Skip to main content
SpringerLink
Log in

Antibiotika

  • Chapter
Dermatologische Externatherapie

Zusammenfassung

Es wird nur auf die Antibiotika eingegangen, die in Deutschland eine therapeutische Rolle spielen. Nicht eingegangen wird auf Mupirocin, da dieses nur in Nasensalben verwendet werden sollte, vor allem zur Bekämpfung von Methicillin resistenten Staphylococcus aureus (MRSA) Besiedelungen in der Nase. Um Resistenzinduktionen vorzubeugen, sollte eine dermatologische Behandlung unterbleiben. Nicht ausführlich besprochen wird auch Nadifloxacin, das in Japan als Spezialität zur Verfügung steht, nicht aber in Deutschland. Auch Kanamycin bleibt außer Betracht, da es in Deutschland ausschließlich in Ophthalmologica verwendet wird.

ArticleFootNote

unter Mitarbeit von J. Fluhr

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
eBook
USD 19.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 39.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 39.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Similar content being viewed by others

Literatur

  • Abeck D, Mempel M (1998) Staphylococcus aureus colonization in atopic dermatitis and its therapeutic implications. Br J Dermatol 139 Suppl 53: 13–16

    Article  PubMed  Google Scholar 

  • Akamatsu H, Niwa Y, Kurokawa I, Masuda R, Nishijima S, Asada Y (1991a) Effects of subminimal inhibitory concentrations of minocycline on neutrophil chemotactic factor production in comedonal bacteria, neutrophil phagocytosis and oxygen metabolism. Arch Dermatol Res 283: 524–528

    Article  PubMed  CAS  Google Scholar 

  • Akamatsu H, Nishijima S, Takahashi M, Ushijima T, Asada Y (1991b) Effects of subminimal inhibitory concentrations of erythromycin, tetracycline, clindamycin, and minocycline on the neutrophil chemotactic factor production in propionibacterium acne biotypes 1–5. J Dermatol 18: 247–251

    PubMed  CAS  Google Scholar 

  • Chu A, Huber EJ, Plott AT (1997) The comparative efficacy of benzoyl peroxide 5%/erythromycin 3% gel and erythromycin 4%/zink 1.2% solution in the treatment of acne vulgaris. Br J Dermatol 136: 235–238

    Article  PubMed  CAS  Google Scholar 

  • Cork MJ (1996) The role of staphylococcus aureus in atopic eczema: treatment strategies. J Europ Acad Dermatol Venereol 7 Suppl 1: 31–37

    Article  Google Scholar 

  • Crawford WJ, Crawford IP, Stoughton RB, Cornell RC (1979) Laboratory induction and clinical occurence of combined clindamycin and erythromycin resistance in Corynebacterium acnes. J Invest Dermatol 72: 187–190

    Article  PubMed  CAS  Google Scholar 

  • Dalziel K, Dykes PJ, Marks R (1987) The effect of tetracycline and erythromycin in a model of acne type inflammation. Br J Exp Pathol 68: 67–70

    PubMed  CAS  Google Scholar 

  • Dhar S, Kanwar AJ, Kaur S, Sharma P, Ganguly (1992) Role of bacterial flora in the pathogenesis and management of atopic dermatitis. Indian J Med Res 95: 234–238

    PubMed  CAS  Google Scholar 

  • Eady EA, Cove JH, Holland KT, Cunliffe WJ (1989) Erythromycin resistant propionibacteria in antibiotic treated acne patients: association with therapeutic failure. Br J Dermato1 121: 51–57

    Article  CAS  Google Scholar 

  • Eady EA, Cove JH, Joanes DN, Cunliffe WJ (1990) Topical antibiotics for the treatment of acne vulgaris: a critical evaluation of the literature on their clinical benefit and comparative efficacy. J Dermatol Treatm 1: 215–226

    Article  Google Scholar 

  • Eady EA, Ingham E, Walters CE, Cove JH, Cunliffe WJ (1993). Acne patients treated with tetracyclines. J Invest Dermatol l00: 86–91

    Article  Google Scholar 

  • Eady EA, Jones CE, Vyakrnam S, Cove JH, Cunliffe WJ (1997) Increasing prevalence of antibiotic resistant propionibacteria on the skin of acne patients: results of a five year study. Br J Dermatol 137 Suppl 50: 34

    Google Scholar 

  • Elewki BE, Sam M jr, Gammon WR (1983) In vivo suppression of neutrophil chemotaxis by systemically and topically administered tetracycline. J Am Acad Dermatol 8: 807–812

    Article  Google Scholar 

  • Eller MG, Smith RB, Philips JP (1989) Absorption kinetics of topical clindamycin preparations. Biopharm Drug Disp l0: 505–512

    Article  CAS  Google Scholar 

  • Esser B (1987) Vergleich zwischen Zineryt (Erythromycin 4% + Zinkacetat) and Erythromycin 2% bei der topischen Behandlung der Acne vulgaris. Dtsch Dermatol 35: 297–301

    Google Scholar 

  • Esterly NB, Koransky JS, Furey NL, Trevisan M (1984) Neutrophilic chemotaxis in patients with acne receiving oral tetracycline therapy. Arch Dermatol 120: 1308–1313

    Article  PubMed  CAS  Google Scholar 

  • Fluhr JW, Gloor M, Merkel W, Warnecke J, Höffler U, Lehmacher W, Glutsch J (1998) Antibacterial and sebosuppressive efficacy of a combination of chloramphenicol and pale sulfonated shale oil. Arzneimittelforschung 48: 188–196

    PubMed  CAS  Google Scholar 

  • Fluhr JW, Gloor M, Dietz P, Höffler U (1999a) In vitro activity of 6 antimicrobials against propionibacteria isolates from untreated acne papulopustulosa. Zentralbi Bakteriol 289: 53–61

    Article  CAS  Google Scholar 

  • Fluhr JW, Bösch B, Gloor M, Höffler U (1999b) Efficacy of zinc acetate alone and in combination with erythromycin against propionibacteria in vitro and in vivo. Zentralbi Bakteriol 289: 445–456

    Article  CAS  Google Scholar 

  • Forssmann Th, Gloor M, Gehring W (1994) Antibiotikaresistenzen bei Acne vulgaris - Eine retrospektive Untersuchung an einem antibiotisch vorbehandelten and einem unbehandelten Kollektiv. Z Hautkr 69: 828–832

    Google Scholar 

  • Gardner KJ, Cunliffe WJ, Eady EA, Cove JH (1994) Variation in comedonal antibiotic concentra-tions following application of topical tetracycline for acne vulgaris. Br J Dermato 1131: 649–654

    Article  Google Scholar 

  • Gehring W, Forssmann Th, Jost G, Gloor M (1996) Die keimreduzierende Wirkung von Erythro-mycin and Triclosan bei der atopischen Dermatitis. Akt Dermatol 22: 28–31

    Google Scholar 

  • Gloor M, Bauer W (1979) Die Gesichtsmaske als Grundlage der externen Klindamycintherapie der Acne vulgaris. Hautarzt 30: 380–383

    PubMed  CAS  Google Scholar 

  • Gloor M, Kraft H, Franke M (1978) Effectiveness of topically applied antibiotics on anaerobic bacteria in the pilo-sebaceous duct. Dermatologica 157: 96–104

    Article  PubMed  CAS  Google Scholar 

  • Gloor M, Pfahler E, Neumann W, Höffler U, Hoffmann M, Schmid U (1982a) Lokale Aknetherapie mit Erythromycin and Benzoylperoxid. Z Hautkr 57: 867–878

    PubMed  CAS  Google Scholar 

  • Gloor M, Peters G, Stoika D (1982b) On the resident aerobic bacterial skin flora in unaffected skin of patients with atopic dermatitis and in healthy controls. Dermatologica 164: 258–265

    Article  PubMed  CAS  Google Scholar 

  • Gollnik H, Melzer A (1997) Erythromycin and eine Erythromycin-Zink-Kombination in der to-pischen Aknetherapie. Z Dermatol 183: 8–18

    Google Scholar 

  • Guin JD, Huber DS, Gielerac PL (1979) Antibiotic sensivity of comedonal propionibacterium acnes. Acta Derm Venereol (Stockh) 59: 552–554

    CAS  Google Scholar 

  • Guin JD, Reynolds R, Gielerac PL (1980) Penetration of topical clindamycin into comedones. J Am Acad Dermatol 3: 153–156

    Article  PubMed  CAS  Google Scholar 

  • Habbema L, Koopmans B, Menke HE, Doornweerd S, Boulle KD (1989) A 4% erythromycin and zinc combination (Zineryt) versus 2% erythromycin (Eryderm) in acne vulgaris: a randomized, double blind comparative study. Br J Dermatol 121: 497–502

    Article  PubMed  CAS  Google Scholar 

  • Harkaway KS, McGinley KJ, Foglia AN, Lee WL, Fried F, Shalita AR, Leyden JJ (1992) Antibiotic resistance patterns in coagulase negative staphylocci after treatment with topical erythromycin, benzoyl peroxide, and a combination therapy. Br J Dermatol 126: 586–590

    Article  PubMed  CAS  Google Scholar 

  • Höffler U, Gloor M, Nicolai Hy (1981) Neuraminidase production by propionibacterium acnesstrains isolated from patients with acne vulgaris, seborrhoic eczema and healthy subjects. Zentralbi Bakteriol Hyg I Abt Orig A 250: 122–126

    Google Scholar 

  • Höger PH (1998) Topische Antibiotika-und Antiseptika-Agentien, Spektren, Nebenwirkungen. Hautarzt 49: 331–347

    Article  PubMed  Google Scholar 

  • Hoogdalem EJ van, Terpstra IJ, Baven ALM (1996) Evaluation of the effect of zinc acetate on the stratum corneum penetration kinetics of erythromycin in healthy male volunteers. Skin Pharmacol 9: 104–110

    Article  PubMed  Google Scholar 

  • Hoogdalem EJ van (1998) Transdermal absorption of topical anti-acne agents in man: review of clinical pharmacokinetic data. J Eur Acad Dermatol Venerol 11 Suppl 1: 13–19

    Article  Google Scholar 

  • Knight AG, Vickers CRH, Percival A (1969) The percutaneous absorption of antibacterial sub-stances. Br J Dermatol 84, Suppl 4: 88–91

    Google Scholar 

  • Korting H Ch, Abeck D, Grimm W, Schiller Y (1990) Heutige in vitro Empfindlichkeit von Hautbakterien gegenüber unterschiedlichen Chemotherapeutika. Quantitative Ergebnisse des Mikrodilutionstests. Akt Dermatol 16: 27–31

    Google Scholar 

  • Kresken M, Hafner D (1996) Praevalenz der Antibiotikaresistenz bei klinisch wichtigen Infektionserregern in Mitteleuropa. Chemother 5: 225–230

    Google Scholar 

  • Kurokawa I, Nishijima S, Asada Y (1988) The antibiotic susceptibility of propionibacterium acnes: a 15 year bacteriological study and retrospective evaluation. J Dermatol 15: 149–154

    PubMed  CAS  Google Scholar 

  • Lehmann L, Becker A, Gloor M (1998a) Lokalantibiotika in der Ulkustherapie. Therapeutische Empfehlungen auf der Basis der aktuellen Resistenzsituation. Phlebologie 27: 25–31

    Google Scholar 

  • Lehmann L, Clemens M, Gloor M, Fluhr JW (1998b) Über die Effektivität von Tretinoin in Lokaltherapeutika - Lösungs-versus Suspensionszubereitungen - Wechselwirkungen mit Erythromycin. Akt Dermatol 24: 51–55

    Google Scholar 

  • Leung DYM, Haub P, Strickland I, Travers JB, Norris DA (1998) The role of superantigens in human diseases: therapeutic implications for the treatment of skin diseases. Br J Dermatol 139 Suppl 53: 17–29

    Article  PubMed  CAS  Google Scholar 

  • Leyden JJ, McGinley KJ, Cavalieri St, Webster GF, Mills OH, Kligman AM (1993) Propionibac-terium acnes resistance to antibiotics in acne patients J Am Acad Dermatol 8: 41–45

    Google Scholar 

  • Mills OH, Kligman AM (1978) Treatment of acne vulgaris with topically applied erythromycin and tretinoin. Acta Derm Venereol (Stockh) 58: 555–557

    Google Scholar 

  • Mills OH, Berger RS (1992) A double blind evaluation of tretinoin alone and in combination with erythromycin/benzoyl peroxide in acne vulgaris. Cutis 49: 12–15

    Google Scholar 

  • Milstone EB, McDonald AJ, Scholhamer CF (1981) Pseudomembraneous colitis after topical application of clindamycin. Arch Dermatol 117: 154–155

    Article  PubMed  CAS  Google Scholar 

  • Monographie Chloramphenicol (1994) BAnz 46: 9128

    Google Scholar 

  • Monographie Gentamycin (1994) BAnz 46: 7359

    Google Scholar 

  • Monographie Polymycin B (1994) BAnz 46: 9236

    Google Scholar 

  • Monti G, Tonetto P, Mostert M, Oggero R (1996) Staphylococcus aureus skin colonization in infants with atopic dermatitis. Dermatology 193: 83–87

    Article  PubMed  CAS  Google Scholar 

  • Niedner R (1992) Antibiotika. In: Niedner R, Ziegenmeyer J (Hrsg) Dermatika - Therapeutischer Einsatz, Pharmakologie und Pharmazie, Wissenschaftliche Verlagsgesellschaft, Stuttgart, S 88–99

    Google Scholar 

  • Nishijima S, Akamatsu H, Kurokawa I, Asada Y (1994) The antibiotic susceptibility of propionibacterium acnes and staphylococcus epidermidis isolated from acne. J Dermatol 21: 166–171

    PubMed  CAS  Google Scholar 

  • Packman AM, Brown RH, Dunlap FE, Kraus SJ, Webster GF (1996) Treatment of acne vulgaris: combination of 3% erythromycin and 5% benzoyl peroxide in a gel compared to clindamycin. Int J Dermatol 35: 209–211

    Article  PubMed  CAS  Google Scholar 

  • Parry MF, Rha CK (1986) Pseudomembraneous colitis caused by topical clindamycin phosphate. Arch Dermatol 122: 583–584

    Article  PubMed  CAS  Google Scholar 

  • Puschmann M, Meyer-Rohn J (1982) The efficacy of a topical preparation containing erythromycin in the treatment of acne. Dermatologica 164: 343-349

    Article  PubMed  CAS  Google Scholar 

  • Rietschel R, Duncan BS (1983) Clindamycin phosphate used in combination with tretinoin in the treatment of acne. Int J Dermatol 22: 41–43

    Article  PubMed  CAS  Google Scholar 

  • Sawchuk RJ, Rector TS (1980) Drug kinetics in burn patients. Clin Pharmacokin 5: 548–556

    Article  CAS  Google Scholar 

  • Simon S, Stille W (1994) Antibiotika Therapie in Klinik und Praxis, 8. Aufl., Schattauer, Stuttgart New York

    Google Scholar 

  • Stoughton RB (1970) Bioassay of antimicrobials - a method for measuring penetration of agents into human skin. Arch Derm 101: 160–167

    Article  PubMed  CAS  Google Scholar 

  • Stüttgen G, Täubner U, Bauer E, Zesch A (1986) Die lokale und transcutane Pharmakotherapie. Hautarzt 37: 65–76

    PubMed  Google Scholar 

  • Thong UH, Ferrante A (1979) Inhibition of mitogen induced human lymphocyte proliferation responses by tetracycline analogs. Clin Exp Immunol 35: 443–446

    PubMed  CAS  Google Scholar 

  • Toyoda M, Morohashi M (1998) An overview of topical antibiotics for acne treatment. Dermatology 196: 130–134

    Article  PubMed  CAS  Google Scholar 

  • Tucker SB, Tausend R, Cochran R, Flannigan SA (1984) Comparison of topical clindamycin phosphate, benzoyl peroxide, and a combination of the two for the treatment of acne vulgaris. Br J Dermatol 110: 487–492

    Article  PubMed  CAS  Google Scholar 

  • Webster GF, McGinley KJ, Leyden JJ (1981) Inhibition of lipase production in propionibacterium acnes by subminimal inhibitory concentrations of tetracycline and erythromycin. Br J Dermatol 104: 453–457

    Article  PubMed  CAS  Google Scholar 

  • Wechsler HL, Kirk J, Slone J (1978) Acne treated with a topical tetracycline preparation: results of a one year multi-group study. Int J Dermatol 17: 237–242

    Article  PubMed  CAS  Google Scholar 

  • Williams JV, Vowels BR, Honig PH, Leyden JJ (1998) S. aureus isolation from the lesions, the hands, and the anterior nares of patients with atopic dermatitis. Pediatric Dermatol 15: 194–198

    Article  CAS  Google Scholar 

  • Zesch A (1986) Short and long term risks of topical drugs. Br J Dermatol 115 Suppl 31: 63–70

    Article  PubMed  Google Scholar 

Download references

Authors
  1. M. Gloor
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Gloor, M. (2000). Antibiotika. In: Dermatologische Externatherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58308-7_11

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58308-7_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63533-5

  • Online ISBN: 978-3-642-58308-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation