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Clinical Overview

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Aspects of Lyme Borreliosis

Abstract

As with syphilis, Lyme borreliosis develops in three stages (Steere et al. 1984, 1986a; Weber et al. 1984b; Asbrink 1985; Pfister and Einhäupl 1986; Weber 1986, 1988, 1989a, b; Asbrink and Hovmark 1988; Herzer 1989; Steere 1989). The first two stages, which occur within a few weeks or months after infection due to Borrelia burgdorferi, represent the early phase of the disease (Asbrink and Hovmark 1988; Weber 1988; Steere 1989). The third stage arises after several months or years and is, therefore, considered to be the late phase of the disease (Table 1).

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References

  • Ackermann R, Gollmer E, Rehse-Küpper B (1985) Progressive Borrelien-Enzephalomyelitis. Dtsch Med Wochenschr 110:1039–1042

    Article  PubMed  CAS  Google Scholar 

  • Ackermann R, Rehse-Küpper B, Gollmer E, Schmidt R (1988) Chronic neurologic manifestations of rythema migrans borreliosis. Ann NY Acad Sci 539:16–23

    Article  PubMed  CAS  Google Scholar 

  • Asbrink E, Hovmark A (1987) Cutaneous manifestations in Ixodes-borne borrelia spirochetosis. Int J Dermatol 26:215–223

    Article  PubMed  CAS  Google Scholar 

  • Asbrink E, Hovmark A (1988) Early and late cutaneous manifestations in Ixodes-borne borreliosis (erythema migrans borreliosis, Lyme borreliosis). Ann NY Acad Sci 539:4–15

    Google Scholar 

  • Asbrink E, Olsson I (1985) Clinical manifestations of erythema chronicum migrans Afzelius in 161 patients. Acta Derm Venereol (Stockh) 65:43–52

    CAS  Google Scholar 

  • Asbrink E, Hovmark A, Hederstedt B (1984) The spirochetal etiology of acrodermatitis chronica atrophicans Herxheimer. Acta Derm Venereol (Stockh) 64:506–512

    CAS  Google Scholar 

  • Asbrink E, Hovmark A, Olsson I (1989) Lymphadenosis benigna cutis solitaria-borrelia lym-phocytoma in Sweden. Zentralbl Bakteriol (Suppl) 18:156–163

    Google Scholar 

  • Bannwarth A (1941) Chronische lymphocytäre Meningitis, entzündliche Polyneuritis and “Rheumatismus”. Arch Psychiatr Nervenkr 113:284–376

    Article  Google Scholar 

  • Bozsik BP, Lakos A, Budai J, Telegdy L, Ambrozy G (1986) Occurrence of Lyme borreliosis in Hungary. Zentralbl Bakteriol Hyg (A) 263:466–467

    Google Scholar 

  • Hauser W (1955) Zur Kenntnis der Akrodermatitis chronica atrophicans. Arch Dermatol Syph 199:350–393

    Article  CAS  Google Scholar 

  • Hauser W (1965) Wahrscheinliche Infektionskrankheiten der Haut. Springer, Berlin Heidelberg New York, pp 556–629 (Handbuch der Haut- und Geschlechtskrankheiten, vol IV, part 1 A)

    Google Scholar 

  • Herzer P (1989) Lyme-Borreliose. Steinkopf: Darmstadt

    Google Scholar 

  • Herzer P, Schattenkirchner M, Zöllner N (1983) Lyme-Arthritis-eine zu selten bedachte Diagnose? Verh Dtsch Ges Inn Med 89:299–302

    Google Scholar 

  • Herzer P, Wilske B, Preac-Mursic V, Schierz G, Schattenkirchner M, Zöllner N (1986) Lyme arthritis: clinical features, serological and radiographic findings of cases in Germany. Klin Wochenschr 64:206–215

    Article  PubMed  CAS  Google Scholar 

  • Hörstrup P, Ackermann R (1973) Durch Zecken übertragene Meningopolyneuritis (Garin-Bujadoux, Bannwarth). Fortschr Neurol Psychiatr 41:583–606

    Google Scholar 

  • Hollström E (1958) Penicillin treatment of erythema chronicum migrans Afzelius. Acta Derm Venereol (Stockh) 38:285–289

    Google Scholar 

  • Hopf HC (1966) Acrodermatitis chronica atrophicans (Herxheimer) und Nervensystem. Springer, Berlin Heidelberg New York (Monographien aus dem Gesamtgebiet der Neurologie und Psychiatrie, vol 114)

    Google Scholar 

  • Killmann H, Lind P, Stanek G (1987) Akute Hepatitis bei Lyme-Borreliose. Wien Med Wochenschr 137:343–346

    PubMed  CAS  Google Scholar 

  • Kohlhepp W, Mertens HG, Oschmann P, Rohrbach E (1987) Akute und chronische Erkrankung bei zeckenvermittelter Borreliose. Nervenarzt 58:557–563

    PubMed  CAS  Google Scholar 

  • Kristoferitsch W (1989) Neuropathien bei Lyme-Borreliose. Springer, Vienna New York

    Book  Google Scholar 

  • Krüger H, Reuss K, Pulz M, Rohrbach E, Pflughaupt KW, Martin R, Mertens HG (1989) Meningoradiculitis and encephalomyelitis due to Borrelia burgdorferi: a follow-up study of 72 patients over 27 years. J Neurol 236:322–328

    Article  PubMed  Google Scholar 

  • MacDonald AB, Benach JL, Burgdorfer W (1987) Stillbirth following maternal Lyme disease. NY J State Med 87:615–616

    CAS  Google Scholar 

  • Marcus LC, Steere AC, Duray PH, Anderson AE, Mahoney EB (1985) Fatal pancarditis in a patient with coexistent Lyme disease and babesiosis. Ann Intern Med 103:374–376

    PubMed  CAS  Google Scholar 

  • May EF, Jabbari B (1990) Stroke in neuroborreliosis. Stroke 21:1232–1235

    Article  PubMed  CAS  Google Scholar 

  • Meurers B, Kohlhepp W, Gold R, Rohrbach E, Mertens HG (1990) Histopathological findings in the central and peripheral nervous system in neuroborreliosis. J Neurol 237:113–116

    Article  PubMed  CAS  Google Scholar 

  • Neubert U, Münchhoff P, Völker B, Reimers CD, Pflüger KH (1988) Borrelia burgdorferi infections in Bavarian forest workers. Ann NY Aca Sci 539:476–479

    Google Scholar 

  • Pfister HW, Einhäupl KM (1986) Lyme Borreliosis - eine durch Borrelia burgdorferi hervorgerufene Multisystemerkrankung. Internist Welt 3:76–84

    Google Scholar 

  • Pfister HW, Einhäupl KM, Wilske B, Preac-Mursic V (1986a) Bannwarth’s syndrome and the enlarged neurological spectrum of arthropod-borne borreliosis. Zentralbl Bakteriol Hyg (A) 263:343–347

    Google Scholar 

  • Pfister HW, Neubert U, Wilske B, Preac-Mursic V, Einhäupl KM, Borasio GD (1986b) Reinfection withBorrelia burgdorferi (letter). Lancet 11:984–985

    Article  Google Scholar 

  • Pfister HW, Preac-Mursic V, Wilske B, Einhäupl KM, Weinberger K (1989a) Latent Lyme neuroborreliosis: presence of Borrelia burgdorferi in the cerebrospinal fluid without concurrent inflammatory signs. Neurology 39:1118–1120

    PubMed  CAS  Google Scholar 

  • Pfister HW, Wilske B, Preac-Mursic V, Einhäupl KM (1989b) Clinical and serological follow up of patients with Bannwarth’s syndrome: comparison of patients with and without penicillin treatment. Zentralbl Bakteriol (Suppl) 18:276–279

    Google Scholar 

  • Prinz A, Weiss P, Stanek G (1986) Generalized exanthema, acute hepatitis with porphyrinuria and eosinophilia. Zentralbl Bakteriol Hyg (A) 263:389–391

    Google Scholar 

  • Reimers CD, Pongratz DE, Neubert U, Pilz A, Hübner G, Naegele M, Wilske B, Duray PH, DeKoning J (1989) Myositis caused byBorrelia burgdorferi. Report of 4 cases. J Neurol Sci 91:215–226

    Article  PubMed  CAS  Google Scholar 

  • Schaltenbrand G (1967) Durch Arthophoden übertragene Erkrankung der Haut und des Nervensystems. Verh Dtsch Ges Inn Med 72:975–1005

    Google Scholar 

  • Schlesinger PA, Duray PH, Burke BA, Steere AC, Stillmann T (1985) Maternal-fetal transmission of the Lyme disease spirochete, Borrelia burgdorferi. Ann Intern Med 103:67–68

    PubMed  CAS  Google Scholar 

  • Schmutzhard E, Willeit J, Gerstenbrand F (1986) Meningopolyneuritis Bannwarth with focal nodular myositis. Klin Wochenschr 64:1204–1208

    Article  PubMed  CAS  Google Scholar 

  • Shresta M, Grodzicki RL, Steere AC (1985) Diagnosing early Lyme disease. Am J Med 78:235–240

    Article  Google Scholar 

  • Stanek G, Flamm H, Barbour AG, Burgdorfer W (eds) (1987) Lyme borreliosis. Fischer, Stuttgart

    Google Scholar 

  • Stanek G, Klein J, Bittner R, Glogar D (1990) Isolation of Borrelia burgdorferi from the myocardium of a patient with longlasting cardiomyopathy. N Engl J Med 322:249–252

    Article  PubMed  CAS  Google Scholar 

  • Steere AC (1989) Lyme disease. N Engl J Med 321:586–596

    Article  PubMed  CAS  Google Scholar 

  • Steere AC, Malawista SE, Hardin JA, Ruddy S, Askenase PW, Andimann WA (1977) Erythema chronicum migrans and Lyme arthritis: the enlarging clinical spectrum. Ann Intern Med 86:685–698

    PubMed  CAS  Google Scholar 

  • Steere AC, Malawista SE, Newman JH, Spieler PN, Bartenhagen NH (1980a) Antibiotic therapy in Lyme disease. Ann Intern Med 93:1–8

    PubMed  CAS  Google Scholar 

  • Steere AC, Batsford WP, Weinberg M, Alexander J, Berger HJ, Wolfson S, Malawista SE (1980b) Lyme carditis: cardiac abnormalities of Lyme disease. Ann Intern Med 93:8–16

    PubMed  CAS  Google Scholar 

  • Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Rahn DW, Sigal LH, Spieler PN, Stenn KS, Malawista SE (1983) The early clinical manifestations of Lyme disease. Ann Intern Med 99:76–82

    PubMed  CAS  Google Scholar 

  • Steere AC, Malawista SE, Bartenhagen NH, Spieler PN, Newman JH, Rahn DW, Hutchinson GJ, Green J, Snydman DR, Taylor E (1984) The clinical spectrum and treatment of Lyme disease. Yale J Biol Med 57:453–461

    PubMed  CAS  Google Scholar 

  • Steere AC, Bartenhagen NH, Craft JE, Hutchinson GJ, Newman JH, Pachner AR, Rahn DW, Sigal LH, Taylor E, Malawista SE (1986a) Clinical manifestation of Lyme disease. Zentralbl Bakteriol Hyg (A) 263:201–205

    CAS  Google Scholar 

  • Steere AC, Taylor E, Wilson ML, Levine JF, Spielman A (1986b) Longitudinal assessment of the clinical and epidemiological features of Lyme disease in a defined population. J Infect Dis 154:295–300

    Article  PubMed  CAS  Google Scholar 

  • Steere AC, Schoen RT, Taylor E (1987) The clinical evolution of Lyme arthritis. Ann Intern Med 107:725–731

    PubMed  CAS  Google Scholar 

  • Weber K (1974) Erythema-chronicum-migrans-Meningitis - eine bakterielle Infektionskrankheit. Munch Med Wochenschr 116:1993–1998

    CAS  Google Scholar 

  • Weber K (1986) Die Lyme-Borreliose. Hautarzt 37:583–586

    PubMed  CAS  Google Scholar 

  • Weber K (1988) Klinik der Erythema-migrans- (Lyme-) Borreliose. Z Hautkr 63:314–319

    PubMed  CAS  Google Scholar 

  • Weber K (1989a) Borrelien-bedingte Dermatosen. Berichtsband der Medicinale XIX, Iserlohn

    Google Scholar 

  • Weber K (1989b) Clinical differences between European and North-American Lyme borreliosis — a review. Zentralbl Bakteriol (Suppl) 118:146–155

    Google Scholar 

  • Weber K, Neubert U (1986) Clinical features of early erythema migrans disease and related disorders. Zentralbl Bakteriol Hyg (A) 263:209–228

    CAS  Google Scholar 

  • Weber K, Puzik A, Becker T (1983) Erythema-migrans-Krankheit: Beitrag zur Klinik und Beziehung zur Lyme-Krankheit. Dtsch Med Wochenschr 108:1182–1190

    Article  PubMed  CAS  Google Scholar 

  • Weber K, Schierz G, Wilske B, Preac-Mursic V (1984a) Zur Klinik und Ätiologie der Acrodermatitis chronica atrophicans. Hautarzt 35:571–577

    PubMed  CAS  Google Scholar 

  • Weber K, Schierz G, Wilske B, Preac-Mursic V (1984b) European erythema migrans disease and related disorders. Yale J Biol Med 57:463–471

    PubMed  CAS  Google Scholar 

  • Weber K, Schierz G, Wilske B, Preac-Mursic V (1985) Das Lymphozytom - eine Borreliose? Z Hautkr 60:1585–1598

    PubMed  CAS  Google Scholar 

  • Weber K, Neubert U, Thurmayr R (1986a) Antibiotic therapy in early erythema migrans disease and related disorders. Zentralbl Bakteriol Hyg (A) 263:377–388

    Google Scholar 

  • Weber K, Schierz G, Wilske B, Neubert U, Krampitz HE, Barbour AG, Burgdorfer W (1986b) Reinfection in erythema migrans disease. Infection 14:32–35 (Abstract: Zentralbl Haut Geschlechtskr (1985) 150:628–629)

    Article  PubMed  CAS  Google Scholar 

  • Weber K, Preac-Mursic V, Neubert U, Thurmayr R, Herzer P, Wilske B, Schierz G, Marget W (1988) Antibiotic therapy of early European Lyme borreliosis and acrodermatitis chronica atrophicans. Ann NY Acad Sci 539:324–345

    Article  PubMed  CAS  Google Scholar 

  • Weber K, Preac-Mursic V, Wilske B, Thurmayr R, Neubert U, Scherwitz C (1990) A randomized trial of ceftriaxone versus oral penicillin for the treatment of early European Lyme borreliosis. Infection 18:91–96

    Article  PubMed  CAS  Google Scholar 

  • Wilske B, Münchhoff P, Schierz G, Preac-Mursic V, Roggendorf M, Zoulek G (1985) Zur Epidemiologie derBorrelia-burgdorferi-Jnfektion bei Waldarbeitern aus Oberbayern. Munch Med Wochenschr 127:171–172

    Google Scholar 

  • Wolf G (1970) Über die chronische lymphozytäre Meningitis unter dem Bilde der Polyneuritis (Bannwarth). Fortschr Neurol Psychiatr 38:221–234

    CAS  Google Scholar 

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Authors
  1. K. Weber
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  2. H.-W. Pfister
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  3. C. D. Reimers
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Editor information

Editors and Affiliations

  1. Rosenstr.6, 8000, München 2, Germany

    Klaus Weber (Dermatologist in Private Practice) (Dermatologist in Private Practice)

  2. Laboratory of Vectors and Pathogens, Rocky Mountain Laboratories, Department of Health and Human Services, Public Health Service,National Institutes of Health, National Institute of Allergy and Infectious Diseases, 59840, Hamilton, MT, USA

    Willy Burgdorfer Ph.D.,M.D.(h.c.)

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© 1993 Springer-Verlag Berlin Heidelberg

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Weber, K., Pfister, HW., Reimers, C.D. (1993). Clinical Overview. In: Weber, K., Burgdorfer, W., Schierz, G. (eds) Aspects of Lyme Borreliosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-77614-4_7

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  • DOI: https://doi.org/10.1007/978-3-642-77614-4_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-77616-8

  • Online ISBN: 978-3-642-77614-4

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