Skip to main content
SpringerLink
Log in

Externagrundlagen bei speziellen Indikationen

  • Chapter
Dermatologische Externatherapie

Zusammenfassung

Die Hornschichtlipide werden im Stratum granulosum synthetisiert. Sie bilden liposomenähnliche Strukturen und werden aus den Keratinozyten in die Interzellularräume ausgeschleust. Dort fließen sie zusammen und bilden multilamelläre Strukturen, in denen sich jeweils eine lipophile und eine hydrophile Schicht abwechseln (Gloor 1994; Schäfer u. Redelmeier 1996). Getrennt davon verläuft die Synthese der Membranlipide der Korneozyten. Sie enthalten Omega-Hydroxyalkylsphingoside, die eine Esterbildung mit den Proteinen der Korneozytenwand aufweisen (Schwartzendruber et al. 1987).

Article FootNote

1unter Mitarbeit von J. Fluhr

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 19.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 39.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 39.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Literatur

  • Adachi K, Aoki T (1989) IgE antibody to sweat in atopic dermatitis. Acta Derm Venereol Suppl (Stockh) 144: 83–87

    CAS  Google Scholar 

  • Angelini G (1995) Topical drugs In: Rycroft RIG, Menné T, Frosch PJ (eds) Textbook of contact dermatitis. Springer, Berlin Heidelberg, 2. edn., pp 477–503

    Google Scholar 

  • Berardesca E, Herbst R, Maibach H (1993) Plastic occlusion stress test as a model to investigate the effects of skin delipidization of the stratum corneum on water holding capacity in vivo. Dermatology 187: 91–94

    Article  CAS  PubMed  Google Scholar 

  • Bettinger J, Gloor M, Gehring W (1994) Influence of a pretreatment with emulsions on the dehydration of the skin by surfactants. Int J Cosm Sci 16: 53–60

    Article  CAS  Google Scholar 

  • Di Nardo A, Wertz P, Gianetti A, Seidenari S (1998) Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm Venereol (Stockh) 78: 27–30

    Article  Google Scholar 

  • Friberg SE, Kayali I, Bedkermann W, Rhein LD, Simion A (1990) Water permeability of reaggerated stratum corneum with model lipids. J Invest Dermatol 94: 377–380

    Article  CAS  PubMed  Google Scholar 

  • Gallenkemper G, Rabe E, Bauer R (1998) Contact sensitization in chronic venous insufficiency: modern wound dressings. Contact Dermatitis 38: 274–278

    Article  CAS  PubMed  Google Scholar 

  • Gehring W, Forssmann Th, Jost G, Gloor M (1996) Die keimreduzierende Wirkung von Erythromycin and Triclosan bei der atopischen Dermatitis. Akt Dermatol 22: 28–32

    Google Scholar 

  • Gehring W, Gloor M, Kleesz P (1998) Predicitive washing test for evaluation of individual eczema risk. Contact Dermatitis 39: 8–13

    Article  CAS  PubMed  Google Scholar 

  • Gloor M (1994) Hornschichtbarriere and ihre Modulation. Z Hautkr 69: 656–661

    Google Scholar 

  • Gloor M, Peters G, Stoika D (1982a) On the resident aerobic bacterial skin flora on unaffected skin of patients with atopic dermatitis and in healthy controls. Dermatologica 164: 258–265

    Article  CAS  PubMed  Google Scholar 

  • Gloor M, Pfahler E, Neumann W, Höffler U, Hoffmann M, Schmidt U (1982b) Lokale Acnetherapie mit Erythromycin and Benzoylperoxid. Z Hautkr 57: 867–878

    CAS  PubMed  Google Scholar 

  • Grunewald AM, Gloor M, Gehring W, Kleesz P (1995) Damage to the skin by repetitive washing. Contact Dermatitis 32: 225–232

    Article  CAS  PubMed  Google Scholar 

  • Grunewald AM, Gloor M, Kleesz P (1996) Barrier recompensation mechanisms. Curr Probl Dermatol. Karger, Basel, 25: 206–213

    CAS  Google Scholar 

  • Imokawa G, Hattori M (1985) A possible function of structural lipids in the water holding properties of the stratum corneum. J Invest Dermatol 84: 282–284

    Article  CAS  PubMed  Google Scholar 

  • Imokawa G, Akasaki S, Hattori M, Yoshizuka N (1986) Selective recovery of deranged water holding properties by stratum corneum lipids. J Invest Dermatol 87: 758–761

    Article  CAS  PubMed  Google Scholar 

  • Imokawa G, Abe A, Jin Y, Higaki Y, Kawashima M, Hidano A (1991) Decreased level of ceramides in stratum corneum of atopic dermatitis: an ethiologic factor in atopic dry skin. J Invest Dermatol 96: 523–527

    Article  CAS  PubMed  Google Scholar 

  • Jemec GBE, Wulf HC (1999) Correlation between the greasiness and the plasticizing effect of moisturizers. Acta Derm Venereol (Stockh) 79: 115–117

    Article  CAS  Google Scholar 

  • Jensen O, Petersen SH, Vesterager L (1980) Contact sentization to benzoyl peroxide following topical treatment of chronic leg ulcers. Contact Dermatitis 6: 179–182

    Article  CAS  PubMed  Google Scholar 

  • John SM, Geier J (1998) Unterschenkelekzem bei chronisch-venöser Insuffizienz. Aktuelle allergologische Aspekte. Z Dermatol 184: 16–23

    Google Scholar 

  • Kerkhof PCM van de, Mare S de, Arnold WP, Erp PEJ van (1995) Epidermal regeneration and occlusion. Acta Derm Venereol (Stockh) 75: 6–8

    Google Scholar 

  • Lodén M, Olsson H, Axéll T, Linde YW (1992) Friction, capacitance and transepidermal water loss (TEWL) in dry atopic and normal skin. Br J Dermatol 126: 137–141

    Article  PubMed  Google Scholar 

  • Man MA, Feingold KR, Elias PM (1993) Exogenous lipids influence permeability barrier recovery in acetone treated murine skin. Arch Dermatol 129: 728–738

    Article  CAS  PubMed  Google Scholar 

  • Melnik BC, Hollmann J, Erler E, Verhoeven B, Plewig G (1988a) Microanalytic screening of all major stratum corneum lipids by sequential high performance thin layer chromatography. J Invest Dermatol 92: 231–234

    Article  Google Scholar 

  • Melnik B, Hohmann J Hofman U, Yuh MS, Plewig G (1988b) Decreased stratum corneum ceramides in atopic individuals: a pathobiochemical factor in xerosis?. Br J Dermatol 119: 547–548

    Article  CAS  PubMed  Google Scholar 

  • Melnik B, Hollmann J Hofman U, Yuh MS, Plewig G (1990) Lipid composition of outer stratum corneum and nails in atopic and control subjects. Arch Dermatol Res 282: 549–551

    Article  CAS  PubMed  Google Scholar 

  • Proksch E, Feingold KR, Mao-Quiang M, Elias PM (1991) Barrier function regulates epidermal DNA synthesis. J Clin Invest 87: 1668–1673

    Article  CAS  PubMed  Google Scholar 

  • Proksch E, Brasch J, Sterry W (1996) Integrity of the permeability barrier regulates epidermal Langehans cell density. Br J Dermatol 134: 630–638

    Article  CAS  PubMed  Google Scholar 

  • Rajka G (1974) Transepidermal water loss on the hands in atopic dermatitis. Arch Dermatol Res 251: 111–115

    Article  CAS  Google Scholar 

  • Schäfer L, Kragballe K (1991) Abnormities in the epidermal lipid metabolism in patients with atopic dermatitis. J Invest Dermatol 96: 10–15

    Article  PubMed  Google Scholar 

  • Schäfer H, Redelmeier ThE (1996) Skin barrier-Principles of percutaneous absorption. Karger, Basel, pp 66–70

    Google Scholar 

  • Schnyder UW, Gloor M, Taugner M (1977) Über die sozialmedizinische Bedeutung von Alkaliresistenz, Alkalineutralisation and Hautoberflächenlipidmenge bei Neurodermitis atopica and Ichthyosis vulgaris. Berufsdermatosen 25: l01–107

    Google Scholar 

  • Schwartzendruber DC, Wertz PW, Madison KC, Downing DT (1987) Evidence that the corneocyte has a chemically bound lipid envelope. J Invest Dermatol 88: 709–713

    Article  Google Scholar 

  • Squier CA, Cox P, Wertz PW (1991) Lipid content and water permeability of skin and oral mucosa. J Invest Dermatol 96: 123–126

    Article  CAS  PubMed  Google Scholar 

  • Sulzberger MB, Hermann F, Borota A, Strauss MB (1953) Studies of sweating, 6. On the urticariogenic properties of human sweat. J Invest Dermatol 21: 293–303

    CAS  PubMed  Google Scholar 

  • Triebskorn A, Gehring W, Gloor M, Borelli S (1991) Hornschichthydratation and Barrierefunktion bei Neurodermitikern vor and nach Therapie im Hochgebirgsklima. Z Hautkr 66: 145–147

    Google Scholar 

  • Thune P (1989) Evaluation of the hydratation and the water holding capacity in atopic skin and in socalled dry skin. Acta Derm Venereol (Stockh) Suppl 144: 133–135

    CAS  Google Scholar 

  • Welzel J, Wilhelm KP, Wolff HH (1995) Occlusion does not influence the repair of the permeability barrier in human skin. Curr Probl Dermatol 23: 180–186

    CAS  PubMed  Google Scholar 

  • Welzel J, Wilhelm KP, Wolff HH (1996) Skin permeability barrier and occlusion: No delay of repair in irritated human skin. Contact Dermatitis 35: 163–168

    Article  CAS  PubMed  Google Scholar 

  • Werner Y (1982) The water content of the stratum corneum in patients with atopic dermatitis-measurements with the corneometer CM 420. Acta Derm Venereol (Stockh) 66: 334–336

    Google Scholar 

  • Werner Y, Lindberg M, Forslind B (1982) The water binding capacity of stratum corneum in dry non eczematous skin of atopic eczema. Acta Derm Venereol (Stockh) 62: 334–336

    CAS  Google Scholar 

  • Wertz PW, Downing DT (1991) Epidermal lipids In: Goldsmith LA (ed) Physiology, biochemistry, and molecular biology of the skin. Oxford University Press, Oxford, pp 205–235

    Google Scholar 

  • Wirth H, Gloor M, Stoika D (1981) Sebaceous glands in uninvolved skin of patients suffering from atopic dermatitis. Arch Dermatol Res 270: 167–168

    Article  CAS  PubMed  Google Scholar 

  • Yamamoto A, Serizawa S, Ito M, Sato Y (1991) Stratum corneum lipid abnormalities in atopic dermatitis. Arch Dermatol Res 283 342–346

    Article  Google Scholar 

Download references

Authors
  1. M. Gloor
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gloor, M. (2000). Externagrundlagen bei speziellen Indikationen. In: Dermatologische Externatherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58308-7_6

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58308-7_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63533-5

  • Online ISBN: 978-3-642-58308-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation