Abstract
Environmental factors such as smoking, diet, and pollutants act in concert with individual susceptibility to cause most human cancers. This article briefly reviews molecular evidence that two types of susceptibility factors — common predisposing genetic traits and young age at exposure — convey heightened risk from certain exposures. Examples are drawn from molecular epidemiologic studies of common environmental carcinogens such as polycyclic aromatic hydrocarbons (PAH) and aromatic amines. Understanding of both genetic and acquired susceptibility in the population will be instrumental in developing health and regulatory policies that adequately protect of the more susceptible groups from risks of environmental carcinogens.
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References
Ambrosone CB, Freudenheim JL, Graham S, Marshal JR, Vena JE, Brasure JR, Michalek AM, Laughlin R, Nemoto T, Gillenwater KA et al (1996) Cigarette smoking, n-acetyltransferase 2 genetic polymorphisms, and breast cancer risk. JAMA 276: 1494–1501
Bartsch J, Hietanen E (1996) The role of individual susceptiblity in cancer burden related to environmental exposure. Environ Health Perspect 104 (Suppl) 3: 569–577
Bearer CF (1995) Environmental health hazards: how children are different from adults. Future Child 5: 11–26
Bell DA, Taylor JA, Paulson DE, Robertson CN, Mohler JL, Lucier GW (1993) Genetic risk and carcinogen exposure: a common inherited defect of the carcinogen-metabolism gene glutathione S-transferase Ml (GSTM1) that increases susceptibility to bladder cancer. J Natl Cancer Inst 85: 1159–1164
Goldman LR (1995) Children-unique and vulnerable. Environmental risks facing children and recommendations for response. Environ Health Perspect 103 (Suppl) 6: 13–18
Hayashi S, Watanabe J, Kawajiri K (1992) High susceptibility to lung cancer analyzed in terms of combined genotype of P450IA1 and Mu-class Glutathione S-transferase genes. Jpn J Cancer Res 83: 866–870
Hegmann KT, Fraser AM, Keaney RP, Moser SE, Nilasena DS (1993) The effect of age at smoking initiation on lung cancer risk. Epidemiology 4: 444–448
Kang DH, Correa-Villasenor A, Breysse PN, Strickland PT (1995) Correlation of urinary 1hydroxypyrene glucuronide concentration between children and their mothers. Proc Am Assoc Cancer Res 36: 107
Kato S, Bowman ED, Harrington AM, Blomeke B, Shields PG (1995) Human lung carcinogen-DNA adduct levels mediated by genetic polymorphisms in vivo. J Natl Cancer Inst 87: 902–907
Kawajiri K, Eguchi H, Nakachi K, Sekiya T, Yamamoto M (1996) Association of CYP1A1 germ line polymorphisms with mutations of the p53 gene in lung cancer. Cancer Res 56: 72–76
Landi MT, Zocchetti C, Bernucci I, Kadlubar FF, Tannenbaum S, Skipper P, Bartsch H, Mala-veille C, Shields P, Caporaso NE et al (1996) Cytochrome P4501A2: enzyme induction and genetic control in determining 4-aminobiphenyl-hemoglobin adduct levels. Cancer Epidemiol Biomarkers Prey 5: 693–698
McGlynn KA, Rosvold EA, Lustbader ED, Hu Y, Clapper ML, Zhou T, Wild CP, Xia X-L, Baffoe-Bonnie A, Ofori-Adjei D et al (1995) Susceptibility to hepatocellular carcinoma is associated with genetic variation in the enzymatic detoxification of aflatoxin B1. Proc Natl Acad Sci USA 92: 2384–2397
McWilliams JE, Sanderson BJS, Harris EL, Richert-Boe KE, Henner WD (1995) Glutathione S-transferase M1 (GSTM1) deficiency and lung cancer risk. Cancer Epidemiol Biomarkers Prey 4: 589–594
Millikan R, DeVoto E, Newman B, Savitz D (1995) Studying environmental influences and breast cancer risk: suggestions for an integrated population-based approach. Breast Cancer Res Treat 35: 79–89
Mooney LA, Bell DA, Santella RM, Van Bennekum AM, Ottman R, Paik M, Blaner WS, Lucier GW, Covey L, Young TL et al (1997) Contribution of genetic and nutritional factors to DNA damage in heavy smokers. Carcinogenesis 18: 503–509
Mott L, Vance F, Curtis J (1994) Handle with care: children and environmental carcinogens. Natural Resources Defense Council, New York
Nakachi K, Imai K, Hayashi S, Watanabe J, Kawajiri K (1991) Genetic susceptibility to squamous cell carinoma of the lung in relation to cigarette smoking dose. Cancer Res 51: 5177–5180
National Academy of Sciences (1993) Pesticides in the diets of infants and children. National Academy Press, Washington, DC
National Academy of Sciences (1994) Science and judgement of risk assessment. National Academy Press, Washington, DC
Perera FP (1996) Molecular epidemiology: insights into cancer susceptibility, risk assessment, and prevention. J Natl Cancer Inst 88: 496–509
Perera FP (1997) Environment and cancer: who are susceptible? Science 278: 1068–1073
Perera FP, Weinstein IB (1982) Molecular epidemiology and carcinogen-DNA adduct detection: new approaches to studies of human cancer causation. J Chronic Dis 35: 581–600
Ryberg D, Hewer A, Phillips DH, Haugen A (1194a) Different susceptibility to smoking-induced DNA damage among male and female lung cancer patients. Cancer Res 54: 5801–5803
Ryberg D, Kure E, Lystad S, Skaug V, Stangeland L, Mercy K, Borresen AL, Haugen A (1994b) mutations in lung tumors: relationship to putative susceptibility markers for cancer. Cancer Res 54: 1551–1555
Tokunaga M, Land CE, Yamamoto T, Asano M, Tokvoka S, Ezaki H et al (1987) Incidence of female breast cancer among atomic bomb survivors. Hiroshima and Nagasaki 1950–1980. Radiat Res 112: 243–272
Vineis P, Bartsch H, Caporaso N, Harrington AM, Kadlubar FF, Landl MT, Malaveille C, Shields PG, Skipper P, Talaska G et al (1994) Genetically based N-acetyltransferase metabolic polymorphism and low-level environmental exposure to carcinogens. Nature 369: 154–156
Whyatt RM, Santella RM, Jedrychowski W, Garte SJ, Bell DA, Ottman R, Gladek-Yarborough A, Cosma G, Young T-L, Cooper TB, Randall MC, Manchester DK, Perera FP (1998) Relationship between ambient air pollution and procarcinogenic DNA damage in Polish mothers and newborns. Env Health Persp 106 (Suppl 3): 821–826
Whyatt RM, Bell DA, Jedrychowski W, Santella RM, Garte SJ, Gladek-Yarborough A, Cosma G, Manchester DK, Randall MC, Young T-L, Cooper TB, Ottman R, Perera FP: Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 enzyme induction and genotype. Carcinogenesis.
Yu MC, Skipper PL, Taghizadeh K, Tannenbaum SR, Chan KK, Henderson BE, Ross RK (1994) Acetylator phenotype, aminobiphenyl-hemoglobin adduct levels, and bladder cancer risk in white, black and Asian men in Los Angeles, California. J Natl Cancer Inst 86: 712–716
Yu MC, Ross RK, Chan KK, Henderson BE, Skipper PL, Tannenbaum SR, Coetzee GA (1995) Glutathione S-transferase Ml genotype affects aminobiphenyl-hemoglobin adduct levels in White, Black and Asian smokers and nonsmokers. Cancer Epidemiol Biomarkers Prey 4: 861–864
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Perera, F.P. (1998). Molecular Epidemiology of Environmental Carcinogenesis. In: Schwab, M., Rabes, H.M., Munk, K., Hofschneider, H.P. (eds) Genes and Environment in Cancer. Recent Results in Cancer Research, vol 154. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46870-4_3
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DOI: https://doi.org/10.1007/978-3-642-46870-4_3
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