zürich, Schweiz

    K. Kerl

  2. Universitäts-Hautklinik Münster, Von-Esmarch-Str. 56, 49149, Münster, Deutschland

    D. Metze

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  1. K. Kerl
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  2. D. Metze
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Correspondence to K. Kerl .

Editor information

Editors and Affiliations

  1. Universitätsklinik für Dermatologie, Medizinische Universität Graz, Graz, Austria

    Lorenzo Cerroni

  2. Universitäts-Hautklinik, Eberhard-Karls-Universität, Tübingen, Germany

    Claus Garbe

  3. Universitäts-Hautklinik Münster, Münster, Germany

    Dieter Metze

  4. Dermatopathologie Friedrichshafen, Friedrichshafen, Germany

    Heinz Kutzner

  5. Universitätsklinik für Dermatologie und, Medizinische Universität Graz, Graz, Steiermark, Austria

    Helmut Kerl

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Kerl, K., Metze, D. (2016). Kutane Arzneireaktionen. In: Cerroni, L., Garbe, C., Metze, D., Kutzner, H., Kerl, H. (eds) Histopathologie der Haut. Springer Reference Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-662-45133-5_12

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  • DOI: https://doi.org/10.1007/978-3-662-45133-5_12

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